BDI

Biographical Details:

July 2011 - Present: Integration Manager, Biomedical Diagnostics Institute. September 2009 - June 2011: Laboratory Manager, Centre for Bioanalytical Sciences, Dublin City University. December 2005 - August 2009: Postdoctoral Researcher. Centre for Bioanalytical Sciences and Applied Biochemistry Group, Dublin City University. October 2004 - November 2005: Postdoctoral Researcher. Prion Research Group, University College Dublin. October 1999 - April 2004: Ph.D. Researcher. Polyketide Engineering Group, University College Dublin.

Research Interests:

Antibody engineering, glycobiology, prion pathogenesis and polyketide engineering

Selected Peer Reviewed Journals

• Musante L, Saraswat M, Duriez E, Byrne B, Ravida A, Domon B and Holthofer H. 2012. Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment. Plos One, 7, 7, ppe3727-.
• Welbeck K, Leonard P, Gilmartin N, Byrne B, Viguier C, Arora S and O'Kennedy R. 2011. Generation of an anti-NAGase single chain antibody and its application in a biosensor-based assay for the detection of NAGase in milk. Journal Of Immunological Methods, 364, 1-2, pp14-20.
• O'Kennedy, R., Townsend, S., Donohoe, G.G., Leonard, P., Hearty, S. and Byrne, B. 2010. Speedy, Small, Sensitive and Specific - reality or myth for future analytical methods. Analytical Letters, 43, 10, pp1630-1648.
• Hearty, S., Conroy, P., Ayyar, B.V., Byrne, B. and O'Kennedy, R. 2010. Surface Plasmon Resonance for Vaccine Design and Efficacy Studies: Recent Applications and Future Trends. Expert Review Of Vaccines, 9, 6, pp645-664.
• McGrath, R.T., McKinnon, T.A., Byrne, B., O'Kennedy, R., Terraube, V., McRae, E., Preston, R.J., Laffan, M.A. and O'Donnell, J.S. 2010. Expression of terminal {alpha}2-6 linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13. Blood, 115, 13, pp2666-2673.
• Reeves, E.P., Williamson, M., Byrne, B., Bergin, D.A., Smith, S.G.J., Greally, P., O'Kennedy, R., O'Neill, S.J. and McElvaney, N.G. 2010. IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis. Journal Of Immunology, 184, 3, pp1642-1652.
• Byrne B., Stack E., Gilmartin N. and O'Kennedy R. 2009. Antibody-based sensors: principles, problems and potential for detection of pathogens and associated toxins. Sensors, 9, 6, pp4407-4445.
• Byrne B., Donohoe G. and O'Kennedy R. 2007. Sialic acids: carbohydrate moieties that influence the biological and physical properties of biopharmaceutical proteins and living cells.. Drug Discovery Today, 12, 7-8, pp319-326.
• Carmody M., Murphy B., Byrne B., Power P., Rai D., Rawlings B. and Caffrey P. 2005. Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.. Journal Of Biological Chemistry, 280, 41, pp34420-34426.
• Carmody M., Byrne B., Murphy B., Breen C., Lynch S., Flood E., Finnan S. and Caffrey P. 2004. Analysis and manipulation of amphotericin biosynthetic genes by means of modified phage KC515 transduction techniques. Gene, 343, 1, pp107-115.
• Byrne B., Carmody M., Gibson E., Rawlings B. and Caffrey P.. 2003. Biosynthesis of deoxyamphotericins and deoxyamphoteronolides by engineered strains of Streptomyces nodosus. Chemistry & Biology, 10, 12, pp1215-1224.

Selected Chapters

• Byrne, B., Stack, E. and O'Kennedy, R. 2012. The application of biosensors for the sensitive detection of agricultural contaminants, pathogens and food-borne toxins. , pp1482-1520.
• Arora, S., Pastorella, G., Byrne, B., Marsili, E. and O'Kennedy, R. 2010. Microbial cells and biosensing: a dual approach. Reviews in Pharmaceutical and Biomedical Analysis. In Press.
• Byrne B., Carolan N. and O'Kennedy R. 2008. Biosensor-based technologies for the evaluation of quality. Post Harvest Biology and Technology of Fruits, Vegetables and Flowers, pp418-442.

Selected Non-peer Reviewed Journals

• McGrath, R., McKinnon, T.A.J., Byrne, B., O'Kennedy, R., Laffan, M.A., McRae, E., Preston, R.J.S. and O'Donnell, J.S. 2009. Terminal alpha-2,6-linked sialic acid expression enhances VWF proteolysis by ADAMTS13. Blood, 114, pp18-18.
• Reeves, E.P., Williamson, M. Byrne, B., O'Kennedy, R., O'Neill, S.J., Greally, P. and McElvaney, N.G. 2009. A tale of two cytokines: interleukin-8 and interleukin-18 competitively compete for survival within the cystic fibrosis lung. Pediatric Pulmonology, 44, pp257-257.

• Byrne, B. and Caffrey, P., Novel polyenes produced by engineered Streptomyces nodosus strains., Society for General Microbiology (SGM) Meeting 2004., - ,
• Reeves, E.P., Williamson, M., Byrne, B., O'Kennedy, R., O'Neill, S.J., Greally, P. and McElvaney, N.G., Interleukin-8 dictates glycosaminoglycan binding and stability of interleukin-18 in cystic fibrosis., Annual North American Cystic Fibrosis Conference, 2009., - ,
• McGrath, R., McKinnon, T.A.J., Byrne, B., O¿Kennedy, R., Laffan, M.A., McRae, E., Preston, R.J.S. and O¿Donnell, J.S., Terminal alpha-2,6-linked sialic acid expression enhances VWF proteolysis by ADAMTS13., In: Blood ed.51st American Society of Haematology Meeting and Exposition, 2009., - ,
• McGrath, R.T., McKinnon, T.A.J., Byrne, B., O'Kennedy, R., Terraube, V., McRae, E., Preston, R.J.S., Laffan, M. and O'Donnell, J.S., Sialic Acid Expression on von Willebrand Factor - A Novel Critical Regulator of ADAMTS13 Proteolysis and Functional Activity., 51st American Society of Haematology Meeting and Exposition, 2009., - ,
• McGrath, R.T., McKinnon, T.A.J., Byrne, B., O'Kennedy, R., Terraube, V., McRae, E., Preston, R.J.S., Laffan, M. and O'Donnell, J.S., Sialic Acid Expression on von Willebrand Factor - A Novel Critical Regulator of ADAMTS13 Proteolysis and Functional Activity., Haematology Association Ireland, Annual Meeting, 2009., - ,
• McGrath, R.T., Van den Biggelaar, M., Byrne, B., McRae, E., Rawley, O., Preston, R.J.S., O'Kennedy, R., Voorberg, J. and O'Donnell, J.S., Platelet-derived von Willebrand factor demonstrates specific resistance to ADAMTS13 proteolysis., Haematology Association Ireland, Annual Meeting, 2010., - ,