Registry
Module Specifications
Current Academic Year 2012 - 2013
Please note that this information is subject to change.
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| Description | |||||||||||||||||||||||||||||||||||||||||
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To introduce the student to the theory and practices of modern chemical separation techniques. To provide the necessary background to allow the student to select an appropriate separation technique for a given analysis.To introduce the student to the application of chromatography within a wide number of key areas, particularly chemical, pharmaceutical and environmental analysis. | |||||||||||||||||||||||||||||||||||||||||
| Learning Outcomes | |||||||||||||||||||||||||||||||||||||||||
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1. Understand the thermodynamic and molecular basis for equilibrium separation 2. Calculate and measure tr, k, a, R, N and H for a given separation 3. Explain the individual and collective contributions to band broadening and ways in which they can be minimised 4. Describe the sample preparation, method development parameters and instrumentation required for (i) gas chromatography, (ii) high performance liquid chromatography (iii) ion chromatography, (iv) capillary electrophoresis and other separation techniques. 5. Critically evaluate the optimum parameters for a range of separations | |||||||||||||||||||||||||||||||||||||||||
All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml |
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| Indicative Content and Learning Activities | |||||||||||||||||||||||||||||||||||||||||
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Chemical Equilibria. Chemical equilibria; activity, acid-base chemistry, formation constants, solubility products. Thermodynamics of separation. distribution coefficients, chemical potential and conditions for equilibrium, solvent extractions.. Molecular basis for equilibrium separation. the effect of molecular structure on the distribution of a compound between two phases. Chromatography separation. definition and classification of chromatographic mechanisms, sorption isotherms, retention behaviour, distribution co-efficients, capacity factor, column selectivity, column efficiency, bond broadening, diffusion, mass transfer, resolution, quantitative methods. Sample preparation. solid phase extraction and derivatisation. Gas chromatography. principles, stationary phases and instrumentation. High-performance liquid chromatography (HPLC). classification, basic LC concepts (k , a, R and N), instrumentation used (pumps, injectors, columns, detectors), chromatographic modes (reversed-phase, normal-phase, ion-exchange, size-exclusion, affinity) and applications. Capillary electrophoresis (CE). classification, basic CE concepts (m, v, EOF, N and R), instrumentation used (power supply, injectors, capillaries, detectors), CE modes (CZE, CGE, MECC, CEC, chiral CE). Chiral chromatography and Ion chromatography. Other separation techniques including LC-MS. | |||||||||||||||||||||||||||||||||||||||||
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| Indicative Reading List | |||||||||||||||||||||||||||||||||||||||||
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| Other Resources | |||||||||||||||||||||||||||||||||||||||||
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| Array | |||||||||||||||||||||||||||||||||||||||||
| Programme or List of Programmes | |||||||||||||||||||||||||||||||||||||||||
| GCPA | GradDip Adv Chemical Pharmaceut Analysis | ||||||||||||||||||||||||||||||||||||||||
| MCPA | MSc Adv Chemical Pharmaceutical Analysis | ||||||||||||||||||||||||||||||||||||||||
| Timetable this semester: Timetable for CS502 | |||||||||||||||||||||||||||||||||||||||||
| Date of Last Revision | 29-OCT-10 | ||||||||||||||||||||||||||||||||||||||||
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