Health & Human Performance

Research Interests:

➢ Regulation of the vascular cytoskeletal architecture via haemodynamic forces -the role of cytoskeletal adaptor proteins. ➢ Nuclear actin dynamics. ➢ Mechano-transduction and the regulation of vascular cellular fate and function. ➢ The investigation of uPAR-integrin interactions on integrin state (affinity, avidity) and integrin-dependent signaling pathways. ➢ MicroRNAs, micromanagers of the vascular transcriptome (collaboration with Applied Biosystems). ➢ Intergin-microRNA-GTPase signalling nexus in the vasculature. ➢ Microparticles as biomarkers: In vitro studies and in vivo testing of adverse effects of biologics, devices and drugs. ➢ Stratification of clinical trials by molecular and cellular techniques, e.g. Pharmacogenomics. ➢ Development of molecular/cellular prognostics and diagnostics for cardiovascular disease. ➢ Exercise, diet and lifestyle on vascular health and competence. ➢ Cell biology of platelets and megakaryocytes. ➢ Cell adhesion and migration.

Selected Peer Reviewed Journals

• Fitzpatrick PA, Guinan AF, Walsh TG, Murphy RP, Killeen MT, Tobin NP, Pierotti AR, Cummins PM. 2009. Down-Regulation of Neprilysin (EC3.4.24.11) Expression in Vascular Endothelial Cells by Laminar Shear Stress Involves NADPH Oxidase-Dependent ROS Production. International Journal Of Biochemistry & Cell Biology, 41, 11, pp2287-2294.
• Michael Harrison*, Ronan P. Murphy*, Paul L. O'Connor, Donal J. O'Gorman, Noel McCaffrey, Philip M. Cummins, Niall M. Moyna. *Co-Authors. 2009. Cellular Microparticle Response to a High Fat Meal with and without Prior Exercise. European Journal Of Applied Physiology, 106, 4, pp555-562.
• Nicholas P. Tobin, Gary T. Henehan, Ronan P. Murphy, Stephen W. Kerrigan, Dermot Cox, Paul A. Cahill, Philip M. Cummins. 2008. Helicobacter pylori Modulates Bovine Aortic Endothelial Cell Fate and Function in an Atherogenic Manner. American Journal Of Physiology-heart And Circulatory Ph, 295, 4, ppH1403-H1413.
• Olga C. Colgan, Nora T. Collins, Gail Ferguson, Ronan P. Murphy, Yvonne A. Birney, Paul A. Cahill, Philip M. Cummins. 2008. Influence of basolateral condition on the regulation of brain microvascular endothelial tight junction properties and barrier function. Brain Research, 1193,
• Olga C. Colgan, Gail Ferguson, Nora T. Collins, Ronan P. Murphy, Gerardeane Meade, Paul A. Cahill, Philip M. Cummins. 2007. Regulation of Bovine Brain Microvascular Endothelial Tight Junction Assembly and Barrier Function by Laminar Shear Stress. American Journal Of Physiology-heart And Circulatory Ph, 292, 6, ppH3190-H3197.
• Wei Gao, Gail Ferguson, Paul Connell, Tony Walshe, Ronan Murphy, Yvonne A. Birney, Colm O¿Brien, Paul A. Cahill. 2007. High Glucose Concentrations alter Hypoxia-induced Control of Vascular Smooth Muscle Cell Growth via a HIF-1α-Dependent Pathway. Journal Of Molecular And Cellular Cardiology, 42, 3, pp609-619.
• Morrow D, Sweeney C, Birney YA, Guha S, Collins N, Cummins PM, Murphy R, Walls D, Redmond EM, Cahill PA. 2007. Biomechanical Regulation of Hedgehog Signaling in Vascular Smooth Muscle Cells in Vitro and in Vivo. American Journal Of Physiology, 292, 1, ppC488-C496.
• Nora T. Collins, Philip M. Cummins, Olga C. Colgan, Gail Ferguson, Yvonne A. Birney, Ronan P. Murphy, Gerardene Meade, Paul A. Cahill. 2006. Cyclic Strain-Mediated Regulation of Vascular Endothelial Occludin and ZO-1: Influence on Intercellular Tight Junction Assembly and Function. Arteriosclerosis Thrombosis And Vascular Biology, 26, 1, pp62-68.
• David Morrow, Agnieszka Scheller, Yvonne A. Birney, Catherine Sweeney, Shaunta Ghua, Philip M. Cummins, Ronan Murphy, Dermot Walls, Eileen M. Redmond, Paul A. Cahill. 2005. Notch Mediated CBF-1/RBP-Jk Dependent Control of Human Vascular Smooth Muscle Cell Phenotype in Vitro. American Journal Of Physiology, 289, 5, ppC1188-C1196.
• Kerrigan SW, Gaur M, Murphy RP, Shattil SJ, Leavitt AD. 2004. Caspase-12: A developmental link between G-protein coupled receptors and integrin alphaIIb beta3 activation. Blood, 104, 5, pp1327-1334.
• Eto K, Murphy R, Kerrigan SW, Bertoni A, Stuhlmann H, Nakano T, Leavitt AD, Shattil SJ. 2002. Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEF1 in integrin signalling. Proceedings Of The National Academy Of Sciences Usa (pnas), 99, 20, pp12819-12824.
• John Fullard, Ronan P. Murphy, Sarah O'Neill, Niamh Moran, Brian Ottridge, and Desmond J Fitzgerald. 2001. A Val193Met mutation in GPIIIa results in a GPIIb/IIIa receptor with a constitutively high affinity for a small ligand. British Journal Of Haematology, 115, 1, pp131-139.
• Fiona O'Connor, Desmond J. Fitzgerald, Ronan P. Murphy. 2000. An automated heteroduplex assay for the PlA polymorphism of glycoprotein IIb/IIIa: multiplexed with two prothrombotic genetic markers, factor V Leiden, and thermolabile methylenetetrahydrofolate reductase(MTHFR C677T). Thrombosis And Haemostasis, 83, 2, pp248-252.
• Ronan P. Murphy, Catherine Donoghue, Ruth J. Nallen, Melwyn D'Mello, Carmen Regan, Alexander S. Whitehead, Desmond J. Fitzgerald. 2000. Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylene tetrahydrofolate reductase polymorphisms in pregnancy. Arteriosclerosis Thrombosis And Vascular Biology, 20, 1, pp266-270.
• K.M. Feeley, J.F. Fullard, M.A. Heneghan, T. Smith, M. Maher, R.P. Murphy, T.A. O'Gorman. 1999. Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis. Journal Of Pathology, 188, 1, pp14-17.

Selected Chapters

• Gabriele Eden, Marco Archinti, Federico Furlan, Paul Fitzpatrick, Ronan Murphy, Bernard Degryse. 2010. The Cell Migration Signalosome. Chemotaxis: Types, Clinical Significance, and Mathematical Models
• Marco Archinti, Gabriele Eden, Ronan Murphy and Bernard Degryse. 2010. Follow the Leader: When the Urokinase Receptor Coordinates Cell Adhesion, Motility, and Proliferation with Cytoskeleton Organisation. Cytoskeleton: Cell Movement, Cytokinesis and Organelles Organization.

Reviews

• Archinti M, Britto M, Eden G, Furlan F, Murphy R, Degryse B. 2010. The Urokinase Receptor in the Central Nervous System. Cns & Neurological Disorders - Drug Targets, Epub ahead of print,

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