Registry

Module Specifications

Current Academic Year 2012 - 2013
Please note that this information is subject to change.

Module Title	Bio-organic and Pharmaceutical Chemistry
Module Code	CS206
School	School of Chemical Sciences
Online Module Resources
Module Co-ordinator	Semester 1: Paraic James Semester 2: Paraic James Autumn: Paraic James
NFQ level	8	Credit Rating	5
Pre-requisite	None
Co-requisite	None
Compatibles	None
Incompatibles	None

Description

Bio-organic Component: This aims to introduce the student to the major classes of compound which come under the heading of Bio-organic molecules.Pharmacology Component: The pharmacology component of this module aims to give a basic introduction to pharmacology and to give an overview of the actions of the major drug types.

Learning Outcomes

1. Describe the structure and role of lipids, carbohydrates, amino acids, proteins and nucleic acids
2. Define fundamental pharmacological parameters
3. Relate drug structure and pharmacological action.
4. Give mode of action of major drug classes.

Workload	Full-time hours per semester
*Type*	*Hours*	*Description*
Lecture	30	No Description
Tutorial	6	No Description
Independent learning	89	No Description
Total Workload: 125

All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml

Indicative Content and Learning Activities

Pharmacology.
Introduction to pharmacology, commonly prescribed drugs, drug nomenclature, mechanisms of drug action, dose-response relationship. Agonists, antagonists. Receptor models. ED50. Therapeutic Index. Drug Administration. Drug Metabolism. ADME, Ideal drug..

Pharmaceuticals:.
Major structural types, Classification of the mode of action of drugs. Sources of drugs. Drug development and production. Natural product sources. The search for lead compounds. Antiinfectives: antibacterials, antivirals and antifungals. Stereochemistry and drug design. The importance of conformation, configuration and stereochemistry with respect to drug action. Pharmacokinetics & drug metabolism. Examples of phase I and phase II metabolic reactions according to functional groups.Cancer chemotherapy. Drugs affecting the CNS; hypnotics, sedatives, tranquilizers, antidepressants, analgesics, general anaesthetics. Cardiovascular drugs..

Bio-organic.
Lipids (Structure and classification of lipids, Physical properties, Chemical reactivity, Cell Membranes, Energy-storage Lipids, Membrane Lipids. Emulsification Lipids, Messenger Lipids, Protective-coating Lipids)Carbohydrates (classification Fischer projection, Haworth formula, D and L System, reactions, monosaccharides, Kiliani-Fischer ascent, Ruff degradation, Acetal/hemiacetal formation, Mutarotation, configuration of glucose, disaccharides, polysaccharides);Proteins (amino acids, isoelectric point, synthesis of protection/deprotection, DCC peptide coupling, peptide links, protein sequencing, secondary structure of proteins);Enzymes (the "ases", modes of action, entropic effect and electronic catalysis, stereochemical aspects, prochirality);Nucleic acids (structure, nucleotides, nucleosides, linkage, base pairing, double helix, Watson and Crick secondary structure, RNA, DNA (sequencing), chemical synthesis of DNA)..

Assessment Breakdown
Continuous Assessment	0%	Examination Weight	100%

Course Work Breakdown
Type	Description	% of total	Assessment Date

Reassessment Requirement
Resit arrangements are explained by the following categories; 1 = A resit is available for all components of the module 2 = No resit is available for 100% continuous assessment module 3 = No resit is available for the continuous assessment component
This module is category 1

Indicative Reading List