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Technologies

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The RAPID Institute focuses on 3 key core technology platforms:

RAPID Lab Disc

Centrifugal-based Point of Need (PoN) Diagnostic Platforms
RAPID Wearables

Novel Wearable Diagnostic Medical Devices
RAPID Organ On A Chip

Organ-on-a-Chip Systems For Physiological Research

Point of Need Diagnostic Platforms

Centrifugal Disc-based diagnostic systems capable of being used for diverse biomarker panels and designed to integrate into current clinical lab workflows.

Lab on a Disc
“Lab on a Disc”
“Lab on a Disc”
  • Pulse-free inertial liquid propulsion
  • Allows closed fluidic systems free from external connectors
  • Sterile, sealed systems that support wet and dry reagent storage i.e. highly portable Point-of-Need (PoN) use
  • Nano- to milli-litres volumes
  • High-fidelity titrering/metering
E-LoaD Technology
E-LoaD Technology
E-LoaD Technology
  • “on-disc” wireless power transfer to enable measurement from lab-on-a-disk platforms under rotation
  • Sensor on the spinning disc that allows a rotation-independent wireless readout
  • Stable and continuous power supply allows more sophisticated on-disc setup
  • Potential for custom embedded systems, allowing complex sensing and actuation schemes
  • Integrated control and bidirectional communication on-disc
Microfluidic sorting system
Microfluidic sorting system
Microfluidic sorting system
  • Cells, exosomes and small particles
  • Count sorted samples via real-time imaging
  • Dispensing capability to well plates
  • Optical tweezers enable non-contact cell/particle manipulation
Microfabrication
Microfabrication
Microfabrication 
  • Ultraprecision milling machine <10µm
    Surface modification (laser ablation and lithography)
Microassembly Fabrication
Microassembly Fabrication
Microassembly Fabrication
  • Automated, high-accuracy “Pick & Place” of integrated sensors, reagent storage modules and valving components
  • Advanced in-line feature detection
  • Feature detection on disc for fine alignment
  • Lateral/Rotational accuracy 0.020 mm/0.014 degrees
High-precision optical surface metrology
High-precision optical surface metrology
High-precision optical surface metrology 
  • Characterisation of functional/technical surfaces - fast, efficient, non-destructive 

Novel Wearable Diagnostic Medical Devices

Wearable Diagnostic Systems incorporating novel, bespoke wearable biochemical sensors (developed in-house). These devices will combine the characteristics and functionality of POC devices, with ergonomics defined by human factors and ‘mobile connectivity’ in a wearable form factor.

Wearable Diagnostic Devices
Wearable Diagnostic Devices
Wearable Diagnostic Devices
  • Multi-Layer lamination assembly
  • Sweat and Volatile Organic Chemical (VOC) harvesting hardware
  • Flexible lens integration
  • Water purification/harvesting hardware
  • Display/human interface systems
  • Flexible sensor integration
Electrochemical sensors for the rapid detection of analytes
Electrochemical sensors
Electrochemical sensors for the rapid detection of analytes
  • Embedded sensors in diagnostic devices
  • Aptamer-based sensor customisation and integration within Lab-on-a-disc and wearable systems
Screen Printed Electrodes
Screen Printed Electrodes
Screen Printed Electrodes
  • Advanced (bio)composite materials for thin, flexible, on-body sensors
  • Low Temperature Printability
  • Biocompatible and biodegradable, electrically conductive, sensor technologies
Laser-etched flexible integrated circuits
Laser-etched flexible integrated circuits
Laser-etched flexible integrated circuits
  • Advanced (bio)composite materials for thin, flexible, on-body sensors
  • Low Temperature Printability
  • Biocompatible and biodegradable, electrically conductive, sensor technologies

Organ-on-a-Chip Systems For Physiological Research

Engineered and microfabricated cultivation systems that support cell assembly into tissue-like structures and enables measurements of physiological characteristics of the mimicked organ.

"Organ-on-a-chip"
"Organ-on-a-chip"
"Organ-on-a-chip"
  • Miniaturised device that simulate organs in their true physiological form at small scale
  • Single cell and particle isolation/screening capability
  • Biosensing applications via integrated novel sensors
  • Organoid manufacture and development platform
  • Fully automated biomarker detection and analysis platforms
Physiological Systems Replication Technologies
Physiological Systems Replication Technologies
Physiological Systems Replication Technologies
  • Microfluidic 3D culture devices can promote structural complexity and incorporate dynamic fluid flow as well as mechanical stimulations
  • Wide variety of OoC designs to recreate different key aspects of human physiology (e.g. cell-cell interfaces, tissue-level organisation of an organ or the systematic interaction of multiple organs)
  • Potential to reproduce tissue barriers, parenchymal tissues as well as inter-organ interactions
  • Micro-engineered systems also enable parallelization and increased throughput Injection moulding
  • Can be combined with in-line electrochemical, mechanical, and optical sensors to incorporate real-time readouts and enable probing of tissue barrier integrity, neuron electrical activity, oxygen utilization, pH, molecular transport, and other parameters