Registry

Module Specifications

Current Academic Year 2012 - 2013
Please note that this information is subject to change.

Module Title	Advanced Topics in Organic Chemistry
Module Code	CS405
School	School of Chemical Sciences
Online Module Resources
Module Co-ordinator	Semester 1: Nick Gathergood Semester 2: Nick Gathergood Autumn: Nick Gathergood
NFQ level	8	Credit Rating	5
Pre-requisite	None
Co-requisite	None
Compatibles	None
Incompatibles	None

Description

The entire module aims to introduce the student to the physical and mechanistic detail of modern chemistry. Particular emphasis is placed on orbital interaction and three dimensional awareness. Stereoselective catalytic methods illustrate the concepts introduced.

Learning Outcomes

1. Complete understanding of how reactions are highly dependent on electronic and steric factors.
2. To conceive basic synthetic pathways for simple molecules, both achiral and chiral
3. To appreciate the benefits of catalytic asymmetric methods
4. Determine and describe the steps of a catalytic cycle and enantioinduction.

Workload	Full-time hours per semester
*Type*	*Hours*	*Description*
Lecture	36	No Description
Independent learning	89	No Description
Total Workload: 125

All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml

Indicative Content and Learning Activities

Retrosynthetic Analysis.
Definitions, 1-group C-X, 2 group C-X and non-obvious disconnection's, organosilicons, organoseleniums,organoborons, organolithiums and organocuprates. Oxidation and reduction..

Catalytic Asymmetricsynthesis.
Introduction: Background, methods, definitions of stereoselective terms, measures ofstereoselectivity. Part A: Catalytic asymmetric hydrogenation, hydrosilylation, carbometallations, oxidation(epoxidation and dihydroxylation), Part B: Catalytic asymmetric C-C bond forming reactions (Aldol, Michael,Mannich, Henry, Friedel-Crafts, Allylic alkylation, Cross-coupling and Heck).

Pericylicreactions.
Electrocyclic reactions, conservation of orbital symmetry, con rotation and dis rotation, orbitalcorrelation diagrams, frontier orbited approach, aromatic transition state approach, cyclo addition reactions,suprafacial and antarafacial approach, regio selectivity, 1, 3-dipolar cyclo additions, sigmatropicrearrangements. Asymmetric cycloaddition reactions.

Organic photochemistry.
photochemistrySinglet and triplet excitedstates; Jablonski diagram; sensitisation and quenching, quantum yield, excited state reactions of thecarbon-carbon and carbon-oxygen double bonds, synthesis and mechanism..

Assessment Breakdown
Continuous Assessment	0%	Examination Weight	100%

Course Work Breakdown
Type	Description	% of total	Assessment Date

Reassessment Requirement
Resit arrangements are explained by the following categories; 1 = A resit is available for all components of the module 2 = No resit is available for 100% continuous assessment module 3 = No resit is available for the continuous assessment component
This module is category 1

Indicative Reading List

Wiley: 0, Essential:N.S. Isaac (2nd ed.) Physical Organic Chemistry, Wiley, P. Sykes. A Guide book to Mechanism in Organic Chemistry.S.W. Warren, Designing Organic Synthesis (Wiley), R.A. Aitken and S.N. Kilney, Asymmetric Synthesis.Supplementary:H. Maskill, The Ph,

Other Resources

None

Array

Programme or List of Programmes

BSc in Chemical and Pharmaceutical Sc.

BSSA

Study Abroad (DCU Business School)

BSSAO

Study Abroad (DCU Business School)

ECSA

Study Abroad (Engineering & Computing)

ECSAO