Chemical Sciences

Biographical Details:

Dr. Dermot Brougham is director of the HEA funded National NMRD Facility located in the School of Chemical Sciences at DCU. This is a collaborative venture involving Irish researchers applying NMRD to study a diverse range of topics including polymer dynamics, contrast agent and other biomedical applications. Dr. Brougham has extensive research experience in NMR spectroscopy. His work has covered high-resolution liquid phase NMR, solid-state NMR using MAS at high fields, low field solid and liquid state NMR, characterisation of porous media by NMR and NMR imaging. His speciality is the development of NMRD applications for materials science. The highlight of his research to date was the demonstration that there is a concerted cyclical hydrogen bond tunnelling mechanism in t-butyl-calix[4]arene. This was the first observation of concerted four-proton transfer and was published recently in Nature, the top ranked scientific journal in the world.

Research Interests:

NMR spectroscopy applied to studying dynamic processes in the solid and liquid state. Specifically we perform temperature- and magnetic field-dependent NMR measurements to study exchange and dynamic processes in interesting material and biological systems. Current research projects include: · Membrane Dynamics in Liposomes / Magnetoliposomes · Nanoparticulate Contrast Agents for Medical Imaging · Transport in Conducting Materials

Selected Peer Reviewed Journals

• Dr. Dermot F Brougham. .
• Dr. Dermot F Brougham. .
• S. K. Das, C. Dickinson, F. Lafir, D. F. Brougham, E. Marsili. 2012. Synthesis, characterization and catalytic activity of gold nanoparticles biosynthesized with Rhizopus oryzae protein extract.. Green Chemistry, 14,, pp1322-1334.
• C. J. Meledandri, D. F. Brougham. 2012. Low field magnetic and magnetic resonance techniques in the development of nanomaterials for biomedical applications.. Analytical Methods, 4, 2, pp331-341.
• Brougham D. F., Ivanova G., Gottschalk M., Collins D. M., Eustace A., O¿Connor R., Havel J. 2011. Artificial neural networks for classification in metabolomic studies of whole cells using 1H nuclear magnetic resonance. Journal Of Biomedicine And Biotechnology,
• C. Davis, S. Carberry, M. Schrettl, I. Singh, J. C. Stephens, S. M. Barry, K. Kavanagh, D. Brougham, S. Doyle. 2011. The Role of Glutathione S-Transferase GliG in Gliotoxin Biosynthesis in Aspergillus Fumigatus. Chemistry & Biology,
• Carla J. Meledandri, Jacek K. Stolarczyk, Dermot F. Brougham. 2011. Hierarchical gold-decorated magnetic nanoparticle clusters with controlled size. Acs Nano, 5, 3, pp1747-1755.
• G.-L. Davies, S. A. Corr, L. Briode, C. J. Meledandri, D. F. Brougham. 2011. NMR Relaxation of Water in Nanostructures: Analysis of Ferromagnetic Cobalt-Ferrite Polyelectrolyte Nanocomposites. Chem Phys Chem, 12, 4, pp772-776.
• H. Sadeghifar, I. Filpponen, S. P. Clarke, D. F. Brougham, D. S. Argyropoulos. 2011. Production of cellulose nanocrystals using hydrobromic acid and click reactions on their surface.. Journal Of Materials Science, 46,, pp7344-7355.
• J. Perlo, C. J. Meledandri, E. Anoardo, D. F. Brougham. 2011. Temperature and size-dependence of membrane molecular dynamics in unilamellar vesicles by fast field-cycling NMR relaxometry. Journal Of Physical Chemistry B, 115,, pp3441-3451.
• L. Xiao, J. Li, D. F. Brougham, E. K. Fox, N. Feliu, A. Bushmelev, A. Schmidt, N. Mertens, F. Kiessling, M. Valldor, B. Fadeel, S. Mathur.. 2011. Water-Soluble Superparamagnetic Magnetite Nanoparticles with Biocompatible Coating for Enhanced Magnetic Resonance Imaging (MRI).. Acs Nano, 5, 8, pp6315-6324.
• Meledandri C. J., Ninjbadgar T., Brougham D. F. 2011. Size-controlled magnetoliposomes with tunable magnetic resonance relaxation enhancements. Journal Of Materials Chemistry, 21, 1, pp214-222.
• T. Ninjbadgar, D. F. Brougham. 2011. Epoxy ring opening phase transfer as a general route to water dispersible superparamagnetic Fe3O4 nanoparticles and their application as positive MRI contrast agents.. Advanced Functional Materials (print), 21,, pp4769-4775.
• Ghosh S, Carty D., Clarke S. P., Corr S. A., Tekoriute R., Gun¿ko Y. K., Brougham D. F. 2010. NMR studies into colloidal stability and magnetic order in fatty acid stabilised aqueous magnetic fluids. Physical Chemistry Chemical Physics, 12,, pp14009-14016.
• Simeonova M, Ivanova G, Enchev V, Markova N, Kamburov M, Petkov C, O¿Connor R, Brougham D. 2009. Physicochemical characterization and in vitro behavior of Daunorubicin loaded onto polymer nanoparticles. Acta Biomaterialia, 5,, pp2109-2121.
• Stolarczyk JK, Ghosh S, Brougham DF. 2009. Controlled growth of nanoparticle clusters through competitive stabilizer desorption. Angewandte Chemie-international Edition In English, 48, 1, pp175-178.
• Meledandri CJ, Perlo J, Farrher E, Brougham DF, Anoardo E. 2009. Interpretation of Molecular Dynamics on Different Timescales in Unilamellar Vesicles using Field-Cycling NMR Relaxometry. Journal Of Physical Chemistry B, 113, 47, pp15532-15540.
• Corr SA, Gun¿ko YK, Tekoriute R, Meledandri CJ, Brougham DF. 2008. Poly(sodium-4-styrene)sulfonate - iron-oxide nanocomposite dispersions with controlled magnetic resonance properties. Journal Of Physical Chemistry Part C: Nanomaterials And Interfaces, 112, 35, pp13324-13327.
• Gottschalk M, Ivanova G, Collins DM, Eustace A, O¿Connor R, Brougham DF. 2008. Metabolomic studies of human lung carcinoma cell lines by in vitro 1H nuclear magnetic resonance of whole cells and cellular extracts. Nmr In Biomedicine, 29,, pp809-819.
• Ivanova GI, Cabrita EJ, O´Connor R, Eustace A, Brougham DF. 2008. Application of diffusion ordered spectroscopy for the analysis of cancer related biological samples. Bulgarian Chemical Communications, 40, 4, pp464-468.
• Meledandri CJ, Stolarczyk JK, Ghosh C, Brougham DF. 2008. Non-aqueous magnetic nanoparticle suspensions with controlled particle size and nuclear magnetic resonance properties. Langmuir, 24, 24, pp14159-149665.
• Murray E, Carty D, Innis P, Wallace GG, Brougham DF. 2008. A field-cycling NMR relaxometry study of dynamic processes in conducting polyaniline. Journal Of Physical Chemistry Part C: Nanomaterials And Interfaces, 112, 45, pp17688-17693.
• Corr SA, Byrne SJ, Tekoriute R, Meledandri, Brougham DF, Lynch M, Kerskens C, O'Dwyer L, Gunko YK. 2008. Linear assemblies of magnetic nanoparticles as MRI contrast agents. Journal Of The American Chemical Society, 130, 13, pp4214-4215.
• Murray E, Stankovic J, Abrahams I, Brougham DF. 2008. Conductivity and fluoride ion dynamics in alpha-PbSnF4; F-19 field-cycling NMR and diffraction studies. Journal Of Physical Chemistry Part C: Nanomaterials And Interfaces, 112, 14, pp5672-5678.
• Alhashimy N., Brougham D., Howarth J., Farrell A., Quilty B., Nolan K. 2007. Homochiral tripodal imidazolium receptors: structural and anion-receptor studies. Tetrahedron Letters, 48, 1, pp125-128.
• Krasnikov S.A. Hanson C.J., Brougham D. F., Cafolla A. A. 2007. Dimer ordering of CuTtertBuPc molecules on the Ag/Si(111)-(¡î3 ¡¿ ¡î3)R30¢ª surface: STM/STS study. Journal Of Physics Condensed Matter, 19,, pp446005-.
• S. A. Corr, A. O¿ Byrne, Y. K. Gun¿ko, S. Ghosh, D. F. Brougham, S. Mitchell, Y. Volkov and A. Prina-Mello. 2006. Magnetic-Fluorescent Nanocomposites for Biomedical Multitasking. Chemical Communications, 43,, pp4474-4476.
• E. Murray and D. F. Brougham. 2005. NMRD of polyaniline based conducting polymers. Synthetic Metals, 155,, pp681-683.
• S. J. Byrne, S. A. Corr, Y. K. Gun¿ko, J. M. Kelly, D. F. Brougham and S. Ghosh. 2004. Magnetic nanoparticle assemblies on denatured DNA show unusual magnetic relaxivity and potential applications for MRI. Chemical Communications, 22,, pp2560-2561.
• T. Gunnlaugsson, D. Brougham, A. Fanning, M. Nieuwenhuyzen John E. O¿Brien and R. Viguier. 2004. T. Gunnlaugsson, D. Brougham, A. Fanning, M. Nieuwenhuyzen John E. O¿Brien and R. Viguier. Organic Letters, 6,, pp4805-4808.
• H. Guan, D. Brougham, K. S. Sorbie and K. J. Packer. 2002. Wettability effects in a sandstone reservoir and outcrop cores from NMR relaxation time distributions. Journal Of Petroleum Science And Engineering, 34,, pp33-52.
• D. F. Brougham, A. J. Horsewill and H. P. Trommsdorff. 1999. A Field-Cycling NMR Relaxometry Investigation of Proton Tunnelling in a Partially Disordered System of Hydrogen Bonds. Chemical Physics, 243,, pp189-199.
• D. F. Brougham, R. Caciuffo and A. J. Horsewill. 1999. Coordinated Proton Tunnelling in a Cyclic Network of Four Hydrogen Bonds in the Solid State. Nature, 397,, pp241-243.
• A. J. Horsewill, D. F. Brougham, R. I. Jenkinson, C. J. McGloin, H. P. Trommsdorff and M. R. Johnson. 1998. The Quantum Dynamics of Proton Transfer in the Hydrogen Bond. Ber. Bunsen Phys. Chem., 102,, pp317-324.
• M. Neumann, D. F. Brougham, C. J. McGloin, M. R. Johnson, A. J. Horsewill and H. P. Trommsdorff. 1998. Proton tunnelling in Benzoic Acid Crystals at Intermediate Temperatures: NMR and Neutron Scattering Studies. Journal Of Chemical Physics, 109,, pp7300-7311.
• D. F. Brougham, A. J. Horsewill and R. I. Jenkinson. 1997. Proton Transfer Dynamics in the Hydrogen Bond: A Direct Measurement of the Rate of Incoherent Tunnelling by NMR and the Quantum to Classical Transition. Chemical Physics Letters, 272,, pp69-74.
• D. F. Brougham, A. J. Horsewill, A. Ikram, R. M. Ibberson, P. J. McDonald and M. Pinter-Krainer. 1996. The Correlation between Hydrogen Bond Dynamics and the Structure of Benzoic Acid Dimers. Journal Of Chemical Physics, 105,, pp979-982.
• D. F. Brougham, P. J. Barrie, G. E. Hawkes, I. Abrahams, M. Motevalli, D. A. Brown and G. J. Long. 1996. Solid State Dynamics of Tricarbonyl(h-1,5-cyclohexadienylium) Iron Tetrafluoroborate and Tricarbonyl(h-1,5-cycloheptadienylium) Iron Tetrafluoroborate. Inorganic Chemistry, 35,, pp5595-5602.
• D. A. Brown, D. F. Brougham, N. J. Fitzpatrick, and W. K. Glass. 1995. Ab Initio Molecular-Orbital and Experimental Studies of Hydride Addition to Phosphine-Substituted Manganese Carbonyl-Complexes. Organometallics, 14,, pp151-156.
• S. Aime, P. J. Barrie, R. Gobetto, D. F. Brougham and G. E. Hawkes. 1995. 1H MAS NMR Spectra of Transition Metal Carbonyl Hydrides. Inorganic Chemistry, 34,, pp3557-3559.
• N. J. Fitzpatrick, D. F. Brougham, P. G. Groarke and M. T. Nguyen. 1994. Effect of Fluorine and Chlorine Substituents on Stabilities of Diphosphaallene, Diphosphirene and Phosphanylphosphaalkyne Isomers (XX'CP2 species, X, X' = H, F and Cl). Chemische Berichte, 127,, pp969-978.

Selected Chapters

• Dermot F Brougham, Yurri K. Goun¿ko. 2009. Magnetic Nanomaterials as MRI Contrast Agents. Magnetic Nanomaterials. Magnetic Nanomaterials. (Challa S. S. R. Kumar Ed.),, pp119-186.
• Trommsdorff HP. 1997. Proton Tunneling in Molecular Crystals. NATO ASI Series

Reviews

• Dr. Dermot F Brougham. 2012. Low field magnetic resonance techniques in the development of nanomaterials for biomedical applications. Analytical Methods, 4, pp331-341.

Selected Non-peer Reviewed Journals

• H. P. Trommsdorff, M. Johnson, M. Neumann, L. von Laue, D. F. Brougham and A. J. Horsewill. 1997. Proton Tunneling in Molecular Crystals. NATO ASI Series, Kluwer Academic Publishers, Dordecht, *, pp369-394.

• Swapankumar Ghosh, Gareth Cooke and Dermot Brougham, School of Chemical Sciences, Dublin City University, Dublin 9. Serena Corr, Yurii Goun¿ko,Department of Chemistry, Trinity College, University of Dublin, Dublin 2, Ireland, SURFACE COATING AND STABILITY OF MAGNETIC NANOPARTICLES, Chainti Conference, 25-MAY-03 - 30-MAY-03, San Miniato, Pisa, Italy
• D. F. Brougham, Solid State NMR Studies of Dynamics in Partially Disordered Systems., CERC3 Workshop on Magnetochemistry/Magnetic Materials., 15-APR-00 - 18-APR-00, Florence, Italy
• D. F. Brougham, A. J. Horsewill, The Role of Excited States in the Translational Tunnelling of Protons in The Hydrogen-Bond., Quantum Tunnelling of Atoms and Molecules in Solids Workshop., 03-SEP-97 - 06-SEP-97, Julich, Germany
• D. F. Brougham, A. J. Horsewill, The Measurement of Proton Tunnelling Dynamics using Field Cycling NMR Relaxometry and Quasi-Elastic Neutron Scattering, NMR Relaxometry in Solids Conference, 01-MAY-97 - 06-MAY-97, Guildford, England
• D. F. Brougham, A. J. Horsewill, The Influence of Hydrostatic Pressure on Hydrogen Bond Tunnelling: A Powder Diffraction Structural Investigation of Benzoic Acid., Quantum Tunnelling of Atoms and Molecules in Solids Workshop, 04-OCT-95 - 07-OCT-95, Seyssins, France