Postgrads - General Info
| Year |
Project |
|||
| Denis Collins | PhD | 2 | Examining the role of the
Multidrug Resistance-associated Proteins (particularly MRP1 and MRP4) in
taxane resistance in lung and leukaemia cell lines and the effects of NSAIDs
on Multi-Drug Resistance (MDR) in general. |
|
| Laura Breen | PhD | 2 | p53 is an important tumour
suppressor, which is mutated in more than half of all tumours. The aim of my
project is to investigate the role of p53 status, (wild-type mutant or
deleted), on the cells' sensitivity to chemotherapy treatment |
|
| Lisa Murphy | Masters | 1 | My project involves using the
newly emerging proteomic technologies to identify a wide range of proteins
for early detection, metastatic detection or treatment monitoring of lung
cancer. Proteins of interest are compared and provisionally identified using
2D databases and finally identified by mass spectrometry |
|
| Aisling Pierce | PhD | 2 |
Am interested in identifying the transcription factors
involved in lung cell differentiation |
|
| Kieran Duffy | PhD | 3 |
Studying the role of Non-Steroidal Anti-inflammatory drugs in
circumventing resistance to anti-cancer drugs |
|
| Eadaoin Mc Kiernan | PhD | 2 |
Diabetes Research: The main project aim is to direct the
differentiation of stem cells towards pancreatic like cells. Glucose
stimulated insulin secretion (GSIS) from a number of cell lines is also
being investigated. |
|
| Vanesa Martinez | Masters | 1 |
Role of cytochromes P450 in chemotherapy resistance. As cytochromes P450 are responsible for the biotransformation of drugs into less or non-toxic derivatives, they might be involved in the development of resistance to chemotherapeutic drugs. My aim is to study the expression and activity of different isozymes in cancer cell lines and tumour samples, and to find out whether they play a prominent role in the development of resistance. |
|
| Elaine Kenny | PhD | 1 |
My project is currently investigating the presence of tumour
marker mRNA transcripts in cell-free extracts taken from cancer cell lines
using RT-PCR. At a later stage I will focus on cell- free serum samples of
lung cancer patients. |
|
| Jason McMorrow | PhD | 3 |
Transcriptional and Translation Control of Lung Cell
Differentiation: The main aim of the project is to elucidate a pathway(s) involved in lung cell differentiation. Regulation of functional gene expression at the transcriptional and translational level is poorly understood in lung cells. Using our model system, we will investigate the role of specific transcription factors, such as c-myc and YY1; as well as translation factors such as eIF4E, play in epithelial differentiation. |
|
| Rasha Linehan | PhD | 5 |
The aim of my project is to investigate the effect of the
anti-apoptotic gene, survivin, on human cancer cell lines. Also to study the
effect of a range of chemotherapy drugs on RPMI 2650. |
|
| William Bryan | PhD | 1 |
Investigation of possible differentiation effects of various
flouropyrmidine analogs (anti-cancer agents) on the phenotypes of poorly
differentiated lung cell lines. This is to be accomplished by the analysis
of specific elements of the translational machinery, translation initiation
factors and differentiation associated marker proteins at both the RNA and
Protein levels. |