Chemical Sciences

Biographical Details:

Andreas Heise received his PhD in Polymer Chemistry in 1997 from the University of Hannover, Germany, under the supervision of Prof. Henning Menzel on grafting of polypeptides to functional surfaces. In 1997 he was awarded a two-year postdoc grant from the German Science Foundation (DFG) for a joint position at the IBM Almaden Research Center and Stanford University, California, USA. During that time he worked closely with the research groups of Dr. Robert Miller and Dr. Jim Hedrick (IBM), and Prof. Curt Frank (Stanford) on the development of functional polymer architectures for low dielectric materials for on-chip applications. In 1999 he moved to an industrial senior scientist position at DSM Research in The Netherlands, which he held until 2008. In the performance materials group he was responsible for the evaluation and development of advanced polymer technologies and their industrial application. Besides his industrial position, in 2002 Andreas Heise accepted a part-time assignment as a research group leader in the polymer chemistry group at the TU Eindhoven, The Netherlands. In 2008 he accepted a SFI Stokes Senior Lecturer position at Dublin City University, Ireland, were he established a Polymer Research group.

Research Interests:

The main research interest is in the rational design of functional polymeric materials for advanced applications. A strong emphasis is on the development of new synthetic routes towards well-defined functional materials, which includes controlled polymerisation and functionalisation techniques as well as biotechnological methods. Target application areas are sensor and biomedical technology, and nanoscience. In a highly interdisciplinary approach synthetic and application driven research is conducted in collaboration with several academic and industrial partners.

Selected Peer Reviewed Journals

• Claudino, M.; van der Meulen, I.; Trey, S.; Jonsson, M.; Heise, A. Johansson, M. 2012. Photoinduced thiol¿ene crosslinking of globalide/ε-caprolactone copolymers: Curing performance and resulting thermoset properties. Journal Of Polymer Science Part A-polymer Chemistry, 50,, pp16-24.
• Ates, Z.; Thornton, P.D.; Heise, A. 2011. Side-chain functionalisation of unsaturated polyesters from ring-opening polymerisation of macrolactones by thiol¿ene click chemistry. Polymer Chemistry, 2,, pp309-.
• Cui Wang; Yan Xiao; Heise, A.; Meidong Lang. 2011. Organometallic and enzymatic catalysis for ring opening copolymerization of ε-caprolactone and 4-methyl-ε-caprolactone. Journal Of Polymer Science Part A-polymer Chemistry, 49,, pp5293-5300.
• Habraken, G.J.M.; Peeters, M.; Thornton, P.D.; Koning, C.E.; Heise, A. 2011. Selective Enzymatic Degradation of Self-Assembled Particles from Amphiphilic Block Copolymers Obtained by the Combination of N-Carboxyanhydride and Nitroxide-Mediated Polymerization. Biomacromolecules, 12,, pp3761-3769.
• Thornton, P.D.; Heise, A.. 2011. Bio-functionalisation to enzymatically control the solution properties of a self-supporting polymeric material. Chemical Communications, 47,, pp3108-.
• van der Meulen, I.; Gubbels, E.; Huijser, S.; Sablong, R.; Koning, C.E.; Heise, A.; Duchateau, R. 2011. Catalytic Ring-Opening Polymerization of Renewable Macrolactones to High Molecular Weight Polyethylene-like Polymers. Macromolecules, 44,, pp4301-4305.
• van der Meulen, I.; Li, Y.; Deumens, R.; Joosten, B.E.A.J. Koning, C.E.; Heise, A. 2011. Copolymers from Unsaturated Macrolactones: Toward the Design of Cross-Linked Biodegradable Polyesters. Biomacromolecules, 12,, pp837-843.
• Ventura, C.; Byrne, R.; Audouin, F.; Heise, A. 2011. Atom transfer radical polymerization synthesis and photoresponsive solution behavior of spiropyran end-functionalized polymers as simplistic molecular probes. Journal Of Polymer Science Part A-polymer Chemistry, 49,, pp3455-3463.
• Yeniad, B; Naik, H; Amir, R; Koning, C.E.; Hawker, C.J.; Heise, A. 2011. Encoded dendrimers with defined chiral composition via `click¿ reaction of enantiopure building blocks. Chemical Communications, 47,, pp9870-9872.
• Ziwei Deng; Habraken, G.J.M.; Peeters, M.; Heise, A.; de With, G.; Sommerdijk, N.A.J.M. 2011. Fluorescein functionalized random amino acid copolymers in the biomimetic synthesis of CaCO3. Soft Matter, 7,, pp9685-9694.
• Antheunis, H.; van der Meer, J.-C.; de Geus, M.; Heise, A.; Koning, C.E.. 2010. An autocatalytic equation describing the change in molecular weight during hydrolytic degradation of aliphatic polyesters. Biomacromolecules, 11,, pp1118-.
• Audouin, F.; Knoop, R.J.I.; Huang, J.; Heise, A. 2010. Star polymers by cross-linking of linear poly(benzyl-L-glutamate) macromonomers via free-radical and RAFT polymerization. A simple route toward peptide-stabilized nanoparticles. Journal Of Polymer Science Part A-polymer Chemistry, 48,, pp6402-.
• Byrne, R.; Ventura, C.; Lopez, F.B.; Walther, A.; Heise, A.; Diamond, D. 2010. Characterisation and analytical potential of a photo-responsive polymeric material based on spiropyran. Biosensors & Bioelectronics, 26,, pp1392-.
• de Geus, M.; van der Meulen, I.; Goderis, B.; Van Hecke, K.; Dorschu, M.; van der Werff, H.; Koning, C.E.; Heise, A. 2010. Performance polymers from renewable monomers: high molecular weight poly(pentadecalactone) for fiber applications. Polymer Chemistry, 1,, pp525-.
• Habraken, G.J.M.; Peeters, M.; Dietz, C.H.J.T.; Koning, C.E.; Heise, A. 2010. How controlled and versatile is N-Carboxy anhydride (NCA) polymerization at 0°C? Effect of temperature on homo, block and graft (co)polymerization. Polymer Chemistry, 1,, pp514-.
• Huang, J.; Habraken, G.; Audouin, F.; Heise, A. 2010. Hydrolytically Stable Bioactive Synthetic Glycopeptide Homo- and Copolymers by Combination of NCA Polymerization and Click Reaction. Macromolecules, 43,, pp6050-.
• Knoop, R.J.I.; de Geus, M.; Habraken, G.J.M.; Koning, C.E.; Menzel, H.; Heise, A.. 2010. Stimuli responsive peptide conjugated polymer nanoparticles. Macromolecules, 43,, pp4126-.
• Thornton, P.D.; Heise, A. 2010. Highly specific dual enzyme-mediated payload release from peptide-coated silica particles. Journal Of The American Chemical Society, 132,, pp2024-.
• Cummins D, Duxbury CJ, Quadflieg PJLM, Magusin PCMM, Koning CE, Heise A. 2009. Click chemistry as a means to functionalize macroporous polyHIPE. Soft Matter, 5, pp804-.
• Duxbury, C.J; Cummins, D.; Heise, A. 2009. Glaser coupling of polymers: side reaction in Huisgens `click¿ coupling reaction and opportunity for polymers with Focal Diacetylene Units in Combination with ATRP. Journal Of Polymer Science Part A-polymer Chemistry, 47,, pp3795-.
• Habraken, G.J.M.; Koning, C.E.; Heise, A. 2009. Peptide Block Copolymers by N-Carboxyanhydride Ring-Opening Polymerization and Atom Transfer Radical Polymerization: The Effect of Amide Macroinitiators. Journal Of Polymer Science Part A-polymer Chemistry, 47,, pp6883-.
• Habraken, G.J.M.; Koning, C.E.; Heuts, J.P.A.; Heise A. 2009. Thiol Chemistry on Well-Defined Synthetic Polypeptides. Chemical Communications, 24,, pp3612-.
• Hans, M.; Yan Xiao, Keul, H.; Heise, A., Moeller, M.. 2009. Novel biodegradable heterografted polymer brushes prepared via a chemoenzymatic approach. Macromolecular Chemistry And Physics, 210,, pp736-.
• Niehoff, A.; Jurjevic, S.; Heise, A.; Menzel, H.. 2009. One-Pot Procedure for the Preparation of Rod-Coil Block Copolymers via a Bifunctional Initiator. Macromolecular Symposia, 275-276,, pp82-.
• Noordover, B.A.J.; Heise, A.; Malanowksi, P.; Senatore, D.; Mak, M.; Molhoek, L. Duchateau, R.; Koning, C.E.; van Benthem R.A.T.M. 2009. Biobased step-growth polymers in powder coating applications. Progress In Organic Coatings, 65,, pp187-.
• Stern, M.; Jurjevic, S.; Heise, A.; Menzel, H. 2009. Synthesis of Polypeptide Based Rod-Coil Block Copolymers by Using TEMPO Based Bifunctional Initiator. Macromolecular Symposia, 275-276,, pp67-.
• Yan Xiao, Takwa, M.; Hult ,K.; Koning, C.E.; Heise, A.; Martinelle, M. 2009. Systematic comparison of hydroxyethyl acrylate (HEA) and hydroxyethyl methacrylate (HEMA) as initiators in enzymatic ring-opening polymerization. Macromolecular Bioscience, 9,, pp713-720.
• Yan Xiao; Coulembier O.; Koning, C.E.; Heise, A.; Dubois, P. 2009. Cumulated advantages of enzymatic and carbene chemistry for the non-organometallic synthesis of (co)polyesters. Chemical Communications, 18,, pp2472-.
• de Geus M, Peeters R, Koning CE, Heise A. 2008. Insights into the initiation process of enzymatic ring-opening polymerization from mono-functional alcohols using liquid chromatography under critical conditions. Biomacromolecules, 9, pp752-.
• Henry GRP, Heise A, Boattai D, Formenti A, Gorio A, di Giullio AM, Koning CE. 2008. Acrylate end-capped poly(ester-carbonate) and poly(ether-carbonate) for polymer-on-multielectrode array devices: synthesis, photocuring and biocompatebility. Biomacromolecules, 9, pp867-.
• Hilker I, Schaafsma A, Peeters R, Heise A, Nijenhuis A. 2008. Insights into lipase catalyzed formation of macrocyclic oligoesters. European Polymer Journal, 44, pp1441-.
• Knoop RJI, Habraken GJM, Gogibus N, Steig S, Menzel H, Koning CE, Heise A. 2008. Synthesis of poly(benzyl glutamate-b-styrene rod-coil block copolymers by dual initiation in one pot. Journal Of Polymer Science Part A-polymer Chemistry, 46, pp3068-.
• Padovani M, Hilker I, Duxbury CJ, Heise A. 2008. Functionalization of polymers with high precision by dual regio- and stereoselective enzymatic reactions. Macromolecules, 41, pp2439-.
• Takwa M, Xiao Y, Simpson N, Malmstroem E, Hult K, Koning CE, Heise A, Martinelle M. 2008. Lipase catalyzed HEMA initiated ring-opening polymerization: In situ formation of mixed polyester methacrylates by transesterification. Biomacromolecules, 9, pp704-.
• van der Meulen I, de Geus M, Antheunis H, Deumens R, Joosten BEAJ, Koning CE, Heise A. 2008. Polymers from functional macrolactones as potential biomaterials: enzymatic ring opening polymerization, biodegradation and biocompatebility. Biomacromolecules, 9, pp3409-.
• Cummins D, Wyman P, Thies J, Koning CE, Heise A. 2007. Synthesis of functional photopolymerized microporous polyHIPEs by atom transfer radical polymerization (ATRP). Chemistry Of Materials, 19, pp5285-.
• Duxbury CJ, Cummins D, Heise A. 2007. Selective enzymatic grafting by steric control. Macromolecular Rapid Communications, 28, pp235-.
• Duxbury CJ, Hilker I, de Wildeman SMA, Heise A. 2007. Enzyme responsive materials: Chirality to program polymer reactivity. Angewandte Chemie-international Edition In English, 46, pp8452-.
• Hans M, Keul H, Heise A, Moeller M. 2007. Chemoenzymatic approach towards heterografted bottle brushes. Macromolecules, 40, pp8872-.
• Steig S, Cornelius F, Heise A, Knoop RJL, Habraken GJM, Gogibus N, Koning CE, Menzel H. 2007. Synthesis of rod-coil copolymers using two controlled polymerization technique. Macromolecular Symposia, 248, pp199-.
• Villarroya S, Thurecht KJ, Heise A, Howdle SM. 2007. Supercritical CO2: An effective medium for the chemo-enzymatic synthesis of block copolymers?. Chemical Communications,, pp3508-.
• de Geus M, Schormans L, Palmans ARA, Koning CE, Heise A. 2006. Block copolymers by chemoenzymatic cascade polymerization: A comparison of consecutive and simultaneous reaction. Journal Of Polymer Science Part A-polymer Chemistry, 44, pp4290-.
• Hilker I, Rabani G, Verzijl GKM, Palmans ARA, Heise A. 2006. Chiral polyesters by dynamic kinetic resolution polymerization. Angewandte Chemie-international Edition In English, 45, pp2130-.
• Marcilla R, de Geus M, Mercerreyes D, Koning CE, Heise A. 2006. Enzymatic polyester synthesis on ionic liquids. European Polymer Journal, 42, pp1215-.
• Noordover BAJ, van Staalduinen VG, Duchateau R, Koning CE, van Benthem RATM, Mak M, Heise A, Frissen AE, van Haveren J. 2006. Co- and terpolyester based on isosorbide and succinic acid for coating applications: Synthesis and characterization. Biomacromolecules, 7, pp3406-.
• Thurecht KJ, Gregory AM, Villarroya S, Zhou J, Heise A, Howdle SM. 2006. Simultaneous enzymatic ring-opening polymerization and RAFT-mediated polymerization in supercritical CO2. Chemical Communications, 42, pp4383-.
• Thurecht KJ, Heise A, de Geus M, Villarroya S, Zhou J, Wyatt MF, Howdle SM. 2006. Kinetics of enzymatic ring-opening polymerization of caprolactone in supercritical carbon dioxide. Macromolecules, 39, pp7967-.
• Villarroya S, Zhou J, Duxbury CJ, Heise A, Howdle SM. 2006. Synthesis of semifluorinate block copolymers containing copoly(e-caprolactone) by the combination of ATRP and enzymatic ROP in scCO2. Macromolecules, 39, pp633-.
• de Geus M, Peeters J, Wolffs M, Hermans T, Palmans ARA, Koning CE, Heise A. 2005. Investigation of factors influencing the chemoenzymatic synthesis of block copolymers. Macromolecules, 38, pp4220-.
• Duxbury CJ, Wang W, de Geus M, Heise A, Howdle SM. 2005. Can block copolymers be synthesized by a single-step chemoenzymatic route in supercritical carbon dioxide?. Journal Of The American Chemical Society, 127, pp2384-.
• Peeters J, Palmans ARA, Meijer EW, Koning CE, Heise A. 2005. Chemoenzymatic synthesis of branched polyesters. Macromolecular Rapid Communications, 26, pp684-.
• Steig S, Cornelius F, Witte P, Koning CE, Heise A, Menzel H. 2005. Synthesis of polypeptide based rod-coil block copolymers. Chemical Communications, 43, pp5420-.
• van As B, van Buijtenen J, Heise A, Broxterman QB, Verzijl GKM, Palmans ARA, Meijer EW. 2005. Chiral oligomers by iterative tandem polymerization. Journal Of The American Chemical Society, 127, pp9964-.
• Peeters J, Palmans ARA, Veld M, Schijen F, Heise A, Meijer EW. 2004. Cascade synthesis of chiral block copolymers combining lipase catalyzed ring opening polymerization and atom transfer radical polymerization. Biomacromolecules, 5, pp1862-.
• van As B, Thomassen P, Palmans ARA, Kalra B, Gross RA, Heise A. 2004. One-pot chemoenzymatic cascade polymerization under kinetic resolution conditions. Macromolecules, 37, pp8973-.
• Yoo M, Heise A, Hedrick JL, Miller RD, Frank CW. 2003. Photophysical characterization of conformational rearrangements for amphiphilic 6-arm star block copolymers in selective solvent mixtures. Macromolecules, 36, pp268-.
• Meyer U, Palmans ARA, Loontjens T, Heise A. 2002. Enzymatic ring-opening polymerization and atom transfer radical polymerization from a bifunctional initiator. Macromolecules, 35, pp2873-.
• Heise A, Diamanti S, Hedrick JL, Frank CW, Miller RD. 2001. Investigation of the initiation behavior of a dendritic 12-arm initiator in atom transfer radical polymerization. Macromolecules, 34, pp3798-.
• Heise A, Trollsas M, Magbitang T, Hedrick JL, Frank CW, Miller RD. 2001. Star polymers with alternating arms from miktofunctional initiators using consecutive atom transfer radical polymerization and ring opening polymerization. Macromolecules, 34, pp2798-.
• Heise A, Nguyen C, Malek R, Hedrick JL, Frank CW, Miller RD. 2000. Starlike polymeric architectures by atom transfer radical polymerization: templates for the production of low dielectric constant thin films. Macromolecules, 33, pp2346-.
• Schnitter M, Engelking J, Heise A, Miller RD, Menzel H. 2000. Adsorption of linear and star-shaped poly(arylic acid) to model surfaces fromed by amphiphiles at the air water interface. Macromolecular Chemistry And Physics, 201, pp1504-.
• Heise A, Hedrick JL, Frank CW, Miller RD. 1999. starlike block copolymers with amphiphilic arms as models for unimolecular micelles. Journal Of The American Chemical Society, 121, pp8647-.
• Heise A, Hedrick JL, Trollsas M, Miller RD, Frank CW. 1999. Novel starlike poly(methyl methacrylate)s by controlled dendritic free radical initiation. Macromolecules, 32, pp231-.
• Klaerner G, Trollsas M, Heise A, Husemann M, Atthoff B, Hawker CJ, Hedrick JL, Miller RD. 1999. Concurrent chain and stepwise polymerization for the preparation of bock copolymers in one step. Macromolecules, 32, pp8227-.
• Hedrick JL, Trollsas M, Hawker CJ, Atthoff B, Claesson H, Heise A, Miller RD, Mecerreyes D, Jerome R, Dubois P. 1998. Dendrimer-like star block and amphiphilic copolymers by combination of ring opening and atom transfer radical polymerization. Macromolecules, 31, pp8691-.
• Heise A, Stamm M, Rausher M, Duschner H, Menzel H. 1998. Mixed silane self assembled monolayers and their in situ modification. Thin Solid Films, 199, pp327-.
• Heise A, Menzel H, Yim H, Foster MD, Wieringa RH, Schouten AJ, Erb V, Stamm M. 1997. Grafting of polypeptides on solid substrates by initiation of N-carboxyanhydride polymerization by amino-terminated self-assembled monolayers. Langmuir, 13, pp723-.

Selected Chapters

• I. van der Meulen, A. Heise. 2011. Enzymatic polymer synthesis in green chemistry. Green Polymerization Methods, pp291-312.
• S. Howdle, A. Heise. 2011. Enzymes in the synthesis of block and graft copolymers. Biocatalysis in Polymer Chemistry, pp305-322.
• D. M. Cummins, P. C. M. M. Magusin, A. Heise. 2009. Functionalisation of polyHIPE Materials by ATRP Surface Grafting. ACS Symp. Ser., pp327-341.

Reviews

• Heise, A.; Palmans, A.R.A. 2012. Hydrolases in Polymer Chemistry: Chemoenzymatic Approaches to Polymeric Materials. Advances In Polymer Science, 237, pp79-.
• Yeniad, B.; Naik, H.; Heise, A. 2011. Lipases in polymer chemistry. Advances In Biochemical Engineering Biotechnology, 125, pp69-95.