NICB

Biographical Details:

1989-1993: BSc (Hons) Biotechnology, Dublin City University 1993-1997: Ph.D, National Cell and Tissue Culture Centre (NCTCC), DCU Oct 1997-May 2001: Post-doctoral Research Scientist, NCTCC, DCU June 2001-present: Senior Research Scientist, NICB, DCU October 2007-present: Programme Leader, Proteomics Core Facility, NICB, DCU

Research Interests:

proteomics, mass spectrometry, bioprocessing, uveal melanoma

Selected Peer Reviewed Journals

• Clarke C, Henry M, Doolan P, Kelly S, Aherne S, Sanchez N, Kelly P, Kinsella P, Breen L, Madden SF, Zhang L, Leonard M, Clynes M, Meleady P, Barron N.. 2012. Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate.. Bmc Genomics, 13, 1, pp656-.
• Meleady P, Gallagher M, Clarke C, Henry M, Sanchez N, Barron N, Clynes M. 2012. Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells.. Journal Of Biotechnology, 160, 3-4, pp251-262.
• Linge A, Kennedy S, O'Flynn D, Beatty S, Moriarty P, Henry M, Clynes M, Larkin A, Meleady P.. 2012. Differential expression of fourteen proteins between uveal melanoma from patients who subsequently developed distant metastases versus those who did not.. Investigative Opthamology & Visual Science, 53, 8, pp4634-4643.
• O'Connell K, Prencipe M, O'Neill A, Corcoran C, Rani S, Henry M, Dowling P, Meleady P, O'Driscoll L, Watson W, O'Connor R.. 2012. The use of LC-MS to identify differentially expressed proteins in docetaxel-resistant prostate cancer cell lines.. Proteomics, 12, 13, pp2115-2126.
• Clarke C, Doolan P, Barron N, Meleady P, Madden SF, DiNino D, Leonard M, Clynes M.. 2012. CGCDB: a web-based resource for the investigation of gene coexpression in CHO cell culture.. Biotechnology And Bioengineering, 109, 6, pp1368-1370.
• Meleady P, Hoffrogge R, Henry M, Rupp O, Bort JH, Clarke C, Brinkrolf K, Kelly S, Müller B, Doolan P, Hackl M, Beckmann TF, Noll T, Grillari J, Barron N, Pühler A, Clynes M, Borth N.. 2012. Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics. Biotechnology And Bioengineering, 109, 6, pp1386-1394.
• Doolan P, Barron N, Kinsella P, Clarke C, Meleady P, O¿Sullivan F, Melville M, Leonard M, Clynes M. 2012. Microarray expression profiling identifies several genes associated with regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines. Biotechnology Journal, 7, 4, pp516-526.
• Reeves EP, Bergin DA, Fitzgerald S, Hayes E, Keenan J, Henry M, Meleady P, Vega-Carrascal I, Murray MA, Low TB, McCarthy C, O¿Brien E, Clynes M, Gunaratnam C, McElvaney NG. 2012. A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis. Journal Of Cystic Fibrosis, 11, 2, pp100-107.
• Zaborowska I, Kellner K, Henry M, Meleady P, Walsh D. 2012. Recruitment of host translation initiation factor eIF4G by the Vaccinia Virus ssDNA-binding protein I3. Virology, 425, 1, pp11-22.
• Egan E, Dowling P, O¿Connor PL, Henry M, Meleady P, Zierath JR, O¿Gorman. 2011. 2D-DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training. Proteomics, 11, 8, pp1413-1428.
• Eustace AJ, Dowling P, Henry M, Doolan P, Meleady P, Clynes M, Crown J, O'Donovan N.. 2011. 2D-DIGE analysis of phospho-enriched fractions from dasatinib-treated melanoma cell lines.. Journal Of Proteomics, 74, 4, pp490-501.
• Clarke C, Doolan, P., Barron, N., Meleady, P., O'Sullivan, F., Gammell, P., Melville, M., Leonard, M., Clynes, M. 2011. Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity. Journal Of Biotechnology, 155, 3, pp350-359.
• Meleady P, Doolan P, Henry M, Barron N, Keenan J, O'Sullivan F, Clarke C, Gammell P, Melville M, Leonard M, Clynes M.. 2011. Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype.. Bmc Biotechnology, 11, 78
• Barron N, Kumar N, Sanchez N, Doolan P, Clarke C, Meleady P, O'Sullivan F, Clynes M.. 2011. Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7.. Journal Of Biotechnology, 151, 2, pp204-211.
• Clarke, C., Doolan, P., Barron, N., Meleady, P., O'Sullivan, F., Gammell, P., Melville, M., Leonard, M., Clynes, M.. 2011. Predicting cell-specific productivity from CHO gene expression.. Journal Of Biotechnology, 151, 2, pp159-165.
• Bergin D, Reeves E, Meleady P, Henry M, McElvaney O, Carroll T, Condron C, Chotirmall S, Clynes M, O'Neill S, McElvaney NG. 2010. Alpha-1 antitrypsin regulates immune complex and interleukin-8 induced neutrophil chemotaxis. Journal Of Clinical Investigation, 120, 12, pp4236-4250.
• Linge A, Meleady P, Henry M, Clynes M, Kasper M, Barth K. 2010. Bleomycin treatment of A549 human lung cancer cells results in association of MGr1-Ag and caveolin-1 in lipid rafts. International Journal Of Biochemistry & Cell Biology,
• Doolan P, Meleady P, Barron N, Henry M, Gallagher R, Gammell P, Melville M, Sinacore M, McCarthy K, Leonard M, Charlebois T, Clynes M. 2010. Microarray and proteomics expression profiling identifies several candidates, including the Valosin-containing Protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines. Biotechnology And Bioengineering, 106, 1, pp42-56.
• Muniyappa MK, Dowling P, Henry M, Meleady P, Doolan P, Gammell P, Clynes M, Barron N. 2009. MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines. European Journal Of Cancer, 45, 17, pp3104-3118.
• Keenan J, Murphy L, Henry M, Meleady P, Clynes M. 2009. Proteomic analysis of multidrug-resistance mechanisms in adriamycin-resistant variants of DLKP, a squamous lung cancer cell line. Proteomics, 9, 6, pp1556-1566.
• Walsh N, O'Donovan N, Kennedy S, Henry M, Meleady P, Clynes M, Dowling P. 2009. Identification of pancreatic cancer invasion-related proteins by proteomic analysis. Proteome Science, 7, 3
• Dowling P, Wormald R, Meleady P, Henry M, Curran A, Clynes M. 2008. Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis. Journal Of Proteomics, 71, 2, pp168-175.
• Kumar N*, Maurya P*, Gammell P, Clynes M & Meleady P. 2008. Proteomic profiling of secreted proteins from CHO cells using Surface Enhanced Laser Desorption Ionisation Time of Flight Mass Spectrometry (SELDI-TOF MS). Biotechnology Progress, 24, 1, pp273-278.
• Meleady P, Henry M, Gammell P, Doolan P, Sinacore M, Melville M, Francullo L, Leonard M, Charlebois T, & Clynes M. 2008. Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol. Proteomics, 8, 13, pp2611-2624.
• Walsh N, Dowling P, O¿Donovan N, Henry M, Meleady P, Clynes M. 2008. Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells. Journal Of Proteomics, 2, 71, pp561-571.
• Murphy L, Henry M, Meleady P, Clynes M, Keenan J Dr. Paula Meleady. 2008. Proteomic investigation of taxol and taxotere resistance and invasiveness in a squamous lung carcinoma cell line. Biochimica Et Biophysica Acta-proteins And Proteomics, 1784, 9, pp1184-1191.
• Doolan P*, Melville M* Gammell P, Sinacore M, Meleady P, McCarthy K, Francullo L, Leonard M, Charlebois T, Clynes M. 2008. Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2. Molecular Biotechnology, 39, 3, pp187-199.
• Kumar N., Gammell P, Meleady P, Henry M. & Clynes M. 2008. Proteome Analysis of Differential Protein Expression Following Low Temperature Culture of Suspension CHO-K1 Cells. Bmc Biotechnology, 8, 42
• Dowling P, Maurya P, Meleady P, Glynn SA, Dowd AJ, Henry M, Clynes M. 2007. Purification and Identification of a 7.6kDa Protein in Media Conditioned by Superinvasive Cancer Cells. Anticancer Research, 27, 3A, pp1309-1317.
• Dowling P, Meleady P, Dowd A, Henry M, Glynn S, Clynes M. 2007. Proteomic analysis of isolated membrane fractions from superinvasive cancer cells. Biochimica Et Biophysica Acta-proteins And Proteomics, 1774, 1, pp93-101.
• Dowling P, O¿ Driscoll L, Meleady P, Henry M, Roy S, Ballot J, Moriarty M, Crown J, Clynes. 2007. Two-dimensional difference gel electrophoresis of the lung squamous cell carcinoma versus normal sera demonstrates consistent alterations in the levels of 10 specific proteins. Electrophoresis, 28, 23, pp4302-4310.
• Dowling P, O¿ Driscoll L, Meleady P, Henry M, Roy S, Ballot J, Moriarty M, Crown J, Clynes M. 2007. Two-dimensional difference gel electrophoresis of the lung squamous cell carcinoma versus normal sera demonstrates consistent alterations in the levels of 10 specific proteins. Electrophoresis, 28, 23, pp4302-4310.
• Dowling P, O¿Driscoll L, O¿Sullivan F, Dowd A, Henry M, Jeppesen PB, Meleady P*, Clynes M*. 2006. Proteomic screening of glucose-responsive and glucose non-responsive MIN-6 beta cells reveals differential expression of proteins involved in protein folding, secretion and oxidative stress. Proteomics, 6, 24, pp6578-6587.
• Walsh, D.*, Meleady, P.*, Power, B., Morley, S.J. and Clynes, M. 2003. Increased levels of the translation initiation factor, eIF4E, in differentiating epithelial lung tumour cell lines. Differentiation, 71, , pp126-134.
• Liang, Y., Meleady, P., Cleary, I., McDonnell, S., Connolly, L. and Clynes, M. 2001. Selection with melphalan, or taxol, yields variants with different patterns of multidrug resistance, and integrin expression and in vitro invasiveness. European Journal Of Cancer, 37, , pp1041-1052.
• Meleady, P, Clynes, M. 2001. Bromodeoxyuridine induces integrin expression at transcriptional (b2 subunit) and post-transcriptional (a1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines. Cell Communication And Adhesion, 8, , pp45-59.
• Meleady, P. and Clynes, M. 2001. Bromodeoxyuridine increases keratin 19 protein expression at a post-transcriptional level in two human lung tumor cell lines. In Vitro Cellular & Developmental Biology-animal, 37, , pp536-542.
• McBride, S., Walsh, D., Meleady, P., Daly, N. and Clynes, M. 1999. Bromodeoxyuridine induces keratin protein expression in lung tumour cell lines at a posttranscriptional level. Differentiation, 64, , pp185-193.
• McBride, S., Meleady, P., Baird, A., Dinsdale, D. and Clynes, M. 1998. Human lung carcinoma cell line DLKP contains 3 distinct subpopulations with different growth and attachment properties. Tumor Biology, 19, , pp88-103.
• Meleady, P. and Clynes, M. 1995. Growth of a human lung cell line in a defined serum-free medium. Journal Of Experimental & Clinical Cancer Research, 14(1), , pp68-70.

Selected Chapters

• Dowling P, Clynes M and Meleady P. 2011. Sample preparation techniques for cancer proteomics. , pp813-828.
• Henry M and Meleady P. 2011. Clinical proteomics ¿Liquid Chromatography-Mass Spectrometry (LC/MS) purification systems. , pp473-483.
• Meleady P. 2011. 2D electrophoresis and mass spectrometry identification and analysis of proteins. , pp123-137.
• Meleady, P, O'Connor R. 2006. General Procedures for Cell Culture. Cell Biology, A Laboratory Handbook, pp13-20.
• Keenan, J., Meleady, P. and Clynes, M. 1998. Serum-free media. Animal Cell Culture Techniques, pp67-81.
• Meleady, P., O'Sullivan, F., McBride, S. and Clynes, M. 1998. Isolation, cultivation and differentiation of lung type II epithelial cells. In: Animal Cell Culture Techniques. Animal Cell Culture Techniques, pp357-370.
• O'Sullivan, F., Meleady, P., McBride, S. and Clynes, M. 1998. Primary culture. Animal Cell Culture Techniques, pp115-128.

Reviews

• Dowling P, Meleady P, Henry M, Clynes M. 2010. Recent advances in clinical proteomics using mass spectrometry. Bioanalysis, 2, pp1609-1615.
• Jenkins N, Meleady P, Tyther R, Murphy L. 2009. Strategies for analysing and improving the expression and quality of recombinant proteins made in mammalian cells. Biotechnology And Applied Biochemistry, 6, pp73-83.
• Maurya P, Meleady P, Dowling P, Clynes M. 2007. Proteomic Approaches For Serum Biomarker Discovery In Cancer. Anticancer Research, 27, pp1247-1256.
• Paula Meleady. 2007. Proteomic profiling of recombinant cells from large-scale mammalian cell culture processes. Cytotechnology, 53, pp23-31.
• Clynes M, O'Connor R, O'Driscoll L, Daly C, Meleady P. 2003. Challenges in molecular analysis for individualized cancer therapy. Drug Discovery Today, 8, pp531-.
• Daly, N., Meleady, P., Walsh, D. and Clynes, M. 1998. Regulation of keratin and integrin gene expression in cancer and drug resistance. Cytotechnology, 27, pp321-344.

• O' Flynn D, Linge A, Larkin A, Henry M, Beatty S, Moriarty P, Clynes M, Kennedy S, Meleady P, Triosephosphate Isomerase and Fatty Acid Binding Protein, Heart Type as Potential Protein Biomarkers of Metastatic Uveal Melanoma. , Irish Melanoma Forum Annual Meeting, 23-NOV-12 - 23-NOV-12, Dublin
• Meleady p, Impact of miRNAs on the CHO proteome¿, Biotechnology in Action: Stem Cells and Tissue Engineering, Biopharmaceutical Production and Cancer Biomarkers, 04-SEP-12 - 06-SEP-12, Dublin, Ireland
• Ramasamy P, Henry M, Linge A, Horgan N, Murphy C, Clynes M, Kennedy S, Meleady P. , Proteomic Analysis of Uveal Melanoma. Biotechnology , Biotechnology in Action: Stem Cells and Tissue Engineering, Biopharmaceutical Production and Cancer Biomarkers, 04-SEP-12 - 06-SEP-12, Dublin
• Meleady P, Proteomic Analysis of Chinese hamster ovary cells:Application to understanding the role of miRNAs as potential engineering targets in bioprocess-relevant pathways¿, Bioprocessing and Stem Cells Europe, Cell Culture Europe, 27-JUN-12 - 28-JUN-12, London, UK
• Meleady P, Proteomic analysis of recombinant CHO cells and the potential for biomanufacturing process improvement¿, The Bioprocessing Summit, 22-AUG-11 - 23-AUG-11, Boston, USA
• 5. Ravida A, Kreivi M, Musante L, Miinalainen I, Grassi P, Byrne B, Saraswat M, Henry M, Meleady P, O¿Sullivan F, Clynes M, Dell A, Holthofer H. , Novel insights in the glycobiology of diabetic nephropathy: a study with diagnostic potential. , Eurocarb, 03-AUG-11 - 07-AUG-11, Sorrento, Italy
• Linge A*, Kennedy S*, O¿Flynn D, Beatty S, Larkin A, Henry M, Clynes M and Meleady P, Proteomic profiling helps distinguish between patients with metastatic and non-metastatic uveal melanoma, 8th BSPR-EBI Meeting, From the visible to the hidden proteome. , 12-JUL-11 - 14-JUL-11, Wellcome Trust Conference Centre, Hinxton, UK.
• Linge A, Maurya P, Henry M, Clynes M, Meleady P. , Functional proteomic analysis suggests a possible role for RAD23B in breast cancer invasion. , EMBO Conference Series, Cancer Proteomics, Systems Biology, Developmental Models and Data Integration. , 20-JUN-11 - 23-JUN-11, Dublin, Ireland
• Kathleen O¿Connell, Maria Prencipe, Michael Henry, Paula Meleady, Martin Clynes, William Watson, Robert O¿Connnor. , Prediction of Resistance Markers to Docetaxel in Prostate Cancer Cell Lines. , EMBO Conference Series, Cancer Proteomics, Systems Biology, Developmental Models and Data Integration. , 20-JUN-11 - 23-JUN-11, Dublin, Ireland
• Power, M, Henry, M, Clynes, M, Meleady, P. , Label Free LC-MS Characterisation of Host Cell Proteins in Late Stage Culture of Hybridoma Cells, 22nd ESACT Meeting, 15-MAY-11 - 18-MAY-11, Vienna, Austria
• Linge A, Maurya P, Henry M, Clynes M, Meleady P. , Functional proteomic analysis of membrane proteins from breast cancer cell lines with different invasive phenotypes, BSPR-EBI Meeting 2010, Quantitative Proteomics: From qualitative to quantitative. , 13-JUL-10 - 16-JUL-10, Wellcome Trust Conference Centre, Hinxton, UK.
• Meleady P, Proteomics of biopharmaceutical cells, Irish Mass Spectrometry Meeting, 12-MAY-10 - 12-MAY-10, Dublin, Ireland
• Izabela Zaborowska, Kerstin Kellner, Michael Henry, Paula Meleady, Martin Clynes and Derek Walsh, A role for Vaccinia Virus I3L in the redistribution of host translation factors to cytosolic viral replication compartments., EMBO Conference Series on Protein Synthesis and Translational Control, 09-SEP-09 - 13-SEP-09, Heidelberg, Germany
• Maurya P, Henry M, Kumar N, Clynes M and Meleady P, Proteomic analysis suggests a functional role for thioredoxin reductase 1 in breast cancer invasion, BSPR-EBI Meeting 2009, Multiscale Proteomics: From Cells to Organisms, 14-JUL-09 - 16-JUL-09, Wellcome Trust Conference Centre, Hinxton, UK.
• Browne B, McDermott M, Crown J, Henry M, Meleady M, Clynes M, Dowling P, O¿Donovan N., Phosphoproteomic profiling of lapatnib resistant breast cancer cells., EMBO Conference `Cancer Proteomics 2009: Mechanistics Insights, Technological Advances, and Molecular Medicine¿, 08-JUN-09 - 11-JUN-09, Dublin, Ireland
• Meleady P, Barron N, Doolan P, Gammell P, Melville M, Brennan S, Chervincky K, Francullo L, Leonard M, Charlebois T, Clynes M., Target Validation in Recombinant Chinese Hamster Ovary (CHO) Cell Lines in Order to Improve Growth and Productivity., 21st Meeting of the European Society for Animal Cell Technology (ESACT) `Cellular Solutions for Clinical Challenges, 07-JUN-09 - 10-JUN-09, Dublin, Ireland
• Doolan, P., Meleady, P., Barron, N., Henry, M., Gammell, P., Melville, M., Sinacore, M., McCarthy, K., Leonard, M., Charlebois, T. and Clynes, M., Transcriptomic and proteomic expression profiling analysis of multiple CHO production cell lines with varying growth rate phenotypes, 21st Meeting of the European Society for Animal Cell Technology (ESACT) `Cellular Solutions for Clinical Challenges, 07-JUN-09 - 10-JUN-09, Dublin, Ireland
• Kumar N, Sanchez N, Gammell P, Meleady P, Henry M, Barron N, Clynes M ., Proteomic profiling of temperature-shifted cells to identify genes that impact on both cell growth and recombinant protein productivity in suspension culture., 21st Meeting of the European Society for Animal Cell Technology (ESACT) `Cellular Solutions for Clinical Challenges,, 07-JUN-09 - 10-JUN-09, Dublin, Ireland
• Melville M, Doolan P, Clarke C, Di Nino D, McCarthy K, Anderson K, Gammell P, Meleady P, Barron N, Leonard M, Clynes M and Charlebois T., A Combined Approach of Genomics and Proteomics has led to Fundamental Insights into CHO Cell Biology and Performance in Production Conditions., 21st Meeting of the European Society for Animal Cell Technology (ESACT) `Cellular Solutions for Clinical Challenges, 07-JUN-09 - 10-JUN-09, Dublin, Ireland
• Meleady P, Effects of microRNA on the proteome and possible implications for biopharmaceutical production systems, Cell Line Development and Engineering, 03-MAR-09 - 06-MAR-09, Berlin,Germany
• Doolan, P., Barron, N., Henry, M., Meleady, P. Gammell, P., Leonard, M., McCarthy, K., Melville, M., Sinacore, M., Charlebois, T. and Clynes, M., MICROARRAY GENE PROFILING COMBINED WITH FUNCTIONAL VALIDATION IDENTIFIES TARGETS LEADING TO INCREASED PRODUCTION OF BIOPHARMACEUTICALS IN CHO., ESACT UK Annual Meeting 2009, 05-JAN-09 - 06-JAN-09, Wellcome Trust Conference Centre, Hinxton, UK
• Meleady P, Proteomic Profiling and Target Gene Validation to Improve Productivity in Recombinant CHO Cells¿, ESACT UK Annual Meeting 2009, 05-JAN-09 - 06-JAN-09, Wellcome Trust Conference Centre, Hinxton, UK
• Doolan, P., Barron, N., Henry, M., Meleady, P. Gammell, P., McCarthy, K., Leonard, M., Melville, M., Sinacore, M., Charlebois, T. and Clynes, M., MICROARRAY PROFILING AND TARGET GENE VALIDATION LEADING TO MORE EFFICIENT PRODUCTION OF BIOPHARMACEUTICALS IN CHO., International Meeting of the Microarray and Gene Expression Data Society, 01-SEP-08 - 04-SEP-08, Riva del Garda, Italy.
• Maurya P, Henry M, Clynes M, Meleady P., Proteomic Analysis Of Isolated Membrane Fractions From Normal and Cancerous Breast Cell Lines, The 7th Annual World Congress HUPO 2008, 16-AUG-08 - 20-AUG-08, Amsterdam, The Netherlands
• Kumar N, Gammell P, Meleady P, Henry M, Barron N, Clynes M, Investigation of Low Culture Temperature Response in CHO-K1 Cells Using Proteomics Tools., The 7th Annual World Congress HUPO 2008, 16-AUG-08 - 20-AUG-08, Amsterdam, The Netherlands
• Meleady P, Novel use of microarrays and proteomics to find biomarkers in CHO., Cell Line Development and Engineering, 23-JUN-08 - 25-JUN-08, San Diego, USA
• Kumar N, Gammell P, Meleady P, Henry M, Barron N, Clynes M, An investigation into the mechanisms regulating the response to low culture temperature in suspension CHO-K1 cells., ESACT UK Annual Meeting, 03-JAN-08 - 04-JAN-08, Wellcome Trust Conference Centre, Hinxton, UK,
• Meleady P, Proteomic profiling of recombinant Chinese hamster ovary cells to gain insights to improving bioprocess productivity, Irish Mass Spectrometry Meeting (IMSS), `Mass Spectrometry for Proteins and Peptides., 30-NOV-07 - 30-NOV-07, Dublin
• Kumar N, Maurya P, Gammell P, Clynes M, Meleady P., Protein profiling of CHO-K1 secretome during different phase of growth cycle using SELDI., BSPR/EBI Conference "Integrative Proteomics: From Molecules to Systems, 25-JUL-07 - 27-JUL-07, Hinxton, Cambridge, UK.
• Maurya P, Clynes M, Meleady P., Proteomic analysis of normal, non-invasive and invasive cancerous breast cell lines., BSPR/EBI Conference "Integrative Proteomics: From Molecules to Systems, 25-JUL-07 - 27-JUL-07, Hinxton, Cambridge, UK.
• Gammell P, Kumar N, Barron N, Meleady P, Henry M & Clynes M., An investigation into the role of miRNA regulation of the cold shock response in suspension CHO-K1 cells., ESACT 2007 `Cells and Culture¿, 17-JUN-07 - 20-JUN-07, Dresden, Germany
• Melville M, Sinacore M, Di Nino D, McCarthy K, Anderson K, Kopycinski K,. Lee G, Max S, Gammell P, Doolan P, Meleady P, Barron N, Leonard M, Clynes M and Charlebois T, Differential Expression Profiling of Industrially Relevant CHO Cell Phenotypes Using a Proprietary CHO-Specific Microarray and Proteomics Technology Platforms, ESACT 2007 `Cells and Culture¿, 17-JUN-07 - 20-JUN-07, Dresden, Germany
• Meleady P, Henry M, Gammell P, Doolan P, O¿ Toole J,. Sinacore M, Melville M, Di Nino D, McCarthy K, Anderson K, Kopycinski K, Leonard M, Charlebois T and Clynes M., Proteomic profiling of recombinant CHO cells to gain insights to improving bioprocess productivity., ESACT 2007 `Cells and Culture¿, 17-JUN-07 - 20-JUN-07, Dresden, Germany
• Meleady P, Exploring the CHO proteome to improve bioprocess, ESACT UK 2007, 04-JAN-07 - 05-JAN-07, Cambridge, UK
• Bryan W, Meleady P, Dowd A, Dowling P, Clynes M., Proteomic analysis of 5-Fluorouracil¿s anti-proliferative effect on normal and cancer cells of the lung., Research applications in cancer and other diseases and in biopharmaceutical production¿, 07-SEP-06 - 08-SEP-06, Dublin, Ireland
• Meleady P., The CHO proteome ¿ challenges in a developing technology¿, Research applications in cancer and other diseases and in biopharmaceutical production, 07-SEP-06 - 08-SEP-06, Dublin, Ireland
• Bryan W, Dowd A, Joyce H, Meleady P, and Clynes M., Proteomic analysis of DLKP and its subpopulations; DLKP-SQ, DLKP-I and DLKP-M and interpretations of altered invasion rates observed in these clones. Poster presented at `Research applications in cancer and other diseases and in biopharmaceutical production¿, Research applications in cancer and other diseases and in biopharmaceutical production¿, 07-SEP-06 - 08-SEP-06, Dublin, Ireland
• Kumar N, Gammell P, Meleady P, Doolan P, Clynes M., Proteomic profiling of suspension animal cell cultures., Research applications in cancer and other diseases and in biopharmaceutical production¿, 07-SEP-06 - 08-SEP-06, Dublin, Ireland
• Sinacore M, Melville M, Hann L, DiNino D, McCarthy K, Anderson K, Kopycinski K, Gammell P, Doolan P, Meleady P, Leonard M, Clynes M & Charlebois M, Differential expression profiling analysis of industrially relevant CHO cell phenotypes through integrated use of DNA microarray & proteomics analysis platforms., CCE (Cell Culture Engineering) X, 24-APR-06 - , USA
• Doolan P, McMorrow J., Dowd A J., Ryan E, Henry M, Dowling P, Bryan W, Meleady P and Clynes M, Microarray & proteomics analysis of BrdU-DLKP: a systems biology approach to understanding differentiation in lung cancer cells., Cold Spring Harbour Symposia; Systems Biology: Global Regulation of Gene Expression, 23-MAR-06 - 26-MAR-06, Cold Spring Harbor, USA
• Maurya, P*., Dowling, P*., Meleady, P., Glynn, S.A., and Clynes, M., Purification and Identification of a 7.6 kDa Protein in media conditioned by a Superinvasive Human Cancer Cell Lines using Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI)., Joint IACR/ISMO Cancer Research 2006 Annual Meeting, 03-MAR-06 - 04-MAR-06, Galway, Ireland
• Bryan W, Meleady P, Dowd A, Dowling P and Clynes M., Difference Gel Electrophoresis (DIGE) analysis of the proteomic changes induced by fluorouracil and fluoropyrimidine analogues in the lung carcinoma, DLKP. Poster presented at the EMBO Conference on Protein Synthesis and Translational Control, EMBO Conference on Protein Synthesis and Translational Control, 14-SEP-05 - 18-SEP-05, Heidelberg, Germany
• Meleady P, Dowd A, Dowling P, Henry M, O'Callaghan M and Clynes M, Two-Dimensional Difference Gel Electrophoresis (DIGE) of a Bromodeoxyuridine-Treated Human Lung Carcinoma Cell Line., The HUPO 4th Annual World Congress, 29-AUG-05 - 01-SEP-05, Munich, Germany
• Murphy L, Keenan J, Meleady P and Clynes M., Detection of Potential Drug Resistant Markers in Lung Cancer., The HUPO 4th Annual World Congress, 29-AUG-05 - 01-SEP-05, Munich, Germany
• Dowling P, Dowd A, Meleady P, Clynes M., DIGE Analyses Indicates Phenotypic Changes Between Glucose-responsive And Glucose Non-responsive Min-6 Beta Cells., The HUPO 4th Annual World Congress, 29-AUG-05 - 01-SEP-05, Munich, Germany
• Meleady P, Dowd A and Clynes M, Proteomics at the NICB., Bioinformatics Inforum, 14-FEB-05 - , Dublin City University, Dublin 9
• Power, B, Walsh, D., Meleady, P. and Clynes, M., Investigation into the role of the translation initiation factor, eIF4E in the regulation of differentiation in a very poorly differentiated human lung carcinoma cell line., Translation UK, 04-MAY-02 - 05-MAY-02, Manchester, UK
• , , Proteomic Forum, 15-SEP-01 - 19-SEP-01, Technical University Munich, Munich, Germany
• Meleady, P., Walsh, D., and Clynes, M., Bromodeoxyuridine increases eIF-4E expression in the poorly differentiated human lung tumour cell line, DLKP., Translational Control Meeting, 06-SEP-00 - 10-SEP-00, Cold Spring Harbor, New York, USA.
• Meleady, P. and Clynes, M., Bromodeoxyuridine differentially regulates integrin gene expression in human lung epithelial cell lines., Beatson International Cancer Conference, Invasion and Metastasis, 27-JUN-99 - 30-JUN-99, Glasgow, Scotland, UK
• Daly, N., Walsh, D., McBride, S., Meleady, P. and Clynes, M., Regulation of keratin synthesis in human lung epithelial cells., Translational Control Meeting, 09-SEP-98 - 13-OCT-98, Cold Spring Harbor, New York, USA
• Meleady, P., McBride, S. and Clynes, M., Induction of a number of differentiation and epithelial associated genes in a human lung carcinoma cell line., 9th International Conference of the International Society of Differentiation (ISD), 28-SEP-96 - 02-OCT-96, Pisa, Italy
• Meleady, P. and Clynes, M., Chemotherapy drug toxicity profiles of a human squamous cell carcinoma cell line of the lung cultivated long-term in defined, serum-free conditions., British Association of Lung Research (BALR)/ BIOMED Spring Meeting, 03-APR-95 - 04-APR-95, Leicester, UK
• O¿Toole A, Meleady P, Clynes M, Agitation resistance of Chinese hamster ovary cells, 1st European Conference for Young Researchers in Chemical Engineering - The 1995 IChemE Research Event, 05-JAN-95 - 06-JAN-95, University of Edinburgh, Edinburgh, Scotland
• Meleady, P. and Clynes, M., Growth of a human lung cell line DLKP in a defined serum-free medium., 41st International Congress of the European Tissue Culture Society, 09-OCT-94 - 12-OCT-94, Verona, Italy