NICB

Biographical Details:

B.Sc. in Biotechnology, Dublin City University 1996. Ph.D. at the National Cell and Tissue Culture Centre, Dublin City University, 2000. Post-doctoral training at Columbia University, New York 2000-2001 and NYU School of Medicine, New York, 2002-2006. Returned to Ireland in October 2006 to establish a virus research group after being awarded an SFI Principal Investigator Grant.

Research Interests:

Our lab is interested in cellular control of protein synthesis, in particular how DNA viruses manipulate the host cells protein synthesis machinery in order to replicate and its potential as a target for therapeutic intervention.

Selected Peer Reviewed Journals

• McMahon, R., Zaborowska, I. and Walsh, D. 2011. Noncytotoxic inhibition of viral infection through eIF4F-independent suppression of translation by 4EGi-1. Journal Of Virology, 85, 2, pp853-864.
• Walsh, D. 2010. Manipulation of the host translation initiation complex eIF4F by DNA viruses. Biochemical Society Transactions, 38, 6, pp1511-1516.
• Zabarowska, I and Walsh, D. 2009. PI3K signaling regulates rapamycin-insensitive translation initiation complex formation in Vaccinia Virus-infected cells. Journal Of Virology, 83, 8, pp3988-3992.
• Arias, C., D. Walsh, J. Harbell, A. Wilson and I. Mohr. 2009. Activation of host translational control pathways by a viral developmental switch. Plos Pathogens, 5(3):10.1371/journal.ppat.1000334.,
• McMahon, R and Walsh, D. 2008. Efficient quiescent infection of Normal Human Diploid Fibroblasts with wild-type Herpes Simplex Virus type 1. Journal Of Virology, 82, 20, pp10218-10230.
• Walsh D, Arias C, Perez C, Halladin D, Escandon M, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Mohr I. 2008. eIF4F Architectural Alterations Accompany Translation Initiation Factor Redistribution in Poxvirus-infected Cells. Molecular Cell Biology, 28, 8, pp2648-2658.
• Walsh, D and Mohr, I. 2006. Assembly of an active translation initiation factor complex by a viral protein. Genes & Development, 20, 4, pp461-472.
• Walsh D, Perez C, Notary J and Mohr I. 2005. Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells. Journal Of Virology, 79, 13, pp8057-8064.
• Walsh,D and Mohr, I. 2004. Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells. Genes & Development, 18, 6, pp660-672.
• Walsh D, Meleady P, Power B, Morley SJ and Clynes M. 2003. Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines. Differentiation, 71, 2, pp126-134.
• McBride, S., D. Walsh, P. Meleady, N. Daly and M. Clynes. 1999. Bromodeoxyuridine induces keratin protein synthesis at a post-transcriptional level in human lung tumour cell lines. Differentiation, 64, 3, pp185-193.
• Daly, N., P. Meleady, D. Walsh, and M. Clynes. 1998. Keratin and Integrin Expression in Lung Cancer and MDR. Cytotechnology, 27, , pp321-344.

• McMahon, R and D. Walsh, Host MEK-ERK signalling is required for efficient reactivation of quiescent herpes simplex virus type 1, 34th International Herpesvirus Workshop., 25-JUN-09 - 25-JUN-09, Cornell, Ithaca, New York, U.S.A.
• Arias, C., Walsh, D., Perez, C., Halladin, D., Ueda, T., Watanabe-Fukunaga, R., Fukunaga, R, and Mohr, I., Remodeling, redistribution and modification of eIF4F-core and associated components in poxvirus-infected cells., Translational Control, 03-SEP-08 - 07-SEP-08, Cold Spring Harbor Laboratories, New York, U.S.A.
• Arias, C., Walsh, D., Harbell, J., Wilson, A. and Mohr, I., Execution of viral developmental decisions activates host translational control pathways., Translational Control, 03-SEP-08 - 07-SEP-08, Cold Spring Harbor Laboratories, New York, U.S.A.
• McMahon, R and Walsh, D., CONTROL OF PROTEIN SYNTHESIS DURING ENTRY INTO AND REACTIVATION FROM HERPES SIMPLEX VIRUS TYPE 1 QUIESCENCE, Translational Control, 03-SEP-08 - 07-SEP-08, Cold Spring Harbor Laboratories, New York, U.S.A.
• Zaborowska, I and Walsh, D., RELOCALISATION OF TRANSLATION FACTORS TO VIRAL FACTORIES BY THE VACCINIA VIRUS ssDNA-BINDING PROTEIN I3L, Translational Control, 03-SEP-08 - 07-SEP-08, Cold Spring Harbor Laboratories, New York, U.S.A.
• Zaborowska, I. Arias, C., Perez, C., Halladin, D., Escandon, M., Ueda, T., Watanabe-Fukunaga, R., Fukunaga, R., Mohr, I, and Walsh, D., eIF4F Architectural Alterations Accompany Translation Initiation Factor Redistribution in Vaccinia Virus-infected Cells., XVII International Poxvirus and Iridovirus Conference, 07-JUN-08 - 12-JUN-08, Grainau, Germany
• Arias, C., Walsh, D., Harbell, J., Wilson, A. and Mohr, I., MODIFICATION OF TRANSLATION INITIATION FACTOR COMPLEXES UPON REACTIVATION OF LATENT KSHV, 10th International Workshop on Kaposi's Sarcoma Associated Herpesvirus (KSHV) and Related Agents, 01-AUG-07 - 05-AUG-07, Portland, Oregon, USA
• Walsh, D et al., Suppression of Poxvirus Replication by an inhibitor of the eIF4E kinase, Mnk, Cold Spring Harbor Meetings, 09-SEP-06 - 13-SEP-06, Cold Spring Harbor Laboratories, New York
• Walsh, D and Mohr, I., Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells. , Cold Spring Harbor Meetings, Translational Control, 08-SEP-04 - 12-SEP-04, Cold Spring Harbor Laboratories, New York
• Walsh, D and Mohr, I, ICP0-dependent phosphorylation of the cap-binding protein eIF4E and the translational represor 4E-BP1 in HSV-1 infected cells, International Herpesvirus Workshop, 07-AUG-03 - 12-AUG-03, Madison, Wisconsin
• Walsh, D and Mohr, I., Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells., Cold Spring Habor Meetings, Translational Control, 07-SEP-02 - 11-SEP-02, Cold Spring Harbor Laboratories, New York
• Walsh, D et al., Bromodeoxyuridine induces keratin synthesis at a post-transcriptional level in human lung tumour cell lines: A Role for Translation, Translation UK, 01-AUG-99 - 06-AUG-99, University of Dundee, Dundee