Targeted Therapeutics & Theranostics
Advanced Technologies in Therapeutics
Module Title: Advanced Technologies in Therapeutics
Module Code: BE 552 |
School: School of Biotechnology/ICNT |
Module Coordinators: Dr. Christine Loscher
Office No: X2.18 |
Level: 5
Credit Rating: 10
Pre-requisite(s): None
Co-requisite(s): None |
Module Aims:
- To provide training in key technologies relevant to the area of therapeutics. These will include automated screening, confocal microscopy, x-ray crystallography, flow cytometry/cell sorting, HPLC/Mass spectrometry and phage display.
- To provide practical experience of these technologies.
- To provide a detailed understanding of the methodologies associated with these technologies and how they are applied in the research setting.
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Learning Outcomes:- Practical experience of two of the technologies available within this practical module.
- A working knowledge of the methodologies associated with the technologies.
- An understanding of the application of these technologies in thee research environment.
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Indicative Time Allowances:
Lectures:
Laboratories:
Tutorials:
Seminars:
Independent Learning Time:
TOTAL: |
Hours
0
90
50
150 |
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Note: Assume that a 10 credit module load represents approximately 150 hours’ work, which includes all teaching, in-course assignments, laboratory work or other specialised training and an estimated private learning time associated with the module. |
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Indicative Syllabus
- Students will choose 2 of the following technologies
- Automated screening of therapeutics on recombinant targets
- Live cell monitoring of the functional effects of therapeutics by 2-photon microscopy
- Structure elucidation of candidate drugs by X-ray crystallography
- Sorted cell populations as models for assessing drug action
- Isolation and analysis of biotherapeutics and small organic drugs by HPLC/Mass spectrometry.
- Robotics in phages display of potential therapeutics.
- In all of the technologies outlined above, the students will receive practical hands-on training in a research environment.
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Assessment: 100% continuous assessment
Only include components relevant to this module
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Assignment 1:
Assignment 2:
In-course test: |
50%
50%
% |
Practical Ability:
Laboratory Write-up:
Oral Examination:End of module test: |
%
%
%% |
Indicative Reading List:
Essential:
- Practical manual for the course
Supplementary:
- Radbruch: Flow cytometry and Cell sorting. (Springer Laboratory)
- Diaspro: Confocal and two-photon microscopy: Foundations, applications and advances.
- Sidhu: Phage Display in Biotechnology and Drug Discovery.
- Aguilar: HPLC of peptides and proteins: Methods and protocols.
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