Biotechnology

Dr Mary O'Connell

Dr Mary O'Connell
Name:Dr Mary O'Connell
Phone Number5112
Department:Biotechnology
Room:X215
E-Mail Address:
Work Area:Academic Staff

Biographical Details:


Dr Mary J. O'Connell is the Principal Investigator of the Bioinformatics and Molecular Evolution Group. The group currently consists of six postgraduate research students and is funded by Science Foundation Ireland and IRCSET. Dr O'Connell graduated with her PhD in 2005 in Human Molecular Evolution. She was an SFI postdoctoral fellow in UCC before commencing her academic and group leader roles in DCU in 2006.


Research Interests:


Primarily our research is focussed on understanding mammalian evolution and disease from a molecular perspective. Our research involves comparative genomics, phylogenetics and evolutionary analysis of coding and non-coding DNA.


Selected Peer Reviewed Journals



Selected Chapters


  • O'Connell, M.J.* and McInerney, J.O. 2007. Reconstructing the ancestral eukaryote - lessons from the past. Ancestral Sequence reconstruction, pp103-113., Oxford University Press
  • McInerney, J.O., Pisani, D.E., O'Connell, M.J., Fitzpatrick, D.A., Creevey, C.J. 2007. Evolutionary History of Prokaryotes: Tree or no tree?. Reconstructing the Tree of Life, pp45-55., CRC press

Conferences:


  • Webb AE, Morgan CC, Walsh TA and O'Connell MJ, "Selective pressure analysis of human and mouse innate immune genes at both the species and population level.", MPEII: mechanisms of protein evolution second annual international conference., 07-FEB-13 - 12-FEB-13, Denver Colorado USA
  • Morgan CC, Webb AE, Loughran NB and O'Connell MJ* (INVITED KEYNOTE: The George C. Williams Keynote on Evolutionary Medicine), "The George C. Williams Keynote on Evolutionary Medicine: Uncovering the molecular basis of phenotypic disunity in innate immunity" , In: David Pollock ed.MPEII: mechanisms of protein evolution second annual international conference. , 07-FEB-13 - 12-FEB-13, Denver Colorado USA
  • McRae KM, Good B, Hanrahan JP, Sweeney T, O¿Connell MJ and Keane OM. (Merial medal winner for best talk), Characterising Gastrointestinal Nematode Resistance in Scottish Blackface Lambs, Annual Irish Parasitology Conference, 25-JAN-13 - 25-JAN-13, Dublin, Ireland
  • Morgan CC, Creevey CJ, Kilroy-Glynn P, and O'Connell MJ, "The use of mitochondrial data to infer the mammalian phylogeny - a cautionary tale", Society for Molecular Biology and Evolution Annual international conference, 23-JUN-12 - 26-JUN-12, Dublin, Ireland
  • Morgan CC, Foster PG, Webb AE, Pisani D, McInerney JO, and MJ O¿ Connell, "Heterogeneous models place the root of placental mammals", Society for Molecular Biology and Evolution Annual international conference, 23-JUN-12 - 26-JUN-12, Dublin, Ireland
  • Webb AE, Morgan CC, Walsh TA and O'Connell MJ, A phylomedicine approach to modeling human innate immunity in mouse. , Society for Molecular Biology and Evolution Annual international conference, 23-JUN-12 - 26-JUN-12, Dublin Ireland
  • Webb AE, Morgan CC, Walsh TA and O'Connell MJ, "Immunoinformatics: comparative genomic analysis of the human and mouse innate immune system reveals species-specific patterns", Society for molecular biology and evolution satellite meeting on Phylomedicine., 23-MAR-12 - 26-MAR-12, Phoenix, Arizona USA
  • Walsh TA, Holohan K, O¿Brien A, Carton R., Velasquez E, Morgan CC, Loughran NB, and MJ O¿Connell, Evolution of placenta specific genes and their regulatory elements., International Society for Computational Biology, 9th Annual Rocky Mountain Bioinformatics Conference, 08-DEC-11 - 10-DEC-11, Aspen/Snowmass, CO.
  • Morgan CC, Foster PG, Webb AE, Pisani D, McInerney JO, and MJ O¿ Connell, Inferring the Mammalian Phylogeny using a Heterogeneous Approach, International Society for Computational Biology, 9th Annual Rocky Mountain Bioinformatics Conference, 08-DEC-11 - 10-DEC-11, Aspen/Snowmass, CO.
  • Morgan CC, Creevey CJ, Kilroy-Glynn P, and MJ O¿Connell., An issue of caution in the use of Mitochondrial data to infer the Mammalian Phylogeny., International Society for Computational Biology, 9th Annual Rocky Mountain Bioinformatics Conference, 08-DEC-11 - 10-DEC-11, Aspen/Snowmass, CO.
  • Loughran NB, O¿Connor B, Ó Fágáin C, Nauseef W, and MJ O'Connell , Functional consequence of positive selection revealed through rational mutagenesis of human myeloperoxidase, 2011 SMBE satellite meeting on Mechanisms of Protein Evolution, 05-DEC-11 - 07-DEC-11, University of Colorado School of Medicine, Denver, CO, USA
  • Morgan CC, Foster PG, Webb AE, Pisani D, McInerney JO, and MJ O¿ Connell., Inferring the Mammalian Phylogeny using a Heterogeneous Approach., 2011 SMBE satellite meeting on Mechanisms of Protein Evolution, 05-DEC-11 - 07-DEC-11, University of Colorado School of Medicine, Denver, CO, USA
  • Walsh TA, Holohan K, O¿Brien A, Carton R., Velasquez E, Morgan CC, Loughran NB, and MJ O¿Connell, Evolution of placenta specific genes and their regulatory elements., 2011 SMBE satellite meeting on Mechanisms of Protein Evolution, 05-DEC-11 - 07-DEC-11, University of Colorado School of Medicine, Denver, CO, USA
  • Morgan CC, Foster PG, Webb AE, Pisani D, McInerney JO, and MJ O¿ Connell., Inferring the Mammalian Phylogeny using a Heterogeneous Approach, Young systematists Forum 2011, 01-DEC-11 - 01-DEC-11, Natural History Museum, London
  • Morgan CC, Foster PG, Webb AE, Pisani D, McInerney JO, and MJ O¿ Connell, Mammalian Phylogeny & Evolution: A Heterogeneous Modeling Approach, Evolution 2011, 17-JUN-11 - 21-JUN-11, Norman, Oklahoma, USA
  • Walsh T.A., Holohan K.J., O¿Brien A.C., Velasquez E, and MJ O¿Connell., Evolution of placenta specific genes and their regulatory elements., Annual meeting of the Society for Molecular Biology and Evolution, SMBE 2010, 04-JUL-10 - 08-JUL-10, Lyon, France
  • Walsh T.A., Holohan K.J., O¿Brien A.C., Velasquez E, and MJ O¿Connell., Evolution of Placenta specific genes and their regulatory networks, Evolution 2010, 25-JUN-10 - 29-JUN-10, Portland, Oregon
  • Loughran N.B., O¿Connor B., Fagan C., and MJ O¿Connell., Functional effect of positively selected sites: rational mutagenesis of human myeloperoxidase, International Society for Computational Biology, 7th Annual Rocky Mountain Bioinformatics Conference, 10-DEC-09 - 13-DEC-09, Aspen/Snowmass, CO.
  • Loughran, N. B., O¿Connor, B., Ó Fágáin, C., and MJ O¿Connell, The phylogeny of mammalian heme peroxidases: insights into their functional specificity from comparative genomic analyses., Iowa Inflammation Program Seminar Series, 22-MAY-09 - 22-MAY-09, Carver College of Medicine, University of Iowa, Iowa, USA
  • Loughran N.B., O¿Connor B., Fagan C., and MJ O¿Connell, The Phylogeny of the Mammalian Heme Peroxidases and the evolution of their diverse functions, 6th International Human Peroxidase Meeting, 19-APR-09 - 22-APR-09, Chapel Hill, North Carolina, NC
  • O¿Connell, M.J.*, Loughran N., Donoghue M., Schmid K. and Spillane C., The mammalian imprintome ¿ testing the theories, International Society for Computational Biology, 6th Annual Rocky Mountain Bioinformatics Conference, 03-DEC-08 - 07-DEC-08, Aspen/Snowmass, CO.
  • McGettigan, P and O'Connell M.J.*, Cancer Selection Hypothesis: darwinian evolution of a well known DNA damage response pathway., SMBE, Society for Molecular Biology and Evolution Annual international conference, 22-JUN-07 - 29-JUN-07, Hallifax University, Nova Scotia, CA
  • O'Connell, M.J., Foster, P.G. and McInerney, J.O., "Estimating the number of amino acid fixations in the human lineage since divergence from mouse", Genomes, Evolution and Bioinformatics 2006, 24-MAY-06 - 30-MAY-06, Arizona State University
  • O'Connell, M.J., "Towards an understanding of the role of Positive Selection in Protein Moleculr Evolution", Evolution 2005, 10-JUN-05 - 15-JUN-05, University of Fairbanks, Alaska
  • O'Connell, M.J., *, Using Ancestral Sequence reconstruction to understand protein function, 29-MAR-05 - 31-MAR-05, Kristineberg, Sweden
  • O'Connell, M.J. and McInerney, J.O., Gamma chain receptor interleukins: evidence for positive selection driving the evolution of cell-to-cell communicators in the mammalian immune system., The 12th international conference on intelligent systems for molecular biology and the 3rd European conference on computational biology., 31-JUL-04 - 04-AUG-04, Glasgow, Scotland
  • O'Connell, M.J., Adaptive evolution of the gamma chain dependent cytokines across the mammalia: implications for disease modeling., VIBE Biannual research meeting, 06-MAY-04 - 06-MAY-04, National University of Ireland Maynooth.
  • O'Connell, M.J., The making of Man: large scale bioinformatic approaches for comparative genomic analysis of the human and mouse proteomes., School of Biotechnology seminar series, DCU., 02-MAR-03 - 02-MAR-03, Dublin City University
  • O'Connell, M.J. and McInerney J.O., Extensive lineage specific rate heterogeneity between the human and mouse proteomes., Higher Education Authority Annual Meeting, 08-JAN-03 - 08-JAN-03, Royal College of Surgeons Ireland
  • O'Connell, M.J. and McInerney, J.O., Rate Heterogeneity in Human and Mouse proteomes, an example of positive selection at work., VIBE Biannual research meeting., 25-NOV-02 - 25-NOV-02, Royal College of Surgeons Ireland
  • O'Connell, M.J., McInerney, J.O. and Perriere G., Lineage Specific rate heterogeneity in the human and mouse proteomes., Molecular Evolution (Evolution, Genomics, bioinformatics) annual meeting. Jointly organised by the International Society for Molecular Evolution (ISME) and the Society for Molecular Biology and Evolut, 13-JUN-02 - 16-JUN-02, Sorrento (Naples), Italy
  • O'Connell, M.J. and McInerney J.O., Human evolution and the Y chromosome, The 7th annual meeting of PhD students in Evolutionary Biology, 21-MAR-01 - 24-MAR-01, Munich, Germany