Nicholas Dunne

Prof

Contact Details


Sa310

T: Ext. 5712
E: Nicholas.Dunne@dcu.ie
Professor of Mechanical and Manufacturing Engineering

S364
Stokes Building
Dublin City University
Glasnevin
Dublin 9

T: 353-1-7005712
F: 44-75-14324361
M: 353-1-7007148
E: nicholas.dunne@dcu.ie

Biography

Professor Nicholas Dunne is the Chair of Mechanical and Manufacturing Engineering in the School of Mechanical and Manufacturing, the Executive Director of Biodesign Europe and the Executive Director of the Medical Engineering Research Centre Engineering (MedEng) at DCU. Professor Dunne is also a Visiting Research Professor of Biomaterials Engineering at the School of Pharmacy at Queen's University of Belfast, an Adjunct Professor of the School of Mechanical Engineering at Trinity College Dublin and Principal Investigator in the Trinity Centre for Bioengineering.

Prior to his appointment at DCU, he was the Professor of Biomaterials Engineering at Queen’s University of Belfast. He has also held Joint-Directorship positions of the Advanced Materials and Processes Research Cluster and the Polymer Processing Research Centre at Queen’s University of Belfast

Professor Dunne’s research programme lies at the interface of materials science, engineering and biology. He leads a multidisciplinary group working at the host/biomaterial interface that has played a leading role in the development of biomaterials that simulate an efficacious drug delivery or therapeutic response. This work spans fundamental mechanisms at the host/material interface as well as translational research to target non-union bone defects, bone metastases and chronic wounds. This research has been developed via a strong, interdisciplinary programme complemented with over-arching institutional and industrial collaborations.

Internationally he is recognised as an authority on biomaterials for orthopaedic applications, having been awarded an Orthopaedic Research Society/British Orthopaedic Research Society Fellowship (2008) and the RAEng/Leverhulme Trust Senior Research Fellow Award (2010). His work has been supported continuously by RCUK, EU and Charity funding organisations and also attracts significant interest from industrial partners. To date, he has secured ≈€12M PI research funding (and €15M as CI) - from funders including EPSRC, MRC, Innovate UK, SFI, The Royal Academy of Engineering and several major multinational medical device companies.

He has authored +190 peer-reviewed journal publications and delivered +350 research presentations at national and international biomaterials and biomechanics conferences He is a member of the editorial boards of Materials Science and Engineering C, Materials Science: Materials in Medicine, Regenerative Biomaterials BioMed Research International and ISRN Biomaterials

He is also highly passionate about engaging new and young researchers on matters that are important to their research career and professional development. This enthusiasm and motivation have been hardened during his time as President of Northern Ireland Bioengineering Society (2008-2015) and Spokesperson of the Young Scientist Fora of the European Society of Biomaterials (2010-2014) and UK Society of Biomaterials (2011-2015). He was the VP and Secretary of the Executive Organising Committee of the 11th World Biomaterials Congress (Glasgow, 2020) and also on the Executive Organising Committee member of the 8th World Biomechanics Congress (Dublin, 2018).

Book Chapters

  Year Publication
2019 'Emerging areas of bone repair materials: nucleic acid therapy and drug delivery'
Chambers P, McCarthy HO, Dunne NJ. (2019) 'Emerging areas of bone repair materials: nucleic acid therapy and drug delivery' In: Bone Repair Biomaterials: Regeneration and Clinical Applications. UK: Woodhead Publishing. [DOI] [Details]
2018 'Microneedles for Gene Therapy: Overcoming Extracellular and Intracellular Barriers'
Cole, G;Dunne, NJ;McCarthy, HO (2018) 'Microneedles for Gene Therapy: Overcoming Extracellular and Intracellular Barriers' In: MICRONEEDLES FOR DRUG AND VACCINE DELIVERY AND PATIENT MONITORING. CHICHESTER: JOHN WILEY & SONS LTD. [Details]
2018 'Microneedles for Gene Therapy: Overcoming Extracellular and Intracellular Barriers'
Cole G, Dunne NJ, McCarthy HO. (2018) 'Microneedles for Gene Therapy: Overcoming Extracellular and Intracellular Barriers' In: Microneedles for Drug and Vaccine Delivery and Patient Monitoring. USA: Wiley & Sons. [DOI] [Details]
2018 'Hydrogels for Bone Regeneration'
Pentlavalli S, McCarthy HO, Dunne NJ. (2018) 'Hydrogels for Bone Regeneration' In: Hydrogels: Design, Synthesis and Application in Drug Delivery and Regenerative Medicine. USA: CRC Press. [Details]
2017 'The Mechanical Properties of the Scaffolds Reinforced by Fibres or Tubes for Tissue Repair'
Pentlavalli S, McCarthy HO, Dunne NJ. (2017) 'The Mechanical Properties of the Scaffolds Reinforced by Fibres or Tubes for Tissue Repair' In: Tissue Repair. Singapore: Springer. [DOI] [Details]
2016 'Bio-inspired calcium phosphate materials for hard-tissue repair'
Cunningham E, Walker G, Buchanan F, Dunne N. (2016) 'Bio-inspired calcium phosphate materials for hard-tissue repair' In: Biomineralization and Biomaterials. UK: Woodhead Publishing. [DOI] [Details]
2014 'Acrylic cements for bone fixation in joint replacement'
Dunne N, Clements J, Wang JS. (2014) 'Acrylic cements for bone fixation in joint replacement' In: Joint Replacement Technology. Singapore: Woodhead Publishing. [DOI] [Details]
2014 'Injectable calcium phosphate cements for spinal bone repair'
O’Hara R, Buchanan F, Dunne N. (2014) 'Injectable calcium phosphate cements for spinal bone repair' In: Biomaterials for Bone Regeneration. UK: Woodhead Publishing. [DOI] [Details]
2013 'Carbon nanotubes in acrylic bone cement'
Dunne N, Ormsby R, Mitchell CA. (2013) 'Carbon nanotubes in acrylic bone cement' In: Biologically Responsive Biomaterials for Tissue Engineering. New York: Springer. [DOI] [Details]
2011 'Biomedical/bioengineering applications of carbon nanotube-based nanocomposites'
Dunne N, Mitchell C. (2011) 'Biomedical/bioengineering applications of carbon nanotube-based nanocomposites' In: Polymer–Carbon Nanotube Composites: Preparation, Properties and Applications. UK: Woodhead Publishing. [DOI] [Details]
2011 'MWCNT Used in Orthopaedic Bone Cements'
Dunne N, Ormsby RW. (2011) 'MWCNT Used in Orthopaedic Bone Cements' In: Carbon Nanotubes-Growth and Applications. UK: InTech. [DOI] [Details]
2008 'Mechanical properties of bone cements'
Dunne NJ. (2008) 'Mechanical properties of bone cements' In: Orthopaedic Bone Cements. UK: Woodhead Publishing. [DOI] [Details]
2008 'Bone Cement Fixation: Acrylic Cements'
Wang JS, Dunne NJ. (2008) 'Bone Cement Fixation: Acrylic Cements' In: Joint Replacement Technology: New Developments. UK: Woodhead Publishing. [DOI] [Details]

Peer Reviewed Journals

  Year Publication
2021 'Design of a novel electrospun PVA platform for gene therapy applications using the CHAT peptide'
Mulholland EJ, McErlean EM, Dunne N, McCarthy HO. (2021) 'Design of a novel electrospun PVA platform for gene therapy applications using the CHAT peptide'. International Journal of Pharmaceutics, 598 [DOI] [Details]
2021 'Hydroxyapatite sonosensitization of ultrasound‐triggered, thermally responsive hydrogels: An on‐demand delivery system for bone repair applications'
Levingstone T, Ali B, Kearney C, Dunne N. (2021) 'Hydroxyapatite sonosensitization of ultrasound‐triggered, thermally responsive hydrogels: An on‐demand delivery system for bone repair applications'. Materials Science and Engineering C, [DOI] [Details]
2021 'Advances in biofabrication techniques for collagen-based 3D in vitro culture models for breast cancer research'
Redmond J, McCarthy H, Buchanan P, Levingstone TJ, Dunne NJ. (2021) 'Advances in biofabrication techniques for collagen-based 3D in vitro culture models for breast cancer research'. Materials Science and Engineering C, 122 [DOI] [Details]
2021 'Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery'
McErlean EM, Ziminska M, McCrudden CM, McBride JW, Loughran SP, Cole G, Mulholland EJ, Kett V, Buckley NE, Robson T, Dunne NJ, McCarthy HO. (2021) 'Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery'. Journal of controlled release : official journal of the Controlled Release Society, 330 :1288-1299 [DOI] [Details]
2021 'Rational Design and Characterisation of an Amphipathic Cell Penetrating Peptide for Non-Viral Gene Delivery'
McErlean EM, McCrudden CM, McBride JW, Cole G, Kett VL, Robson T, Dunne NJ, McCarthy HO. (2021) 'Rational Design and Characterisation of an Amphipathic Cell Penetrating Peptide for Non-Viral Gene Delivery'. International Journal of Pharmaceutics, [DOI] [Details]
2021 'Feasibility of the Use of Poultry Waste as Polymer Additives and Implications for Energy, Cost and Carbon'
McGauran T, Dunne N, Smyth BM, Cunningham E. (2021) 'Feasibility of the Use of Poultry Waste as Polymer Additives and Implications for Energy, Cost and Carbon'. Journal of Cleaner Production, [DOI] [Details]
2021 'Advanced G-MPS-PMMA Bone Cements: Influence of Graphene Silanisation on Fatigue Performance, Thermal Properties and Biocompatibility'
Paz E, Ballesteros Y, Abenojar J, Del Real JC, Dunne N. (2021) 'Advanced G-MPS-PMMA Bone Cements: Influence of Graphene Silanisation on Fatigue Performance, Thermal Properties and Biocompatibility'. Journal of Nanomaterials, 11 (1) [DOI] [Details]
2021 'Influence of preoperative femoral orientation on radiographic measures of femoral head height in total hip replacement'
O'Connor JD, Hill JC, Beverland DE, Dunne NJ, Lennon AB. (2021) 'Influence of preoperative femoral orientation on radiographic measures of femoral head height in total hip replacement'. Clinical Biomechanics, 81 [DOI] [Details]
2020 'Improving the Intercellular Uptake and Osteogenic Potency of Calcium Phosphate via Nanocomplexation with the RALA Peptide'
O'Doherty, M;Mulholland, EJ;Chambers, P;Pentlavalli, S;Ziminska, M;Chalanqui, MJ;Pauly, HM;Sathy, BN;Donahue, TH;Kelly, DJ;Dunne, N;McCarthy, HO (2020) 'Improving the Intercellular Uptake and Osteogenic Potency of Calcium Phosphate via Nanocomplexation with the RALA Peptide'. Journal of Nanomaterials, 10 [DOI] [Details]
2020 'Binder jetting additive manufacturing of hydroxyapatite powders: Effects of adhesives on geometrical accuracy and green compressive strength'
Zhou, ZX;Lennon, A;Buchanan, F;McCarthy, HO;Dunne, N (2020) 'Binder jetting additive manufacturing of hydroxyapatite powders: Effects of adhesives on geometrical accuracy and green compressive strength'. Additive Manufacturing, 36 [DOI] [Details]
2020 'Improved osteogenic differentiation of human amniotic mesenchymal stem cells on gradient nanostructured Ti surface'
Wang W, Wang Z, Fu Y, Dunne N, Liang C, Luo X, Liu K, Li X, Pang X, Lu K. (2020) 'Improved osteogenic differentiation of human amniotic mesenchymal stem cells on gradient nanostructured Ti surface'. Journal of Biomedical Materials Research - Part A, 108 (9):1824-1833 [DOI] [Details]
2020 'Collagen/GAG scaffolds activated by RALA-siMMP-9 complexes with potential for improved diabetic foot ulcer healing'
Yan L.P.;Castaño I.M.;Sridharan R.;Kelly D.;Lemoine M.;Cavanagh B.L.;Dunne N.J.;McCarthy H.O.;O'Brien F.J. (2020) 'Collagen/GAG scaffolds activated by RALA-siMMP-9 complexes with potential for improved diabetic foot ulcer healing'. Materials Science and Engineering C, 114 [DOI] [Details]
2020 'Synthesis and evaluation of a thermoresponsive degradable chitosan-grafted PNIPAAm hydrogel as a smart gene delivery system'
Ziminska M.;Wilson J.J.;McErlean E.;Dunne N.;McCarthy H.O. (2020) 'Synthesis and evaluation of a thermoresponsive degradable chitosan-grafted PNIPAAm hydrogel as a smart gene delivery system'. Materials, 13 (11) [DOI] [Details]
2019 'Delivery of RALA/siFKBPL nanoparticles via electrospun bilayer nanofibres: An innovative angiogenic therapy for wound repair'
Mulholland EJ, Ali A, Robson T, Dunne NJ, McCarthy HO. (2019) 'Delivery of RALA/siFKBPL nanoparticles via electrospun bilayer nanofibres: An innovative angiogenic therapy for wound repair'. Journal of controlled release : official journal of the Controlled Release Society, 28 (316):53-65 [Details]
2019 'Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration'
Levingstone TJ;Herbaj S;Dunne NJ; (2019) 'Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration'. Journal of Nanomaterials, 9 (11) [DOI] [Details]
2019 'Graphene and graphene oxide functionalisation with silanes for advanced dispersion and reinforcement of PMMA-based bone cements'
Paz E.;Ballesteros Y.;Forriol F.;Dunne N.;del Real J. (2019) 'Graphene and graphene oxide functionalisation with silanes for advanced dispersion and reinforcement of PMMA-based bone cements'. Materials Science and Engineering C, 104 [DOI] [Details]
2019 'Incorporation of multi-walled carbon nanotubes to PMMA bone cement improves cytocompatibility and osseointegration'
Wang C, Yu B, Fan Y, Ormsby RW, McCarthy HO, Dunne N, Li X. (2019) 'Incorporation of multi-walled carbon nanotubes to PMMA bone cement improves cytocompatibility and osseointegration'. Materials Science and Engineering C, 103 [Details]
2019 'Nanocomposite-coated porous templates for engineered bone scaffolds: a parametric study of layer-by-layer assembly conditions'
Ziminska M, Chalanqui MJ, Chambers P, Acheson JG, McCarthy HO, Dunne NJ, Hamilton AR. (2019) 'Nanocomposite-coated porous templates for engineered bone scaffolds: a parametric study of layer-by-layer assembly conditions'. Biomedical Materials, 14 (6) [Details]
2019 'DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen'
Cole G, Ali AA, McErlean E, Mulholland EJ, Short A, McCrudden CM, McCaffrey J, Robson T, Kett VL, Coulter JA, Dunne NJ, McCarthy HO. (2019) 'DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen'. Acta Biomaterialia, 15 (96):480-490 [DOI] [Details]
2019 'Characterisation and constitutive modelling of biaxially stretched poly (L-lactic acid) sheet for application in coronary stents'
Blair RW, Dunne NJ, Lennon AB, Menary GH. (2019) 'Characterisation and constitutive modelling of biaxially stretched poly (L-lactic acid) sheet for application in coronary stents'. Journal of the Mechanical Behavior of Biomedical Materials, 1 (97):346-354 [DOI] [Details]
2019 'Peptide‐modified bone repair materials: Factors influencing osteogenic activity'
Liao J, Wu S, Li K, Fan Y, Dunne N, Li X. (2019) 'Peptide‐modified bone repair materials: Factors influencing osteogenic activity'. Journal of Biomedical Materials Research - Part A, 107 (7):1491-1512 [DOI] [Details]
2019 'Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues'
Gonzalez-Fernandez T, Rathan S, Hobbs C, Pitacco P, Freeman FE, Cunniffe GM, Dunne NJ, McCarthy HO, Nicolosi V, O'Brien FJ, Kelly DJ. (2019) 'Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues'. Journal of controlled release : official journal of the Controlled Release Society, 10 (301):13-27 [Details]
2019 'Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells'
Sathy BN, Daly A, Gonzalez-Fernandez T, Cunniffe G, McCarthy HO, Dunne N, Jeon O, Alsberg E, Donahue TL, Kelly DJ. (2019) 'Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells'. Acta Biomaterialia, 1 (88):314-324 [Details]
2019 'Operative and radiographic acetabular component orientation in total hip replacement: Influence of pelvic orientation and surgical positioning technique'
Rutherford M, O'Connor JD, Gill HS, Hill J, Beverland D, Lennon AB, Dunne NJ. (2019) 'Operative and radiographic acetabular component orientation in total hip replacement: Influence of pelvic orientation and surgical positioning technique'. Medical Engineering and Physics, 64 :7-14 [Details]
2019 'Graphene oxide and graphene reinforced PMMA bone cements: Evaluation of thermal properties and biocompatibility'
Paz E.;Ballesteros Y.;Abenojar J.;del Real J.;Dunne N. (2019) 'Graphene oxide and graphene reinforced PMMA bone cements: Evaluation of thermal properties and biocompatibility'. Materials, 12 (19) [DOI] [Details]
2019 'Graphene Oxide and Graphene Reinforced PMMA Bone Cements: Evaluation of Thermal Properties and Biocompatibility'
Chalanqui MJ, Pentlavalli S, McCrudden C, Chambers P, Ziminska M, Dunne N, McCarthy HO (2019) 'Graphene Oxide and Graphene Reinforced PMMA Bone Cements: Evaluation of Thermal Properties and Biocompatibility'. Materials Science and Engineering C, 95 :409-421 [Details]
2019 'Biomechanical studies on biomaterial degradation and co-cultured cells: mechanisms, potential applications, challenges and prospects'
Wang L, Wu S, Cao G, Fan Y, Dunne N, Li X. (2019) 'Biomechanical studies on biomaterial degradation and co-cultured cells: mechanisms, potential applications, challenges and prospects'. Journal of Materials Chemistry B, 7 (47):7439-7459 [Details]
2019 'Multi-objective optimisation of material properties and strut geometry for poly (L-lactic acid) coronary stents using response surface methodology'
Blair RW, Dunne NJ, Lennon AB, Menary GH. (2019) 'Multi-objective optimisation of material properties and strut geometry for poly (L-lactic acid) coronary stents using response surface methodology'. PLoS ONE, 14 (8) [Details]
2019 'Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues'
Gonzalez-Fernandez T., Rathan S, Hobbs C, Pitacco P, Freeman FE⁠, Cunniffe GM Dunne NJ⁠, McCarthy HO, Nicolosi V., O'Brien FJ, Kelly DJ. (2019) 'Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues'. Journal of Controlled Release, [DOI] [Details]
2019 'Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells'
Sathy BN, Daly A, Gonzalez-Fernandez T, Olvera D, Cunniffe G, McCarthy HO, Dunne NJ, Jeon O, Alsberg E, Donahue TH, Kelly DJ. (2019) 'Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells'. Acta Biomaterialia, [DOI] [Details]
2019 'Peptide-modified bone repair materials: Factors influencing osteogenic activity'
Liao J, Wu S, Li K, Fan Y, Dunne N, Li X. (2019) 'Peptide-modified bone repair materials: Factors influencing osteogenic activity'. Journal of Biomedical Materials Research - Part A, [DOI] [Details]
2019 'Operative and radiographic acetabular component orientation in total hip replacement: Influence of pelvic orientation and surgical positioning technique'
Rutherford M, O'Connor JD, Gill HS, Hill J, Beverland D, Lennon AB, Dunne NJ. (2019) 'Operative and radiographic acetabular component orientation in total hip replacement: Influence of pelvic orientation and surgical positioning technique'. Medical Engineering and Physics, 64 (1):7-14 [DOI] [Details]
2019 'Patient positioning and cup orientation during total hip arthroplasty: assessment of current UK practice'
Rutherford M, O’Connor JD, Hill JC, Beverland DE, Lennon AB, Dunne NJ. (2019) 'Patient positioning and cup orientation during total hip arthroplasty: assessment of current UK practice'. HIP International, 29 (1):89-95 [DOI] [Details]
2018 'Development of three-dimensional printing polymer-ceramic scaffolds with enhanced compressive properties and tuneable resorption'
Zhou Z, Cunningham E, Lennon A, McCarthy HO, Buchanan F, Dunne N. (2018) 'Development of three-dimensional printing polymer-ceramic scaffolds with enhanced compressive properties and tuneable resorption'. Materials Science and Engineering C, 93 (1):975-986 [DOI] [Details]
2018 'Gene therapy with RALA/iNOS composite nanoparticles significantly enhances survival in a model of metastatic prostate cancer'
McCrudden CM, McBride JW, McCaffrey J, McErlean EM, Dunne NJ, Kett VL, Coulter JA, Robson T, McCarthy HO. (2018) 'Gene therapy with RALA/iNOS composite nanoparticles significantly enhances survival in a model of metastatic prostate cancer'. Cancer Nanotechnology, 9 (1):1-5 [DOI] [Details]
2018 'Long-term hip loading in unilateral total hip replacement patients is no different between limbs or compared to healthy controls at similar walking speeds'
O'Connor JD, Rutherford M, Bennett D, Hill JC, Beverland DE, Dunne NJ, Lennon AB. (2018) 'Long-term hip loading in unilateral total hip replacement patients is no different between limbs or compared to healthy controls at similar walking speeds'. Journal of Biomechanics, 80 :8-15 [DOI] [Details]
2018 'Processing-property relationships of biaxially stretched poly (L-lactic acid) sheet for application in coronary stents'
Blair RW, Dunne NJ, Lennon AB, Menary GH. (2018) 'Processing-property relationships of biaxially stretched poly (L-lactic acid) sheet for application in coronary stents'. Journal of the Mechanical Behavior of Biomedical Materials, 86 :113-121 [DOI] [Details]
2018 'Effect of combined flexion and external rotation on measurements of the proximal femur from anteroposterior pelvic radiographs'
O’Connor JD, Rutherford M, Hill JC, Beverland DE, Dunne NJ, Lennon AB. (2018) 'Effect of combined flexion and external rotation on measurements of the proximal femur from anteroposterior pelvic radiographs'. Journal of Orthopaedics and Traumatology, 104 (4):449-454 [DOI] [Details]
2018 'DNA vaccination for cervical cancer: Strategic optimisation of RALA mediated gene delivery from a biodegradable microneedle system'
Cole G, Ali AA, McCrudden CM, McBride JW, McCaffrey J, Robson T, Kett VL, Dunne NJ, Donnelly RF, McCarthy HO (2018) 'DNA vaccination for cervical cancer: Strategic optimisation of RALA mediated gene delivery from a biodegradable microneedle system'. European Journal of Pharmaceutics and Biopharmaceutics, 127 :288-297 [DOI] [Details]
2018 'Statistical Shape Model Based 2D–3D Reconstruction of the Proximal Femur—Influence of Radiographic Femoral Orientation on Reconstruction Accuracy'
O’Connor J, Rutherford M, Hill J, Beverland D, Dunne N, Lennon A. (2018) 'Statistical Shape Model Based 2D–3D Reconstruction of the Proximal Femur—Influence of Radiographic Femoral Orientation on Reconstruction Accuracy'. Computer methods in biomechanics and biomedical engineering, :153-160 [DOI] [Details]
2018 'Effect of combined flexion and external rotation on measurements of the proximal femur from anteroposterior pelvic radiographs'
O’Connor JD, Rutherford M, Hill JC, Beverland DE, Dunne NJ, Lennon AB. (2018) 'Effect of combined flexion and external rotation on measurements of the proximal femur from anteroposterior pelvic radiographs'. Journal of Orthopaedic Surgery and Research, 104 (4):449-454 [DOI] [Details]
2018 'Composite cryogels for dual drug delivery and enhanced mechanical properties'
de Lima GG, Traon F, Moal E, Canillas M, Rodriguez MA, McCarthy HO, Dunne N, Devine DM, Nugent MJD. (2018) 'Composite cryogels for dual drug delivery and enhanced mechanical properties'. Polymer Composites, [DOI] [Details]
2018 'Effect of microporosity on scaffolds for bone tissue engineering'
Zhang K, Fan Y, Dunne N, Li X. (2018) 'Effect of microporosity on scaffolds for bone tissue engineering'. Regenerative Medicine, [DOI] [Details]
2017 'Influence of alginate backbone on efficacy of thermo-responsive alginate-gP (NIPAAm) hydrogel as a vehicle for sustained and controlled gene delivery'
Chalanqui, MJ and Pentlavalli, S and McCrudden, C and Chambers, P and Ziminska, M and Dunne, N and McCarthy, HO (2017) 'Influence of alginate backbone on efficacy of thermo-responsive alginate-gP (NIPAAm) hydrogel as a vehicle for sustained and controlled gene delivery'. Materials Science and Engineering C, [DOI] [Details]
2017 'RALA complexed α-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo'
Sathy BN, Olvera D, Gonzalez-Fernandez T, Cunniffe GM Pentlavalli S, Chambers P, Jeon O, Alsberg E, McCarthy HO, Dunne NJ, Haut Donahue TL, Kelly DJ. (2017) 'RALA complexed α-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo'. Journal of Materials Chemistry B, 5 (9):1753-1764 [DOI] [Details]
2017 'Systemic RALA/iNOS nanoparticles: A potent gene therapy for metastatic breast cancer coupled as a biomarker of treatment'
McCrudden CM, McBride JW, McCaffrey J, Ali AA, Dunne NJ, Kett VL, Coulter JA, Robson T, McCarthy HO. (2017) 'Systemic RALA/iNOS nanoparticles: A potent gene therapy for metastatic breast cancer coupled as a biomarker of treatment'. Molecular Therapy - Nucleic Acids, 6 (3):249-258 [DOI] [Details]
2017 'Hierarchically structured electrospun scaffolds with chemically conjugated growth factor for ligament tissue engineering'
Pauly HM, Sathy BN, Olvera D, McCarthy HO, Kelly DJ, Popat KC, Dunne NJ, Haut Donahue TL. (2017) 'Hierarchically structured electrospun scaffolds with chemically conjugated growth factor for ligament tissue engineering'. Tissue Engineering, 23 (8):823-836 [DOI] [Details]
2017 'Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector'
Gonzalez-Fernandez T, Sathy BN, Hobbs C, Cunniffe GM, McCarthy HO, Dunne NJ, Nicolosi, O’Brien FJ, Kelly DJ. (2017) 'Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector'. Acta Biomaterialia, 55 (6):226-238 [DOI] [Details]
2017 'Graphene oxide versus graphene for optimisation of PMMA bone cement for orthopaedic applications'
Paz E, Forriol F, del Real JC, Dunne NJ. (2017) 'Graphene oxide versus graphene for optimisation of PMMA bone cement for orthopaedic applications'. Materials Science and Engineering C, 77 :1003-1011 [DOI] [Details]
2017 'Critical Review: Injectability of calcium phosphate pastes and cements'
O’Neill R, McCarthy HO, Montufar E, Ginebra MP, Wilson DI, Dunne N. (2017) 'Critical Review: Injectability of calcium phosphate pastes and cements'. Acta Biomaterialia, 50 (3):1-19 [DOI] [Details]
2017 'DNA vaccination for cervical cancer: a novel technology platform of RALA mediated gene delivery via polymeric microneedles'
Ali AA, McCrudden CM, McCaffrey , McBride JW, Cole G, Dunne NJ, Robson T, Kissenpfennig A, Donnelly RF, McCarthy HO. (2017) 'DNA vaccination for cervical cancer: a novel technology platform of RALA mediated gene delivery via polymeric microneedles'. Nanomedicine: Nanotechnology, Biology, and Medicine, 13 (3):921-932 [DOI] [Details]
2017 'Effects of poly (ε-caprolactone) coating on the properties of three-dimensional printed porous structures'
Zhou Z, Cunningham E, Lennon E, McCarthy HO, Buchanan F, Clarke SA, Dunne N. (2017) 'Effects of poly (ε-caprolactone) coating on the properties of three-dimensional printed porous structures'. Journal of the Mechanical Behavior of Biomedical Materials, 70 (6):68-83 [DOI] [Details]
2017 'Surrogate outcome measures of in vitro osteoclast resorption of beta-tricalcium phosphate'
Clarke SA, Martin J, Nelson J, Hornez JC, Bohner M, Dunne N, Buchanan F. (2017) 'Surrogate outcome measures of in vitro osteoclast resorption of beta-tricalcium phosphate'. Advanced healthcare materials, 6 (1) [DOI] [Details]
2017 'MicroRNA as therapeutic targets for chronic wound healing'
Mulholland EJ, Dunne N, McCarthy HO (2017) 'MicroRNA as therapeutic targets for chronic wound healing'. Molecular Therapy - Nucleic Acids, 8 (9):46-55 [DOI] [Details]
2017 'Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) injectable thermoresponsive hydrogel with the potential for localized and sustained delivery of stem cells and bioactive molecules'
Pentlavalli S, Chambers P, Sathy BN, O’Doherty M, Chalanqui M, Kelly DJ, Haut-Donahue T, McCarthy HO, Dunne NJ (2017) 'Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) injectable thermoresponsive hydrogel with the potential for localized and sustained delivery of stem cells and bioactive molecules'. Macromolecular Bioscience, 17 (11) [DOI] [Details]
2016 'Biocompatibility of calcium phosphate bone cement with optimised mechanical properties'
Palmer I, Nelson J, Schatton W, Dunne N, Buchanan F, Clarke SA. (2016) 'Biocompatibility of calcium phosphate bone cement with optimised mechanical properties'. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 104 (2):308-315 [DOI] [Details]
2016 'Biocompatibility of calcium phosphate bone cement with optimised mechanical properties: an in vivo study'
Palmer I, Nelson J, Schatton W, Dunne NJ, Buchanan F, Clarke SA. (2016) 'Biocompatibility of calcium phosphate bone cement with optimised mechanical properties: an in vivo study'. Journal of Materials Science: Materials in Medicine, 27 (12):191-201 [DOI] [Details]
2016 'Extent and mechanism of phase separation during the extrusion of calcium phosphate pastes'
O’Neill R, Montufar E, Ginebra M-P, D. Wilson I, Cunningham E, McCarthy HO, Lennon A, Dunne N. (2016) 'Extent and mechanism of phase separation during the extrusion of calcium phosphate pastes'. Journal of Materials Science: Materials in Medicine, 27 (2):29-42 [DOI] [Details]
2016 'Osteogenic cell response to 3-D hydroxyapatite scaffolds developed via replication of natural marine sponges'
Clarke SA, Choi SY, McKechnie M, Burke G, Dunne N, Walker G, Cunningham E, Buchanan F. (2016) 'Osteogenic cell response to 3-D hydroxyapatite scaffolds developed via replication of natural marine sponges'. Journal of Materials Science: Materials in Medicine, 27 (2):22-33 [DOI] [Details]
2016 'MiRNA 34a: A therapeutic target for castration-resistant prostate cancer'
Chalanqui MJ, O’Doherty M, Dunne NJ, McCarthy HO. (2016) 'MiRNA 34a: A therapeutic target for castration-resistant prostate cancer'. Expert Opinion on Therapeutic Targets, 20 (9):1075-1085 [DOI] [Details]
2016 'Mechanical properties and cellular response of novel electrospun nanofibers for ligament tissue engineering: Effects of orientation and geometry'
Pauly HM, Kelly DJ, Popat KC, Trujillo NA, Dunne NJ, McCarthy HO, Haut Donahue TL. (2016) 'Mechanical properties and cellular response of novel electrospun nanofibers for ligament tissue engineering: Effects of orientation and geometry'. Journal of the Mechanical Behavior of Biomedical Materials, 61 (8):258-270 [DOI] [Details]
2016 'Porous materials with tunable structure and mechanical properties via templated layer-by-layer assembly'
Ziminska M, Dunne N, Hamilton A. (2016) 'Porous materials with tunable structure and mechanical properties via templated layer-by-layer assembly'. ACS applied materials & interfaces, 8 (34):21968-21973 [DOI] [Details]
2016 'Development of TMTP-1 targeted designer biopolymers for gene delivery to prostate cancer'
McBride JW, Massey AS, McCaffrey J, M McCrudden C, Coulter JA, Dunne NJ, Robson T, McCarthy HO. (2016) 'Development of TMTP-1 targeted designer biopolymers for gene delivery to prostate cancer'. International Journal of Pharmaceutics, (1-2):144-153 [DOI] [Details]
2016 'Mechanical and thermal behaviour of an acrylic bone cement modified with a triblock copolymer'
Paz E, Abenojar J, Ballesteros Y, Forriol F, Dunne NJ, Del Real JC. (2016) 'Mechanical and thermal behaviour of an acrylic bone cement modified with a triblock copolymer'. Journal of Materials Science: Materials in Medicine, 27 (4):71-81 [DOI] [Details]
2015 'Twinning anisotropy of tantalum during nanoindentation'
Goel S, Beake B, Chan CW, Faisal NH, Dunne N. (2015) 'Twinning anisotropy of tantalum during nanoindentation'. MATERIALS SCIENCE AND ENGINEERING A, 627 (11):249-261 [DOI] [Details]
2015 'Critical evaluation of pulse-echo ultrasonic test method for the determination of setting and mechanical properties of acrylic bone cement: Influence of mixing technique'
Hagan C, Orr JF, Mitchell CA, Dunne NJ. (2015) 'Critical evaluation of pulse-echo ultrasonic test method for the determination of setting and mechanical properties of acrylic bone cement: Influence of mixing technique'. Ultrasonics, :279-286 [DOI] [Details]
2014 'Optimisation of a two-liquid component pre-filled acrylic bone cement system: A design of experiments approach to optimise cement final properties'
Clements J, Walker G, Pentlavalli S, Dunne NJ. (2014) 'Optimisation of a two-liquid component pre-filled acrylic bone cement system: A design of experiments approach to optimise cement final properties'. JOURNAL OF MATERIALS SCIENCE : MATERIALS IN MEDICINE, 25 (10):2287-2296 [DOI] [Details]
2014 'Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery'
McCarthy HO, McCaffrey J, McCrudden CM, Zholobenko A, Ali A, McBride JW, Massey AS, Pentlavalli S, Chen K-H, Cole G, Loughran SP, Dunne NJ, Donnelly RF, Kett VL, Robson T. (2014) 'Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery'. Journal of Controlled Release, 189 (10):141-149 [DOI] [Details]
2014 'Printability of calcium phosphate:calcium sulphate powders for the application of tissue engineered bone scaffolds using the 3D printing technique'
Zhou Z, Buchanan F, Mitchell C, Dunne NJ. (2014) 'Printability of calcium phosphate:calcium sulphate powders for the application of tissue engineered bone scaffolds using the 3D printing technique'. Materials Science and Engineering C, 38 :1-19 [DOI] [Details]
2014 'Carboxyl functionalised MWCNT/Polymethyl methacrylate bone cement for orthopaedic applications'
Ormsby RW, Modreanu M, Mitchell CA, Dunne NJ. (2014) 'Carboxyl functionalised MWCNT/Polymethyl methacrylate bone cement for orthopaedic applications'. 29 (2):209-221 [DOI] [Details]
2014 'A combined experimental and finite element modelling approach to predict, evaluate and compaschre the use of PMMA and calcium phosphate cements for augmentation of traumatically fractured porcine vertebrae using vertebroplasty'
Tarsuslugil S, O’Hara R, Dunne NJ, F Buchanan, J Orr, D Barton, R Wilcox. (2014) 'A combined experimental and finite element modelling approach to predict, evaluate and compaschre the use of PMMA and calcium phosphate cements for augmentation of traumatically fractured porcine vertebrae using vertebroplasty'. Annals of Biomedical Engineering, 42 (4):751-762 [DOI] [Details]
2014 'Chemical modification of multiwalled carbon nanotube with a bifunctional caged ligand for radioactive labelling'
Ormsby RW, McNally T, Mitchell C, Musumeci A, Schiller T, Halley P, Gahan L, Martin D, Smith SV, Dunne NJ. (2014) 'Chemical modification of multiwalled carbon nanotube with a bifunctional caged ligand for radioactive labelling'. Acta Materialia, 64 (2):54-61 [DOI] [Details]
2013 'Development of calcium phosphate cements for the augmentation of traumatically fractured porcine specimens using vertebroplasty'
Tarsuslugil S, O’Hara R, Dunne NJ, F Buchanan, J Orr, D Barton, R Wilcox. (2013) 'Development of calcium phosphate cements for the augmentation of traumatically fractured porcine specimens using vertebroplasty'. Journal of Biomechanics, 46 (4):711-715 [DOI] [Details]
2012 'Development of a bovine collagen-apatitic calcium phosphate cement for potential fracture treatment through vertebroplasty'
O’Hara R, Orr J, Buchanan F, Wilcox R, Barton D, Dunne NJ. (2012) 'Development of a bovine collagen-apatitic calcium phosphate cement for potential fracture treatment through vertebroplasty'. Acta Biomaterialia, 8 (11):4043-4052 [DOI] [Details]
2012 'Hydrothermal synthesis of coccolith rich chalk to hydroxyapatite'
Fee K, Walker G, Dunne NJ, Buchanan FJ. (2012) 'Hydrothermal synthesis of coccolith rich chalk to hydroxyapatite'. International Journal of Nano and Biomaterials, 4 (2):81-95 [DOI] [Details]
2012 'Fatigue and biocompatibility properties of a poly(methyl methacrylate) bone cement with multi-walled carbon nanotubes'
Ormsby R, McNally T, O’Hare P, Burke G, Mitchell C, Dunne NJ. (2012) 'Fatigue and biocompatibility properties of a poly(methyl methacrylate) bone cement with multi-walled carbon nanotubes'. Acta Biomaterialia, 8 (3):1201-1212 [DOI] [Details]
2012 'Effect of liquid/powder ratio on the setting, handling and mechanical properties of collagen–apatitic cements'
Dunne NJ, O’Hara R, Buchanan F, Orr J. (2012) 'Effect of liquid/powder ratio on the setting, handling and mechanical properties of collagen–apatitic cements'. Key Engineering Materials, 493-494 :415-421 [DOI] [Details]
2012 'Identification of a suitable sterilisation method for collagen derived from a marine Demosponge'
Palmer I. Clarke SA, Nelson J, Schatton W, Dunne NJ, Buchanan Fj. (2012) 'Identification of a suitable sterilisation method for collagen derived from a marine Demosponge'. International Journal of Nano and Biomaterials, 4 (2):148-163 [DOI] [Details]
2012 'Static and dynamic degradation of sintered calcium phosphate ceramics'
Newe C, Cunningham E, Buchanan F, Walker G, Prendergast P, Lennon A, Dunne N. (2012) 'Static and dynamic degradation of sintered calcium phosphate ceramics'. Key Engineering Materials, 493-494 :861-865 [DOI] [Details]
2011 'Comparative characterization of 3-D hydroxyapatite scaffolds developed via replication of synthetic polymer foams and natural marine sponges'
Cunningham E, Dunne NJ, Clarke SA, Choi SY, Walker G, Wilcox R, Unger RE, Buchanan F, Kirkpatrick CJ. (2011) 'Comparative characterization of 3-D hydroxyapatite scaffolds developed via replication of synthetic polymer foams and natural marine sponges'. Journal of Tissue Engineering, 1 :1-9 [DOI] [Details]
2011 'Effect of MWCNT addition on the thermal and rheological properties of polymethyl methacrylate bone cement'
Ormsby R, McNally T, Mitchell C, Halley P, Martin D, Nicholson T, Dunne N. (2011) 'Effect of MWCNT addition on the thermal and rheological properties of polymethyl methacrylate bone cement'. Carbon, 49 (11):2893-2904 [DOI] [Details]
2010 'Performance of calcium deficient hydroxyapatite–polyglycolic acid composites: an in vitro study'
Dunne NJ, Jack, V, O'Hara R, Farrar D, Buchanan FJ. (2010) 'Performance of calcium deficient hydroxyapatite–polyglycolic acid composites: an in vitro study'. Journal of Materials Science: Materials in Medicine, 21 (8):2263-2270 [DOI] [Details]
2010 'Optimisation of the mechanical and handling properties of an injectable calcium phosphate cement'
O’Hara RM, Dunne NJ, Orr JF, Buchanan FJ, Wilcox RK, Barton DC. (2010) 'Optimisation of the mechanical and handling properties of an injectable calcium phosphate cement'. Journal of Materials Science: Materials in Medicine, 21 (8):2299-2305 [DOI] [Details]
2010 'Influence of multiwall carbon nanotube functionality and loading on mechanical properties of PMMA/MWCNT bone cements'
Ormsby R, McNally T, Mitchell CA, Dunne NJ. (2010) 'Influence of multiwall carbon nanotube functionality and loading on mechanical properties of PMMA/MWCNT bone cements'. Journal of Materials Science: Materials in Medicine, 21 (8):2287-2292 [DOI] [Details]
2010 'Hydroxyapatite bone substitutes developed via replication of natural marine sponges'
Cunningham E, Dunne NJ, Walker G, Maggs C, Wilcox R, Buchanan FJ. (2010) 'Hydroxyapatite bone substitutes developed via replication of natural marine sponges'. Journal of Materials Science: Materials in Medicine, 21 (8):2255-2261 [DOI] [Details]
2010 'Investigations on drop penetration and wetting characteristics of powder-liquid systems in relation to the mixing of acrylic bone cement'
McEleney P, Walker G, Orr JF. Dunne NJ. (2010) 'Investigations on drop penetration and wetting characteristics of powder-liquid systems in relation to the mixing of acrylic bone cement'. International Journal of Nano and Biomaterials, 3 (1):20-35 [DOI] [Details]
2010 'Incorporation of multiwalled carbon nanotubes to acrylic based bone cements: Effects on mechanical and thermal properties'
Ormsby R. McNally T, Mitchell C, Dunne NJ. (2010) 'Incorporation of multiwalled carbon nanotubes to acrylic based bone cements: Effects on mechanical and thermal properties'. Journal of the Mechanical Behavior of Biomedical Materials, 3 (2):136-145 [DOI] [Details]
2010 'Effect of vacuum mixing and manual pressurisation on residual strains in polymethyl methacrylate bone cement mantles'
Hingston JA, Looney L, Dunne NJ, McGuinness GB. (2010) 'Effect of vacuum mixing and manual pressurisation on residual strains in polymethyl methacrylate bone cement mantles'. International Journal of Nano and Biomaterials, 3 (1):49-64 [DOI] [Details]

Review Articles

  Year Publication
2020 Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration.
de Armentia, SL;del Real, JC;Paz, E;Dunne, N (2020) Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration. BASEL: Review Articles [DOI] [Details]
2020 Applications of materials for dural reconstruction in pre-clinical and clinical studies: Advantages and drawbacks, efficacy, and selections.
Bi X.;Liu B.;Mao Z.;Wang C.;Dunne N.;Fan Y.;Li X. (2020) Applications of materials for dural reconstruction in pre-clinical and clinical studies: Advantages and drawbacks, efficacy, and selections. Review Articles [DOI] [Details]
2020 Electrospinning of natural polymers for the production of nanofibres for wound healing applications.
Juncos Bombin A.D.;Dunne N.J.;McCarthy H.O. (2020) Electrospinning of natural polymers for the production of nanofibres for wound healing applications. Review Articles [DOI] [Details]
2020 Calcium Phosphate Nanoparticles-Based Systems for RNAi Delivery: Applications in Bone Tissue Regeneration.
Levingstone, TJ;Herbaj, S;Redmond, J;McCarthy, HO;Dunne, NJ (2020) Calcium Phosphate Nanoparticles-Based Systems for RNAi Delivery: Applications in Bone Tissue Regeneration. BASEL: Review Articles [DOI] [Details]
2019 Applications of carbon nanotubes in bone tissue regeneration and engineering: Superiority, concerns, current advancements, and prospects.
Pei B.;Wang W.;Dunne N.;Li X. (2019) Applications of carbon nanotubes in bone tissue regeneration and engineering: Superiority, concerns, current advancements, and prospects. Review Articles [DOI] [Details]

Honours and Awards

  Year Title Awarding Body
2017 Journal of Materials Science: Materials in Medicine Award Best Paper Award Journal of Materials Science: Materials in Medicine Award Best Paper Award (Springer)
2010 Royal Academy of Engineering/Leverhulme Trust Senior Research Fellow Award Royal Academy of Engineering & Leverhulme Trust
2009 Northern Ireland Biomedical Engineering Society Best Paper Award Northern Ireland Biomedical Engineering Society
2009 Orthopaedic Research Society/British Orthopaedic Research Society Travel Fellowship Orthopaedic Research Society & British Orthopaedic Research Society
2008 UK Society of Biomaterials Best Paper Award UK Society of Biomaterials
2008 DePuy International Award Best Paper Award Northern Ireland Biomedical Engineering Society
2008 Institute of Materials, Minerals and Mining Best Paper Award Institute of Materials, Minerals and Mining
2007 Journal of Materials Science: Materials in Medicine Award Best Paper Award European Society Meeting
2006 Reserve Royal Academy of Medicine in Ireland Bronze medal Royal Academy of Medicine in Ireland
2002 IMechE: Medical Engineering Division Duncan Dowson Prize Institution of Mechanical Engineers

Professional Associations

  Association Function From / To
Institute of Materials, Minerals and Mining Fellow 01-JAN-09 /
Higher Education Academy Member 01-JAN-04 /
Institute of Materials, Minerals and Mining Chartered Engineer 01-JAN-00 /

Committees

  Committee Function From / To
8th World Biomechanics Congress Executive Organising Committee Member 2015 / 2018
11th World Biomaterials Congress VP and Secretary 2012 / 2020
UK Society of Biomaterials Committee Member 2011 / 2015
European Society of Biomaterials Spokesperson for the Young Scientist Fora 2010 / 2014
Northern Ireland Biomedical Engineering Society President & Secretary 2008 / 2015
Journal of Materials Science – Materials in Medicine Editorial Board Member 2014 / Ongoing
ISRN Biomaterials Editorial Board Member 2012 / Ongoing
BioMed Research International Editorial Board Member 2012 / Ongoing
International Journal of Nano and Biomaterials Editorial Board Member 2010 / Ongoing
The Open Mechanical Engineering Journal Editorial Board Member 2007 / Ongoing

Employment

  Employer Position From / To
Trinity College Dubliin Adjunct Professor of Biomaterials Engineering 01-MAY-16 /
Queen's University of Belfast Visiting Research Professor of Biomaterials Engineering 01-APR-16 /
Dublin City University Director of Centre for Medical Engineering Research 01-JAN-16 /
Dublin City University Full Professor (Chair) of Mechanical & Manufacturing Engineering 01-JAN-16 /
Queen's University of Belfast Full Professor of Biomaterials Engineering 01-JUN-15 / 31-DEC-15
Queen's University of Belfast Director of Advanced Materials and Processes Research Cluster 01-JAN-13 / 13-NOV-17
Queen's University of Belfast Director of Polymer Processing Research Centre 01-DEC-13 / 31-DEC-15
Queen's University of Belfast Reader 01-OCT-10 / 30-MAY-15
Queen's University of Belfast Senior Lecturer of Mechanical & Manufacturing Engineering 01-OCT-08 / 30-SEP-10
Queen's University Belfast Lecturer of Mechanical & Manufacturing Engineering 01-FEB-03 / 03-SEP-08
Dublin City University Lecturer of Mechanical & Manufacturing Engineering 01-FEB-00 / 31-JAN-03
Cork Institute of Technology Lecturer of Mechanical & Manufacturing Engineering 01-SEP-98 / 31-JAN-00
DePuy International, Leeds (UK) Biomaterials Engineer 01-SEP-96 / 31-AUG-98

Education

  Year Institution Qualification Subject
2017 Dublin City University / Institute of Leadership & Management University Leadership and Management Programme Leadership & Management
1996 Queen's University of Belfast Ph.D. Biomaterials Engineering
2004 Queen's University of Belfast Postgraduate Certificate in Higher Education Teaching Higher Education & Teaching
1993 Athlone Regional Technical College B.Sc. (Hons.) Polymer Science & Technology

Research Interests

Professor Dunne leads a multidisciplinary group focussed on the development of biomaterials and medical devices that simulate an efficacious drug delivery or therapeutic response. This research programme spans understanding fundamental mechanisms at the host/material interface as well as translational research to target non-union bone defects, bone metastases and chronic wounds. 

Research Projects

  Title Funder From - To Role Award
Learning to search with structure (LESS), a unifying algorithmic framework for gray box optimization of biomanufacturing systems National Science Foundation 01-SEP-21 - 31-AUG-25 DCU PI 422,467.00
Biomechanical evaluation of reality-based navigation in total hip replacement DePuy Synthes 01-JAN-21 - 31-DEC-24 DCU Co-I 103,592.00
Influence of Surface Coating on the Biofunctionalisation of Additively Manufactured Metallic Orthopaedic Implants Science Foundation Ireland Spoke Funding 01-OCT-20 - 30-SEP-22 DCU PI 60,000.00
Multifunctional bone scaffold materials: development-characterisation of mechanically robust nanocomposite-coated porous structures with controlled degradation rate and tuneable local surface stiffness fabricated via LbL assembly - Ali Sahebalzami Irish Research Council 01-OCT-20 - 30-SEP-24 DCU PI 108,728.02
Application of artificial intelligence in the development of bioprinted scaffolds for cartilage tissue engineering Science Foundation Ireland (Centre for Research Training – Machine Learning) 01-OCT-20 - 30-SEP-24 DCU Co-I 166,000.00
Osteoinduction Augmented Magnesium Medical Implants for Skeletal Repair Engineering Physical Science Research Council-Science Foundation Ireland (Doctoral Training Centre) 01-OCT-20 - 30-SEP-24 DCU PI 166,000.00
Combing artificial intelligence and lab-on-a-chip technologies for biomaterials optimisation Science Foundation Ireland (Centre for Research Training – Artificial Intelligence) 01-OCT-20 - 30-SEP-24 DCU Co-I 166,000.00
Osteoinduction Augmented Magnesium Medical Implants for Skeletal Repair PBC Biomed 01-OCT-20 - 30-SEP-24 DCU PI 59,040.00
Development of a Bioresorbable and Biomimetic Bone Adhesive for the Regeneration of Bone Defects - Antzela Tzagiollari Irish Research Council 01-OCT-20 - 30-SEP-23 DCU PI 80,889.78
Collagen bioink optimisation for 3D bioprinting using artificial intelligence methods Science Foundation Ireland (Centre for Research Training – Artificial Intelligence) 01-OCT-19 - 30-SEP-23 Co-Investigator 166,000.00
3D Printed Medical-Grade Metal-based Microneedles as a Modular Platform for Minimally Invasive Therapeutic Delivery Engineering Physical Science Research Council-Science Foundation Ireland (Doctoral Training Centre) 01-OCT-19 - 31-DEC-23 DCU PI 166,000.00
Safety and efficacy of a Class III medical device loaded with nanoparticles for non-union fracture repair Versus Arthritis 01-SEP-19 - 30-AUG-21 DCU PI 115,117.00
Non-viral Delivery of Genetic Cargo on Biomaterial Scaffolds for Bone Regeneration Science Foundation Ireland 01-FEB-19 - 31-JAN-22 DCU PI 87,180.60
Bioceramic-based Adhesives for Surgery and Tissue Engineering PBC Biomed 28-JAN-19 - 27-JAN-23 DCU PI 116,000.00
Active aGeIng and Osteoporosis: The next challenge for smarT nanobiOmaterials and 3D technologies (GIOTTO) H2020-NMBP-TR-IND-22-2018 01-JAN-19 - 31-MAR-22 PI 5,700,000.00
Additive manufacturing of advanced hybrid medical devices Medical Research Council - Concept in Confidence 01-JAN-19 - 31-DEC-19 Co-I 76,000.00
Non-viral delivery of genetic cargo on biomaterial scaffolds for bone regeneration US-Ireland Tripartite award 01-JAN-19 - 31-DEC-21 Co-I 1,000,000.00
Development of a Nanomedicine in an Electrospun Patch for Wound Healing Marie Curie COFUND Programme 01-OCT-18 - 30-SEP-22 Co-I 140,000.00
Development of a Class III medical device loaded with nanoparticles for enhanced in situ bone regeneration Medical Technologies IKC 01-MAR-18 - 28-FEB-19 Co-I 112,060.00
Development of an ultrasound triggered, thermally responsive hydrogel as an on-demand delivery system for bone repair Kuwait Government 01-MAR-18 - 28-FEB-19 Co-I 35,000.00
Engineering collagen based scaffolds for advanced ex vivo culture of breast tumours in a metastatic bone microenvironment O'Hare Scholarship 02-OCT-17 - 30-SEP-19 PI 45,000.00
Equipment Maintenance Award 2016-17 Dublin City University 01-DEC-16 - 30-NOV-17 DCU PI 6,000.00
Identify new life like materials used in medical simulation training that are cost effective, durable and manufacturable using existing technologies Innovate UK 01-NOV-16 - Co-I 226,102.00
IRC Government of Ireland 2016 postgraduate scholarship award to Simona Herbaj Irish Research Council 01-OCT-16 - 30-SEP-20 DCU PI 95,020.00
A new pro-angiogenic nanomedicine for chronic wound healing Invest Northern Ireland 02-OCT-16 - 30-SEP-16 Co-I 118,784.00
FKBPL Gene Therapy: An alternative anti-angiogenic for macular degeneration Medical Research Council 01-SEP-16 - Co-I 95,251.00
Advanced thermo-sensitive medical devices for targeted regeneration of endochondral bone at the bone-tissue interface EPSRC 01-SEP-15 - 31-AUG-16 PI 56,030.00
Building the QUB anti-microbial research (AMR) network EPSRC 01-SEP-15 - 30-SEP-17 Co-I 440,807.00
Bi-axial Stretching of PLLA-WS2 nanocomposites for thinner and stronger biomedical bi-stretch-4-biomed scaffolds European Commission - RISE 01-SEP-15 - 31-AUG-19 Co-I 184,900.00
Development of novel biopolymer functional additives from poultry waste streams ESPRC 01-SEP-15 - 30-APR-19 Co-I 128,869.00
Development of multi-functional thermo-sensitive hydrogels for the treatment of bone metastases Medical Research Council 01-SEP-14 - Co-I 128,869.00
Femoral and acetabular implant placement optimisation during total hip arthroplasty Belfast Arthroplasty Research Trust 01-SEP-14 - 28-FEB-18 PI 100,854.00
Growing synthetic load-bearing materials: Nanoscale fabrication of bioinspired materials for macro-scaler structural and biomedical application FP7-PEOPLES-2013-CIG 01-AUG-14 - 31-JUL-18 Co-I 100,000.00
Enhanced process monitoring and control technology to accelerate development of bioresorbable polymeric medical devices FP7-SME-2013-CAPACITIES 01-DEC-13 - 30-NOV-16 Co-I 1,000,000.00
Development of a novel bioinspired fibre reinforced hydrogel that recapitulates the developmental processes to regenerate the bone-ligament interface US-Ireland Tripartite award 01-DEC-13 - 30-NOV-16 PI 991,734.00
Bio TP Seal-Reduction Plastics Innovate UK 01-DEC-13 - 30-NOV-16 PI 146,800.00
Development of thermo-sensitive growth factor delivering hydrogels incorporating CaP releasing nanoparticles for the targeted promotion of endochondral bone formation to facilitate strategic regeneration of bone-tissue interface Medical Research Council 01-OCT-13 - 30-SEP-15 PI 84,045.00
Development of a fully integrated intelligent bone cement mixing and delivery system Invest Northern Ireland 01-OCT-13 - 30-SEP-15 PI 118,784.00
Measurement and control of pelvic orientation during total hip arthroplasty Belfast Arthroplasty Research Trust 01-SEP-13 - PI 91,329.00
Novel polymer systems for closure of laparoscopic port defects Intertrade Ireland 01-JUL-13 - 30-JUN-15 PI 71,718.00
A minimally invasive solution for the treatment of spinal fractures UK Orthopaedic Research 01-SEP-12 - 31-AUG-14 PI 89,648.00

Contract Researchers

  Researcher Name Project Role Funding Body
Subrata Mondal (Current) Multiscale modelling and design of nanomaterial-based medical devices for osteoporotic fracture repair Postdoctoral Researcher
Lynn Jena (Current) Safety and efficacy of a Class III medical device loaded with nanoparticles for non-union fracture repair Postdoctoral Researcher
Monika Ziminska (Current) Non-viral delivery of genetic cargo on biomaterial scaffolds for bone regeneration Postdoctoral Researcher
Peter Bennett (Current) Subcutaneous implantable cardiac defibrillator PhD Student
Ghayadah Al-Kharusi (Current) Collagen bioink optimisation for 3D bioprinting using artificial intelligence methods PhD Student
Adrian Juncos Bombin (Current) Development of a Nanomedicine in an Electrospun Patch for Wound Healing PhD Student
Halima Boutouil (Current) Application of artificial intelligence in the development of bioprinted scaffolds for cartilage tissue engineering PhD Student
Brian Collins (Current) Combing artificial intelligence and lab-on-a-chip technologies for biomaterials optimisation PhD Student
Oscar Denton (Current) Biomechanical evaluation of reality-based navigation in total hip replacement PhD Student
Cesar Faurat-Narkisian (Current) Growing synthetic load-bearing biomaterials PhD Student
Tina Sadat Hashemi (Current) Osteoinduction augmented magnesium medical implants for skeletal repair PhD Student
Sara López de Armentia Hernández (Current) Development of nanomaterial based scaffolds for bone tissue regeneration PhD Student
John Redmond (Current) Engineering collagen based scaffolds for advanced ex vivo culture of breast tumours in a metastatic bone microenvironment PhD Student
Chayanika Saha (Current) Development of a controlled release DNA vaccine for ovarian cancer PhD Student
Mohammadali Sahebalzamani (Current) Multifunctional bone scaffold materials for segmental bone defect repair PhD Student
Nikoletta Sargioti (Current) 3D printed medical grade metal-based microneedles as a modular platform for minimally invasive therapeutic delivery PhD Student
Ying Sun (Current) 3D printed drug-biomaterial combinations for bone tissue engineering PhD Student
Antzela Tzagiollari (Current) Development of a Bioresorbable and Biomimetic Bone Adhesive for the regeneration of bone defects PhD Student
Miftakuk Munir (Current) Development of an inhalable nanomedicine for lung cancer therapy Masters (Research) Student
Yixuan Chen (Current) Delivery systems for the genetic engineering of T-Cells Masters (Research) Student
Beth Macaulay (Current) Influence of surface coating on the biofunctionalisation of additively manufactured metallic orthopaedic implants Masters (Research) Student
Ahlam Abdunnabi Ali (Completed) A new pro-angiogenic nanomedicine for chronic wound healing Postdoctoral Researcher
John McBride (Completed) Additive manufacturing of advanced hybrid medical devices Postdoctoral Researcher
Philip Chambers (Completed) Development of the RALA delivery platform Postdoctoral Researcher
Grace Cole (Completed) FKBPL Gene Therapy: An alternative anti-angiogenic for macular degeneration Postdoctoral Researcher
Eoin Cunningham (Completed) Collagen fibre-calcium phosphate cement Postdoctoral Researcher
Rebecca Lane (Completed) Development of a fully integrated intelligent bone cement mixing and delivery system Postdoctoral Researcher
Ashley Massey (Completed) Collagen fibre-calcium phosphate cement Postdoctoral Researcher
Emma McErlean (Completed) Development of a mRNA vaccine in a Microneedle Patch for Castrate Resistant Prostate Cancer Postdoctoral Researcher
Michelle O’Doherty (Completed) Advanced manufacture of thermo-sensitive medical devices for targeted regeneration of endochondral bone at the bone-tissue interface Postdoctoral Researcher
Ross Ormsby (Completed) Minimally invasive solution for spinal fractures Postdoctoral Researcher
Iwan Palmer (Completed) Collagen fibre-calcium phosphate composite cement Postdoctoral Researcher
Sreekanth Pentlavalli (Completed) Novel bioinspired fibre reinforced hydrogel to regenerate the bone-ligament interface Postdoctoral Researcher
Monika Ziminska (Completed) Development of a Class III medical device loaded with nanoparticles for enhanced in situ bone regeneration Postdoctoral Researcher
Jonathan Acheson (Graduated) Layer by layer assembly as a bottom-up nanofabrication technique for the manufacture of engineered bone tissue scaffolds PhD Student
Ross Blair (Graduated) Combined experimental and computational framework to optimise processing and design of PLLA bioresorbable vascular scaffolds PhD Student
Marine Chalanqui (Graduated) Development of multi-functional thermo-sensitive hydrogels for the treatment of bone metastases PhD Student
Philip Chambers (Graduated) Development of a novel bioinspired fibre reinforced hydrogel PhD Student
James Clements (Graduated) Optimisation of PMMA bone cement mixing and delivery PhD Student
Kathryn Fee (Graduated) Development of marine-derived biomaterials for bone tissue engineering PhD Student
Badriah Fma Al (Graduated) Development of an ultrasound triggered, thermally responsive hydrogel as an on-demand delivery system for bone repair Masters (Research) Student
Chiara MacBhrien (Graduated) Development of computational models of multi-walled carbon nanotube reinforced bone cements to enable long-term simulation of fatigue failure of cemented orthopaedic implants PhD Student
Thomas McGauran (Graduated) Development of Biopolymers additives from poultry waste PhD Student
Joanne Millar (Graduated) Cell mediated bioresorption of calcium phosphate bone substitutes PhD Student
Eoghan Mulholland (Graduated) Nucleic acid based nanomedicine for chronic wound treatment PhD Student
Caroline Newe (Graduated) Development of tissue engineered scaffolds PhD Student
John O’Connor (Graduated) Femoral and acetabular implant placement optimisation during total hip arthroplasty PhD Student
Rory O’Neill (Graduated) Computational and experimental optimisation of calcium phosphate for bone augmentation through vertebroplasty PhD Student
Iwan Palmer (Graduated) In-vitro and In-vivo testing of biomaterials for spinal repair PhD Student
Paul Ricketts (Graduated) Direct adsorption of antibiotics onto hydroxyapatite surfaces PhD Student
Megan Rutherford (Graduated) Measurement and control of pelvic orientation during total hip arthroplasty PhD Student
Zuoxin Zhou (Graduated) Design and optimisation of tissue engineering scaffolds PhD Student
Monika Ziminska (Graduated) Nanocomposite-coated foams for mechanical reinforcement of bone tissue scaffolds and targeted drug delivery PhD Student

External Collaborators

  Name Organisation / Institute Country
Fergal O'Brien Royal College of Surgeons in Ireland IRELAND
Professor Helen McCarthy Queen's University Belfast UNITED KINGDOM
Giulia Pedrielli Arizona State University U.S.A.
Chiara Vitale-Brovarone Politecnico di Torino ITALY
Seth Donahue University of Massachusetts, Amherst U.S.A.

Teaching Interests

The modules that I teach at Undergraduate and Postgraduate level include:

  1. Strength of Materials I (MM211)
  2. Product Development & Regulatory Compliance (MM371)
  3. Biomaterials (MM413)
  4. Advanced Engineering Materials & Manufacturing Processes (MM409)
  5. Research Practice & Methodologies (MM533)

Modules Coordinated

  Term (ID)) Title Link Subject
2021 Research Practice & Methodology MM533Research Practice & Methodology
2021 Strength of Materials I MM211Strength of Materials I