Mechanical and Manufacturing Engineering

Biographical Details:

B.Eng. (first class) in Mechanical Engineering from University of Limerick. M.Eng. by research in computational biofluids from University of Limerick. PhD from Trinity College Dublin in the area of cardiovascular biomechanics and finite element modelling in 2004. Dr. Lally joined DCU as a lecturer in Biomedical Engineering in 2004.

Research Interests:

Biofluids, Cardiovascular biomechanics, Finite element modelling, Soft tissue testing and constitutive modelling, Vascular Tissue Engineering, Medical device design

Selected Peer Reviewed Journals

• Dr. Caitriona Lally. .
• A. Colombo, S. Guha, J. N. Mackle, P. A. Cahill, C Lally. 2012. Cyclic strain amplitude dictates the growth response of vascular smooth muscle cells in vitro: role in in-stent restenosis and inhibition with a sirolimus-drug eluting stent. Biomechanics And Modeling In Mechanobiology,
• A. Creane, E. Maher, S. Sultan, N. Hynes, D. Kelly, C. Lally. 2012. A Remodelling Metric For Angular Fibre Distributions And Its Application To Diseased Carotid Bifurcations. Biomechanics And Modeling In Mechanobiology, 11, 6, pp869-882.
• C. Brackmann, J.-O. Dahlberg, E. Vrana, C. Lally, P. Gatenholm, A. Enejder. 2012. Non-linear microscopy of smooth muscle cells in artificial extracellular matrices made by cellulose. Journal Of Biophotonics, 5, 5-6, pp404-414.
• E. Campbell, P. A. Cahill, C. Lally. 2012. Investigation of a small-diameter decellularised artery as a potential scaffold for vascular tissue engineering; Biomechanical evaluation and preliminary cell seeding. Journal Of The Mechanical Behavior Of Biomedical Materials, 14,, pp130-142.
• E. Maher; A. Creane; S. Sultan; N. Hynes; C. Lally, D. Kelly. 2012. An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue. Journal Of The Mechanical Behavior Of Biomedical Materials, 12,, pp9-19.
• E. Maher; A. Creane; S. Sultan; N. Hynes; C. Lally, D. Kelly. 2012. Site Specific Inelasticity of Arterial Tissue, Journal of Biomechanics. Journal Of Biomechanics, 45, 8, pp1393-1399.
• H. Zahedmanesh, H. van Oosterwyck, C. Lally. 2012. A multiscale mechanobiological model of in-stent restenosis; deciphering the role of matrix metalloproteinase and extracellular matrix changes.. Computer Methods In Biomechanics And Biomedical Engineering,
• V. Flamini, C. Kerskens, C. Simms, C. Lally. 2012. Fibre orientation of fresh & frozen porcine aorta determined non-invasively using diffusion tensor imaging. Medical Engineering & Physics,
• Zahedmanesh, H. and C. Lally. 2012. A multiscale mechanobiological modelling framework using agent based models and finite element analysis; Application to vascular tissue engineering. Biomechanics And Modeling In Mechanobiology, 11,, pp363-377.
• A. Creane, E. Maher, S. Sultan, N. Hynes, D. Kelly, C. Lally. 2011. A Remodelling Metric For Angular Fibre Distributions And Its Application To Diseased Carotid Bifurcations. Biomechanics And Modeling In Mechanobiology, 10, 6, pp831-843.
• Creane, A., E. Maher, S. Sultan, N. Hynes, D. Kelly, C. Lally. 2011. Prediction of fibre architecture and adaptation in diseased carotid bifurcations. Biomechanics And Modeling In Mechanobiology, 10, 6, pp831-843.
• E. Maher; A. Creane; S. Sultan; N. Hynes; C. Lally, D. Kelly. 2011. Inelasticity of Human Carotid Atherosclerotic Plaque. Annals Of Biomedical Engineering, 39,, pp2445-2455.
• S. Guha, J.P. Cullen, D. Morrow, A. Colombo, C. Lally, D. Walls, E.M. Redmond, P.A. Cahill. 2011. Glycogen Synthase Kinase 3 beta (GSK-3ß) positively regulates Notch signaling in vascular smooth muscle cells: Role in cell proliferation and survival. Basic Research In Cardiology, 106, 5, pp773-785.
• Zahedmanesh, H., J.N. Mackle, A. Sellborn, K. Drotz, A. Bodin, P. Gatenholm, C. Lally,. 2011. Bacterial cellulose as a potential vascular graft: Mechanical characterization and constitutive model development. Journal Of Biomedical Materials Research, Part B : Applied Biomaterials, 97B, 1, pp105-113..
• A. Colombo, H. Zahedmanesh, D.M. Toner, P.A. Cahill, C. Lally. 2010. A method to develop mock arteries suitable for cell seeding and in-vitro cell culture experiments.. Journal Of The Mechanical Behavior Of Biomedical Materials, 6, 3, pp470-477.
• A.P. Creane, E.J. Maher; S. Sultan, N. Hynes, D.J. Kelly, C. Lally. 2010. Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography. Computers In Biology And Medicine, 40, 4, pp419-429.
• C.J. Boyle, A. Lennon, M. Early, D.J. Kelly, C. Lally, P.J. Prendergast. 2010. Cell-centred computational simulation methodologies for mechanobiological modelling: Application to neointima development in stents. Philosophical Transactions Of The Royal Society Of London Series B - Bio Sci, 368, , pp2919-2935.
• K. M. Moerman, C. Kerskens, C. Lally, V. Flamini and C. Simms. 2010. Evaluation of a validation method for MR imaging-based motion tracking using image simulation. In Special issue on Image Processing and Analysis in Biomechanics. Eurasip Journal On Image And Video Processing, Article ID 942131,
• V. Flamini, C. Kerskens, K.M. Moerman, C. Simms and C. Lally. 2010. Imaging arterial fibres using diffusion tensor imaging ¿ Feasibility study & preliminary results. In Special issue on Image Processing and Analysis in Biomechanics. Eurasip Journal On Image And Video Processing, Article ID 904091,
• Zahedmanesh, H., D.J. Kelly, C. Lally.. 2010. Simulation of a balloon expandable stent in a realistic coronary artery; Determination of the optimum modelling strategy. Journal Of Biomechanics, 43, 11, pp2126-2132.
• H. Zahedmanesh, C. Lally. 2009. Determination of the Influence of Stent Strut Thickness Using the Finite Element Method: Implications for Vascular Injury and In-Stent Restenosis,. Medical & Biological Engineering & Computing, 47, 4, pp385-393.
• I. Pericevic, C. Lally, D. Toner, D. Kelly. 2009. The influence of plaque composition on underlying arterial wall stress during stent expansion: The case for lesion-specific stents. Medical Engineering & Physics, 31, , pp428-433.
• M. Early, C. Lally, P.J. Prendergast, D.J. Kelly. 2009. Stresses in peripheral arteries following stent placement: A finite element analysis. Computer Methods In Biomechanics And Biomedical Engineering, 12, 1, pp25-33.
• Maher, E., A. Creane, S. Sultan, N. Hynes, C. Lally, D. J. Kelly. 2009. Tensile and compressive properties of fresh human carotid atherosclerotic plaques. Journal Of Biomechanics, 42, 16, pp2760-2767.
• A. Colombo, P.A. Cahill, C. Lally. 2008. An analysis of the strain field in biaxial Flexcell membranes for different waveforms and frequencies. Proceedings Of The Institution Of Mechanical Engineers, Part H, 222, H8, pp1235-1245.
• A. Colombo, P.A. Cahill, C.Lally. 2007. The frequency of cyclic stretch determines the proliferative and apoptotic capacity of vascular smooth muscle cells in vitro. Arteriosclerosis Thrombosis And Vascular Biology, 27, 6, ppE74-E74.
• C. Lally. 2007. Cardiovascular stent design and vessel stresses: A finite element analysis. Irish Journal Of Medical Science, 176 Suppl 2, 1, pp2-2.
• D. Toner, F. Basir and C. Lally. 2006. An investigation into the effect of stent strut thickness on restenosis using the finite element method and validation using an in-vitro compliant artery model. Journal Of Biomechanics, 39 Suppl. 1, , ppS403-S403.
• Dr. Caitriona Lally. 2006. A computational model of in-stent restenosis.. Journal Of Biomechanics, 39 Supplement 1, , ppS641-S641.
• Dr. Caitriona Lally. 2006. All metal stents are not alike in the SFA: What is the impact of stent fractures and can biodegradable stents help?. Irish Journal Of Medical Science, 175 Suppl 2, , pp2-2.
• Lally C, Dolan F, Prendergast PJ. 2005. Cardiovascular stent design and vessel stresses: a finite element analysis.. Journal Of Biomechanics, 38, 8, pp1574-1581.
• Lally C, Reid AJ, Prendergast PJ. 2004. Elastic behaviour of porcine coronary artery tissue under uniaxial and equibiaxial tension.. Annals Of Biomedical Engineering, 32, , pp1355-1364.
• Prendergast PJ, Lally C, Daly S, Reid AJ, Lee TC, Quinn D, Dolan F. 2003. Analysis of prolapse in cardiovascular stents: a constitutive equation for vascular tissue and finite element modelling.. Journal Of Biomechanical Engineering - Transactions Of Asme, 125, , pp692-699.
• Lally C., P.J. Prendergast, T.C. Lee, D. Quinn and F. Dolan. 2001. Finite element analysis to quantify tissue prolapse within three designs of cardiovascular stents. In Technology and Health Care. 9,, pp110-112.

Selected Chapters

• H. Zahedmanesh, C. Lally. 2013. Multiscale Modeling in Vascular Disease and Tissue Engineering.
• A. Creane, D. J. Kelly, C. Lally. 2012. Patient Specific Computational Modelling in Cardiovascular Mechanics.
• E. M. Redmond, C. Lally, P.A. Cahill. 2012. Hemodynamic Control of Vascular Smooth Muscle Function.
• H. Zahedmanesh, P.A. Cahill, C. Lally,. 2012. Vascular stent design optimisation using numerical modelling techniques.
• C. Lally, D.J. Kelly, P.J. Prendergast. 2006. Stents. Encyclopedia of Biomedical Engineering
• C. Lally, P.J. Prendergast. 2006. Simulation of in-stent restenosis and its relationship with cardiovascular stent design. Mechanics of Biological Tissue, pp233-245.

• P.J. Prendergast, N.C. Nowlan, C. Lally, Experiment and computation in mechanobiology, and new application in cardiology and evolution, In: J. Piekarski ed.Advanced Course on Tissue remodeling, - , , 219 - 240
• C. Lally, Cardiovascular stent design and vessel stresses: A finte element analysis, 5th Annual Western Vascular Symposium, 11-MAY-07 - , , 60 - 60
• A. Colombo, P.A. Cahill, C.Lally, The frequency of cyclic stretch determines the proliferative and apoptotic capacity of vascular smooth muscle cells in vitro., Arteriosclerosis, Thrombosis and Vascular Biology, 19-APR-07 - 21-APR-07, Chicago, IL, USA, E74 - E74
• P. Kearney, C. Lally, P.J. Prendergast, D. J. Kelly., Computational modelling of drug diffusion following expansion of drug eluting stents, Bioengineering in Ireland (13) and the 27th Meeting of the Northern Ireland Biomedical Engineering Society, 26-JAN-07 - 28-JAN-07, Enniskillen, N. Ireland, 63 - 63
• D. Toner, F. Dolan, C. Lally, Validation of numerical models of stent expansion using an in-vitro compliant artery model., In Proceedings of Bioengineering in Ireland (13) and the 27th Meeting of the Northern Ireland Biomedical Engineering Society, 26-JAN-07 - 28-JAN-07, Enniskillen, N. Ireland, 61 - 61
• A. Colombo, P.A. Cahill, F. Dolan, C.Lally, Mechanical evaluation and calibration of the FX-4000 Flexercell tension plus system for different waveforms and amplitudes, Bioengineering in Ireland (13) and the 27th Meeting of the Northern Ireland Biomedical Engineering Society, 26-JAN-07 - 28-JAN-07, Enniskillen, N. Ireland, 60 - 60
• R. McLoughlin, P. O¿Reilly, C. Lally, F. Dolan, P.J. Prendergast., An experimental investigation of damage accumulation in porcine coronary arterial tissue using fatigue tests., Bioengineering in Ireland (13) and the 27th Meeting of the Northern Ireland Biomedical Engineering Society, 26-JAN-07 - 28-JAN-07, Enniskillen, N. Ireland,, 100 - 100
• D. Toner, F. Basir and C. Lally, An investigation into the effect of stent strut thickness on restenosis using the finite element method and validation using an in-vitro compliant artery model., Joint European Society of Biomechanics and World Congress of Biomechanics meerting, 29-JUL-06 - 04-AUG-06, Munich, S403 - S403
• C. Lally and P.J. Prendergast, A computational model of in-stent restenosis, Joint European Society of Biomechanics and World Congress of Biomechanics conference, 29-JUL-06 - 04-AUG-06, Munich, S641 - S641
• C.Lally , All metal stents are not alike in the SFA: What is the impact of stent fractures and can biodegradable stents help?, In: Irish Journal of Medical Science, 175 Suppl 2,2006 ed.The 4th Annual Western Vascular Symposium, 10-MAY-06 - 12-MAY-06, Galway, 2 - 2
• E. Campbell, C. Lally. , Investigation of the influence of tissue preservation methods on the mechanical properties of porcine aortic tissue., Northern Ireland Biomedical Engineering Society Spring Meeting,, 07-APR-06 - , Belfast, N. Ireland,, 22 -
• F. Basir, D. Toner, C. Lally., An investigation into the influence of stent strut thickness on in-stent restenosis using the finite element method. , In: Prof. Peter McHugh and Dr. David Fitzpatrick ed.The 12th Annual Conference on the Section of Bioengineering of the Royal Academy of Medicine in Ireland, 26-JAN-06 - , Galway, Ireland, 111 -
• F.F. Basir, C. Lally. S. Hashmi., An investigation into the effect of stent strut thickness on in-stent restenosis using the finite element method., Northern Ireland Biomedical Engineering Society Spring Meeting,, 07-APR-05 - , Belfast, N. Ireland
• D. Toner, C. Lally., The relationship between variations in uniaxial tensile properties of porcine aortic tissue and distance from the heart., Northern Ireland Biomedical Engineering Society Spring Meeting,, 07-APR-05 - , Belfast, N. Ireland
• F.F. Basir, C. Lally. S. Hashmi., An investigation into the influence of strut thickness on stent deployment using the finite element method, 8th Annual Sir Bernard Crossland Symposium,, 01-MAR-05 - , Antrim, N. Ireland
• Lally C., F. Dolan, P.J. Prendergast., A comparison of the stress distribution in an atherosclerotic vessel stented with a flexible versus a rigid stent, 14th European Society of Biomechanics, 04-JUL-04 - 07-JUL-04, 's-Hertogenbosch, The Netherlands
• Prendergast PJ, C. Lally. , Simulation of in-stent restenosis and its relationship with cardiovascular stent design., IUTAM Symposium on Mechanics of Biological Tissue, 27-JUN-04 - 02-JUL-04, Graz, Austria
• Lally C, Prendergast PJ. , Simulation of in-stent restenosis and its relationship with cardiovascular stent design., IUTAM Symposium on Mechanics of Biological Tissue, 27-JUN-04 - 02-JUL-04, Graz, Austria
• Lally C, F. Dolan, P.J. Prendergast., A computational model of in-stent restenosis in response to mechanical stress., 10th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland., 30-JAN-04 - 31-JAN-04, Limerick, Ireland
• Lally C, Prendergast PJ., An investigation into the applicability of a Mooney-Rivlin constitutive equation for modelling vascular tissue in cardiovascular stenting procedures., International Congress on Computational Biomechanics, 24-SEP-03 - 26-SEP-03, Zaragoza, Spain
• Lally C., P.J. Prendergast, T.C. Lee, D. Quinn and F. Dolan., Arterial tissue damage formation under cyclic loading and simulation of in-stent restenosis., 9th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, 24-JAN-03 - 25-FEB-03, Cavan, Ireland
• Lally C., P.J. Prendergast, A.B. Lennon, D. Quinn, F. Dolan., Finite element analysis of tissue prolapse within intravascular stents calculated using a single repeating unit of a stent and a full 3D model of a stent. , The 13th European Society of Biomechanics , 01-SEP-02 - 04-SEP-02, Wroclaw, Poland, 537 - 538
• Lally C., P.J. Prendergast, F. Dolan., 3D finite element analysis of an intravascular stenting procedure using a NIROYAL stent., 4th World Congress of Biomechanics., 04-AUG-02 - 09-AUG-02, Calgary, Canada
• Lally C., P.J. Prendergast, F. Dolan., A biomechanical analysis of intravascular stenting of coronary arteries using the finite element method., 5th Annual Sir Bernard Crossland Symposium., 12-MAR-02 - 13-MAR-02, Antrim, N. Ireland
• Lally C., P.J. Prendergast, F. Dolan., A biomechanical analysis of intravascular stenting of coronary arteries using the finite element method., 5th Annual Sir Bernard Crossland Symposium, 12-MAR-02 - 13-MAR-02, Antrim, N. Ireland
• Lally, C, P.J. Prendergast, J.C. Messenger, S.J. Chen, A. Wu, J. Carroll and F. Dolan., Finite element analysis of the stress distribution within an atherosclerotic coronary artery during balloon angioplasty., The 8th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland and the 16th Meeting of the Northern Ireland Biomedical Engineering Society., 26-JAN-02 - 27-JAN-02, Sligo, Ireland
• Lally C., P.J. Prendergast, T.C. Lee, D. Quinn and F. Dolan., Finite element analysis to quantify tissue prolapse within three designs of cardiovascular stents., European Society of Engineering in Medicine (ESEM) Conference., 04-MAY-01 - 05-MAY-01, Belfast, N. Ireland, 110 - 112
• Lally C., P.J. Prendergast, T.C. Lee, D. Quinn and F. Dolan., An investigation of the extent of tissue prolapse within various stent designs using the finite element method., The 7th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, 28-JAN-01 - 29-JAN-01, Louth, Ireland
• Lally C, McGloughlin T., The role of graft/artery Geometry in blood flow., 12th European Society of Biomechanics, 28-AUG-00 - 30-AUG-00, Dublin, Ireland
• Lally C, McGloughlin T., Effects of Geometry on the Flow Patterns of Femoral End-to-Side Distal Graft-Artery Anastomoses., The University of Limerick Biomedical Institute 3rd Annual Research Day, 25-JUN-00 - 25-JUN-00, Limerick, Ireland
• Lally C, McGloughlin T., Geometrical influences on flow patterns in distal graft-artery anastomoses., The Sylvestor O'Halloran Surgical Scientific Meeting, Irish Journal of Medical Science., 03-MAR-00 - 04-MAR-00, Limerick, Ireland
• Lally C, McGloughlin T., Effects of Geometry on the Flow Patterns of Femoral End-to-Side Distal Graft-Artery Anastomoses., University of Limerick Biomedical Institute 2nd Annual Research Day., 25-JUN-99 - 25-JUN-99, Limerick, Ireland