Current VHRC Research Opportunities

VASCULAR DISEASE is the major cause of death and morbidity in humans in the western world. Our goal is to explore the pathophysiology of vascular diseases and to develop novel therapeutics. Our primary emphasis is on arterial vessel walls with a focus on endothelial and smooth muscle cell biology. Using molecular and cellular biology techniques, in combination with functional genomics and proteomics strategies, the Vascular Biology Research Group in DCU is focusing on the following specific areas of research:

• Vascular and developmental biology
• Biomechanical induction of vascular remodeling
• Nutritional regulation of vascular structure/gene expression
• Molecular pharmacology and signal transduction
• Vascular disease and diabetes
• Vascular genomics and proteomics

Our overall goal is to understand how the vascular system responds to physiological and pathological changes. Understanding these processes will provide new insight into novel therapeutic approaches including tissue engineering, vascular replacement therapy and gene therapy to treat vascular diseases such as hypertension, coronary artery disease, stroke and artherosclerosis.

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Please e-mail comments to: phil.cummins@dcu.ie