Nursing and Human Sciences

Research Interests:

Viral Immunology particularly immune responses associated with respiratory viruses such as Human Parainfluenza Virus (HPIV), Influenza, Respiratory Syncytial Virus (RSV) and Rhino Virus (RV). Viral subversion of immune responses and the induction of immune regulation. Role of anti-viral immune responses in the development of associated secondary conditions such as bacterial superinfections and asthma. Development of human cellular model systems to predict immune responses to viruses, viral vaccines and other therapeutic interventions.

Selected Peer Reviewed Journals

• Madsen D, Cantwell ER, O¿Brien T, Johnson PA and Mahon BP. 2009. AAV-2 induces cell mediated immune responses directed against multiple epitopes of the capsid protein VP1.. Journal Of General Virology, 90,, pp2622-2633.
• Noone, C.M., Lewis, E.A., Loetscher, M., Newman, R.W., Johnson, P.A. 2008. Natural killer cells regulate T cell proliferation during Human Parainfluenza Virus infection. Journal Of Virology, 82, Published online ahead of print
• Noone CM, Lewis EA, Newman RW and Johnson PA. 2007. Artificially generated dendritic cells misdirect antiviral immune responses. Journal Of Leukocyte Biology, 8, 4, pp952-956.
• Noone C M, Frawely AB, Doyle MF, Mahon BP, Mills KH and. Johnson PA. 2005. Novel mechanism of immunosuppression by influenza virus haemagglutinin: selective suppression of IL-12p35 transcription. Journal Of General Virology, 86, 7, pp1885-1890.
• Daly L M,. Johnson PA. Nicolson C, Robertson J and Kingston H.G. Mills. 2005. Innate IL-10 rpromotes the induction of type 2 T cell responses with plasmid DNA coding for HIVgp120. Vaccine, 23, 7, pp967-974.
• Johnson P.A. 2002. Molecules that target key events in macrophage migration. Expert Opinion In Therapeutic Patents, 12, 10, pp1517-1525.
• Daly LM, Johnson PA, Mills KHG. 2000. DNA vaccines strategies for selective induction of Th1 or Th2 cells. Journal of Clinical Virology. 18, , pp303-303.
• McGuirk P, Johnson PA, Ryan EJ and Mills KHG. 2000. Filamentous haemagglutin and pertussis toxin from Bordetella pertussis modulate immune responses to unrelated antigens. Journal Of Infectious Disease, 182, 4, pp1286-1289.
• Johnson PA, Conway M, Daly L, Nicolson C, Robertson J, Mills KHG. 2000. Plasmid DNA coding for influenza virus haemagglutinin induces Th1 cells and protects against respiratory infection despite its limited ability to generate antibody. Journal Of General Virology, 81, 7, pp1737-1745.
• Johnson PA, Conway M, Cox-Brokstad R, Haaheim L, Daly J, Robertson J, Mills KHG. 1999. Selective Induction of Th1 cells with Plasmid DNA coding for influenza virus haemaggluttin. In Proceedings of European Biotechnology meeting on Vaccines.
• Johnson PA, Conway M and Mills KHG. 1998. DNA vaccines: Mechanism of antigen presentation leading to selective induction of Th1 cells. Immunology, 95, 1, pp16-.
• Johnson PA, Alexander HD, McMillan SA, Maxwell AP. 1997. Up-regulation of the endothelial cell adhesion molecule intercellular adhesion molecule-1 (ICAM-1) by autoantibodies in autoimmune vasculitis. Clinical And Experimental Immunology, 108, 2, pp234-242.
• Johnson PA, Alexander HD, McMillan SA, Maxwell AP. 1997. The up-regulation of the granulocyte adhesion molecule Mac-1 in Autoimmune Vasculitis. Clinical And Experimental Immunology, 107, 3, pp513-519.

Selected Chapters

• Johnson PA. 2003. Immune Vasculitis. Nature Encyclopedia of Life Sciences, pp2150 online-2159.

Reviews

• Power P, Loughran S and Johnson PA. 2010. Modelling the Effect of Infection on Asthma. . Drug Discovery Today, 6, pp107-112.
• Johnson PA, Mills KHG. 1998. Naked DNA-the vaccine of the future. The Irish Scientist, pp82-83.
• Mahon BP, Moore A, Johnson PA, Mills KH. 1998. Approaches to New Vaccines. Critical Reviews In Biotechnology, 18, pp257-282.