Method and System for Sample Collection, Storage, Preparation and Detection
Orion Scott, Christopher Birch, Daniel Mills, Brian ROOT, James Landers, Jingyi Li, Matthew Yeung, David Saul, David Vigil, Guy Andrew, Stan Wada, Betina De Gorordo, Steward Dodman, Tom Moran, Stuart Knowles
United States Patent and Trademark Office
School of Mechanical and Manufacturing Engineering
United States Patent and Trademark Office
Abstract

A collection device for a biological sample to capture target compounds such as viruses or other pathogens or particles for testing from within the sample and move the captured target compound to a separate chamber for subsequent processing. The collection device can include an openable substance blister including capture particles located in a cup interior. Capture particles can attract and bind the target compounds from the sample. An extraction tube extracts any nucleic acid from the target compound for storage or subsequent amplification and testing to confirm presence of known microorganisms. The extraction tube can comprise a heat-deformable material and can be connected to a microfluidic cartridge for further processing of nucleic acid including, amplification and detection. The microfluidic cartridge includes valves and a plurality of chambers for amplification.