Optical Sensors Research
Optical Sensors (OSL) Group Members: Prof. Colette McDonagh
The Optical Sensors Laboratory, led by Professor Colette McDonagh, develops optical solutions to real-world measurement problems in biomedical sensing and bioprocess monitoring. In recent years, the main focus has been on the development of fluorescence-based sensors. Three sensor categories have been prioritised:
- Fluorescence-based sol-gel sensors. These encapsulate analyte-sensitive dye in a porous sol-gel matrix. Recent projects include the development of fluorescence-based oxygen and pH sensors for bioprocess monitoring and optical carbon dioxide sensors for environmental monitoring. Current projects include an optical fibre-based pH sensor for in-vivo monitoring of pH in tissue.
- Fluorescence-based immunosensors and nucleic acid sensors for diseases including cancer and meningitis. For these sensors, a number of novel fluorescence enhancement strategies have been developed e.g. ultra-bright silica nanoparticle labels, plasmonic-enhancement platforms and Supercritical Angle Fluorescence (SAF)-based sensor platforms. This work is carried out in the Biomedical Diagnostic Institute (BDI).
- Intracellular sensing of oxygen and pH using silica nanoparticles in which are encapsulated analyte-sensitive dyes as in fluorescence-based sol-gel sensors.