BDI
Dr Vladimir Gubala
| Name: | Dr Vladimir Gubala |
|---|---|
| Phone Number | 6560 |
| Room: | A228 |
| E-Mail Address: |
Dr Vladimir Gubala
Biographical Details:
I was born in Slovakia and I obtained my BSc and MSc degree from the Slovak University of Technology in 1999 and 2001, respectively. My research project focused on Organic synthesis, and characterization of enantiomerically pure derivatives of unnatural amino acids in the synthesis of pharmaceutically active compounds. In 2001, I enrolled in the chemistry graduate programme of University of Puerto Rico, USA, where I was working on project called `Self-assembled Nanostructures based on 8-Aryl-2'-deoxyguanosine analogues¿. I defended my doctoral thesis in 2006 and moved to University of Florida, USA, where I was working as a post-doctoral associate in Dr. Castellano¿s group. In May 2007, I started my appointment at DCU, specifically at the Biomedical Diagnostics Institute. In total, I have published 20 peer-reviewed articles (4 of which as corresponding author), one book chapter and I have filed two patent applications as a lead inventor. I have given 6 oral presentations (one INVITED) at international conferences, including the American Chemical Society national meetings, The Electrochemical Society meeting, Biosensors and Conference on Advanced Material and Nanotechnology. I find Ireland as a great place to pursue my hobbies, which include football and off-road cycling. I¿m a nature enthusiast and I teach my two sons to respect and know the environment they¿re living in.
Selected Peer Reviewed Journals
- Gandhiraman R.P., Coyle C., Gubala V., Hoai Le N. C., Swift P., Daniels S., Williams D. E. 2011. Tetraethyl Orthosilicate and Acrylic Acid Forming Robust Carboxylic Functionalitities on Plastic Surfaces for Biodiagnostics. Plasma Processes And Polymers (online),
- Hoai Le N. C., Gubala V., Gandhiraman R., Daniels S., Williams D. E. 2011. Evaluation of different non-specific binding blocking agents deposited inside poly(methyl methacrylate) (PMMA) microfluidic flow-cells. Langmuir,
- Dr. Vladimir Gubala, Carol Crean (née Lynam), Robert Nooney, Stephen Hearty, Barry McDonnell, Katherine Heydon, Richard O'Kennedy, Brian D. MacCraith and David E. Williams. 2011. Kinetics of immunoassays with particles as labels: effect of antibody coupling using dendrimers as linkers. The Analyst, 136, 12, pp2533-2541.
- C. Charlton, V. Gubala, R. P. Gandhiraman, J. Wiechecki, N. C. Hoai Le, C. McDonagh, B. D. MacCraith, D. E. Williams. 2011. TIRF Microscopy as a Screening Method for Non-Specific Binding on Surfaces. Journal Of Colloid And Interface Science, 354, 1, pp405-409.
- C. W. Evans, V. Gubala, R. Nooney, D. E. Williams, M. A. Brimble, A.L. Devries. 2011. How do Antarctic notothenioid fishes cope with internal ice? A novel function for antifreeze glycoproteins. Antarctic Science, 23, 1, pp57-64.
- V. Gubala, N. C. Hoai Le, R. P. Gandhiraman, C. Coyle, S. Daniels and D. E. Williams. 2010. Functionalization of cyclo olefin polymer substrates by plasma oxidation: Stable film containing carboxylic acid groups for capturing biorecognition elements. Colloids And Surfaces B: Biointerfaces, 81, , pp544-549.
- Mariana Martín-Hidalgo, Karla Camacho-Soto, Vladimir Gubala, José M. Rivera. 2010. Self-assembled cation transporters made from lipophilic 8-phenyl-2¿-deoxyguanosine derivatives. Supramolecular Chemistry, 22, 11-12, pp862-869.
- N. C. Hoai Le, V.Gubala, R. P. Gandhiraman, C. Coyle, S. Daniels, D. E. Williams. 2010. Total internal reflection ellipsometry (TIRE) as a label-free detection technique for the monitoring of bioassays on a functionalized cyclo olefin polymer surface. Analytical And Bioanalytical Chemistry, 398, 5, pp1927-1936.
- C. Volcke, R. P. Gandhirman, V. Gubala, C. Doyle, P. A. Thiry, A. A. Cafolla, B. James, D. E. Williams. 2010. Plasma functionalization of AFM tips for measurement of chemical interactions. Journal Of Colloid And Interface Science, 348, 2, pp322-328.
- R.P. Gandhiraman, V. Gubala, Le Cao Hoai Nam, C. Volcke, C.Doyle, B. James, S. Daniels, D.E. Williams. 2010. Deposition of chemically reactive and repellent sites on biosensor chips for reduced non-specific binding. Colloids And Surfaces B: Biointerfaces, 7, 1, pp270-275.
- R. P. Gandhiraman, C. Volcke, V. Gubala, C. Doyle, J. Raj, L. Basabe-Desmonts, M. Iacono, R. I. Nooney, G. Herzog, S. Daniels, D. W. M. Arrigan, B. James and D. E. Williams. 2010. High Efficiency Amine Functionalization of Cyclo Olefin Polymer Surfaces for Biodiagnostics. Journal Of Materials Chemistry, 20, , pp4116-4127.
- V. Gubala, R. P. Gandhiraman, C. Volcke, C. Doyle, C. Coyle, B. James, S. Daniels and D. E. Williams. 2010. Silanation of Cyclo Olefin Polymer Surfaces. Comprehensive characterization of (3-Aminopropyl) tris-ethoxysilane coatings by PECVD: from the Contact Layer into the Bulk. The Analyst, 135, , pp1375-1381.
- V. Gubala, X. Le Guevel, R. Nooney, B. MacCraith and D. E. Williams. 2010. A comparison of mono and multivalent linkers and their effect on the colloidal stability of nanoparticle and immunoassays performance. Talanta, 81, , pp1833-1839.
- C. Volcke, R. P. Gandhirman, V. Gubala, J. Raj, T. Cummins, G. Fonder, R. I. Nooney, Z. Mekhalif, G. Herzog, S. Daniels, D.W.M. Arrigan, A. A. Cafolla, D. E. Williams. 2010. Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials. Biosensors & Bioelectronics, 8, 25, pp1875-1880.
- C. Volcke, R.P. Gandhiraman, L. Basabe-Desmonts, M. Iacono, V. Gubala, F. Cecchet, A.A. Cafolla and D.E. Williams. 2010. Protein pattern transfer for biosensor applications. Biosensors & Bioelectronics, 25, , pp1295-1300.
- Betancourt, J. E.; Martín-Hidalgo, M.; Gubala, V.; Rivera, J. M. 2009. Solvent-Induced High Fidelity Switching Between two Discrete Supramolecules. Journal Of The American Chemical Society, 131, 9, pp3186-3188.
- Le Guevel, X.; MacCraith, B.; Nooney, R.; Gubala, V.; Stranik, O.; McDonagh, C.; Wang, F. 2009. Synthesis, Stabilization and functionalization of silver nanoplates for biosensor applications. Journal Of Physical Chemistry Part C: Nanomaterials And Interfaces, 113, , pp16380-16383.
- Rivera-Sánchez, M.; Andújar-de-Sanctis, I.; Garcia-Arriaga, M.; Gubala, V.; Hobley, G.; Rivera, J. M. 2009. Walking a supramolecular tightrope: A self-assembled dodecamer from an 8-Aryl-2¿-deoxyguanosine derivative. Journal Of The American Chemical Society, 131, 30, pp10403-10405.
- Hobley, G.; Gubala, V.; Rivera-Sanchez, M.C.; Rivera, J. M. 2008. Synthesis of 8-Heteroaryl-2'-deoxygaunosine Derivatives. Synlett, 10, , pp1510-1514.
- Hernandez Prada, J. A.; Ferreira, A. J.; Katovich, M. J.; Shenoy, V.; Qi, Yanfei; Santos, R. A. S.; Castellano, R. K.; Lampkins, A. J.; Gubala, V.; Ostrov, D. A.; Raizada, M. K. 2008. Structure-Based Identification of Small-Molecule Angiotensin-Converting Enzyme 2 Activators as Novel Antihypertensive Agents. Hypertension, 51, 5, pp1312-1317.
- Gubala, V.; Rivera-Sanchez, M.C.; Hobley, G; Rivera, J.M. 2007. The impact of 8-aryl- and 8-heteroaryl-2'-deoxyguanosine derivatives on G-quadruplex formation. Nucleic Acids Symposium Series, 51, , pp39-40.
- Gubala, V.; De Jesús, D.; Rivera, J. M.,. 2006. Self-assembled ionophores based on 8-aryl-2¿-deoxyguanosine analogues. Tetrahedron Letters, 47, 9, pp1363-1488.
- Gubala, V.; Betancourt, J. E.; Rivera, J. M. 2004. Expanding the Hoogsteen Edge of 2'-Deoxyguanosine: Consequences for G-Quadruplex Formation. Organic Letters, 6, 25, pp4735-4738.
Selected Chapters
- Dr. Vladimir Gubala. 2011. Dye Doped Nanoparticles. Encyclopedia of Nanotechnology, pp00148-00223.
- V. Gubala, R.P. Gandhiraman, C. Charlton, N.C H. Le, and D. E. Williams, Recent advances in the surface chemistry of dye-doped nanoparticles and disposable, plastic substrates for highly sensitive and rapid bioassay devices, Fifth International Conference on Advanced Materials and Nanotechnology, 07-FEB-11 - 11-FEB-11, Wellington, New Zealand
- Ram Prasad Gandhiraman, Vladimir Gubala, David E Williams, Carol Lynam, Christy O'Mahony, Nam Cao Hoai Le, Designing low sample-volume, high-sensitivity, high-precision, single-use immunoassay devices, Biosensors 2010, 26-MAY-10 - 28-MAY-10, Glasgow
- Vladimir Gubala, Dirk Kurzbuch, Ram P. Gandhiraman, Carol Lynam, Robert Nooney, Xavier Le Guevel, Brian MacCraith, David E. Williams, Inexpensive optical platform based on supercritical angle fluorescence and the use of dye doped silica nanoparticles for sensitive bioassays, Europtrode X, 27-MAR-10 - 31-MAR-10, Prague, Czech Republic
- V. Gubala, R. Nooney, X. Le Guevel, B. MacCraith, Labeling of biomolecules with near-infrared dye doped silica nanoparticles: improved protocol using multivalent linkers, 4th NANOSMAT 2009, 19-OCT-09 - 22-OCT-09, Rome, Italy
- Vladimir Gubala, Robert Nooney, Xavier Le Guevel, Katarzyna Grochowska, Carol Lynam, David E. Williams, Labeling of biomolecules with near-infrared dye doped silica nanoparticles: improved protocol using multivalent linkers, International Symposium on Functional Nanomaterials, 10-SEP-09 - 11-SEP-09, Dublin
- V. Gubala, R.P. Gandhiraman, C. Volcke, S. Daniels, B. MacCraith and D. E. Williams, Optimizing activation of plastic substrate for the development of biosensor binding surface, 215th The Electrochemical Society Meeting, 24-MAY-09 - 29-MAY-09, San Francisco, USA
- V. Gubala, R. P. Gandhiraman, C. Volcke, L.-B. Desmonts, S. Daniels, B. D. MacCraith, Stability Studies of Amine Functional Coatings Deposited by PECVD on COP Surfaces for Biosensor Applications, 13th International Conference on Biomedical Engineering, 03-DEC-08 - 06-DEC-08, Suntec Centre, Singapore
- Basabe-Desmonts, L.; Kurzbuch, D.; Gubala, V.; Ricco, A. J.; Lee, L. J.; Pitner, B.; MacCraith, B. D, Maltose detection using a maltose binding protein monolayer and an inexpensive platform based on supercritical angle fluorescence collection, Europtrode IX, 30-MAR-08 - 02-APR-08, Dublin
- Gubala, V.; Yuan, L.; Javed, A.; Mattler, J.; Castellano, R. K., Ester functionalized AATs and their precursors, Florida Annual Meeting and Exposition of the American Chemical Society, 10-MAY-07 - 12-MAY-07, Orlando, FL, USA
- Gubala, V.; Hobley, G.; Rivera, J. M., Self-assembled G-quadruplexes based on 8HetdG analogues, 231st American Chemical Society National Meeting & Exposition, 26-MAR-06 - 30-MAR-06, Atlanta, GA, USA
- Gubala, V.; Vilkas, M. J.; Ishikawa, Y.; Rivera, J. M., NMR and ab-initio studies on the factors controlling the supramolecular structure and dynamics of self-assembled G-analogues, 229th American Chemical Soc. National Meeting & Exposition, 13-MAR-05 - 17-MAR-05, San Diego, CA, USA
- Rivera, J. M.; Gubala, V., Modulating the supramolecular structure and properties of G-quadruplexes by using 8- phenyl-2¿-deoxyguanosine analogues, 229th American Chemical Soc. National Meeting & Exposition, 13-MAR-05 - 17-MAR-05, San Diego, CA, USA
- Gubala, V.; Rivera, J. M., Self-assembled nanostructures based on 8-aryl-2¿-deoxyguanosine analogues, 227th American Chemical Society National Meeting & Exposition, 28-MAR-04 - 01-APR-04, Anaheim, CA, USA
- Betancourt, J. E.; Gubala, V.; Rivera, J. M., Fluorescent properties of 8-Aryl-2¿-Deoxyguanosine Analogues, ACS-PR Section Senior Technical Meeting, 07-NOV-03 - 08-NOV-03, Guajataca, PR, USA
- Gubala, V.; Rivera, J. M., Synthesis and Self-assembling Properties of 8-Aryl-2¿-Deoxyguanosine Analogue, ACS-PR Section Senior Technical Meeting, 07-NOV-03 - 08-NOV-03, Guajataca, PR, USA










