Health & Human Performance

Research Interests:

Skeletal muscle contraction as a regulator of gene transcription and protein content Muscle contraction is an important stimulus of gene transcription and it is known that in trained individuals across all age groups, the number of mitochondria and the content of key regulators of metabolism are increased. We are looking at the role of contraction intensity on the regulation of gene transcription. Insulin and non-insulin mediated glucose transport The evaluation of insulin-mediated signalling pathways is central to our understanding of glucose transport. We also use the model of muscular contraction to elicit improvements in GLUT-4 translocation and subsequent improvements in metabolic function. This model is useful for the study of insulin and non-insulin mediated pathways of glucose transport and especially useful in the identification of novel pathways that may become pharmacological targets. Cellular and molecular regulation of substrate utilisation The regulation of energy expenditure, especially glucose-free fatty acid cycling in skeletal muscle, contributes to the progressive decrease in insulin sensitivity.

Selected Peer Reviewed Journals

• Ashley DT, O¿Sullivan EP, Davenport C, Devlin N, McCaffrey N, Moyna NM, Smith D, O¿Gorman DJ. 2011. Obesity is associated with a decrease in serum osteoprotegerin and adiponectin, but not TRAIL, in a cohort of healthy subjects. Metabolism: Clinical And Experimental, 60,, pp994-1000.
• Cooper D and O¿Gorman DJ. 2011. Exercise training has diverse responses in patients with type 2 diabetes. DIABETES MANAGEMENT. 1, 6, pp575-587.
• Davenport C, Ashley DA, O¿Sullivan E, O¿Gorman DJ, Smith D. 2011. Identifying coronary artery disease in males with type 2 diabetes; osteoprotegerin, pulse wave velocity, and other biomarkers of cardiovascular risk.. Journal Of Hypertension, 29,, pp2469-2475.
• Egan B, Dowling P, O¿Connor PL, Henry M, Meleady P, Zierath JR, O¿Gorman DJ.. 2011. 2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to fourteen consecutive days of endurance exercise training. Proteomics, 11,, pp1413-1428.
• O'Gorman DJ, Krook A. 2011. Exercise and the treatment of diabetes and obesity. MEDICAL CLINICS OF NORTH AMERICA. 95,, pp953-969.
• Alsaraj F, O'Gorman D, McAteer S, McDermott J, Hawi Z, Sreenan S. 2010. Haplotype Association of Calpain 10 Gene Variants with Type 2 Diabetes Mellitus in an Irish Sample. Irish Journal Of Medical Science, 179,, pp269-272.
• Coyle S, Lau K-T, Moyna N, O¿Gorman D, Diamond D, Di Francesco F, Costanzo D, Salvo P, Trivella MG, De Rossi DE, Taccini N, Paradiso R, Porchet J-A, Ridolfi A, Luprano J, Chuzel C, Lanier T, Revol-Cavalier F, Schoumacker S, Mourier V, Chartier I, Convert R, De-Moncuit H, Bini C. 2010. BIOTEX: Biosensing Textiles for Personalised Healthcare Management. IEEE Transactions on Information Technology in Biomedicine. 14, 2, pp364-370.
• Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR, O¿Gorman DJ. 2010. Exercise intensity-dependent regulation of PGC-1α mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. Journal Of Physiology (london), 588,, pp1779-1790.
• O¿Sullivan EP, Ashley DT, Davenport C, Devlin N, Crowley R, Agha A, Thompson CJ, O¿Gorman DJ, Smith D. 2010. Elevated osteoprotegerin in Type 2 Diabetes may reflect a different underlying process to traditional inflammatory markers. Diabetes/Metabolism Research and Reviews.
• Walls RJ, McHugh G, O¿Gorman DJ, Moyna NM, O¿Byrne JM. 2010. Effects of preoperative neuromuscular electrical stimulation on quadriceps strength and functional recovery in total knee arthroplasty. A pilot study. Bmc Musculoskeletal Disorders, 11,, pp119-127.
• O¿Sullivan EP, Ashley DT, Davenport C, Kelly J, Devlin N, Crowley R, Leahy AL, Kelly CJ, Agha A, Thompson CJ, O¿Gorman DJ, Fitzgerald P, Smith D. 2010. Osteoprotegerin is higher in peripheral arterial disease regardless of glycaemic status. Thrombosis Research, 126,, pp423-427.
• Connaghan D, Hughes S, May G, Kelly P, O¿Conaire C, O¿Connor NE, O¿Gorman DJ, Smeaton AF, Moyna N. 2009. A Sensing Platform for Physiological and Contextual Feedback to Tennis Athletes IEEE Wearable and Implantaable Body Sensor Network. , pp224-229.
• Harrison M, Murphy RP, O'Connor PL, O'Gorman DJ, McCaffrey N, Cummins PM, Moyna NM. 2009. The endothelial microparticle response to a high fat meal is not attenuated by prior exercise. European Journal Of Applied Physiology, 106,, pp555-562.
• Harrison M, O¿Gorman DJ, McCaffrey N, Hamilton MT, Zderic TW, Carson BP, Moyna NM. 2009. Influence of acute exercise with and without carbohydrate replacement on postprandial lipid metabolism. Journal Of Applied Physiology, 106,, pp943-949.
• MacEneaney OJ, Harrison M, O¿Gorman DJ, Pankratieva EV, O¿Connor PL, Moyna NM. 2009. Effect of prior exercise on postprandial lipemia and markers of inflammation and endothelial activation in normal weight and overweight adolescent boys. European Journal Of Applied Physiology, 106,, pp721-729.
• Woods CB, Nelson NM, O'Gorman DJ, Foley E, Moyna NM. 2009. The Take PART study (Physical Activity Research for Teenagers): rationale and methods. Journal of Physical Activity and Health. 6, 2, pp170-177.
• Nelson NM, Foley E, O¿Gorman DJ, Moyna NM, Woods CB. 2008. Active commuting to school: How far is too far?. International Journal Of Behavioral Nutrition And Physical Activity, 5, , pp1-9.
• O'Driscoll L, Kenny E, Mehta JP, Doolan P, Joyce H, Gammell P, Hill A, O'Daly B, O'Gorman DJ and Clynes M. 2008. Feasibility and relevance of global expression profiling of gene transcripts in serum from breast cancer patients using whole genome microarrays and quantitative RT-PCR. Cancer Genomics And Proteomics, 5, , pp95-104.
• O¿Gorman DJ and Krook A. 2008. Exercise and the treatment of diabetes and obesity. Endocrinology and Metabolism Clinics of North America. 37, , pp887-903.
• O¿Gorman DJ, Yousif O, Dixon G, McQuaid S, Murphy E, Rahman Y, Gasparro D, Pacini G, Newsholme P,Nolan JJ. 2008. In vivo and in vitro studies of GAD-antibody positive subjects with Type 2 diabetes: a distinct sub-phenotype. Diabetes Research and Clinical Practice. 80, , pp365-370.
• Woods, C.B., Nelson, N., Foley, E., O¿Gorman, D. and Moyna, N. 2008. Take PART Study: Rationale and Methodology.. Journal Of Physical Activity And Health, 1,, pp1-28.
• Brady S, Carson B, O'Gorman DJ, Moyna N, Diamond, D. 2007. Combining wireless with wearable technology for the development of on-body networks. Journal of Communications. 2, , pp1-6.
• O¿Gorman DJ, Karlsson HKR, McQuaid S, Yousif O, Rahman Y, Gasparro D, Glund S, Chibalin AV, Zierath JR, Nolan JJ. 2006. Exercise training increases insulin-stimulated glucose disposal and GLUT-4 protein content in patients with Type 2 diabetes. Diabetologia, 49, 12, pp2983-2992.
• McQuaid S, O¿Gorman DJ, Yousif, O, Yeow T.-P, Rahman Y, Gasparro D, Pacini G, Nolan JJ. 2005. Early Onset Insulin Resistant Diabetes in Obese Caucasians has Features of Typical Type 2 Diabetes, but Three Decades Earlier. Diabetes Care, Diabetes Care 28, 5, pp1216-1218.
• Kirwan, J.P., D.J. O'Gorman, D. Cyr-Campbell, W.W. Campbell, K.E. Yarasheki, and W.J. Evans. 2001. Effects of a moderate glycemic meal on exercise duration and substrate utilization. Medicine And Science In Sport And Exercise, 33(9),, pp1517-1523.
• Kirwan, J.P., L.F. del Aguila, D.L. Williamson, D.J. O'Gorman, R.M. Lewis, and R.K. Krishnan. 2000. Regular exercise enhances insulin activation of IRS-1 associated PI 3-kinase in human skeletal muscle. Journal Of Applied Physiology, 88,, pp797-803.
• O'Gorman, D.J., L.F. del Aguila, D. L. Williamson, R.K. Krishnan, and J.P. Kirwan. 2000. Insulin and Exercise Differentially Regulate IRS-1-Associated PI3-Kinase and Glycogen Synthase in Human Skeletal Muscle During Immediate Recovery from Exercise. Journal Of Applied Physiology, 89,, pp1412-1419.
• O'Gorman, D.J.. A. Hunter, C. McDonnacha, and J.P. Kirwan. 2000. Validity of field tests to evaluate endurance capacity in competitive and international level sports participants. Journal Of Strength And Conditioning Research, 14(1),, pp62-67.
• Kirwan, J.P., D.J. O'Gorman, and W.J. Evans. 1998. A moderate glycemic meal prior to endurance exercise can enhance performance. Medicine And Science In Sport And Exercise, 84(1),, pp53-59.
• Krishnan, R.K., J.M. Hernandez, D.L. Williamson, D.J. O'Gorman, W.J. Evans, and J.P. Kirwan. 1998. Age-related differences in the pancreatic B-cell response to hyperglycemia after eccentric exercise. American Journal Of Physiology, 275(5),, ppE463-E470.

Selected Chapters

• O'Gorman DJ, Nolan JJ. 2005. Exercise in Diabetes and Obesity. Exercise Therapy: Prevention and treatment of disease, pp59-76.

• O'Gorman, D., Exercise in the prevention and treatment of Type 2 diabetes, Association of Clinical Biochemists of Ireland,2002, - , Ireland
• F. AlSaraj, H. Thabit, D. O¿Gorman, S. McAteer, Z. Hawi, S.K. Sreenan, Variation in the Calpain 10 Gene in Irish Patients with Type 2 Diabetes Mellitus., American Diabetes Association Conference 2006, - ,
• O. Yousif, D.J. O'Gorman, D. O'Donghaile, D. Gasparro, G. Pacini and J. J. Nolan., GAD Positive Type 2 Diabetes: Insulin Resistance with a Pronounced Defect in First Phase Insulin Secretion, American Diabetes Association, - , Philadelphia, USA
• O'Gorman, D.J., Yousif, O., O'Donghaile, D., Murphy, E., Gasparro, D., Pacini, G. and Nolan, J.J., Early Onset Type 2 diabetes: Severe Obesity with Classical Insulin Resistance Phenotype, European Congress on Obesity, - , Vienna, Austria
• E. Murphy, D.J. O'Gorman, G. Pacini, D. Gasparro, K.L. Jones, and J.J. Nolan., Type 2 diabetes in Mexican American and Caucasian adolescents and young adults: a similar metabolic phenotype., European Association for the Study of Diabetes Annual Meeting, - , Israel
• Kirwan, J.P., R.K. Krishnan, S.N. Sistrun, D.L. Williamson, R. Lewis, D.J. O'Gorman, L.F. del Aguila, D.A. Kriz, and C.M. Marchetti., Decreased visceral fat after exercise and caloric reduction is related to improved glucose tolerance in 57-77 year old obese men and women with impaired glucose tolerance (IGT)., Gerontology Conference, - , United States
• O'Gorman, D.J., L.F. del Aguila, M.R. Lewis, D.L. Williamson, and J.P. Kirwan., ERK-1 phosphorylation following exercise and feeding., European College of Sports Science Annual Conference, - , United Kingdom
• del Aguila, L.F., D.J. O'Gorman, M.R. Lewis, D.L. Williamson, and J.P. Kirwan., Differential activation of PI3-K following a single bout of exercise and a physiological feeding., European College of Sports Science Annual Conference, 1998, - , United Kingdom
• Kirwan, J.P., Krishnan, R.K., Marchetti, C.M., Williamson, D.L., del Aguila, L.F., O'Gorman, D.J., and Stetzer, B.P, Effects of age on free fatty aid induced insulin resistance, Gerontology Conference, - , United States
• O'Gorman, D.J., Yousif, O., O'Donghaile, D., Gasparro, D., and Nolan, J.J. ., Exercise training improves insulin sensitivity and the insulin resistance syndrome in Type 2 diabetes, Irish Endocrine Society, - , Ireland
• Chan, S.N., O'Gorman, D.J., Yousif, O., and Nolan, J.J., Physiological and metabolic profiling of women with Type 2 diabetes and former gestational diabetes, Irish Endocrine Society 2001, - , Ireland
• Kirwan, J.P., J.M. Hernandez, L.F. del Aguila, D.L.Williamson, D.J. O'Gorman, M.R. Lewis, and R.J. Krishnan., Effects of exercise training on insulin mediated phosphatidylinositol 3-kinase activation in human skeletal muscle., American Diabetes Association, 1998, - , Boston, USA
• Krishnan, R.K., J.M. Hernandez, D.L. Williamson, D.J. O'Gorman, W.J. Evans, and J.P. Kirwan., Age-related differences in the pancreatic b-cell response to hyperglycemia following eccentric exercise., American College of Sports Medicine Conference, 1998, - , United States
• Kirwan, J.P., D.J. O'Gorman, D. Campbell, K.E. Yarasheski, and W.J. Evans., Effects of a pre-exercise breakfast cereal on exercise performance and glucose production., American College of Sports Medicine Conference, 1997, - , United States
• Kirwan, J.P., R.K. Krishnan, D.L. Williamson, D.J. O'Gorman, J.M. Hernandez, P.A. Farrell, and W.J. Evans., Effects of eccentric resistance exercise on the pancreatic b-cell response to hyperglycemia in 59-73 year old healthy men., Gerontology Conference, 1997, - , United States
• O'Gorman, D.J., A. Hunter, C. MacDonncha, and J.P. Kirwan., Validity of field tests as predictors of aerobic capacity in athletes., American College of Sports Medicine Conference, 1996, - , United States
• Kirwan, J.P., D.J. O'Gorman, D. Campbell, G. Sporay, and W.J. Evans., A low glycemic meal 45 minutes before exercise improves performance., American College of Sports Medicine Conference, 1996, - , United States
• Williamson, D.L., R.K. Krishnan, D.J. O'Gorman, C. Lakatta, J.M. Hernandez, W.J. Evans, and J.P. Kirwan., A single bout of resistance exercise increases basal metabolic rate in healthy 60-70 year old men., American College of Sports Medicine Conference, 1996, - , United States
• R.K. Krishnan, J.M. Hernandez, D.L. Williamson, D.J. O'Gorman, W.J. Evans, and J.P. Kirwan., Delayed Glucose Clearance In Healthy Older Men Is Related To Abdominal Adiposity., American Diabetes Association, - , United States
• O'Donghaile, D., O'Gorman, D.J., Yousif, O., and Nolan, J.J., The investigation of the Pro12Ala polymorphism of PPAR?2 in an Irish diabetes population, Irish Endocrine Society, - , Ireland
• Lewis, M.R., D.L. Williamson, D.J. O'Gorman, L. F. del Aguila, R.K. Krishnan, and J.P. Kirwan., Free fatty acid suppression of insulin mediated glucose metabolism in older overweight individuals., American College of Sports Medicine Conference 1998, - , United States
• O'Connor, A.M., C.F. Johnson, D.J. O'Gorman, J.P. Kirwan, K.D. Buchnan, and K. Alberti., Glucose intolerance following endurance exercise., Hormone Research Conference,1995, - , *
• O¿Gorman, D.J., McQuaid, S., Yousif, O., Rahman, Y., Gasparro, D., Yeow, T.P. and Nolan, J.J., The effects of acute and chronic exercise on insulin sensitivity in obesity and type 2 diabetes., Irish Endocrine Society 2002, - ,
• S.McQuaid, Y.Rahman, O.Yousif, D.J.O¿Gorman, D. Gasparro, J.J. Nolan, The Clinical and Metabolic Features of Irish Patients with Acanthosis Nigricans, Irish Endocrine Society 2002, - ,
• Kirwan, J.P., Krishnan, R.K., Marchetti, C.M., Williamson, D.L., del Aguila, L.F., O¿Gorman, D.J., and Stetzer, B., Effects of age on free fatty aid induced insulin resistance, Gerontology Conference, 2002, - ,
• S. McQuaid, Y. Rahman, D.J. O¿Gorman, O Yousif, D. Gasparro, J.J. Nolan., The clinical and metabolic features of Irish patients with Acanthosis Nigricans, European Chapter of the American Association of Clinical Nutrition, 2002, - , Greece
• O¿Gorman, D.J., McQuaid, S., Yousif, O., Rahman, Y., Gasparro, D., Yeow, T.P. and Nolan, J.J., Exercise mediated enhancement of whole body glucose disposal and intra-cellular insulin signalling: the prevention of Type 2 diabetes, Association of Clinical Biochemists of Ireland, 2002., - ,
• MacDonncha, C., S. McGrath, D.J. O¿Gorman, G.D. Warrington, The relationship between muscle flexibility and sagittal spinal posture in Gaelic Football players., American College of Sports Medicine 2003, - , USA
• R. Sohun, C. MacDonncha, S.McGrath, DJ O¿Gorman, E. McGowan, G.D.Warrington, The impact of an exercise and mutritional intervention on physiological function in manual employees., American College of Sports Medicine 2003, - , USA
• O¿Gorman, D.J., S. McGrath, G. Warrington, C. MacDonncha., The role of physical fitness screening in the recruitment of Irish fire fighters., American College of Sports Medicine 2003, - , USA
• McQuaid, S., O¿Gorman, DJ, Cosgrove, J., Yeow, TP, Mulvihill, N., and Nolan, JJ, Endothelial dysfunction in obese and early onset Type 2 diabetes subjects. I, Irish Angiology Conference 2003, - , Ireland
• O¿Gorman, D.J., McQuaid, S., Karlsson, H., Yousif, O., Gasparro, D., Chibalin, A., Zierath, J.R., Nolan, J.J., The effect of acute and chronic exercise on glucose disposal and PI3-K activity in obese and Type 2 diabetes patients., International Biochemistry of Exercise Conference 2003, - , The Netherlands
• O¿Gorman, D.J., McQuaid, S., Karlsson, H., Yousif, O., Gasparro, D., Chibalin, A., Zierath, J.R., Nolan, J.J., IRS-1, IRS-2 and phosphotyrosine associated PI3-K activity following exercise in subjects with Type 2 diabetes., Association of Physicians 2004, - , Ireland
• F AlSaraj, D O¿Gorman, S McAteer, Z Hawi and S Sreenan., A study of variation in the Calpain 10 Gene in Irish Patients with Type 2 Diabetes Mellitus, Irish Endocrine Conference 2005, - , Ireland
• Yousif, O., O'Gorman, D.J., O'Donghaile, D., Gasparro, D., Pacini, G., Lavin, C. and Nolan, J.J., Fast acting insulin secretagogues improve glycaemic control in Type 2 diabetes., Irish Endocrine Society, 2001, - , Kerry