Neurotherapeutics

DESCRIPTION:  An introduction to General Neurobiology and membrane biophysical properties and physiology
properties of ion channel and patch clamp technique as methods studying biophysical properties of ion channels
Basic introduction to cell to cell communication through chemical and electrical synapses. The use of Neurotoxin in therapeutics targeting exocytosis and neurotransmission processes.

Date :- From: 25-02-08 to: 29-02-08

Place :-

		Lecturer	Time
Day one	Introduction to Neurobiology		Start	End
1	Introduction to Neurotherapeutics (General overview)	Oliver	08:30	09:15
2	Cell to cell communications (chemical, electrical synapses, ion channels)	Hamdy	09:15	10:00
3	Biophysical properties of cell membrane (Nernst, membrane potential, lipid bilayer, membranepotential, Action potential…)	Jon	10:15	11:00
	Exocytosis, neurotoxin (presynaptic release, BOTOX,)	Oliver	11:15	12:00
Day two	Signal transduction I
4	Ion channels (types, structure, biophysical properties, ligand binding)	Jon	09:15	10:00
5	Pharmacology of ion channels (agonist, antagonist, IC50,pharmakinetics)	Astrid	10:15	11:00
6	SNARE-mediated membrane fusion (mechanism of Neurotoxin entry)	Gary	11:15	12:00
Day three	Signal transduction II
7	Neurotransmission ( (GABA A,B, Excitatory, Inhibitory signaling), cholinergic, serotonergic, ...ect)	Hamdy	09:15	10:00
8	Cell signal cascade (GPCR, Kinases…)	Malle	10:15	11:00
9	Excitable cell (Immune cell) (or pain)	Christine	11:15	12:00
Day four	Methods of investigations
10	Voltage clamp (biophysical properties of ion channel IV Curve, GV, Boltzmann)	Jon	09:15	10:00
11	In vivo recording and brain activity imaging (EEG,ECG,fMNR,...)	Hamdy	10:15	11:00
12	Molecular biology and biochemistry	Jafhu	11:15	12:00
Day five	Neurophysiology
13	Synaptic plasticity and memory (LTP, LTD, memory formation, NMDA Receptors)	Hamdy	09:15	10:00
14	Neuromuscular junction and motor neurons	Gary	10:15	11:00
15	Neurotoxin as therapeutics  (closing session discussion)	Oliver	11:15	12:00