Biotechnology

Professor Paul Cahill

Name:Professor Paul Cahill
Phone Number8466
Room:X219
E-Mail Address:
Work Area:Assoc. Professor

Professor Paul Cahill

Professor Paul Cahill

Biographical Details:

1990-1991; Post Doctoral Fellow, Department of Pharmacology, New York Medical College, Valhalla, NY, USA: 1991-1992; Research Associate, Department of Physiology & Biophysics, University of Tennessee, Memphis, TN, USA, 1992-1995; Instructor, Department of Surgery, Johns Hopkins University Hospital, Baltimore MD, USA; 1995-1997 Assistant Professor, Department of Surgery, Georgetown University, Washington DC, USA, 1997-1999; Associate Professor, Department of Surgery, Georgetown University, Washington DC, USA; 1999 Professor of Surgery, University of Rochester Medical Center, Rochester NY, USA, 1999-2005; Adjunct Professor, Department of Surgery, University of Rochester Medical Center, Rochester NY, USA, 1999-2001; Wellcome Trust New Blood Fellow/Senior Lecturer, School of Biotechnology, DCU, 2001- to date; Associate Professor, School of Biotechnology, DCU, 2001-2006; Director, Vascular Health Research Centre,DCU

Research Interests:

Cardiovascular diseases remain a major cause of mortality worldwide. Vascular biology is an exciting and rapidly advancing area of biomedical research, with many new and emerging pathophysiological links to an increasing number of diseases. Several advances made have led to significant insights into the treatment not only of vascular diseases such as atherosclerosis, restenosis, ischaemic and congenital heart disorders, stroke, thrombosis and hypertension, but also diabetes and tumor development. ● RESEARCH AREAS ● - ✱ The role of recapitulation of developmental gene regulatory networks (Notch and Hedgehog) in controlling vascular smooth muscle and endothelial cell phenotype and fate. ✱ The role of developmental gene regulatory networks in dictating vascular remodeling following vascular injury and in-stent restenosis ✱ The role of Notch and hedgehog signaling gene regulatory networks in controlling mesenchymal stem cell (MSC) fate; differentiation into vascular cells. ✱ The role of Notch and hedgehog signaling pathways in vascular tissue engineering ✱

Selected Peer Reviewed Journals

Selected Chapters

  • Redmond EM, Guha S, Walls D, Cahill PA. 2011. Hemodynamic regulation of vascular smooth muscle function. Muscle: Fundamental Biology and Mechanisms and Disease
  • Guha, S, Walls, D, Redmond EM, Cahill PA. 2010. Pathogenetic mechanisms in Alagille syndrome. Encyclopedia of Life Sciences

Reviews

  • Morrow D, Guha S, Sweeney C, Birney Y, Walshe T, O'Brien C, Walls D, Redmond EM, Cahill PA. 2008. Notch and vascular smooth muscle cell phenotype. Circ Res. 103, pp1370-1382.
  • Cummins PM, von Offenberg Sweeney N, Killeen MT, Birney YA, Redmond EM, Cahill PA. 2007. Cyclic strain-mediated matrix metalloproteinase regulation within the vascular endothelium: a force to be reckoned with. Am J Physiol Heart Circ Physiol. 292, ppH38-H42.
  • Cummins PM, Cotter EJ, Cahill PA. 2004. Hemodynamic regulation of metallopeptidases within the vasculature. Protein Pept Lett. 11, pp433-442.
  • Kim SI, Grum-Tokars V, Swanson TA, Cotter EJ, Cahill PA, Roberts JL, Cummins PM, Glucksman MJ. 2003. Novel roles of neuropeptide processing enzymes: EC3.4.24.15 in the neurome. J Neurosci Res. 74, pp456-467.
  • Birney Y, Redmond EM, Sitzmann JV, Cahill PA. 2003. Eicosanoids in cirrhosis and portal hypertension. Prostaglandins Other Lipid Mediat. 72, pp3-18.
  • Cahill PA, Redmond EM, Sitzmann JV. 2001. Endothelial dysfunction in cirrhosis and portal hypertension. Pharmacol Ther. 89, pp273-293.
  • Redmond EM, Sitzmann JV, Cahill PA. 2000. Potential mechanisms for cardiovascular protective effect of ethanol. Acta Pharmacol Sin. 21, pp385-390.
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