NCTCC

Biographical Details:

1988 Diploma in Biology, J.Gutenberg University,Mainz, Germany. 1988-1990 Research student, Max Planck Institute, Munich, Germany. 1994 Ph.D University of Zurich, Switzerland 1995 First Post-doc, Brain Research Institute, Zurich, Switzerland 1996-1998 Second Post-doc, Victoria Hospital, London, Ontario, Canada. 1998-2002 Carrier break to start a family since 2002 research scientist at the NICB, DCU, Dublin Ireland.

Research Interests:

Cellular and molecular studies on tumour-host interaction, tumour cell invasion and multidrug resistance in malignant brain tumours, testing of a large pannel of inhibitory and/or toxic compounds with respect to future therapeutical applications, Identification of microRNAs in primary brain tumour cell lines, Identification of biomarkers in blood serum of brain tumour patients.

Selected Peer Reviewed Journals

• Breen L, Heenan M, Amberger-Murphy V and Clynes MDr. Verena R Murphy. 2007. Investigation of the role of p53 in chemotherapy resistance of lung cancer cell lines. Anticancer Research, 27, , pp1361-1364.
• Amberger-Murphy V. 2004. Cell death induction by betulinic acid, ceramide and TRAIL in primary glioblastoma multiforme cells ¿ Comment. Acta Neurochirurgica - The European Journal Of Neurosurgery, 146, 7, pp729-.
• Breen L, Amberger-Murphy V, Cronin D, Heenan M, Clynes M. 2004. The involvement of p53 on resistance to chemotherapy in lung cancer cells. Anticancer Research, 24, , pp529-529.
• Amberger-Murphy V, Kinsella P, Walsh N, Clynes M. 2004. Why does PCV chemotherpay not work on high-grade glioma? A possible answer and what we can learn from it. Anticancer Research, 24, 4D, pp3422-3422.
• Amberger-Murphy V. 2003. Glioma Invasion: mechanism, modulation and future possibilities. Acta Neurochirurgica - The European Journal Of Neurosurgery, 145, 8, pp613-614.
• Bauman GS, Fisher BJ, McDonald W, Amberger VR, Moore E, Del Maestro RF. 1999. Effects of radiation on a three-dimensional model of malignant glioma invasion. International Journal Of Developmental Neuroscience, 17, 5-6, pp643-651.
• Bauman GS, MacDonald W, Moore E, Ramsey DA, Fisher BJ, Amberger VR, Del Maestro RM.. 1999. Effects of radiation on a model of malignant glioma invasion. Journal Of Neuro-oncology, 44, 3, pp223-231.
• Hensel T, Amberger VR, Schwab ME. 1998. A metalloprotease activity from C6 glioma cells inactivates the myelin-associated neurite growth inhibitors and can be neutralized by antibodies. British Journal Of Cancer, 78, 12, pp1564-1572.
• Amberger VR, Hensel T, Ogata N, Schwab ME. 1998. Spreading and migration of human glioma and rat C6 cells on central nervous system myelin in vitro is correlated with tumor malignancy and involves a metalloproteolytic activit. Cancer Research, 58, 1, pp149-158.
• Tamaki M, McDonald W, Amberger VR, Moore E, Del Maestro RF. 1997. Implantation of C6 astrocytoma spheroid into collagen type I gels: invasive, proliferative, and enzymatic characterizations. Journal Of Neurosurgery, 87, 4, pp602-609.
• Spillmann AA, Amberger VR, Schwab ME. 1997. High molecular weight protein of human central nervous system myelin inhibits neurite outgrowth: an effect which can be neutralized by the monoclonal antibody IN-1. European Journal Of Neuroscience, 9, 3, pp549-555.
• Amberger VR, Avellana-Adalid V, Hensel T, Baron-van Evercooren A, Schwab ME. 1997. Oligodendrocyte-type 2 astrocyte progenitors use a metalloendoprotease to spread and migrate on CNS myelin. European Journal Of Neuroscience, 9, 1, pp151-162.
• Amberger, VR and Schwab, ME. 1994. C6 glioblastoma cells express a new metalloprotease which seems to play an important role in tumor invasion. Journal Of Cellular Biochemistry, 18, D, pp141-.
• Amberger VR, Paganetti PA, Seulberger H, Eldering JA, Schwab ME. 1994. Characterization of a membrane-bound metalloendoprotease of rat C6 glioblastoma cells. Cancer Research, 54, 15, pp4017-4025.
• Diehl-Seifert B, Amberger V, Gramzow M, Batel R, Bachmann M, Schroder M, Muller WEG. 1989. Directed Migration of Cells from the Sponge Geodia-Cydonium. Tissue & Cell, 21, 1, pp25-36.
• Schroder HC, Amberger V, Renneisen K, Bachmann M, Kurelec B, Uhlenbruck G, Muller WE.. 1989. Protein kinase C phosphorylates the sponge aggregation receptor after its binding to the homologous aggregation factor. European Journal Of Cell Biology, 48, 1, pp142-149.

Selected Non-peer Reviewed Journals

• Hensel T, Amberger VR, Schwab ME. 1997. Chicken Antibodies raised against a membrane -bound C6 glioblastoma metalloendoprotease. . Neural Notes, 8/III, pp9-11.
• Del Maestro RF, Tamaki M, McDonald W and Amberger V. 1997. The C6 astrocytoma spheroid invasion model: evidence for the presence of a glial-repellent factor(s). Canadian Journal of Neurolological Science, 24, ppS3-66-S3-66.

• , , , - ,
• Amberger-Murphy V, Search for new Targets; Brain Cancer Research at the NICB, 1st Brain Tumour Meeting held in Dublin and organised by the Irish Cancer Society and Beaumont Hospital,, 13-OCT-06 - 13-OCT-06, Royal Academy of Surgeons, Dublin
• Parker, K Amberger-Murphy, V, Comparison of tricyclic antidepressant drug effects on a variety of tumour cells v. normal cells, In: Terzis, J Bjerkvig, R Niclou, S ed.Cancer Stem Cells and Invasion, Glioma Invasion Forum 2006, 15-JUN-06 - 17-JUN-06, Luxembourg
• Amberger-Murphy, V, Tyrosine Kinase Inhibitors, In: Terzis, J Bjerkvig, R Niclou, S ed.Cancer Stem Cells and Invasion, Glioma Invasion Forum 2006, 15-JUN-06 - 17-JUN-06, Luxembourg
• Amberger-Murphy, V Kinsella, P Murphy, L Walsh, N Clynes, M, A three-dimensional in vitro model to study invasion, In: Lah Turnsek, T Sersa, G Kos, J Association of Radiology and Oncology ed.Fourth Conference on Experimental and Translational Oncology, 22-MAR-06 - 26-MAR-06, Kranjska gora, Slovenia, 60 -
• Amberger-Murphy, V, INvasion-Proliferation, two exclusive actions in glioma; Implications on therapy., Second Meeting of the World Federation of NeuroOncology and the 6th Meeting of the European Association for NeuroOncology, 05-MAY-05 - 08-MAY-05, Edinburgh, UK
• Amberger-Murphy, V Kinsella, P, Classical PCV chemotherpay tested in an in vitro glioblastoma model: A possible scientific answer to a clinical problem, NICB Cancer Day, 08-APR-05 - ,
• Amberger-Murphy, V Kinsella, P Walsh, N. Clynes, M, Why are classical chemotherapy drugs ineffective on high-grade glioma?, Annual Meeting of the Irish Association for Cancer Research, 11-MAR-05 - 12-MAR-05, Kilkenny, Ireland
• Amberger-Murphy, V Kinsella, P Walsh , N Clynes, M, Why does PCV Chemotherapy not work on high-grade glioma? A possible answer and what we could learn from it. , In: Anticaner Research 2004; 24(5D) ed.Seventh International Conference of Anticancer Research, 25-OCT-04 - 30-OCT-04, Corfu, Greece, 3422 -
• Amberger-Murphy, V, Brain Cancer Research at the NICB, Open Day of the NICB, 11-JUN-04 - , DCU