Biotechnology

Biographical Details:

Dr. Anne Parle-McDermott joined the School of Biotechnology, Dublin City University as a Lecturer in Genetics in 2006 from Trinity College Dublin (TCD) where she was a Lecturer at the Smurfit Institute of Genetics (2005-2006) and a postdoctoral research fellow in the School of Immunology and Biochemistry from 1999-2005. Anne completed her Ph.D thesis at the Royal College of Surgeons in Ireland in 1999 and was awarded her Ph.D by TCD in 2000. Anne is currently the Chairperson of the B.Sc. in Genetics & Cell Biology degree, Principal Investigator of the Nutritional Genomics Group, Indian Liaison Officer for the School of Biotechnology and is President of the Irish Society of Human Genetics.

Research Interests:

The Nutritional Genomics Group at DCU focuses on understanding the interaction between nutrition (folate specifically), genomics and human disease. Current projects in the group focus on: 1. Further investigation of the newly identified human folate gene, DHFRL1, in relation to its function and role in disease. DHFRL1 was recently discovered by the Parle-McDermott lab and published in PNAS 108(37): 15157-62 (2011). 2. The impact of folic acid intervention on DNA methylation and gene expression patterns. 3. Further investigation of novel folate responsive genes and their potential role in health and disease.

Selected Peer Reviewed Journals

• Dr. Anne Parle-McDermott. .
• Carroll N, Hughes L, McEntee G, Parle-McDermott A. 2012. Investigation of the molecular response to folate metabolism inhibition. J Nutr Biochem, Mar 6
• Minguzzi S, Molloy AM, Peadar K, Mills J, Scott JM, Troendle J, Pangilinan F, Brody L, Parle-McDermott A. 2012. Genotyping of a tri-allelic polymorphism by a novel melting curve assay in MTHFD1L: an association study of nonsyndromic Cleft in Ireland.. Bmc Medical Genetics, 13, 1, pp29-.
• Harrison A, Parle-McDermott A. 2011. DNA methylation: a timeline of methods and applications. Frontiers in Genetics. 2: 74,
• Parle-McDermott A, Ozaki M. 2011. The impact of nutrition on differential methylated regions of the genome. Advances in Nutrition 2: 463-471. 2:,, pp463-471.
• McEntee G, Minguzzi S, O'Brien K, Ben Larbi N, Loscher C, O'Fagain C, Parle-McDermott A. 2011. The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional.. Proceedings Of The National Academy Of Sciences Usa (pnas), 108, 37, pp15157-15162.
• Carroll N, Pangilinan F, Molloy AM, Troendle J, Mills JL, Kirke PN, Brody LC, Scott JM, Parle-McDermott A. 2009. Analysis of the MTHFD1 promoter and risk of neural tube defects. Human Genetics. 125, 3, pp247-256.
• Parle-McDermott A (Corresponding), Pangilinan F, O'Brien KK, Mills JL, Magee AM, Troendle J, Sutton M, Scott JM, Kirke PN, Molloy AM, Brody LC. 2009. A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency. Human Mutation. 30, 12, pp1650-1656.
• Mills JL, Molloy AM, Parle-Mcdermott A, Troendle JF, Brody LC, Conley MR, Cox C, Pangilinan F, Orr DJ, Earley M, McKiernan E, Lynn EC, Doyle A, Scott JM, Kirke PN. 2008. Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate. Birth Defects Res A Clin Mol Teratol. 82, 9, pp636-643.
• Parle-McDermott et al. (Corresponding). 2007. Parle-McDermott A, Pangilinan F, Mills JL, Kirke PN, Gibney ER, Troendle J, O¿Leary VB, Molloy AM, Conley M, Scott JM, Brody LC The 19bp Deletion Polymorphism in Intron-1 of Dihydrofolate Reductase (DHFR) may protect against Spina Bifida risk by increasing gene expression. Am J Med Genet. 143, 11, pp1174-1180.
• Parle-McDermott et al. 2006. Parle-McDermott A, Mills JL, Molloy AM, Carroll N, Kirke PN, Cox C, Conley MR, Pangilinan FJ, Brody LC, The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels. Mol Genet Metab. 88(3):290-4. 88, 3, pp290-294.
• Parle-McDermott et al. 2006. Parle-McDermott A, Kirke PN, Mills JL, Molloy AM, Cox C, O'leary VB, Pangilinan F, Conley M, Cleary L, Brody LC, Scott JM. Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population. Eur J Hum Genet. 14(6): 768-72. 14, 6, pp768-772.
• Parle-McDermott et al. 2005. Parle-McDermott A, Mills JL, Kirke PN, Cox C, Signore CC, Kirke S, Molloy AM, O'Leary VB, Pangilinan FJ, O'Herlihy C, Brody LC, Scott JM. MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae. Am J Med Genet A. 132, 4, pp365-368.
• Parle-McDermott et al. 2005. Parle-McDermott A, Pangilinan F, Mills JL, Signore CC, Molloy AM, Cotter A,Conley M, Cox C, Kirke PN, Scott JM, Brody LC. A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss. Mol Hum Reprod. 11, 7, pp477-480.
• Parle-McDermott et al. 2003. Parle-McDermott A, McManus EJ, Mills JL, O'Leary VB, Pangilinan F, Cox C, Weiler A, Molloy AM, Conley M, Watson D, Scott JM, Brody LC, Kirke PN; Birth Defects Research Group. Polymorphisms within the vitamin B12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects. Mol Genet Metab. 80, 4, pp463-468.
• Parle-McDermott et al. 2003. Parle-McDermott A, Mills JL, Kirke PN, O'Leary VB, Swanson DA, Pangilinan F, Conley M, Molloy AM, Cox C, Scott JM, Brody LC. Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects. J Hum Genet. 48, 4, pp190-193.
• Parle-McDermott* (corresponding). 2002. Brody LC, Conley M, Cox C, Kirke PN, McKeever MP, Mills JL, Molloy AM, O'Leary VB, Parle-McDermott A*, Scott JM, Swanson DA. A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/ methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. Am J Hum Genet. 71, 5, pp1207-1215.
• Parle-McDermott et al. 2000. Parle-McDermott A, McWilliam P, Tighe O, Dunican D, Croke DT. Serial analysis of gene expression identifies putative metastasis-associated transcripts in colon tumour cell lines. Br J Cancer. 83, 6, pp725-728.
• Mahe et al. 1996. Mahe Y, Parle-McDermott A, Nourani A, Delahodde A, Lamprecht A, Kuchler K. The ATP-binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3. Mol Microbiol. 20, 1, pp109-117.
• Parle-McDermott et al. 1996. Parle-McDermott AG, Hand NJ, Goulding SE, Wolfe KH.Sequence of 29 kb around the PDR10 locus on the right arm of Saccharomyces cerevisiae chromosome XV: similarity to part of chromosome I. Yeast. 12, 10B Suppl, pp999-1004.

Reviews

• Parle-McDermott A & Ozaki M. 2011. The impact of nutrition on differential methylated regions of the genome. Advances in Nutrition, pp463-471.
• Harrison A, Parle-McDermott A. 2011. DNA methylation: a timeline of methods and applications. Frontiers in Genetics 2,

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• McEntee G, Minguzzi S, O'Brien K, Ben Larbi N, Loscher C, O'Fagan C, Parle-McDermott A. GM Prize Winner, Identification of a second dihydrofolate reductase activity in humans: the former annotated pseudogene, DHFRL1, is expressed and functional, IAS Biochemical Society Annual Meeting 2011 " Protein folding and misfolding: mechanisms and consequences", 01-DEC-11 - 02-DEC-11, NUI Maynooth
• McEntee G, Minguzzi S, O'Brien K, Ben Larbi N, Loscher C, O'Fagan C, Parle-McDermott A. GM winner of the Young Investigator Award 2011, Identification of a second dihydrofolate reductase activity in humans: the former annotated pseudogene, DHFRL1, is expressed and functional. Winner of Young Investigator Award, In: Ulster Medical Journal 80(3) ed.Irish Society of Human Genetics Annual Meeting, 02-SEP-11 - 02-SEP-11, University College Dublin, 1 - 9
• McEntee G, Minguzzi S, O'Brien K, Ben Larbi N, Loscher C, O'Fagan C, Parle-McDermott A., Identification of a second dihydrofolate reductase activity in humans: the former annotated pseudogene, DHFRL1, is expressed and functional., 8th International Conference on Homocysteine Metabolism, 18-JUN-11 - 22-JUN-11, Lisboa, Portugal
• Anne Parle-McDermott Grainne McEntee Stefano Minguzzi Alan Harrison Mari Ozaki, , Vitamins in early development and healthy aging, 15-JUN-11 - 17-JUN-11, University College Cork