NCSR

Biographical Details:

Dr. Damian Connolly received his B.Sc. (Hons) Degree in Analytical Science (Chemistry Option) from Dublin City University in 1999. He joined Bristol Myers-Squibb Company (Swords Laboratories Ltd) in 1999 as a Quality Control Analyst. In the same year he began a programme of postgraduate research part-time (Development of fast ion chromatography) at Dublin City University under the supervision of Prof. Brett Paull and was awarded a Ph.D within only five years (in 2005) despite having concurrently worked full-time within industry. In January 2006 he took up a position of post-doctoral researcher in the Centre for Bioanalytical Sciences (CBAS) working upon the modification of polymer monoliths using photografting methods. Much work also involved development of novel monolith characterisation protocols involving contactless conductivity. Other projects also included the qualitative and quantitative analysis of raw materials (yeastolates and chemically defined media) and in-process samples supplied by the bio-pharmaceutical industry, which involved close collaboration with CBAS industrial partners. In January 2009, he moved to the Irish Separation Science Cluster as Programme Coordinator (Separation Sciences, DCU), responsible for coordinating research efforts in separation science based in DCU and in close collaboration with academic partners in UCC and numerous industrial partners. Dr. Connolly is a full member of the Royal Society of Chemistry (MRSC) and is an Associate Director of the California Separation Science Society (CASSS). Dr. Connolly is the author of 21 papers in peer-reviewed journals which have been cited a total of 217 times (Web of Science, Aug 2010) and co-author of one book chapter. He is a regular reviewer for peer-reviewed journals in the areas of analytical chemistry and separation science such as Journal of Chromatography A, Analytica Chimica Acta and Analytical Letters.

Research Interests:

All aspects of separation science particularly ion chromatography and capillary liquid chromatography. Fabrication of polymer monoliths in capillary formats and their post-modification using photografting methods and/or nanoparticle coatings. Application of said monoliths for separation of small molecules or small organic/inorganic anions and cations by ion chromatography. Sample preparation using monoliths functionalised with selective ligands. Bioseparations and fabrication of bio-affinity phases based upon polymer monoliths. Characterisation of modified polymer monoliths with non-invasive contactless conductivity detection.

Selected Peer Reviewed Journals

• Connolly D, Twamley B, Paull B. 2010. High-capacity gold nano-particle functionalised polymer monoliths. Chemical Communications, 46, , pp2109-2111.
• Nesterenko EP, Nesternko PN, Connolly D, Lacroix F, Paull B. 2010. Micro-bore titanium housed polymer monoliths for reversed-phase liquid chromatography of small molecules. Journal Of Chromatography A, In press, In press
• Currivan S, Connolly D, Gillespie E, Paull B. 2010. Fabrication and characterisation of capillary polymeric monoliths incorporating continuous stationary phase gradients. Journal Of Separation Science, 33, , pp1-9.
• Connolly D, Barron LP, Gillespie E, Paull B. 2009. The Use of Contactless Conductivity for the On-Column Characterisation and Visualisation of Packing Homogeneity and Band Broadening in Capillary LC. Chromatographia, 70, 5/6, pp915-920.
• Connolly D, Paull B. 2009. High-performance separation of small inorganic anions on a methacrylate-based polymer monolith grafted with [2(methacryloyloxy)ethyl] trimethylammonium chloride. Journal Of Separation Science, 32, 15-16, pp2653-2658.
• Gillespie E, Connolly D, Nesterenko PN, Paull B. 2009. On-column titration and investigation of metal complex formation for aminopolycarboxylate functionalised monoliths using scanning contactless conductivity detection. Journal Of Separation Science, 32, 15-16, pp2659-2667.
• Gillespie E, Connolly D, Paull B. 2009. Using scanning contactless conductivity to optimise photografting procedures and capacity in the production of polymer ion-exchange monoliths. The Analyst, 134, 7, pp1314-1321.
• Gillespie E, Connolly D, Macka M, Hauser P, Paull B. 2008. Development of a contactless conductivity detector cell for 1.6 mm O.D. (1/16th inch) HPLC tubing and micro-bore columns with on-column detection. The Analyst, 133, , pp1104-1110.
• Gillespie E, Connolly D, Nesterenko PN, Paull B. 2008. Accurate non-invasive determination of pKa of surface functionalised ion exchange monoliths using capacitively coupled contactless conductivity detection. The Analyst, 133, 7, pp874-876.
• Connolly D, O'Shea V, Clarke P, O'Connor B, Paull B. 2007. Evaluation of photografted charged sites within polymer monoliths in capillary columns using contactless conductivity detection. Journal Of Separation Science, 30, 17, pp3060-3068.
• Gillespie E, Connolly D, Macka M,Nesterenko PN, Paull B. 2007. Use of contactless conductivity detection for non-invasive characterisation of monolithic stationary-phase coatings for application in capillary ion chromatography. The Analyst, 132, 12, pp1238-1245.
• Nie FQ, Macka M, Barron L, Connolly D, Kent N, Paull B. 2007. Robust monolithic silica-based on-chip electro-osmotic micro-pump. The Analyst, 132, 5, pp417-424.
• O'Riordain C, Gillespie E, Connolly D, Nesterenko PN, Paull B. 2007. Capillary ion chromatography of inorganic anions on octadecyl silica monolith modified with an amphoteric surfactant. Journal Of Chromatography A, 1142, 2, pp185-193.
• Gillespie, E, Macka M, Connolly D, Paull B. 2006. Evaluation of capillary ion exchange stationary phase coating distribution and stability using radial capillary column contactless conductivity detection. The Analyst, 131, 8, pp886-888.
• Connolly D, Victory D, Paull B. 2004. Rapid, low pressure, and simultaneous ion chromatography of common inorganic anions and cations on short permanently coated monolithic columns. Journal Of Separation Science, 27, 10-11, pp912-920.
• Connolly D, Paull B. 2002. Fast ion chromatography of common inorganic anions on a short ODS column permanently coated with didodecyldimethylammonium bromide. Journal Of Chromatography A, 953, 1-2, pp299-303.
• Connolly D, Barron L, Paull B. 2002. Determination of urinary thiocyanate and nitrate using fast ion-interaction chromatography. Journal Of Chromatography B, 767, 1, pp175-180.
• Connolly D, Paull B. 2001. Rapid determination of nitrate and nitrite in drinking water samples using ion-interaction liquid chromatography. Analytica Chimica Acta, 441, 1, pp53-62.
• Connolly D, Paull B. 2001. Fast separation of UV absorbing anions using ion-interaction chromatography. Journal Of Chromatography A, 917, 1-2, pp353-359.

Selected Chapters

• Connolly D, Paull B. 2010. Monolithic ion exchange phases for the separation of small inorganic and organic ions. Monolithic chromatography and its modern applications

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• Moyna A, Connolly D, Macka M, Paull B, Development of a capillary ion chromatography system for the separation of small ions., UNCSR 10 year anniversary symposium, 22-OCT-09 - 22-OCT-09, Dublin City University, Ireland
• Connolly D, Twamley B, Paull B, Functionalisation of polymer monoliths in capillary formats with gold nanoparticles., UNCSR 10 year anniversary symposium, 22-OCT-09 - 22-OCT-09, Dublin City University, Ireland
• Connolly D, Routelous M, Twamley B, Paull B, Selectivity Studies on a High-Capacity Macroporous Latex Agglomerated Anion Exchange Resin Incorporating Electrostatically Adsorbed Gold Nanoparticles., UNCSR 10 year anniversary symposium, 22-OCT-09 - 22-OCT-09, Dublin City University, Ireland
• Currivan S, Connolly D, Gillespie E, Paull B, Use of contactless conductivity detection for the direct visualisation of stationary phase gradients on polymer monoliths., UNCSR 10 year anniversary symposium, 22-OCT-09 - 22-OCT-09, Dublin City University, Ireland
• Connolly D, Alwael H, Paull B, Analysis of Cysteine/Cystine in Bio-Pharma Fermentation Feed-Stocks using Rapid Resolution Liquid Chromatography., 21st International Ion Chromatography Symposium, 21-SEP-09 - 24-SEP-09, Dublin, Ireland
• Currivan S, Connolly D, Gillespie E, Paull B, On Column Visualisation of Stationary Phase Gradients in Polymer Monoliths Using Scanning Contactless Conductivity, 21st International Ion Chromatography Symposium, 21-SEP-09 - 24-SEP-09, Dublin, Ireland
• Connolly D, Routelous M, Paull B, Selectivity Studies on a High-Capacity Macroporous Latex Agglomerated Anion Exchange Resin Incorporating Electrostatically Adsorbed Gold Nanoparticles., 21st International Ion Chromatography Symposium, 21-SEP-09 - 24-SEP-09, Dublin, Ireland
• Moyna A, Connolly D, Gillespie E, Barron L, Paull B, Macka M , Development of a Capillary Ion Chromatography System for the Separation of Ions on Ion Exchange Polymer Monoliths., 21st International Ion Chromatography Symposium, 21-SEP-09 - 24-SEP-09, Dublin, Ireland
• Connolly D, Session Chair, 21st International Ion chromatography Symposium, 21-SEP-09 - 24-SEP-09, Dublin, Ireland
• Connolly D, Moyna A, Paull B, Grafted methacrylate monoliths for ion chromatographic separations of inorganic anions and cations., 21st International Ion Chromatography Symposium, 21-SEP-09 - 24-SEP-09, Dublin, Ireland
• Gillespie E, Connolly D, Nesterenko P, Macka M, Paull B, Scanning contactless conductivity detection: Applications in the characterisation of modifications to stationary phases in capillary formats., EuroAnalysis 2009, 06-SEP-09 - 10-SEP-09, Innsbruck, Austria
• Moyna M, Connolly D, Gillespie E, Barron L, Macka M, Paull B, Development of a capillary ion chromatography system for the separation of ions on ion-exchange polymer monoliths., Euroanalysis 2009, 06-SEP-09 - 10-SEP-09, Innsbruck, Austria
• Nesterenko E, Connolly D, Nesterenko P, Paull B, Microbore titanium-housed polymer monoliths for high temperature and pressure liquid chromatography., Euroanalysis 2009, 06-SEP-09 - 10-SEP-09, Innsbruck, Austria
• Connolly D, Routelous M, Twamley B, Paull B, Selectivity Studies on a High-Capacity Macroporous Latex Agglomerated Anion Exchange Resin Incorporating Electrostatically Adsorbed Gold Nanoparticles, Euroanalysis 2009, 06-SEP-09 - 10-SEP-09, Innsbruck, Austria
• Currivan S, Connolly D, Gillespie E, Paull B, Use of on-column scanning contactless conductivity detection for the direct visualisation of stationary phase gradients on polymer monoliths., Euroanalysis 2009, 06-SEP-09 - 10-SEP-09, Innsbruck, Austria
• Shortt B, Connolly D, McCarthy G, Paull B, McMahon G, Analysis of synovial fluid by immunoaffinity depletion and HPLC for investigation of protein profiles in arthritis, RSC Analytical Research Forum, 13-JUL-09 - 15-JUL-09, University of Kent, Canterbury, UK
• Moyna A, Connolly D, Gillespie E, Barron L, Macka M, Paull B, Development of a capillary ion chromatography system for the separation of inorganic anions on a methacrylate based polymer monolith grafted with [2(methacryloyloxy)ethyl] trimethylammonium chloride., RSC Analytical Research Forum, 13-JUL-09 - 15-JUL-09, University of Kent, Canterbury, UK
• Alwael H, Connolly D, Paull B, Development of a rapid resolution liquid chromatography assay for cysteine/cystine determination in bio-pharma fermentation feed-stocks., RSC Analytical Research Topics, 13-JUL-09 - 15-JUL-09, University of Kent, Canterbury, UK
• Currivan S, Connolly D, Gillespie E, Paull B, Use of on-column scanning contactless conductivity detection for the direct visualisation of stationary phase gradients on polymer monoliths., RSC Analytical Research Forum, 13-JUL-09 - 15-JUL-09, University of Kent, Canterbury, UK
• Shortt B, Connolly D, McCarthy G, Paull B, McMahon G, Analysis of synovial fluid by immunoaffinity depletion and HPLC for investigation of protein profiles in arthritis, 61st Irish Universities Chemistry Colloquium, 18-JUN-09 - 19-JUN-09, DIT, Aungier St, Dublin, Ireland
• Connolly D, Alwael H, Leister K, Paull B, The determination of amino acids, monosaccharides and thiol compounds in raw materials and in-process samples as potential quality control assays within the bio-pharma industry., International Conference on Trends in Bioanalytical Sciences and Biosensors, 26-JAN-09 - 28-JAN-09, Dublin, Ireland
• Alwael H, Connolly D, Leister K, Gacheru S, Paull B, Application of rapid resolution liquid chromatography in the analysis of monosaccharides and sialic acid in bio-fermentation media samples using fluorescence detection., International Conference on Trends in Bioanalytical Sciences and Biosensors, 26-JAN-09 - 28-JAN-09, Dublin, Ireland
• Alwael H, Connolly D, Leister K, Gacheru S, Paull B, A study of the redox activity of cysteine/cystine in bio-pharma fermentation feedstocks by HPLC., International Conference on Trends in Bioanalytical Sciences and Biosensors, 26-JAN-09 - 28-JAN-09, Dublin, Ireland
• Currivan S, Connolly D, Gillespie E, Paull B, Use of contactless conductivity detection for the direct visualisation of stationary phase gradients on polymer monoliths., International Conference on Trends in Bioanalytical Sciences and Biosensors, 26-JAN-09 - 28-JAN-09, Dublin, Ireland
• Connolly D, Gillespie E, Walsh Z, O¿Shea V, Paull B, Advances in evaluation of capillary polymer monolith surface chemistry using photografting methods and contactless conductivity detection., International Conference on Trends in Bioanalytical Sciences and Biosensors, 26-JAN-09 - 28-JAN-09, Dublin, Ireland
• Gillespie E, Connolly D, Macka M, Hauser P, Paull B, A novel contactless conductivity detector for 1/16th¿ PEEK tubing and packed micro-columns., International Ion Chromatography Symposium, 21-SEP-08 - 24-SEP-08, Portland, Oregon, USA
• Connolly D, Gillespie E, Paull B, Characterisation of immobilised crown ether on a polymeric monolithic capillary column using contactless conductivity detection., International Ion Chromatography Symposium, 21-SEP-08 - 24-SEP-08, Portland, Oregon, USA
• Gillespie E, Connolly D, Macka M, Paull B., Use of contactless conductivity detection for the characterisation of stationary phase chemistry in surface modified monolithic capillary columns, International Ion Chromatography Symposium, 21-SEP-08 - 24-SEP-09, Portland, Oregon, USA.
• Connolly D, Alwael H, Paull B, The determination of amino acids, monosaccharides and thiol compounds in raw materials and in-process samples as potential quality control assays within the bio-pharma industry., International Ion Chromatography Symposium, 21-SEP-08 - 24-SEP-08, Portland, Oregon USA
• Connolly D, Barron L, Paull B, Use of contactless conductivity detection for the non-invasive on-column characterisation of packing homogeneity for capillary ion chromatography., International Ion Chromatography Symposium, 21-SEP-08 - 24-SEP-08, Portland, Oregon, USA
• Gillespie E, Connolly D, Macka M, Hauser P, Paull B , A novel contactless conductivity detector for 1/16th¿ PEEK tubing and packed micro-columns, RSC Analytical Research Forum, 21-JUL-08 - 23-JUL-08, University of Hull, Hull, UK.
• Gillespie E, Connolly D, Macka M, Paull B, Use of contactless conductivity detection for the characterisation of stationary phase chemistry in surface modified monolithic capillary columns, RSC Analytical Research Forum, 21-JUL-08 - 23-JUL-08, University of Hull, Hull, UK.
• Alwael H, Connolly D, Paull B, Rapid and sensitive chromatographic assays for monosaccharides and free sialic acids in bio-fermentation media samples, RSC Analytical Research Forum, 21-JUL-08 - 23-JUL-08, University of Hull, Hull, UK
• Connolly D, Gillespie E, Macka M, Paull B, Non-invasive conductivity based techniques for the characterisation of stationary phase chemistry and biochemistry on polymer monoliths., 3rd Monolith Summer School and Symposium on Biochromatography, Bioconversion, and Solid Phase Synthesis, 30-MAY-08 - 04-JUN-08, Portoroz, Slovenia
• O'Shea V, Connolly D, Clarke P, O'Connor B, Paull B , The in-vivo tagging of proteins to study optimum approaches for their efficient immobilisation on polymer methacrylate monoliths., 3rd Monolith Summer School and Symposium on Biochromatography, Bioconversion, and Solid Phase Synthesis, 30-MAY-08 - 04-JUN-08, Portoroz, Slovenia
• Gillespie E, Connolly D, Macka M, Connolly D , Use of contactless conductivity detection for the characterization of stationary phase chemistry on surface modified monolithic capillary columns., 32nd International Symposium on Capillary Chromatography (ISCC), 27-MAY-08 - 30-MAY-08, Riva del Garda, Italy
• Alwael H, Connolly D, Paull B, Selective extracton, separation and analysis of monosaccharides in yeastolates and pre-Innoculation fermentation media samples using rapid liquid chromatography with fluorescence detection, 5th Biennial Conference on Analytical Sciences in Ireland,, 07-MAY-08 - 09-MAY-08, Waterford Institute of Technology, Waterford, Ireland.
• Gillespie E, Connolly D, Macka M, Hauser P, Paull B, A novel contactless conductivity detector for 1/16th¿ PEEK tubing and packed micro-columns, 5th Biennial Conference of Analytical Sciences in Ireland, 07-MAY-08 - 09-MAY-08, Waterford Institute of Technology, Waterford, Ireland
• Gillespie E, Connolly D, Macka M, Paull B, Use of contactless conductivity detection for the characterisation of stationary phase chemistry in surface modified monolithic capillary columns, 5th Biennial Conference of Analytical Sciences in Ireland, 07-MAY-08 - 09-MAY-08, Waterford Institute of Technology, Waterford, Ireland
• Connolly D, Gillespie E, Currivan S, Paull B, Characterisation of immobilised crown ether on a polymeric monolithic capillary column using contactless conductivity detection., 5th Biennial Conference of Analytical Sciences in Ireland,, 07-MAY-08 - 09-MAY-08, Waterford Institute of Technology, Waterford, Ireland.
• Vazquez M, Benito-Lopez F, Diamond D, Alwael H, Connolly D, Paull B, Advanced separations and microfluidic platforms., Glycosciences Ireland, 30-APR-08 - 30-APR-08, Trinity College Dublin, Ireland
• Connolly D, Alwael H, Paull B, Analysis of monosaccharides in yeastolates and pre-innoculation fermentation media samples., 12th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products, 28-JAN-08 - 30-JAN-08, Washington DC, USA
• Connolly D, Gillespie E, Walsh Z, O¿Shea V, Paull.B, Advances in evaluation of capillary polymer monolith surface chemistry using photografting methods and contactless conductivity detection., 12th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products, 28-JAN-08 - 30-JAN-08, Washington DC, USA
• Gillespie E, Macka M, Connolly D, Paull B, 1. Use of contactless conductivity detection for the characterisation of stationary phase chemistry in surface modified monolithic capillary columns; application to ion chromatographic determination of inorganic cations and amino acids., RSC Analytical Research Forum, 16-JUL-07 - 18-JUL-07, University of Strathclyde, Glasgow, Scotland
• Connolly D, Gillespie E, Macka M, Paull B, 1. New possibilities for capillary ion chromatography of inorganic and small organic ions using silica based ion exchangers with on-column contactless conductivity detection., 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2007), 17-JUN-07 - 21-JUN-07, Ghent, Belgium
• Gillespie E, Macka M, Connolly D, Paull B, 1. Use of contactless conductivity detection for the characterisation of stationary phase chemistry in surface modified monolithic capillary columns; application to ion chromatographic determination of inorganic cations and amino acids., 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2007),, 17-JUN-07 - 21-JUN-07, Ghent, Belgium
• Connolly D, Paull B, Rapid and sensitive determination of free amino acids in yeastolates and in-process fermentation samples by capillary-LC., 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2007), 17-JUN-07 - 21-JUN-07, Ghent, Belgium
• Guivarc¿h C, Connolly D, Duffy C, Paull B, Separation of nucleic acid precursors by monolithic zwitterionic ion chromatography using a quaternary gradient., International Ion Chromatography Symposium (IICS), 25-SEP-06 - 27-SEP-06, Pittsburgh, PA, USA
• Gillespie E, Macka M, Connolly D, Paull B. , 1. Evaluation of capillary ion exchange stationary phase coating stability and distribution using capacitively coupled contactless conductivity detection., International Ion Chromatography Symposium (IICS), 25-SEP-06 - 27-SEP-06, Pittsburgh, PA, USA
• O¿Riordain C, Gillespie E, Connolly D, Nesterenko PN, Paull B, Capillary ion chromatography using monolithic columns and across column detection using contactless conductivity detection., RSC Analytical Research Forum,, 17-JUL-06 - 19-JUL-06, University College Cork, Ireland
• O¿Riordain C, Gillespie E, Connolly D, Nesterenko PN, Paull B, Capillary ion chromatography using monolithic columns and across column detection using contactless conductivity detection, 4th Biennial Conference on Analytical Sciences in Ireland, 11-APR-06 - 12-APR-06, DIT, Dublin
• Connolly D, Paull B, Fast ion chromatography of common inorganic anions and cations on short ods monolithic columns, Analytical sciences in Ireland 04, 10-SEP-04 - 11-SEP-04, University College Cork, Ireland
• Connolly D, Paull B, Fast ion chromatography of common inorganic anions and cations on short ods monolithic columns, RSC Analytical Research Forum 2004, 19-JUL-04 - 21-JUL-04, University of Central Lancashire, Preston, UK
• Connolly D, Paull B, Fast ion chromatography using short dynamically and permanently coated monolithic ODS columns for the determination of inorganic anions and cations, International Ion Chromatography Symposium 03, 21-SEP-03 - 24-SEP-03, San Diego, USA
• Connolly D, Paull B, Fast ion chromatography using short dynamically and permanently coated monolithic ODS columns for the determination of inorganic anions and cations, Research and Development Topics, 21-JUL-03 - 23-JUL-03, University of Sunderland, UK
• Damian Connolly and Brett Paull, Rapid ion-exchange chromatography: rapid separation of inorganic anions using short permanently coated columns, Research and Development Topics, 15-JUL-02 - 17-JUL-02, Kingston University, London, UK
• Connolly D, Paull B, Ultra-fast ion chromatography, 54th Irish Universities Chemistry Research Colloquium, 10-APR-02 - 12-APR-02, Queen's University, Belfast, UK
• Connolly D, Paull B, Fast ion chromatographic separation of common inorganic anions using a 3 cm ODS column permanently coated with didodecyldimethylammonium bromide, International Ion Chromatography Symposium 2001, 09-SEP-01 - 12-SEP-01, Chicago, USA
• Connolly D, Paull B, High-sample throughput online analysis of a flowing tap-water stream by ion-pair chromatography, Research and Development Topics, 16-JUL-01 - 18-JUL-01, University of East Anglia, UK
• Connolly D, Paull B, Fast chromatographic separation of nitrate and nitrite in water samples, Environ2001, 26-JAN-01 - 27-JAN-01, Dublin City University, Ireland
• Connolly D, Paull B, Ultra-fast separation of UV absorbing anions using ion-interaction chromatography, Environ2001, 26-JAN-01 - 27-JAN-01, Dublin City University, Ireland
• Connolly D, Paull B, Fast ion chromatography of UV absorbing inorganic ions, International Ion Chromatography Symposium 2000, 11-SEP-00 - 14-SEP-00, Nice, France