NCTCC

Biographical Details:

My role as Program Leader of the microarray/bioinformatics core facility at NICB involves: ¿ Running gene expression profiling experiments in order to identify gene targets for functional validation. Projects involve transcriptome profiling of production cell lines, cancer and diabetes cell systems as well as several other non-mammalian organisms. ¿ Management of the microarray core facility at NICB, with responsibility for budgetary planning, project prioritisation, planning, and evaluation. ¿ Carrying out various bioinformatics analyses on diverse data types that enter the laboratory from the microarray lab or elsewhere. This is a vital component of the microarray analysis suite, whereby genelists are interpreted within a meaningful biological framework to identify gene and protein targets for functional validation. ¿ Management of the bioinformatics lab at NICB, with responsibility for budgetary planning, project prioritisation, planning, and evaluation. ¿ Collaboration with various groups, both within NICB and externally (in DCU or elsewhere), to help design and plan microarray experiments ¿ Training of NICB staff members and students in running microarray experiments and in downstream bioinformatics analyses ¿ Keeping abreast of current developments in the area of microarray and bioinformatics research, achieved by regularly reading publications, attending conferences and keeping in touch with the UKAffy microarray user-group forum. Additional activities in which I am involved at NICB include: ¿ Setting up and supervision of a new bioprocess research laboratory at NICB, focussing specifically on profiling of suspension cell lines in batch culture. ¿ Implementation and administration of the newly-installed NICB Laboratory Information Management System (LIMS). ¿ Design and delivery of lectures and presentations to undergraduate and postgraduate students in DCU and other institutions, visiting dignitaries and industrial collaborators. ¿ Supervision of post-graduate research in the areas of biotechnology, bioengineering, cancer and bioinformatics ¿ Preparation of research grant applications e.g. Science Foundation Ireland, HEA, HRB ¿ Regular publication of research papers, Intellectual Property output (Patent filing) ¿ Quality assurance of projects and laboratory procedures.

Research Interests:

Transcriptome profiling and associated bioinformatics analyses of biological systems including Cancer, Bioprocess Production Cell Lines, Diabetes, HIV/AIDS. Mathematical Modelling of biological systems Systems Biology Functional validation (siRNA/Overexpression)

Selected Peer Reviewed Journals

• Dr. Padraig Doolan. .
• Clarke, C., Doolan, P., Barron, N., Meleady, P., Madden, S.F., DiNino, D., Leonard, M., Clynes, M. 2012. CGCDB: A web-based resource for the investigation of gene coexpression in CHO cell culture. Biotechnology And Bioengineering,
• Keenan, J., Joyce, H., Aherne, S., O'Dea, S., Doolan, P., Lynch, V., Clynes, M.. 2012. Olfactomedin III expression contributes to anoikis-resistance in clonal variants of a human lung squamous carcinoma cell line. Experimental Cell Research,
• Kinsella, P., Howley, R., Doolan, P., Clarke, C., Madden, S.F., Clynes, M., Farrell, M., Amberger-Murphy, V.. 2012. Characterization and Response of Newly Developed High-Grade Glioma Cultures to the Tyrosine Kinase Inhibitors, Erlotinib, Gefitinib and Imatinib. Experimental Cell Research,
• Barron, N., Kumar, N., Sanchez, N., Doolan, P., Clarke, C., Meleady, P., O'Sullivan, F. and Clynes, M. 2011. Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7. Journal Of Biotechnology, 151, 2, pp204-211.
• Clarke, C., Doolan, P., Barron, N., Meleady, P., O'Sullivan, F., Gammell, P., Melville, M., Leonard, M., Clynes M. 2011. Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity. Journal Of Biotechnology, 155, 3, pp350-359.
• Doolan, P.*, Clarke, C.*, Barron, N., Meleady, P., O'Sullivan, F., Gammell, P., Melville, M., Leonard, M. and Clynes, M. 2011. Predicting cell-specific productivity from CHO gene expression. Journal Of Biotechnology, 151, 2, pp159-165.
• Doolan, P.*, Melville, M.*, Mounts, W., Barron, N., Hann, L., Leonard, M., Clynes, M., Charlebois, T. 2011. Development and characterization of a Chinese Hamster Ovary (CHO) cell-specific oligonucleotide microarray. Biotechnology Letters, 33, 9, pp1773-1779.
• Doolan, P., Barron, N., Kinsella, P., Clarke, C., Meleady, P., O'Sullivan, F., Melville, M., Leonard, M., Clynes, M. 2011. Microarray expression profiling identifies several genes associated with regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines. Biotechnology Journal.
• Eustace, A.J., Dowling, P., Henry, M., Doolan, P., Meleady, P., Clynes, M., Crown, J. and O'Donovan, N. 2011. 2-D DIGE analysis of phospho-enriched fractions from dasatinib-treated melanoma cell lines. Journal Of Proteomics, 74, 4, pp490-501.
• Meleady, P., Doolan, P., Henry, M., Barron, N., Keenan, J., O'Sullivan, F., Clarke, C., Gammell, P., Melville, M., Leonard, M., Clynes, M. 2011. Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype. Bmc Biotechnology, 11, 1, pp78-.
• Piskareva, O., Lackington, W., Lemass, D., Hendrick, C., Doolan, P., Barron, N. 2011. The Human L1 Element: A Potential Biomarker in Cancer Prognosis, Current Status and Future Directions. Current molecular medicine. 11, 4, pp286-303.
• Germano, S., Kennedy, S., Rani, S., Gleeson, G., Clynes, M., Doolan, P., McDonnell, S., Hughes, L., Crown, J., O'Driscoll, L. 2011. MAGE-D4B is a novel marker of poor prognosis and potential therapeutic target involved in breast cancer tumorigenesis. International Journal Of Cancer,
• Rani, S., Mehta, J.P., Barron, N., Doolan, P., Jeppesen, P.B., Clynes, M. and O'Driscoll, L.. 2010. Decreasing Txnip mRNA and protein levels in pancreatic MIN6 cells reduces reactive oxygen species and restores glucose regulated insulin secretion. Cellular Physiology And Biochemistry, 25, 6, pp667-674.
• Doolan P, Meleady P, Barron N, Henry M, Gallagher R, Gammell P, Melville M, Sinacore M, McCarthy K, Leonard M, Charlebois T, Clynes M. 2010. Microarray and proteomics expression profiling identifies several candidates, including the valosin-containing protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines. Biotechnology And Bioengineering, 106, 1, pp42-56.
• Muniyappa, M.K., Dowling, P., Henry, M., Meleady, P., Doolan, P., Gammell, P., Clynes, M. and Barron, N. 2009. MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines. European Journal Of Cancer, Epub ahead of print,
• Doolan, P., Clynes, M., Kennedy, S., Mehta, J.P., Germano, S., Ehrhardt, C., Crown, J. and O'Driscoll, L. 2009. TMEM25, REPS2 and Meis 1: Favourable Prognostic and Predictive Biomarkers for Breast Cancer. Tumor Biology, 30, 4, pp200-209.
• Doolan, P.*, Melville, M.*, Gammell, P., Sinacore, M., Meleady, P., McCarthy, K., Francullo, L., Leonard, M., Charlebois, T. and Clynes, M. 2008. Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2. Molecular Biotechnology, 39, 3, pp187-199.
• Meleady, P., Henry, M., Gammell, P., Doolan, P., Sinacore, M., Melville, M., Francullo, L., Leonard, M., Charlebois, T. and Clynes, M. 2008. Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol. Proteomics, 8, 13, pp2611-2624.
• Kennedy, S., Clynes, M., Doolan P., Mehta, J.P., Rani, S., Crown, J. and O¿Driscoll, L. 2008. SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue. British Journal Of Cancer, 98, 10, pp1641-1645.
• O'Driscoll, L., Kenny, E., Mehta, J.P., Doolan, P., Joyce, H., Gammell, P., Hill, A., O¿Daly, B., O¿Gorman, D. and Clynes, M. 2008. Feasibility and Relevance of Global Expression Profiling of Gene Transcripts in Serum from Breast Cancer Patients Using Whole Genome Microarrays and Quantitative RT-PCR. Cancer Genomics And Proteomics, 5, 2, pp94-104.
• Kerr, G., Ruskin, H.J., Crane, M. and Doolan, P. 2008. Techniques for clustering gene expression data. Computers In Biology And Medicine, 38, 3, pp283-293.
• Doolan, P.*, Clynes, M.*, Kennedy, S., Mehta, J.P., Crown, J. and O'Driscoll, L. 2007. Prevalence and prognostic and predictive relevance of PRAME in breast cancer. Breast Cancer Research And Treatment, Jul 12; [Epub ahead of print], Jul 12; [Epub ahead of print]
• Martinez, V., Kennedy, S., Doolan, P., Gammell, P., Joyce, H., Kenny, E., Prakash Mehta, J., Ryan, E., O¿Connor, R., Crown, J., Clynes, M. and O¿Driscoll, L. 2007. Drug metabolism¿related genes as potential biomarkers: analysis of expression in normal and tumour breast tissue. Breast Cancer Research And Treatment, Sep 27; [Epub ahead of print], Sep 27; [Epub ahead of print]
• Mehta, J.P., O'Driscoll, L., Barron, N., Clynes, M. and Doolan, P. 2007. A microarray approach to translational medicine in breast cancer: How representative are cell line models to clinical conditions?. Anticancer Research, 27, , pp1295-1300.
• O'Driscoll, L., McMorrow, J.*, Doolan, P.*, McKiernan, E., Mehta, J.P., Ryan, E., Gammell, P., Joyce, H., O'Donovan, N., Walsh, N. and Clynes, M. 2006. Investigation of the molecular profile of basal cell carcinoma using whole genome microarrays. Molecular Cancer, 15, 5, pp74-.
• Liang, Y., O¿Driscoll, L., McDonnell, S., Doolan, P., Oglesby, I. Duffy K., O'Connor, R. and Clynes, M. 2004. Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. International Journal Of Cancer, 111, 4, pp484-493.

Selected Chapters

• Jai Prakash Mehta, Lorraine O¿Driscoll, Niall Barron, Martin Clynes and Padraig Doolan. 2009. TRANSLATING IN VITRO CELL LINES RESULT INTO CLINICAL PRACTICE. Methods of Cancer Diagnosis, Therapy, and Prognosis. General Overviews, Head and Neck Cancer and Thyroid Cancer. Volume package: Methods of Cancer Diagnosis, Therapy and Prognosis, Vol. 7. Volume package Methods of Cancer Diagnosis, Therapy and Prognosis 2010

Selected Non-peer Reviewed Journals

• Germano, S., Clynes, M., Kennedy, S., Mehta, J. P., Kenny, E., Ryan, E., Doolan, P., Gammell, P., Joyce, H., de Villarreall, M. P., Hill, A., O'Daly, B., Linehan, R., Cronin, D., Daly, C., Glynn, S., O'Driscoll, L. 2009. Novel role of neuronal calcium sensor-1 (NCS-1) as prognostic factor and therapeutic target in breast cancer. Ann. Oncology, 20, ppii49-ii50.
• Doolan, P., McMorrow, J., Dowd, A.J., Ryan, E., Henry, M., Dowling, P., Bryan, W., Meleady, P. and Clynes, M. 2006. Microarray & proteomics analysis of BrdU-DLKP: A systems biology approach to understanding differentiation in lung cancer cells. Systems Biology: Global Regulation of Gene Expression, Cold Spring Harbour Laboratory, New York, USA: Cold Spring Harbour Laboratory Press, pp50-50.
• Doolan, P., Barron, N., Liang, Y. and Clynes, M. 2004. The transcription factors GATA-2 and GATA-3 may play a role in regulating the BrdU-induced expression of various multidrug transporters in lung cancer cell lines. Anticancer Res, 24, pp531-531.
• Doolan, P., Barron, N., Liang, Y. and Clynes, M. 2003. GATA-3: A potential role in regulating the expression of various multidrug transporters in BrdU-treated lung cancer cells?. Mechanisms of Eukaryotic Transcription, Cold Spring Harbour Laboratory, New York, USA: Cold Spring Harbour Laboratory Press., pp80-80.
• Liang, Y., McDonnell, S., Doolan, P., and Clynes, M. 2002. Enhanced in vitro invasiveness and drug resistance in a human lung carcinoma cell line, DLKP, after treatment with mitoxantrone, 5-fluorouracil, methotrexate, BCNU, cisplatin or chlorambucil, and enhanced drug resistance but not in vitro invasiveness with VP-16, vincristine, taxotere or CCNU. Br J Cancer, 86, ppS62-S62.

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• Hayes, C.A., Dowling, P., Negri, J., Henry, M., Buon, L,, Madden, S., Doolan, P., Jakubikova, J., Delmore, J., McMillin, D.W., Jacobs, H.M., van de Donk, N., Dhimolea, E., Lawasut, P., Richardson, P.G., Anderson, K.C., Clynes, M., *O¿ Gorman, P., *Mitsiades, C.S., Proteomic characterization of an isogenic multiple myeloma cell line model of bortezomib resistance, American Society for Hematology (ASH) 53rd Annual Meeting and Exposition, 10-DEC-11 - 13-DEC-11, San Diego, CA, USA
• Prendergast, A., Martin, K., Doolan, P., Clarke, C., Clynes, M., Evoy, D., McDermott, E.W., Crown, J., Kennedy, S, Can the Ki67 proliferation index predict the Oncotype DX Recurrence score in lymph node negative, ER positive breast cancer? , San Antonio Breast Cancer Symposium (CTRC-AACR) 2011, 06-DEC-11 - 10-DEC-11, San Antonio, Texas, USA
• O¿Neill, F., Madden, S., Aherne, S., Clynes, M., Crown, J., Doolan, P., O¿Connor, R, Robust gene changes as markers for early lapatinib response in a panel of breast cancer cell lines, American Association for Cancer Research (AACR) ¿Translation of the Cancer: Scientific, Clinical and Operational Challenges¿ , 15-OCT-11 - 18-OCT-11, San Francisco, CA, USA
• Hennessy, E., Doolan, P. Aherne, S., Clarke, C., Clynes, M. and O¿Sullivan, F, Microarray profiling of definitive endoderm differentiated human iPS cells in 3D culture, Stem Cells in Development and Disease 2011, 11-SEP-11 - 14-SEP-11, Berlin, Germany
• Doolan, P. , Predicting Cell-Specific Productivity from CHO Gene Expression, BioProcessing, Biologics and Biotherapeutics Congress (BBBC) , 20-JUL-11 - 20-JUL-11, Edinburgh, UK
• O¿Neill, F., Madden, S., Aherne, S., Clynes, M., Doolan, P., O¿Connor, R, Gene expression changes as markers for early lapatinib response in a panel of breast cancer cell lines, 2011 IRCC International Conference on Molecular Clinical Oncology, 26-MAY-11 - 28-MAY-11, Turin, Italy
• Doolan, P., Clarke, C., Barron, N., Meleady, P., O¿ Sullivan, F., Gammell, P., Melville, M., Leonard, M. and Clynes, M, Predicting cell-specific productivity from CHO gene expression, Meeting of the European Society for Animal Cell Technology (ESACT) , 15-MAY-11 - 18-MAY-11, Vienna, Austria
• Clarke, C., Doolan, P., Barron, N., Meleady, P., O¿ Sullivan, F., Gammell, P., Melville, M., Leonard, M. and Clynes, M, Guilt-by-association: Large scale coexpression analysis of the CHO transcriptome, 22nd Meeting of the European Society for Animal Cell Technology (ESACT) , 15-MAY-11 - 18-MAY-11, Vienna, Austria
• Satchell, C., Doolan, P., Mehta, J., Clynes, M., Cooper, D., Carr, A., Mallon, P. and on behalf of the SAMA Investigators, Genome-Wide Changes in Subcutaneous Adipose Tissue Gene Expression in HIV-Infected Adults After 2 Weeks of Zidovudine or Stavudine with Lamivudine, 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011), 27-FEB-11 - 02-MAR-11, Boston, USA
• Doolan, P. , Towards Predicting Productivity from CHO Gene Expression, IBC/Informa Life Sciences (2011) Cell Line Development and Engineering, 14-FEB-11 - 18-FEB-11, Munich, Germany
• Savage, R., Aherne, S., Doolan, P., Clarke, C., Clynes, M. and Wild, D, A Bayesian Clustering analysis of Breast Cancer Gene Expression, Cancer Bioinformatics Workshop, 02-SEP-10 - 02-SEP-10, Cambridge, UK
• Doolan, P. , NICB-Pfizer Collaboration: Improving Production of Biopharmaceuticals using Industrially-relevant CHO Cell Lines, SFI/MMI Technology Platform Workshop, 06-JUN-10 - 06-JUN-10, Dublin, Ireland
• Doolan, P., Barron, N., Henry, M., Meleady, P. Gammell, P., McCarthy, K., Leonard, M., Melville, M., Sinacore, M., Charlebois, T. and Clynes, M, Microarray and proteomics expression profiling identifies the Valosin-containing Protein (VCP) involved in regulating high cellular growth rate in production CHO cell lines, IBC/Informa Life Sciences (2010) Cell Line Development and Engineering, 01-MAR-10 - 05-MAR-10, Prague, Czech Republic
• Doolan, P., Meleady, P., Barron, N., Henry, M., Gammell, P., Melville, M., Sinacore, M., McCarthy, K., Leonard, M., Charlebois, T. and Clynes, M, , 21st Meeting of the European Society for Animal Cell Technology (ESACT) , 07-JUN-09 - 10-JUN-09, Dublin, Ireland
• Melville, M., Clarke, C., Doolan, P., Di Nino, D., McCarthy, K., Anderson, K., Gammell, P., Meleady, P., Barron, N., Leonard, M., Clynes, M. and Charlebois, T, A Combined Approach of Genomics and Proteomics has led to Fundamental Insights into CHO Cell Biology and Performance in Production Conditions, 21st Meeting of the European Society for Animal Cell Technology (ESACT), 07-JUN-09 - 10-JUN-09, Dublin, Ireland
• Doolan, P., Barron, N., Henry, M., Meleady, P. Gammell, P., McCarthy, K., Leonard, M., Melville, M., Sinacore, M., Charlebois, T. and Clynes, M., Gene expression profiling of production CHO cells by microarrays combined with target validation leading to increased efficiency of biopharmaceutical production., 4th Cell Line Development and Engineering Meeting (Informa09), 02-MAY-09 - 06-MAY-09, Berlin, Germany
• Doolan, P., Barron, N., Henry, M., Meleady, P. Gammell, P., Leonard, M., McCarthy, K., Melville, M., Sinacore, M., Charlebois, T. and Clynes, M, Microarray gene profiling combined with functional validation identifies targets leading to increased production of biopharmaceuticals in CHO, 19th Annual ESACT-UK Meeting, 05-JAN-09 - 06-JAN-09, Cambridge, UK
• Doolan, P., Barron, N., Henry, M., Meleady, P. Gammell, P., McCarthy, K., Leonard, M., Melville, M., Sinacore, M., Charlebois, T. and Clynes, M., Microarray profiling and target gene validation leading to more efficient production of biopharmaceuticals in CHO, UK Affymetrix Users meeting 7 (UKAffy7), 22-SEP-08 - 23-SEP-08, Nottingham, UK
• Doolan, P., Barron, N., Henry, M., Meleady, P. Gammell, P., McCarthy, K., Leonard, M., Melville, M., Sinacore, M., Charlebois, T. and Clynes, M., Microarray profiling and target gene validation leading to more efficient production of biopharmaceuticals in CHO., Microarray and Gene Expression Data Society Meeting 11 (MGED11), 01-SEP-08 - 04-SEP-08, Riva del Garda, Italy
• Meleady, P., Doolan, P., Barron, N., Gammell, P., Melville, M., Sinacore, M., Leonard, M., Charlebois, T. and Clynes, M., Novel use of microarrays and proteomics to find biomarkers in CHO, IBC 2008 4th annual meeting; Cell Line Development and Engineering, 23-JUN-08 - 25-JUN-08, San Diego, USA
• Melville, M., Sinacore, M., Di Nino, D., McCarthy, K., Anderson, K., Kopycinski, K., Lee, G., Max, S., Gammell, P., Doolan, P., Meleady, P., Barron, N., Leonard, M., Clynes, M. and Charlebois, T., Differential Expression Profiling of Industrially Relevant CHO Cell Phenotypes Using a Proprietary CHO-Specific Microarray and Proteomics Technology Platforms., 20th Meeting of the European Society for Animal Cell Technology (ESACT), 17-JUN-07 - 20-JUN-07, Dresden, Germany
• Meleady, P., Henry, M., Gammell, P., Doolan, P., O¿Toole, J., Sinacore, M., Melville, M., Di Nino, D., McCarthy, K., Anderson, K., Kopycinski, K., Leonard, M., Charlebois, T. and Clynes, M., Proteomic profiling of recombinant CHO cells to gain insights to improving bioprocess productivity, 20th Meeting of the European Society for Animal Cell Technology (ESACT), 17-JUN-07 - 20-JUN-07, Dresden, Germany
• Kennedy, S.M., Tracey, D., Doolan, P., Mehta, J.P., Clynes, M., O'Driscoll, L. , Correlation of the Gene Expression Profile of Primary Breast Carcinoma with Clinical Outcome, 98th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, 07-MAR-07 - 13-MAR-07, Boston, USA
• Mehta, J.P., Doolan, P., Barron, N., O¿Driscoll, L. and Clynes, M., Meta-analysis of estrogen receptor-positive breast cancer data obtained from publicly available large scale Gene Expression analysis, International Conference of Bioinformatics (InCoB), 18-DEC-06 - 20-DEC-06, New Delhi, India
• Kumar, N., Gammell, P., Doolan, P., Meleady, P., Ward, N. and Clynes, M., Proteomic profiling of suspension animal cell cultures, Global mRNA and Protein Expression Analysis, 07-SEP-06 - 08-SEP-06, Dublin City University, Dublin, Ireland
• Gowd, R.*, Kumar, N.*, Ward, N., Doolan, P., Gammell, P. and Clynes, M., Adaptation of adherent human cell lines to suspension culture, Global mRNA and Protein Expression Analysis, 07-SEP-06 - 08-SEP-06, Dublin City University, Dublin, Ireland
• Breen, L., Doolan, P., Ryan, E., Gammell, P., Mehta, J.P. and Clynes, M., Microarray analysis of taxol-resistant cell lines, Global mRNA and Protein Expression Analysis, 07-SEP-06 - 08-SEP-06, Dublin City University, Dublin, Ireland
• Mehta, J.P., Doolan, P. and Clynes, M., How representative are cell line models to clinical conditions? A microarray approach to translational medicine in breast cancer., Global mRNA and Protein Expression Analysis, 07-SEP-06 - 08-SEP-06, Dublin City University, Dublin, Ireland
• Doolan, P., Bray, I., Mehta, J.P., Gammell, P. and Clynes, M., Whole-genome microarray assessment of taxol- and melphalan-resistant RPMI cell lines as a model for drug-induced invasion in cancer and identification of potential therapeutic targets., Global mRNA and Protein Expression Analysis, 07-SEP-06 - 08-SEP-06, Dublin City University, Dublin, Ireland
• Sinacore, M., Melville, M., Hann, L., Di Nino, D., McCarthy, K., Anderson, K., Kopycinski, K., Gammell, P., Doolan, P., Meleady, P., Leonard, M., Clynes, M. and Charlebois, T., Differential expression profiling analysis of industrially relevant CHO cell phenotypes through integrated use of DNA microarray & proteomics analysis platforms, Cell Culture Engineering X (CCE X), 23-APR-06 - 28-APR-06, Whistler, BC, Canada
• O'Driscoll, L., McMorrow, J., Gammell, P., Doolan, P., Ryan, E., Mehta, J.P., Joyce, H., O'Donovan, N., Lynch, V., Walsh, N. and Clynes, M. (2006) . IACR, Feb. 24th 2006 ¿ Poster presentation, Investigation of the molecular profile of basal cell carcinoma using whole genome microarrays, Irish Association for Cancer Research (IACR), 24-FEB-06 - 24-FEB-06, Galway, Ireland
• Doolan, P., Barron, N., Liang, Y. and Clynes, M., The transcription factors GATA-2 and GATA-3 may play a role in regulating the BrdU-induced expression of various multidrug transporters in lung cancer cell lines., Biotechnology, Cancer and Drug resistance: New targets, new diagnosis and new treatment for tumours resistant to current therapies, 07-JUL-03 - 08-JUL-03, Dublin, Ireland