Toxicology


	Toxicology

	In Vitro Toxicology Group Building on its expertise in cell culture and toxicology, the Toxicology Group at the NCTCC offers a wide range of services and carries out research into several aspects of cancer. In particular, it has recognised expertise in anticancer drugs and drug analysis. It has developed a portfolio of well characterised cell lines, of varying levels and mechanisms of resistance, to a range of anticancer drugs. The Toxicology Group collaborates with both academic and clinical partners. Research carried out by the Toxicology Group has led to the setting up of a clinical trial in collaboration with St. Vincent’s hospital to test the influence of NSAIDs in increasing the effectiveness of certain anti-cancer agents.
	Research Areas: Multidrug resistance, apoptosis and cell cycle Development of multidrug resistant cell lines Drug resistance circumvention Drug analysis and transport Anti-cancer drug screening
	Selected Research Publications Maguire AR et al., (2001). Synthesis of indomethacin analogues for evaluation as modulators of MRP activity. Bioorg Med Chem 9: 745-762. O'Loughlin C et al., (2000). Altered cell cycle response of drug-resistant lung carcinoma cells to doxorubicin. Eur J Cancer 36: 1149-1160. NicAmhlaoibh R et al., (1999). Altered expression of mRNAs for apoptosis-modulating proteins in a low level multidrug resistant variant of a human lung carcinoma cell line that also expresses mdr1 mRNA. Int J Cancer 82: 368-376. Duffy CP et al., (1998). Enhancement of chemotherapeutic drug toxicity to human tumour cells in vitro by a subset of non-steroidal anti-inflammatory drugs (NSAIDs). Eur J Cancer 34: 1250-1259. Heenan M et al., (1997). Isolation from a human MDR lung cell line of multiple clonal subpopulations which exhibit significantly different drug resistance. Int J Cancer 71: 907-915.