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International Centre for Neurotherapeutics


Ovsepian, S.V., O’Leary, V.B., Zaborszky, L., Ntziachristos, V., Dolly, J.O. (2018) Synaptic vesicle cycle and amyloid β: Biting the hand that feeds. Alzheimers & Dement. 2018 Apr;14(4):502-513. doi: 10.1016/j.jalz.2018.01.011. Epub 2018 Mar 1

O'Leary, V.B., O'Connell, M., Antyborzec, I., Ntziachristos, V., Dolly, J.O., Ovsepian, S.V. (2018) Alleviation of Trigeminal Nociception Using p75 Neurotrophin Receptor Targeted Lentiviral Interference Therapy. Neurotherapeutics. doi: 10.1007/s13311-018-0608-5. [Epub ahead of print] PMID: 29427180

Nugent, M., Wang, J., Lawrence, G.W., Zurawski, T, Geoghegan, J. A. and Dolly, J.O. (2017) Conjugate of an IgG binding domain with botulinum neurotoxin A lacking the acceptor moiety targets its SNARE-cleaving protease into TrkA-expressing cells when coupled to anti-TrkA IgG or Fc-βNGF. Bioconjugate Chemistry, doi. 10.1021/acs.bioconjchem.7b00157

Wang, J., Casals, L., Zurawski, T., Meng, J., Moriarty, O., Nealon, J., Edupuganti, O.P. and J Dolly, J.O. (2017) A novel therapeutic with two SNAP-25 inactivating proteases shows long-lasting anti-hyperalgesic activity in a rat model of neuropathic pain. Neuropharmacology. 10.1016/j.neuropharm.2017.03.026

Al-Sabi, A., Daly, D., Hoefer, P., Kinsella, G.K., Metais, C., Pickering, M., Herron, C., Kaza, S.K., Nolan, K. and Dolly, J.O. (2017) A rational design of a selective inhibitor for Kv1.1 channels prevalent in demyelinated nerves that improves their impaired axonal conduction. J. Med. Chem. (10.1021/acs.jmedchem.6b01262).

Wang, J., Meng, J., Nugent, M., Tang, M.  and Dolly, J.O. (2017) Neuronal entry and high neurotoxicity of botulinum neurotoxin A require its N-terminal binding sub-domain. Scientific Reports.

Ovsepian, S.V., O’Leary, V.B., Ntziachristos, V. and Dolly, J.O. (2016) Circumventing brain barriers: nanovehicles for retro-axonal therapeutic delivery. Trends in Molecular Medicine. 22(11):983-993

Antiborzec, I., O’Leary, V.B., Dolly, J.O. and Ovespian, S.V. (2016) Low-affinity neurotrophin receptor p75 promotes the transduction of targeted vectors to cholinergic neurons of rat basal forebrain. Neurotherapeutics. 13(4):859-870

Ovsepian, S.V., LeBerre, M., Steuber, V., O’Leary, V.B., Leibold, C. and Dolly, J.O. (2016) Distinctive role of KV1.1 subunit in the biology and functions of low threshold K+ channels with implications for neurological disease. Pharmacol. Ther. 159:93-101

Meng, J., Wang, J. Steinhoff, M. and Dolly, J.O. (2016) TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion. Scientific Reports, Nature, 6:21226

Ovsepian, S.V., Bodeker, M.O., O’Leary, V.B., Lawrence, G.W. and Dolly, J.O. (2015) Internalization and retrograde axonal trafficking of tetanus toxin in motor neurons and transport to central synapses exceeds those of its C-terminal binding fragments. Brain Structure and Function. 220(3):1825-38

Alka, K., Dolly, J.O., Ryan, B.J. and Henehan, G.T.M. (2014) New inhibitors of the Kvβ2 subunit from mammalian Kv1 potassium channels. Int J Biochem Cell Biol. 55:35-9

Daly, D., Al-Sabi, A., Kinsella, G., Kaza, S., Nolan, K. and Dolly, J.O. (2015) Porphyrin derivatives as new, potent and selective blockers of neuronal Kv1 channels. Chem Comm., 21;51(6):1066-9

Ma, H., Meng, J., Wang, J., Hearty, S., Dolly, J.O. and O’Kennedy, R. (2014) Targeted delivery into sensory neurons of a SNARE protease using a single chain antibody (scFv) against the extracellular domain of P2X3 inhibits the release of a pain mediator. Biochem J. 462:247–256

Lawrence, G.W., Wang, J., Brin, M.F., Aoki, K.R., Wheeler, L. and Dolly, J.O.  (2014) Fusion of Golgi-derived vesicles mediated by synaptosomal-associated protein of Mr = 25 k (SNAP-25) is essential for sympathetic neuron outgrowth but relatively insensitive to botulinum neurotoxins in vitro. FEBS J. 281(14):3243-60

Meng, J., Wang, J. and Dolly, J.O. (2014) Selective cleavage of SNAREs in sensory neurons unveils protein complexes mediating peptide exocytosis triggered by different stimuli. Mol. Neurobiol. 50:574-588

Bagchi, B., Al-Sabi, A., Kaza, S., O’Leary, V.B., Scholz, D., Dolly, J.O. and Ovsepian, S.V. (2014) Disruption of myelin leads to ectopic expression of KV1.1 channels with abnormal conductivity of optic nerve axons in a cuprizone-induced model of demyelination. PLoS ONE. 3;9(2):e87736 2014

Ovsepian*, S.V., Antyborzec*, I., O’Leary, V.B., Zaborszky, L., Herms, J. and Dolly, J.O. (2014) Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Ab) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons. Brain Struct. Funct. 219(5):1527-41

Boddul, S., Meng, J., Dolly, J.O. and Wang, J. (2013) SNAP-23 and VAMP-3 contribute to the release of IL-6 and TNF-α from a human synovial sarcoma cell line. FEBS J. 281(3):750-65

O'Leary, V.B., Ovsepian, S.V., Bodeker, M.O. and Dolly, J.O. (2013) Improved lentiviral transduction of ALS motoneurons in vivo via dual targeting. Molecular Pharmaceutics 10(11):4195–4206

Al-Sabi, A., Kaza, S., Wang, J. and Dolly, J.O (2013) Pharmacological characteristics of Kv1.1- and 1.2-containing channels are influenced by the stoichiometry and positioning of their α subunits. Biochem. J. 454 (part 1):101-108

Meng, J., Wang, J., Lawrence, G.W.and Dolly, J.O. (2013) Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons. FASEB J. 27(8):3167-80

Lawrence, G.W., Ovsepian, S.V., Wang, J., Aoki, K.R. and Dolly, J.O.  (2013) Therapeutic effectiveness of botulinum neurotoxin A: potent blockade of transmission by targeted cleavage of only the pertinent SNAP-25. Neuropharmacology 70:287-295

Ovsepian S.V., Le Berre. M, O’Hara. L and Dolly, J.O. (2013) A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the efferent code of deep cerebellar nuclear neurons to thalamic targets. J. Physiol (Lond.) 591:1771-91

Wang, J., Zurawski. T., Meng, J., Lawrence, G.W, Aoki, K.R., Wheeler, L. and Dolly, J.O. (2012) Novel chimeras of botulinum and tetanus neurotoxins yield insights into their distinct sites of neuroparalysis. FASEB J. 26:5035-5048

Edupuganti, O., Ovsepian, S.V., Schmidt, J., Lawrence, G.W., Smith, L., Wang, J., Dolly, J.O. (2012) Targeted delivery into motor nerve terminals of inhibitors for SNARE-cleaving proteases via liposomes coupled to an atoxic botulinum neurotoxin.  FEBS J. 279(14):2555-67

Dolly, J.O., O’Connell, M.A.; (2012) Neurotherapeutics to inhibit exocytosis from sensory neurons for the control of chronic pain. Current Opinion in Pharmacology 12:100–108

Ovsepian, S.V., Dolly, J.O. and Zaborszky, L. (2012) Intrinsic voltage dynamics govern the diversity of spontaneous firing profiles in basal forebrain non-cholinergic neurons. J. Neurophysiol. 108:(2) 406-418

Wang, J., Zurawski, T.H., Bodeker, M.O., Meng, J., Boddul, S., K. Aoki, K.R and Dolly, J.O. (2012) Longer-acting and highly-potent chimeric inhibitors of excessive exocytosis created with domains from botulinum neurotoxin A and B. Biochem. J. (2012) 444 (59-67)

Lawrence G.W., Ovsepian S.V., Wang, J., Aoki, K.R. and Dolly, J.O. (2012) Extravesicular intraneuronal migration of internalised botulinum neurotoxins without detectable inhibition of distal neurotransmission. Biochem. J. 441 (443–452)

Ovsepian, S.V., Dolly, J.O. (2011) Dendritic SNAREs: a new twist to the old theory. Proc. Nat. Acad. Sci. USA 108 (48):19113-19120

Al Sabi, A., Kaza, S., Le Berre, M., O’Hara, L., Bodeker, M.O., Wang, J and Dolly, J.O. (2011) Position-dependent attenuation by Kv1.6 of N-type inactivation of Kv1.4-containing channels. Biochem. J. Cell 438 (issue 2) 389-396

Dolly J.O., Wang, J., Zurawski, T. and Meng, J. (2011) Novel therapeutics based on botulinum neurotoxins to normalise the release of transmitters and pain mediators. FEBS J. 278, 4454–4466

O’Leary, V.B., Ovsepian, S.V., Raghunath, A., Qing, H., Lawrence, G.W., Smith, L., Dolly, J.O. (2011) Innocuous full-length botulinum neurotoxin targets and promotes the expression of lentiviral vectors in central and autonomic neurons. Gene Therapy 18:656-665

Wang, J., Zurawski, T.H., Meng, J., Olango, W.M., Finn, D.P., Wheeler, L. and Dolly, J.O. (2011) A di-leucine in the protease of botulinum toxin A underlies its long-lived neuroparalysis: transfer of longevity to a novel potential therapeutic. J. Biol. Chem. 286:6375-85

Alka, K., Ryan, B. J., Dolly, J.O., Henehan, G. (2010) Substrate profiling and aldehyde dismutase activity of the Kvβ2 subunit of the mammalian Kv1 potassium channel. Internat. J. Biochem. & Cell Biol. 42:2012-2018

Al-Sabi, A., Shamotienko, O., Ní Dhochartaigh, S., Muniyapppa, N., LeBerre , M., Shaban, H., Wang, J., Sack, J. and Dolly, J.O. (2010). Arrangement of Kv1 asubunits dictates sensitivity to tetraethylammonium. J. Gen. Physiol. 136:273-282

Lawrence, G.W., Aoki, K.R. and Dolly, J.O. (2010) Excitatory cholinergic and purinergic signaling in bladder are equally susceptible to botulinum neurotoxin A consistent with co-release of transmitters from efferent fibres. J. Pharmcol. Exp. Therapeutics 334:1080-1086

Meng, J., Ovsepian, S.V., Wang, J., Pickering, M., Sasse, A., Aoki, K.R., Lawrence, G.W. and Dolly, J.O. (2009) Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential. J. Neurosci. 29:4981-4992

Dolly, J.O., Lawrence, G.W., Meng, J., Wang, J. and Ovsepian, S.V. (2009) Neuro-exocytosis: botulinum toxins as inhibitory probes and versatile therapeutics. Current Opinion in Pharmacology 9:326-335

Wang, J., Meng, J., Lawrence, G.W., Zurawski, T. H., Sasse, A., Bodeker, M. O., Gilmore, M. A., Fernandez-Salas, E., Francis, J., Steward, L. E., Aoki, K.R. and Dolly, J.O. (2008) Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics. J. Biol. Chem. 283:16993-7002

Raghunath, A., Perez-Branguli, F., Smith, L. and Dolly, J.O. (2008) Adeno-associated virus transfer of a gene encoding SNAP-25 resistant to botulinum toxin A attenuates neuromuscular paralysis associated with botulism. J. Neurosci. 28:3683-8

Sack, J. T., Shamotienko, O. and Dolly, J.O. (2008) How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits. J. Gen. Physiol. 131:415-20

Meng, J., Wang, J., Lawrence, G. and Dolly, J.O. (2007) Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential. J. Cell Sci. 120:2864-74

Sokolov, M. V., Shamotienko, O., Dhochartaigh, S. N., Sack, J. T. and Dolly, J.O. (2007) Concatemers of brain Kv1 channel alpha subunits that give similar K+ currents yield pharmacologically distinguishable heteromers. Neuropharmacology 53:272-82

Schulte-Baukloh, H., Zurawski, T. H., Knispel, H. H., Miller, K., Haferkamp, A. and Dolly, J.O. (2007) Persistence of the synaptosomal-associated protein-25 cleavage product after intradetrusor botulinum toxin A injections in patients with myelomeningocele showing an inadequate response to treatment. BJU Int. 100:1075-80

Lawrence, G., Wang, J., Chion, C. K., Aoki, K.R. and Dolly, J.O. (2007) Two protein trafficking processes at motor nerve endings unveiled by botulinum neurotoxin E. J. Pharmacol. Exp. Ther. 320:410-8

Dolly, J.O. (2005) Molecular definition of neuronal targets for novel neurotherapeutics: SNAREs and Kv1 channels. NeuroToxicology 26:753-60

Shimamura, T., Shamotienko, O., Akhtar, S., Dolly, J.O. and Iwata, S. (2004) Crystallization and preliminary X-ray analysis of pseudo-merohedrally twinned crystals of the full-length beta(2) subunit of the Kv1 K(+) channel from Rattus norvegicus. Acta Crystallogr D. Biol. Crystallogr 60:912-4

Bagetta, G., Palma, E., Piccirilli, S., Del Duca, C., Morrone, A. L., Nappi, G., Corasaniti, M. T. and Dolly, J.O. (2004) Involvement of a glutamergic mechanism in gamma-dendrotoxin-induced hippocampal neuronal cell loss in the rat. Basic Clin. Pharmacol. Toxicol. 94:132-8

Tang-Liu, D. D., Aoki, K.R., Dolly, J.O., de Paiva, A., Houchen, T. L., Chasseaud, L. F. and Webber, C. (2003) Intramuscular injection of 125I-botulinum neurotoxin-complex versus 125I-botulinum-free neurotoxin: time course of tissue distribution. Toxicon  42:461-9

Fraser, S. P., Grimes, J. A., Diss, J. K., Stewart, D., Dolly, J.O. and Djamgoz, M. B. (2003) Predominant expression of Kv1.3 voltage-gated K+ channel subunit in rat prostate cancer cell lines: electrophysiological, pharmacological and molecular characterisation. Pflugers Arch 446:559-71

Orlova, E. V., Papakosta, M., Booy, F. P., van Heel, M. and Dolly, J.O. (2003) Voltage-gated K+ channel from mammalian brain: 3D structure at 18A of the complete (alpha)4(beta)4 complex. J. Mol. Biol. 326:1005-12

Foran, P. G., Mohammed, N., Lisk, G. O., Nagwaney, S., Lawrence, G.W., Johnson, E., Smith, L., Aoki, K.R. and Dolly, J.O. (2003) Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A. Basis for distinct durations of inhibition of exocytosis in central neurons. J. Biol. Chem. 278:1363-71

Meunier, F. A., Lisk, G., Sesardic, D. and Dolly, J.O. (2003) Dynamics of motor nerve terminal remodeling unveiled using SNARE-cleaving botulinum toxins: the extent and duration are dictated by the sites of SNAP-25 truncation. Mol. Cell Neurosci. 22:454-66

Lawrence, G.W., Foran, P. and Oliver Dolly, J. (2002) Insights into a basis for incomplete inhibition by botulinum toxin A of Ca2+-evoked exocytosis from permeabilised chromaffin cells. Toxicology 181-182:249-53

Akhtar, S., Shamotienko, O., Papakosta, M., Ali, F. and Dolly, J.O. (2002) Characteristics of brain Kv1 channels tailored to mimic native counterparts by tandem linkage of alpha subunits: implications for K+ channelopathies. J. Biol. Chem. 277:16376-82

Lawrence, G.W. and Dolly, J.O. (2002) Ca2+-induced changes in SNAREs and synaptotagmin I correlate with triggered exocytosis from chromaffin cells: insights gleaned into the signal transduction using trypsin and botulinum toxins. J. Cell Sci. 115:2791-800

Lawrence, G.W. and Dolly, J.O. (2002) Multiple forms of SNARE complexes in exocytosis from chromaffin cells: effects of Ca2+, MgATP and botulinum toxin type A. J. Cell Sci. 115:667-73

Manganas, L. N., Akhtar, S., Antonucci, D. E., Campomanes, C. R., Dolly, J.O. and Trimmer, J. S. (2001) Episodic ataxia type-1 mutations in the Kv1.1 potassium channel display distinct folding and intracellular trafficking properties. J. Biol. Chem. 276:49427-34

Li, Y., Foran, P., Lawrence, G., Mohammed, N., Chan-Kwo-Chion, C. K., Lisk, G., Aoki, R. and Dolly, O. (2001) Recombinant forms of tetanus toxin engineered for examining and exploiting neuronal trafficking pathways. J. Biol. Chem. 276:31394-401

Volynski, K. E., Meunier, F. A., Lelianova, V. G., Dudina, E. E., Volkova, T. M., Rahman, M. A., Manser, C., Grishin, E. V., Dolly, J.O., Ashley, R. H. and Ushkaryov, Y. A. (2000) Latrophilin, neurexin, and their signalling-deficient mutants facilitate alpha-latrotoxin insertion into membranes but are not involved in pore formation. J. Biol. Chem. 275:41175-83

Ashton, A. C. and Dolly, J.O. (2000) A late phase of exocytosis from synaptosomes induced by elevated [Ca2+] is not blocked by Clostridial neurotoxins. J. Neurochem. 74:1979-88

Meunier, F. A., Mattei, C., Chameau, P., Lawrence, G., Colasante, C., Kreger, A. S., Dolly, J.O. and Molgo, J. (2000) Trachynilysin mediates SNARE-dependent release of catecholamines from chromaffin cells via external and stored Ca2+. J. Cell Sci. 113:1119-2

Poopalasundaram, S., Knott, C., Shamotienko, O. G., Foran, P. G., Dolly, J.O., Ghiani, C. A., Gallo, V. and Wilkin, G. P. (2000) Glial heterogeneity in expression of the inwardly rectifying K(+) channel, Kir4.1, in adult rat CNS. Glia 30:362-72

O'Sullivan, G. A., Mohammed, N., Foran, P. G., Lawrence, G.W. and Oliver Dolly, J. (1999) Rescue of exocytosis in botulinum toxin A-poisoned chromaffin cells by expression of cleavage-resistant SNAP-25. Identification of the minimal essential C-terminal residues. J. Biol. Chem. 274:36897-904

Akhtar, S., McIntosh, P., Bryan-Sisneros, A., Barratt, L., Robertson, B. and Dolly, J.O. (1999) A functional spliced-variant of beta 2 subunit of Kv1 channels in C6 glioma cells and reactive astrocytes from rat lesioned cerebellum. Biochemistry 38:16984-92

Shamotienko, O., Akhtar, S., Sidera, C., Meunier, F. A., Ink, B., Weir, M. and Dolly, J.O. (1999) Recreation of neuronal Kv1 channel oligomers by expression in mammalian cells using Semliki Forest virus. Biochemistry 38:16766-76

Foran, P. G., Fletcher, L. M., Oatey, P. B., Mohammed, N., Dolly, J.O. and Tavare, J. M. (1999) Protein kinase B stimulates the translocation of GLUT4 but not GLUT1 or transferrin receptors in 3T3-L1 adipocytes by a pathway involving SNAP-23, synaptobrevin-2, and/or cellubrevin. J. Biol. Chem. 274:28087-95

Coleman, S. K., Newcombe, J., Pryke, J. and Dolly, J.O. (1999) Subunit composition of Kv1 channels in human CNS. J. Neurochem. 73:849-58

Li, Y., Aoki, R. and Dolly, J.O. (1999) Expression and characterisation of the heavy chain of tetanus toxin: reconstitution of the fully-recombinant dichain protein in active form. J. Biochem. 125:1200-8

Wang, F. C., Parcej, D. N. and Dolly, J.O. (1999) α Subunit compositions of Kv1.1-containing K+ channel subtypes fractionated from rat brain using dendrotoxins. Eur. J. Biochem. 263:230-7

Wang, F. C., Bell, N., Reid, P., Smith, L. A., McIntosh, P., Robertson, B. and Dolly, J.O. (1999) Identification of residues in dendrotoxin K responsible for its discrimination between neuronal K+ channels containing Kv1.1 and 1.2 alpha subunits. Eur. J. Biochem. 263:222-9

de Paiva, A., Meunier, F. A., Molgo, J., Aoki, K.R. and Dolly, J.O. (1999) Functional repair of motor endplates after botulinum neurotoxin type A poisoning: biphasic switch of synaptic activity between nerve sprouts and their parent terminals. Proc. Natl. Acad. Sci. U S A 96:3200-5

Rahman, M. A., Ashton, A. C., Meunier, F. A., Davletov, B. A., Dolly, J.O. and Ushkaryov, Y. A. (1999) Norepinephrine exocytosis stimulated by alpha-latrotoxin requires both external and stored Ca2+ and is mediated by latrophilin, G proteins and phospholipase C. Philos Trans. R. Soc. Lond. B. Biol. Sci. 354:379-86

Davletov, B. A., Meunier, F. A., Ashton, A. C., Matsushita, H., Hirst, W. D., Lelianova, V. G., Wilkin, G. P., Dolly, J.O. and Ushkaryov, Y. A. (1998) Vesicle exocytosis stimulated by alpha-latrotoxin is mediated by latrophilin and requires both external and stored Ca2+. EMBO J. 17:3909-20

McIntosh, P., Southan, A. P., Akhtar, S., Sidera, C., Ushkaryov, Y., Dolly, J.O. and Robertson, B. (1997) Modification of rat brain Kv1.4 channel gating by association with accessory Kvbeta1.1 and beta2.1 subunits. Pflugers Arch. 435:43-54

Bagetta, G., Palma, E., Piccirilli, S., Nistico, G. and Dolly, J.O. (1997) Seizures and hippocampal damage produced by dendrotoxin-K in rats is prevented by the 21-aminosteroid U-74389G. Exp. Neurol. 147:204-10

Smith, L. A., Reid, P. F., Wang, F. C., Parcej, D. N., Schmidt, J. J., Olson, M. A. and Dolly, J.O. (1997) Site-directed mutagenesis of dendrotoxin K reveals amino acids critical for its interaction with neuronal K+ channels. Biochemistry 36:7690-6

Shamotienko, O. G., Parcej, D. N. and Dolly, J.O. (1997) Subunit combinations defined for K+ channel Kv1 subtypes in synaptic membranes from bovine brain. Biochemistry 36:8195-201

Lawrence, G.W., Foran, P., Mohammed, N., DasGupta, B. R. and Dolly, J.O. (1997) Importance of two adjacent C-terminal sequences of SNAP-25 in exocytosis from intact and permeabilized chromaffin cells revealed by inhibition with botulinum neurotoxins A and E. Biochemistry 36:3061-7

Chen, F., Foran, P., Shone, C. C., Foster, K. A., Melling, J. and Dolly, J.O. (1997) Botulinum neurotoxin B inhibits insulin-stimulated glucose uptake into 3T3-L1 adipocytes and cleaves cellubrevin unlike type A toxin which failed to proteolyze the SNAP-23 present. Biochemistry 36:5719-28

Ashton, A. C. and Dolly, J.O. (1997) Microtubules and microfilaments participate in the inhibition of synaptosomal noradrenaline release by tetanus toxin. J. Neurochem. 68:649-58

Dolly, J.O. and Parcej, D. N. (1996) Molecular properties of voltage-gated K+ channels. J. Bioenerg. Biomembr. 28:231-53

Tibbs, G. R., Dolly, J.O. and Nicholls, D. G. (1996) Evidence for the induction of repetitive action potentials in synaptosomes by K+-channel inhibitors: an analysis of plasma membrane ion fluxes. J. Neurochem. 67:389-97

McNamara, N. M., Averill, S., Wilkin, G. P., Dolly, J.O. and Priestley, J. V. (1996) Ultrastructural localization of a voltage-gated K+ channel alpha subunit (KV1.2) in the rat cerebellum. Eur. J. Neurosci. 8:688-99

Daniels-Holgate, P. U. and Dolly, J.O. (1996) Productive and non-productive binding of botulinum neurotoxin A to motor nerve endings are distinguished by its heavy chain. J. Neurosci. Res. 44:263-71

Poulain, B., De Paiva, A., Deloye, F., Doussau, F., Tauc, L., Weller, U. and Dolly, J.O. (1996) Differences in the multiple step process of inhibition of neurotransmitter release induced by tetanus toxin and botulinum neurotoxins type A and B at Aplysia synapses. Neuroscience 70:567-76

Lawrence, G.W., Foran, P. and Dolly, J.O. (1996) Distinct exocytotic responses of intact and permeabilised chromaffin cells after cleavage of the 25-kDa synaptosomal-associated protein (SNAP-25) or synaptobrevin by botulinum toxin A or B. Eur. J. Biochem. 236:877-86

Bagetta, G., Iannone, M., Palma, E., Nistico, G. and Dolly, J.O. (1996) N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors mediate seizures and CA1 hippocampal damage induced by dendrotoxin-K in rats. Neuroscience 71:613-24

Foran, P., Lawrence, G.W., Shone, C. C., Foster, K. A. and Dolly, J.O. (1996) Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release. Biochemistry 35:2630-6

Ashton, A. C., Li, Y., Doussau, F., Weller, U., Dougan, G., Poulain, B. and Dolly, J.O. (1995) Tetanus toxin inhibits neuroexocytosis even when its Zn(2+)-dependent protease activity is removed. J. Biol. Chem. 270:31386-90

Zhou, L., de Paiva, A., Liu, D., Aoki, R. and Dolly, J.O. (1995) Expression and purification of the light chain of botulinum neurotoxin A: a single mutation abolishes its cleavage of SNAP-25 and neurotoxicity after reconstitution with the heavy chain. Biochemistry 34:15175-81

Figueiredo, D., Turcotte, C., Frankel, G., Li, Y., Dolly, O., Wilkin, G., Marriott, D., Fairweather, N. and Dougan, G. (1995) Characterization of recombinant tetanus toxin derivatives suitable for vaccine development. Infect. Immun. 63:3218-21

Smith, L. A., Olson, M. A., Lafaye, P. J. and Dolly, J.O. (1995) Cloning and expression of mamba toxins. Toxicon 33:459-74

Foran, P., Lawrence, G. and Dolly, J.O. (1995) Blockade by botulinum neurotoxin B of catecholamine release from adrenochromaffin cells correlates with its cleavage of synaptobrevin and a homologue present on the granules. Biochemistry 34:5494-503

Foran, P., Shone, C. C. and Dolly, J.O. (1994) Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments. Biochemistry 33:15365-74

Krizaj, I., Dolly, J.O. and Gubensek, F. (1994) Identification of the neuronal acceptor in bovine cortex for ammodytoxin C, a presynaptically neurotoxic phospholipase A2. Biochemistry 33:13938-45

Li, Y., Foran, P., Fairweather, N. F., de Paiva, A., Weller, U., Dougan, G. and Dolly, J.O. (1994) A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain. Biochemistry 33:7014-20

Hall, A., Stow, J., Sorensen, R., Dolly, J.O. and Owen, D. (1994) Blockade by dendrotoxin homologues of voltage-dependent K+ currents in cultured sensory neurones from neonatal rats. Br. J. Pharmacol. 113:959-67

Rettig, J., Heinemann, S. H., Wunder, F., Lorra, C., Parcej, D. N., Dolly, J.O. and Pongs, O. (1994) Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit. Nature 369:289-94

Lawrence, G.W., Weller, U. and Dolly, J.O. (1994) Botulinum A and the light chain of tetanus toxins inhibit distinct stages of Mg.ATP-dependent catecholamine exocytosis from permeabilised chromaffin cells. Eur. J. Biochem. 222:325-33

Cenci Di Bello, I., Poulain, B., Shone, C. C., Tauc, L. and Dolly, J.O. (1994) Antagonism of the intracellular action of botulinum neurotoxin type A with monoclonal antibodies that map to light-chain epitopes. Eur. J. Biochem. 219:161-9

Heinemann, S.,  Rettig, J., Scott, V. E., Parcej, D. N., Lorra, C., Dolly, J.O. and Pongs, O. (1994) The inactivation behaviour of voltage-gated K-channels may be determined by association of alpha- and beta-subunits. J. Physiol. Paris 88:3:173-80

Scott, V. E., Muniz, Z. M., Sewing, S., Lichtinghagen, R., Parcej, D. N., Pongs, O. and Dolly, J.O. (1994) Antibodies specific for distinct Kv subunits unveil a heterooligomeric basis for subtypes of alpha-dendrotoxin-sensitive K+ channels in bovine brain. Biochemistry 33:1617-23

Bagetta, G., Nair, S., Nistico, G. and Dolly, J.O. (1994) Hippocampal damage produced in rats by alpha-dendrotoxin--a selective K+ channel blocker--involves non-NMDA receptor activation. Neurochem. Int. 24:81-90

Scott, V. E., Rettig, J., Parcej, D. N., Keen, J. N., Findlay, J. B., Pongs, O. and Dolly, J.O. (1994) Primary structure of a beta subunit of alpha-dendrotoxin-sensitive K+ channels from bovine brain. Proc. Natl. Acad. Sci. U S A 91:1637-41

Dolly, J.O., de Paiva, A., Foran, P., Lawrence, G., Daniels-Holgate, P. and Ashton, A. C. (1994) Probing the process of transmitter release with botulinum and tetanus neurotoxins. Seminars in the Neurosciences 6:149-158

McGivern, J., Scholfield, C. N. and Dolly, J.O. (1993) Action of alpha-dendrotoxin on K+ currents in nerve terminal regions of axons in rat olfactory cortex. Br. J. Pharmacol. 109:535-8

McNamara, N. M., Muniz, Z. M., Wilkin, G. P. and Dolly, J.O. (1993) Prominent location of a K+ channel containing the alpha subunit Kv 1.2 in the basket cell nerve terminals of rat cerebellum. Neuroscience 57:1039-45

de Paiva, A., Ashton, A. C., Foran, P., Schiavo, G., Montecucco, C. and Dolly, J.O. (1993) Botulinum A like type B and tetanus toxins fulfils criteria for being a zinc-dependent protease. J. Neurochem. 61:2338-41

de Paiva, A., Poulain, B., Lawrence, G.W., Shone, C. C., Tauc, L. and Dolly, J.O. (1993) A role for the interchain disulfide or its participating thiols in the internalization of botulinum neurotoxin A revealed by a toxin derivative that binds to ecto-acceptors and inhibits transmitter release intracellularly. J. Biol. Chem. 268:20838-44

Smith, L. A., Lafaye, P. J., LaPenotiere, H. F., Spain, T. and Dolly, J.O. (1993) Cloning and functional expression of dendrotoxin K from black mamba, a K+ channel blocker. Biochemistry 32:5692-7

Hall, A. C., Tibbs, G. R., Dolly, J.O., Lieb, W. R. and Franks, N. P. (1993) A simple method for recording single-channel activity from synaptic plasma membranes. J. Neurosci. Methods 49:81-91

McMahon, H. T., Foran, P., Dolly, J.O., Verhage, M., Wiegant, V. M. and Nicholls, D. G. (1992) Tetanus toxin and botulinum toxins type A and B inhibit glutamate, gamma-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. Clues to the locus of action. J. Biol. Chem. 267:21338-43

Muniz, Z. M., Parcej, D. N. and Dolly, J.O. (1992) Characterization of monoclonal antibodies against voltage-dependent K+ channels raised using alpha-dendrotoxin acceptors purified from bovine brain. Biochemistry 31:12297-303

Parcej, D. N., Scott, V. E. and Dolly, J.O. (1992) Oligomeric properties of alpha-dendrotoxin-sensitive potassium ion channels purified from bovine brain. Biochemistry 31:11084-8

Bagetta, G., Nistico, G. and Dolly, J.O. (1992) Production of seizures and brain damage in rats by alpha-dendrotoxin, a selective K+ channel blocker. Neurosci. Lett. 139:34-40

Reid, P. F., Pongs, O. and Dolly, J.O. (1992) Cloning of a bovine voltage-gated K+ channel gene utilising partial amino acid sequence of a dendrotoxin-binding protein from brain cortex. FEBS Lett. 302:31-4

Poulain, B., de Paiva, A., Dolly, J.O., Weller, U. and Tauc, L. (1992) Differences in the temperature dependencies of uptake of botulinum and tetanus toxins in Aplysia neurons. Neurosci. Lett. 139:289-92

Poulain, B., Mochida, S., Weller, U., Hogy, B., Habermann, E., Wadsworth, J. D., Shone, C. C., Dolly, J.O. and Tauc, L. (1991) Heterologous combinations of heavy and light chains from botulinum neurotoxin A and tetanus toxin inhibit neurotransmitter release in Aplysia. J. Biol. Chem. 266:9580-5

Awan, K. A. and Dolly, J.O. (1991) K+ channel sub-types in rat brain: characteristic locations revealed using beta-bungarotoxin, alpha- and delta-dendrotoxins. Neuroscience 40:29-39

Ashton, A. C. and Dolly, J.O. (1991) Microtubule-dissociating drugs and A23187 reveal differences in the inhibition of synaptosomal transmitter release by botulinum neurotoxins types A and B. J. Neurochem. 56:827-35

Scott, V. E., Parcej, D. N., Keen, J. N., Findlay, J. B. and Dolly, J.O. (1990) Alpha-dendrotoxin acceptor from bovine brain is a K+ channel protein. Evidence from the N-terminal sequence of its larger subunit. J. Biol. Chem. 265:20094-7

Poulain, B., Mochida, S., Wadsworth, J. D., Weller, U., Habermann, E., Dolly, J.O. and Tauc, L. (1990) Inhibition of neurotransmitter release by botulinum neurotoxins and tetanus toxin at Aplysia synapses: role of the constituent chains. J. Physiol. (Paris) 84:247-61

Muniz, Z. M., Diniz, C. R. and Dolly, J.O. (1990) Characterisation of binding sites for delta-dendrotoxin in guinea-pig synaptosomes: relationship to acceptors for the K+ channel probe alpha-dendrotoxin. J. Neurochem. 54:343-6

Muniz, Z. M., Tibbs, G. R., Marchot, P., Bougis, P., Nicholls, D. G. and Dolly, J.O. (1990) Homologues of a K+ channel blocker a-dendrotoxin: characterization of synaptosomal binding sites and their coupling to elevation of cytosolic free calcium concentration. Neurochem. Internat. 16:105-112

Matsuoka, I. and Dolly, J.O. (1990) Identification and localization of low-molecular-mass GTP-binding proteins associated with synaptic vesicles and other membranes. Biochim. Biophys. Acta. 1026:99-104

McInnes, C. and Dolly, J.O. (1990) Ca2(+)-dependent noradrenaline release from permeabilised PC12 cells is blocked by botulinum neurotoxin A or its light chain. FEBS Lett. 261:323-6

Dolly, J.O., Ashton, A. C., McInnes, C., Wadsworth, J. D., Poulain, B., Tauc, L., Shone, C. C. and Melling, J. (1990) Clues to the multi-phasic inhibitory action of botulinum neurotoxins on release of transmitters. J. Physiol. (Paris) 84:237-46

de Paiva, A. and Dolly, J.O. (1990) Light chain of botulinum neurotoxin is active in mammalian motor nerve terminals when delivered via liposomes. FEBS Lett. 277:171-4

Ashton, A. C., Edwards, K. and Dolly, J.O. (1990) ADP-ribosylation of cerebrocortical synaptosomal proteins by cholera, pertussis and botulinum toxins. Toxicon 28:963-73

Wadsworth, J. D., Desai, M., Tranter, H. S., King, H. J., Hambleton, P., Melling, J., Dolly, J.O. and Shone, C. C. (1990) Botulinum type F neurotoxin. Large-scale purification and characterization of its binding to rat cerebrocortical synaptosomes. Biochem. J. 268:123-8

Tibbs, G. R., Nicholls, D. G. and Dolly, J.O. (1989) Dendrotoxin and charybdotoxin increase the cytosolic concentration of free Ca2+ in cerebrocortical synaptosomes: an effect not shared by apamin. FEBS Lett. 255:159-62

Tibbs, G. R., Dolly, J.O. and Nicholls, D. G. (1989) Dendrotoxin, 4-aminopyridine, and beta-bungarotoxin act at common loci but by two distinct mechanisms to induce Ca2+-dependent release of glutamate from guinea-pig cerebrocortical synaptosomes. J. Neurochem. 52:201-6

Poulain, B., Wadsworth, J. D., Shone, C. C., Mochida, S., Lande, S., Melling, J., Dolly, J.O. and Tauc, L. (1989) Multiple domains of botulinum neurotoxin contribute to its inhibition of transmitter release in Aplysia neurons. J. Biol. Chem. 264:21928-33

Poulain, B., Wadsworth, J. D., Maisey, E. A., Shone, C. C., Melling, J., Tauc, L. and Dolly, J.O. (1989) Inhibition of transmitter release by botulinum neurotoxin A. Contribution of various fragments to the intoxication process. Eur. J. Biochem. 185:197-203

Pelchen-Matthews, A. and Dolly, J.O. (1989) Distribution in the rat central nervous system of acceptor sub-types for dendrotoxin, a K+ channel probe. Neuroscience 29:347-61

Parcej, D. N. and Dolly, J.O. (1989) Dendrotoxin acceptor from bovine synaptic plasma membranes. Binding properties, purification and subunit composition of a putative constituent of certain voltage-activated K+ channels. Biochem. J. 257:899-903

Breeze, A. L. and Dolly, J.O. (1989) Interactions between discrete neuronal membrane binding sites for the putative K+-channel ligands beta-bungarotoxin, dendrotoxin and mast-cell-degranulating peptide. Eur. J. Biochem. 178:771-8

Marqueze, B., Couraud, F. and Dolly, J.O. (1989) Identification by photoaffinity labelling of a polypeptide of the neuronal acceptor for dendrotoxin, a putative constituent of certain K+ channels. FEBS Lett. 

Parcej, D. N. and Dolly, J.O. (1989) Elegance persists in the purification of K+ channels. Biochem. J. 264:623-4

Maisey, E. A., Wadsworth, J. D., Poulain, B., Shone, C. C., Melling, J., Gibbs, P., Tauc, L. and Dolly, J.O. (1988) Involvement of the constituent chains of botulinum neurotoxins A and B in the blockade of neurotransmitter release. Eur. J. Biochem. 177:683-91

Ashton, A. C. and Dolly, J.O. (1988) Characterization of the inhibitory action of botulinum neurotoxin type A on the release of several transmitters from rat cerebrocortical synaptosomes. J. Neurochem. 50:1808-16

Evans, D. M., Richardson, P. J., Fine, A., Mason, W. T. and Dolly, J.O. (1988) Relationship of acceptors for botulinum toxin (types A and B) in rat CNS with the cholinergic marker, Chol-1. Neurochem. Internat. 13:25-36

Black, A. R., Donegan, C. M., Denny, B. J. and Dolly, J.O. (1988) Solubilization and physical characterization of acceptors for dendrotoxin and beta-bungarotoxin from synaptic membranes of rat brain. Biochemistry 27:6814-20

Dolly, J.O., Gwilt, M., Lacey, G., Newsom-Davis, J., Vincent, A., Whiting, P. and Wray, D. W. (1988) Action of antibodies directed against the acetylcholine receptor on channel function at mouse and rat motor end-plates. J. Physiol. 399:577-89

Poulain, B., Tauc, L., Maisey, E. A., Wadsworth, J. D., Mohan, P. M. and Dolly, J.O. (1988) Neurotransmitter release is blocked intracellularly by botulinum neurotoxin, and this requires uptake of both toxin polypeptides by a process mediated by the larger chain. Proc. Natl. Acad. Sci. U S A 85:4090-4

Pelchen-Matthews, A. and Dolly, J.O. (1988) Distribution of acceptors for beta-bungarotoxin in the central nervous system of the rat. Brain Res. 441:127-38

Poulain, B., Tauc, L., Maisey, E. A., et Dolly, J.O. (1988) Ganglionic synapses of Aplsia as model for the study of the mechanism of action of botulinum neurotoxins. C.R. Acad. Sci. Paris, t. 306 Serie 3: 483-488,

Dolly, J.O. (1988) Potassium channels — what can the protein chemistry contribute? Trends Neurosci. 11:186-8

Dolly, J.O., Lande, S., and Wray, D. (1987) The effects of in vitro application of purified botulinum neurotoxin at mouse motor nerve terminals. J. Physiol. 386:475-484

Stansfeld, C. E., Marsh, S. J., Parcej, D. N., Dolly, J.O. and Brown, D. A. (1987) Mast cell degranulating peptide and dendrotoxin selectively inhibit a fast-activating potassium current and bind to common neuronal proteins. Neuroscience 23:893-902

Sanchez-Prieto, J., Sihra, T. S., Evans, D., Ashton, A., Dolly, J.O. and Nicholls, D. G. (1987) Botulinum toxin A blocks glutamate exocytosis from guinea-pig cerebral cortical synaptosomes. Eur. J. Biochem. 165:675-81

Black, J. D. and Dolly, J.O. (1987) Selective location of acceptors for botulinum neurotoxin A in the central and peripheral nervous systems. Neuroscience 23:767-79

Black, J. D. and Dolly, J.O. (1986) Interaction of 125I-labeled botulinum neurotoxins with nerve terminals. I. Ultrastructural autoradiographic localization and quantitation of distinct membrane acceptors for types A and B on motor nerves. J. Cell Biol. 103:521-34

Black, J. D. and Dolly, J.O. (1986) Interaction of 125I-labeled botulinum neurotoxins with nerve terminals. II. Autoradiographic evidence for its uptake into motor nerves by acceptor-mediated endocytosis. J. Cell Biol. 103:535-44

Mehraban, F., Haines, A. and Dolly, J.O. (1986) Monoclonal and polyclonal antibodies against dendrotoxin: their effects on its convulsive activity and interaction with neuronal acceptors. Neurochem. Internat.  9:11-22

Evans, D. M., Williams, R. S., Shone, C. C., Hambleton, P., Melling, J. and Dolly, J.O. (1986) Botulinum neurotoxin type B. Its purification, radioiodination and interaction with rat-brain synaptosomal membranes. Eur. J. Biochem. 154:409-16

Halliwell, J. V., Othman, I. B., Pelchen-Matthews, A. and Dolly, J.O. (1986) Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors. Proc. Natl. Acad. Sci. U S A 83:493-7)

Tse, C. K., Wray, D., Melling, J. and Dolly, J.O. (1986) Actions of beta-bungarotoxin on spontaneous release of transmitter at muscle end-plates treated with botulinum toxin. Toxicon 24:123-30

Black, A. R. and Dolly, J.O. (1986) Two acceptor sub-types for dendrotoxin in chick synaptic membranes distinguishable by beta-bungarotoxin. Eur. J. Biochem. 156:609-17

Black, A. R., Breeze, A. L., Othman, I. B. and Dolly, J.O. (1986) Involvement of neuronal acceptors for dendrotoxin in its convulsive action in rat brain. Biochem. J. 237:397-404

Rugolo, M., Dolly, J.O. and Nicholls, D. G. (1986) The mechanism of action of beta-bungarotoxin at the presynaptic plasma membrane. Biochem. J. 233:519-23

Nicholls, D., Snelling, R. and Dolly, O. (1985) Bioenergetic actions of beta-bungarotoxin, dendrotoxin and bee-venom phospholipase A2 on guinea-pig synaptosomes. Biochem. J. 229:653-62

Ashton, A. C., Crowther, J. S. and Dolly, J.O. (1985) A sensitive and useful radioimmunoassay for neurotoxin and its haemagglutinin complex from Clostridium botulinum. Toxicon 23:235-46

Conti-Tronconi, B. M., Dunn, S. M., Barnard, E. A., Dolly, J.O., Lai, F. A., Ray, N. and Raftery, M. A. (1985) Brain and muscle nicotinic acetylcholine receptors are different but homologous proteins. Proc. Natl. Acad. Sci. U S A 82:5208-12

Dolly, J.O., Halliwell, J. V., Black, J. D., Williams, R. S., Pelchen-Matthews, A., Breeze, A. L., Mehraban, F., Othman, I. B. and Black, A. R. (1984) Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release. J. Physiol. (Paris) 79:280-303

Dolly, J.O., Black, J., Williams, R. S. and Melling, J. (1984) Acceptors for botulinum neurotoxin reside on motor nerve terminals and mediate its internalization. Nature 307:457-60

Mehraban, F., Kemshead, J. T. and Dolly, J.O. (1984) Properties of monoclonal antibodies to nicotinic acetylcholine receptor from chick muscle. Eur. J. Biochem. 138:53-61

Mehraban, F., Breeze, A. L. and Dolly, J.O. (1984) Identification by cross-linking of a neuronal acceptor protein for dendrotoxin, a convulsant polypeptide. FEBS Lett. 174:116-22

Dolly, J.O., Mehraban, F., Gwilt, M. and Wray, D. (1983) Biochemical and electrophysiological properties of antibodies against pure acetylcholine receptor from vertebrate muscles and its subunits from Torpedo in relation to experimental myasthenia. Neurochem. Internat. 5:445-458

Williams, R. S., Tse, C. K., Dolly, J.O., Hambleton, P. and Melling, J. (1983) Radioiodination of botulinum neurotoxin type A with retention of biological activity and its binding to brain synaptosomes. Eur. J. Biochem. 131:437-45

Othman, I. B., Wilkin, G. P. and Dolly, J.O. (1983) Synaptic binding sites in brain for [3H]ß-bungarotoxin - a specific probe that perturbs transmitter release. Neurochem. Internat. 5:487-496

Barnard, E. A., Beeson, D., Bilbe, G., Brown, D. A., Constanti, A., Conti-Tronconi, B. M., Dolly, J.O., Dunn, S. M., Mehraban, F., Richards, B. M. and et al. (1983) Acetylcholine and GABA receptors: subunits of central and peripheral receptors and their encoding nucleic acids. Cold Spring Harb. Symp. Quant. Biol. 48 Pt 1:109-24

Halliwell, J. V. and Dolly, J.O. (1982) Preferential action of beta-bungarotoxin at nerve terminal regions in the hippocampus. Neurosci. Lett. 30:321-7

Lo, M. M., Barnard, E. A. and Dolly, J.O. (1982) Size of acetylcholine receptors in the membrane. An improved version of the radiation inactivation method. Biochemistry 21:2210-7

Mehraban, F., Dolly, J.O. and Barnard, E. A. (1982) Antigenic similarities between the subunits of acetylcholine receptor from Torpedo marmorata. FEBS Lett. 141:1-5

Sumikawa, K., Mehraban, F., Dolly, J.O. and Barnard, E. A. (1982) Similarity of acetylcholine receptors of denervated, innervated and embryonic chicken muscles. 1. Molecular species and their purification. Eur. J. Biochem. 126:465-72

Sumikawa, K., Barnard, E. A; Dolly, J.O. and (1982) Similarity of acetylcholine receptors of denervated, innervated and embryonic chicken muscles. 2. subunit compositions. Eur. J. Biochem. 126:473-79

MacKenzie, I., Burnstock, G. and Dolly, J.O. (1982) The effects of purified botulinum neurotoxin type A on cholinergic, adrenergic and non-adrenergic, atropine-resistant autonomic neuromuscular transmission. Neuroscience 7:997-1006

Tse, C. K., Dolly, J.O., Hambleton, P., Wray, D. and Melling, J. (1982) Preparation and characterisation of homogeneous neurotoxin type A from Clostridium botulinum. Its inhibitory action on neuronal release of acetylcholine in the absence and presence of beta-bungarotoxin. Eur. J. Biochem. 122:493-500

Othman, I. B., Spokes, J. W. and Dolly, J.O. (1982) Preparation of neurotoxic 3H-beta-bungarotoxin: demonstration of saturable binding to brain synapses and its inhibition by toxin I. Eur. J. Biochem. 128:267-76

Halliwell, J. V. and Dolly, J.O. (1982) Electrophysiological analysis of the presynaptic action of beta-bungarotoxin in the central nervous system. Toxicon 20:121-7

Norman, R. I., Mehraban, F., Barnard, E. A. and Dolly, J.O. (1982) Nicotinic acetylcholine receptor from chick optic lobe. Proc. Natl. Acad. Sci. U S A 79:1321-5

Halliwell, J. V., Tse, C. K., Spokes, J. W., Othman, I. and Dolly, J.O. (1982) Biochemical and electrophysiological demonstrations of the actions of beta-bungarotoxin on synapses in brain. J. Neurochem. 39:543-50

Dolly, J.O., Williams, R. S., Black, J. D., Tse, C. K., Hambleton, P. and Melling, J. (1982) Localization of sites for 125I-labelled botulinum neurotoxin at murine neuromuscular junction and its binding to rat brain synaptosomes. Toxicon 20:141-8

Barnard, E. A. and Dolly, J.O. (1982) Peripheral and central nicotinic acetylcholine receptors - How similar are they? Trends in Neurosciences 5:325-327F

Dolly, J.O., Nockles, E. A., Lo, M. M. and Barnard, E. A. (1981) Tritiation of alpha-bungarotoxin with N-succinimidyl [2,3-3H]propionate. A useful reagent for labelling proteins. Biochem. J. 193:919-23

Lo, M. M., Dolly, J.O. and Barnard, E. A. (1980) Molecular forms of the acetylcholine receptor from vertebrate muscles and Torpedo electric organ. Interactions with specific ligands. Eur. J. Biochem. 116:155-63

Shorr, R. G., Lyddiatt, A., Lo, M. M., Dolly, J.O. and Barnard, E. A. (1981) Acetylcholine receptor from mammalian skeletal muscle. Oligomeric forms and their subunit structures. Eur. J. Biochem. 116:143-53

Chang, L. R., Barnard, E. A., Lo, M. M. and Dolly, J.O. (1981) Molecular sizes of benzodiazepine receptors and the interacting GABA receptors in the membrane are identical. FEBS Lett. 126:309-12

Spokes, J. W. and Dolly, J.O. (1980) Complete purification of beta-bungarotoxin. Characterization of its action and that of tityustoxin on synaptosomal accumulation and release of acetylcholine. Biochim. Biophys. Acta. 596:81-93

Tse, C. K., Dolly, J.O. and Diniz, C. R. (1980) Effects of beta-bungarotoxin and tityustoxin on accumulation of putative amino acid neurotransmitters by rat cortex synaptosomes. Neuroscience 5:135-43

Wolosin, J. M., Lyddiatt, A., Dolly, J.O. and Barnard, E. A. (1980) Stoichiometry of the ligand-binding sites in the acetylcholine-receptor oligomer from muscle and from electric organ. Measurement by affinity alkylation with bromoacetylcholine. Eur. J. Biochem. 109:495-505

Lyddiatt, A., Sumikawa, K., Wolosin, J. M., Dolly, J.O. and Barnard, E. A. (1979) Affinity labelling by bromoacetylcholine of a characteristic subunit in the acetylcholine receptor from muscle and Torpedo electric organ. FEBS Lett. 108:20-4

Lang, B., Barnard, E. A., Chang, L. R. and Dolly, J.O. (1979) Putative benzodiazepine receptor: a protein solubilised from brain. FEBS Lett. 104:149-53

Shorr, R. G., Dolly, J.O. and Barnard, E. A. (1978) Composition of acetylcholine receptor protein from skeletal muscle. Nature 274:283-4

Dolly, J.O. and Barnard, E. A. (1977) Purification and characterization of an acetylcholine receptor from mammalian skeletal muscle. Biochemistry 16:5053-60

Barnard, E. A., Coates, V., Dolly, J.O. and Mallick, B. (1977) Binding of alpha-bungarotoxin and cholinergic ligands to acetylcholine receptors in the membrane of skeletal muscle. Cell Biol. Int. Rep. 1:99-106

Dolly, J.O., Albuquerque, E. X., Sarvey, J., Mallick, B. and Barnard, E. A. (1976) Binding of perhydro-histrionicotoxin to the postsynaptic membrane of skeletal muscle in relation to its blockage of acetylcholine-induced depolarization. Mol. Pharmacol. 13:1-14

Dolly, J.O. and Barnard, E. A. (1975) Complete purification of the acetylcholine receptor protein from mammalian muscle. FEBS Lett. 57:267-71

Dolly, J.O. and Barnard, E. A. (1974) Affinity of cholinergic ligands for the partially purified acetylcholine receptor from mammalian skeletal muscle. FEBS Lett. 46:145-8

Kemp, G., Dolly, J.O., Barnard, E. A. and Wenner, C. E. (1973) Reconstitution of a partially purified endplate acetylcholine receptor preparation in lipid bilayer membranes. Biochem. Biophys. Res. Commun. 54:607-13

Albuquerque, E. X., Barnard, E. A., Chiu, T. H., Lapa, A. J., Dolly, J.O., Jansson, S. E., Daly, J. and Witkop, B. (1973) Acetylcholine receptor and ion conductance modulator sites at the murine neuromuscular junction: evidence from specific toxin reactions. Proc. Natl. Acad. Sci. U S A 70:949-53

Chiu, T. H., Dolly, J.O. and Barnard, E. A. (1973) Solubilization from skeletal muscle of two components that specifically bind –bungarotoxin. Biochem. Biophys. Res. Commun. 51:205-13

Dolly, J.O., Curtis, C. G., Dodgson, K. S. and Rose, F. A. (1972) Metabolism of Sodium Oestrone Sulphate in the Guinea Pig. Biochem. J. 128:347-352

Dolly, J.O., Dodgson, K. S. and Rose, F. A. (1972) Studies on the oestrogen sulphatase and arylsulphatase C activities of rat liver. Biochem. J. 128:337-45

Dolly, J.O., Curtis, C. G., Dodgson, K. S. and Rose, F. A. (1971) Metabolism of sodium oestrone S-35 sulphate in rat. Biochem. J. 119-22.

Dolly, J.O., Dillon, A., Duffy, M. J. and Fottrell, P. F. (1970) Further studies on multiple forms of peptidases in mammalian tissues including intestinal mucosa from children with treated and untreated coeliac disease. Clin. Chim. Acta. 31:55-62

Dolly, J.O. and Fottrell, P. F. (1969) Multiple forms of dipeptidases in normal human intestinal mucosa and in mucosa from children with coeliac disease. Clin. Chim. Acta. 26:555-8


Book chapters and short reviews:

Dolly, J.O. and Wang, J. (2015) The comprehensive sourcebook of bacterial protein toxins (Fourth edition: Joseph E. Alouf, Daniel Ladant, Michael R. Popoff) The Comprehensive Sourcebook of Bacterial Protein Toxins© Elsevier Ltd., pp 995-1015, doi:

Dolly, J.O., O’Leary, V.B., Lawrence, G.W. and Ovsepian, S.V.  (2014) Pharmacology of botulinum neurotoxins : exploitation of their multifunctional activities as transmitter release inhibitors and neuron-targeted delivery vehicles. Springer, 2-volume book ‘Molecular Aspects of Botulinum Neurotoxin’. Edited by K. Foster pp 9-33, 10.1007/978-1-4614-9454-6_2

Dolly, J.O. and Lawrence, G.W. (2014) Molecular basis for the therapeutic effectiveness of botulinum neurotoxin type A. Neurourol. and Urodyn. 33:S14-S20

Lawrence, G.W., Ovsepian, S.V. and Wang, J. (2013) Therapeutic effectiveness of botulinum neurotoxin A: potent blockade of autonomic transmission by targeted cleavage of only the pertinent SNAP-25 with lack of inhibition when applied to distal neurites.  The Botulinum J. vol. 2, nos. 3-4

Dolly, J.O., Meng, J., Wang, J., Lawrence, G.W., Bodeker, M., Zurawski, T. H. and Sasse, A. (2009) Multiple Steps in the Blockade of Exocytosis by Botulinum Neurotoxins in Botulinum Toxin Therapeutic Clinical Practice and Science (ed. Jankovic, J.) 1-14 (Saunders Elsevier, Philadelphia)

Dolly, J.O. and Lawrence, G.W. (2007) Mechanistic basis for the therapeutic effectiveness of botulinum toxin A on overactive cholinergic nerves, in Clinical Uses of Botulinum Toxins, A. B. Ward and M. P. Barnes Ed., Cambridge University Press, Cambridge, pp9-26

Dolly, J.O. and Aoki, K.R. (2006) The structure and mode of action of different botulinum toxins. Eur. J. Neurol. 13 (S4), 1-9.

Dolly, J.O. (2003) Synaptic transmission: inhibition of neurotransmitter release by botulinum toxins. Headache 43 (suppl.7), S116-S124

Dolly, J.O. and Bagetta, G. (2002) Dendrotoxins from mamba snakes. Handbook of Neurotoxicology (Massaro, E. ed.) Humanna Press Inc, Totowa, N. J., pp. 455-473.

Dolly, J.O., Lisk, G., Foran, P. G., Meunier, F., Mohammad, N., O'Sullivan, G. and de Piava, A. (2002) Insights into the Extended Duration of Neuroparalysis by Botulinum Neurotoxin A Relative to the Other Shorter-Acting Serotypes: Differences Between Motor Nerve Terminals and Cultured Neurons. Scientific and Therapeutic Aspects of Botulinum Toxin, M. F. Brin, M. Hallett and J. Jankovic Ed., Lippincott Williams & Wilkins, Philadelphia, pp91-102.

Dolly, J.O., Lawrence, G.W. and Foran, P. (1999) Distinct contributions to exocytosis of two adjacent C-terminal regions of SNAP-25 unveiled by botulinum toxins A and E. Biomedical Aspects of Clostridial Neurotoxins, Oxford, (Tranter, H.S. ed) publisher CAMR, Salisbury, pp. 97-102.

Clementi, F., Dolly, O. J., Onali, P. and Bagetta, G. (1998) Neurotoxins in neurobiology: from basic research to clinical application. Toxicon 36:2043-6

Dolly, J.O. (1997) Therapeutic and research exploitation of botulinum neurotoxins. Eur. J. Neurol. 4:S5-S10

Dolly, J.O. (1994) Molecular mechanisms of the neuroparalytic actions of botulinum toxin. Neue Perspektiven für die therapie mit botulinum toxin A. [Poewe, W. (Hrsg.)], pp.19-42.

Moreno-Lopez, B., De La Cruz, R. R., Dolly, J.O. and Delgado-Garcia, J. M. (1994) Lateral rectus muscle paralysis induced by botulinum toxin: effects on abducens motoneuron discharge characteristics. Information Processing Underlying Gaze Control, (Delgado-Garcia, J. M., Godaux, E. and Videl, P. P. eds), pp.  31-39.

Dolly, J.O., Muniz, Z. M., Parcej, D. N., Hall, A. C., Scott, V. E. S., Awan, K. A. and Owen, D. G. (1994) Subtypes of fast-activating, voltage-gated K+ channels in the nervous system: location and molecular properties unveiled with a-dendrotoxin and homologues. Neurotoxins and Neurobiology, K. F. Tipton and F. Dajas Ed., Ellis Horwood Ltd., Chichester, pp103-122.

Dolly, J.O., Rettig, J., Scott, V. E., Parcej, D. N., Wittkat, R., Sewing, S. and Pongs, O. (1994) Oligomeric and subunit structures of neuronal voltage-sensitive K+ channels. Biochem. Soc. Trans. 22:473-8

Poulain, B., Weller, U., Binz, T., Niemann, H., de Paiva, A., Dolly, J.O., Leprince, C. and Tauc, L. (1993) Functional roles of domains of Clostridial neurotoxins: the contribution from studies on Aplysia. Botulinum and Tetanus neurotoxins: Neurotransmission and Biomedical Aspects,  B. R. DasGupta Ed., Plenum Press, New York, pp345-360.

Ashton, A. C., de Paiva, A. M., Poulain, B., Tauc, L. and Dolly, J.O. (1993) Factors underlying the characteristic inhibition of the neuronal release of transmitters by tetanus and various botulinum toxins. Botulinum and Tetanus Neurotoxins: Neurotransmission and Biomedical Aspects, B. R. Das Gupta, ed. (Plenum Pub. Corp) Ed., pp191-213.

Dolly, J.O. (1993) Mechanism of inhibition of transmitter release. Botulinum and Tetanus Toxins Neuroscience Facts

Poulain, B., Weller, U., Dolly, J.O. and Tauc, L. (1992) Effects of temperature on the inhibition by tetanus toxin and botulinum neurotoxin type A on transmitter release in Aplysia. pp73-74.

Morgan, A., Cenci de Bello, I., Weller, U., Dolly, J.O. and Burgoyne, R. D. (1993) Intracellular control of exocytosis in chromaffin cells. Botulinum and Tetanus Neurotoxins: Neurotransmission and Biomedical Aspects, (DasGupta, B. R., ed.) Plenum Pub. Corp. pp. 95-104.

Poulain, B., Wadsworth, J. D. F., Weller, U., Mochida, S., LePrince, C., Dolly, J.O. and Tauc, L. (1992) Functional studies in Aplysia californica on chimeras of botulinum and tetanus toxins. Bacterial Protein Toxins, Zbl. Bakt. Suppl. 23, (Witholt et al. eds) Gustav Fischer, Stuttgart, pp. 46-54.

Dolly, J.O., de Paiva, A., Poulain, B., Foran, P., Ashton, A. and Tauc, L. (1992) Insights into the neuronal binding, uptake and intracellular activity of botulinum neurotoxins. Proceedings of the 5th European Workshop on Bacterial Protein Toxins, W. e. al Ed., Gustav Fischer, Stuttgart, pp 31-45.

Dolly, J.O. (1992) Polypeptide neurotoxins as probes for certain voltage-dependent K+ channels. Receptor-Ligand Interations: A Practical Approach, E. C. Hulme Ed., IRL Press (OUP), Oxford, pp37-61.

Dolly, J.O. (1992) Peptide toxins that alter neurotransmitter release. Handbook of Experimental Pharmacology, Selective Neurotoxicity, (Herken, H. and Hucho, F. eds.) Springer-Verlag, Berlin, 102, pp. 681-717.

Dolly, J.O. (1991) Components involved in neurotransmission probed with toxins: voltage-dependent K+ channels. Probes for Neurochemical Target Sites, K. F. Tipton and L. L. Iversen Ed., Royal Irish Academy, Dublin, pp127-140.

Dolly, J.O. (1990) Functional components at nerve terminals revealed by neurotoxins. Neuromuscular Transmission - Basic and Applied Aspects, A. Vincent and D. W. Wray Ed., Manchester University Press, Manchester, pp107-131.

Tibbs, G. R., Nicholls, D. G. and Dolly, J.O. (1989) The K+ channel blockers dendrotoxin, and 4-aminopyridine cause an apparently paradoxical increase in Rb efflux from synaptosomes. Proceedings of the Smith, Kiline and French research symposium on Ion Transport

Ashton, A. C., Edwards, K. and Dolly, J.O. (1988) Lack of detectable ADP-ribosylation in synaptosomes associated with inhibition of transmitter release by botulinum neurotoxin A and B. Biochemical Society Transactions 16:883-884

Ashton, A. C., Edwards, K. and Dolly, J.O. (1988) Action of botulinum neurotoxin A on protein phosphorylation in relation to blockade of transmitter release. Biochem. Soc. Trans. 16:885-886

Wadsworth, J. D. F., Shone, C. C., Melling, J. and Dolly, J.O. (1988) Roles of the constituent chains of botulinum neurotoxin type A in the blockade of neuromuscular transmission in mice. Biochemical Society Transactions 16:886-887

Dolly, J.O., Poulain, B., Maisey, E. A., Breeze, A. L., Wadsworth, J. D., Ashton, A. C. and Tauc, L. (1988) Neurotransmitter release and K+ channels probed with botulinum neurotoxins and dendrotoxins. Neurotoxins in Neurochemistry, J.O. Dolly Ed., Ellis Horwood, Chichester, UK, pp79-99.

Dolly, J.O., Ashton, A. C., Evans, D. M., Richardson, P. J., Black, J. D. and Melling, J. (1987)  Molecular action of botulinum neurotoxins: role of acceptors in targeting to cholinergic nerves and in the inhibition of the release of several transmitters. Cellular and Molecular Basis of Cholinergic Function, M. J.O. Dowdall Ed., Ellis Horwood Limited, Chichester, pp517-533.

Parcej, D. N., Stansfeld, C., Marsh, S. J., Halliwell, J. V., Hider, R. C., Breeze, A. L., Dolly, J.O. and Brown, D. A. (1987)  Blockade of voltage sensitive K+ channels by dendrotoxin and mast cell degranulating factor and their interaction with neuronal acceptors. Synaptic transmitters and receptors, S. Tusek Ed., Academia, Prague and Wiley & Sons, Chichester, pp405-410.

Pelchen-Matthews, A. and Dolly, J.O. (1987) Distribution of functional acceptors for dendrotoxin and ß-bungarotoxin in rat brain. Biochem. Soc. Trans. 15:1037-1038,

Dolly, J.O., Stansfeld, C. E., Breeze, A. L., Pelchen-Matthews, A., Marsh, S. J. and Brown, D. A. (1987) Neuronal acceptor sub-types for dendrotoxin and their relation to K+ channels. Neurotoxins and Their Pharmacological Implications, P. Jenner Ed., Raven Press, New York, pp114-116.

Dolly, J.O., Black, J. D., Black, A. R., Pelchen-Matthews, A. and Halliwell, J. V. (1986) Novel roles of neural acceptors for facili­tatory and inhibitory toxins. Animal, Plant and Microbial Toxins, (Harris, J.B. ed.) Oxford University Press, pp. 237-264.

Mehraban, F., Black, A. R., Breeze, A. L., Green, D. G. and Dolly, J.O. (1985) A functional membranous acceptor for dendrotoxin in rat brain: solubilization of the binding component. Biochem. Soc. Trans. 13:507-508,

Dolly, J.O. and Barnard, E. A. (1984) Nicotinic acetylcholine receptors: an overview. Biochem. Pharmacol. 33:841-58,

Othman, I. and O., D. J. (1982) Tritiation of beta-bungarotoxin and its saturable binding to membranes of cerebrocortical synaptosomes. Biochemical Society Transactions 10:386-387

Dolly, J., Tse, C.-K., Black, J. D., Williams, R. S., Wray, D., Gwilt, M., Hambleton, P. and Melling, J. (1981) Botulinum neurotoxin type A as a probe for studying neurotransmitter release. Biomedical Aspects of Botulism, G. Lewis Ed., Academic Press, New York, pp47-64.

Hambleton, P., Capel, B., Bailey, N., Heron, N., Crooks, A., Melling, J., Tse-C-K. and Dolly, J.O. (1981) Production, purification and toxoiding of Clostridium botulinum type A toxin. Biomedical Aspects of Botulism, G. Lewis Ed., Academic Press, New York, pp247-260

Dolly, J.O., Halliwell, J. V. and Spokes, J. W. (1980) Interaction of ß-bungarotoxin with synapses in the mammalian central nervous system. Natural Toxins, D. Eaker and T. Wadström Ed., Pergamon Press, Oxford, pp549-559.

Barnard, E. A., Dolly, J.O., Lyddiatt, A., Sumikawa, K. and Wolosin, J. M. (1980) Current views on the structure of nicotinic acetylcholine receptors from different sources. Synaptic Constituents in Health and Disease, M. Brzin, D. Sket and H. Bachelard Ed., Pergamon Press, Oxford., pp143-145.

Hambleton, P., Tse, C.-K., Capel, B., Dolly, J.O. and Melling, J. (1980) Purification and characterization of Clostridium botulinum type A neurotoxin. Berlin 62

Barnard, E. A., Norman, R.I., Lang, B., Sumikawa, K. and Dolly, J.O. (1980) Nicotinic acetylcholine receptors of the CNS in comparison to peripheral receptors. Neurotransmitters and their Receptors , M. Brzin, D. Sket and H. Bachelard Ed., John Wiley & Sons Ltd., pp271-292.

Dolly, J.O. (1979) Biochemistry of acetylcholine receptors from skeletal muscle. Physiological and Pharmacological Biochemistry, Internat. Rev. Biochem. Vol. 26 (Tipton, K.F. ed.) University Park Press, Baltimore, (1979), pp 9-435

Barnard, E. A., Dolly, J.O., Lang, B., Lo, M. and Shorr, R. G. (1979) Application of specifically acting toxins to the detection of functional components common to peripheral and central synapses. Adv. Cytopharmacol. 3:409-34

Barnard, E. A., Dolly, J.O., Lo, M. and Mantle, T. (1978) Size and molecular properties of the acetylcholine-receptor protein of muscle. Biochem. Soc. Trans. 6:649-51

Dolly, O. J., Barnard, E. A. and Shorr, R. G. (1977) Characterization of acetylcholine-receptor protein from skeletal muscle. Biochem. Soc. Trans. 5:168-70,

Barnard, E. A., Dolly, J.O.(1975) Situation, purification and properties of acetylcholine receptors of striated muscle. Receptors and Cellular Pharmacology, Vol. 2 (Tuomisto, J. and Paasonen, M. K. eds.), pp. 77-86

Barnard, E. A., Dolly, J.O., Porter, C. W. and Albuquerque, E. X. (1975) The acetylcholine receptor and the ionic conductance modulation system of skeletal muscle. Exp. Neurol. 48:1-28