Jianghui Meng
DR
Dr. Jianghui Meng is a PI in Molecular Neuroscience and Neurotherapeutics in the National Institute of Cellular Biotechnology, is funded by SFI, Sanofi, and LEO foundation on the translational neuroscience and dermatology. Dr. Meng’s current research interests are focused on defining the itch and pain signaling pathways, elucidating neuroimmune modulation of chronic itch and pain, and developing novel analgesics and antipruritics. These therapeutics have advantages being effective and cost-efficient, with abilities to change patients’ life in a meaningful way. Dr. Meng has established several novel concepts for itch and pain management and identified novel therapeutic interventions, which formed the new basis for the accomplishment of transformational “mechanism-based” high-quality treatments.
Peer Reviewed Journal
| Year | Publication | |
|---|---|---|
| 2023 | Li, Y; Chen, W; Zhu, X; Mei, H; Steinhoff, M; Buddenkotte, J; Wang, J; Zhang, W; Li, Z; Dai, X; Shan, C; Wang, J; Meng, J (2023) 'Neuronal BST2: A Pruritic Mediator Alongside PAR2 in the Interleukin-27-Driven Itch Pathway'. The Journal of investigative dermatology, . [DOI] | |
| 2023 | Wang, R; Dai, X; Chen, W; Wang, J; Wang, H; Yan, X; Zhang, W; Fan, Q; Li, L; Wang, J; Meng, J (2023) 'MMP9 Plays Crucial Role in Inflammation and Itch in Allergic Contact Dermatitis via Regulating TLR2/TLR1 Signaling'. The Journal of investigative dermatology, . [DOI] | |
| 2023 | Dai, X.; Li, L.; Yan, X.; Fan, Q.; Wang, R.; Zhang, W.; Chen, W.; Liu, Y.; Meng, J.; Wang, J. (2023) 'Myeloid Vamp3 deletion attenuates CFA-induced inflammation and pain in mice via ameliorating macrophage infiltration and inflammatory cytokine production'. Frontiers in Immunology, 14 . [Link] [DOI] | |
| Meng J; Steinhoff M; 'Molecular mechanisms of pruritus'. Current Research In Translational Medicine, 64 (4). [DOI] | ||
| 2023 | Yang, H; Zhu, R; Zhang, W; Chen, W; Yan, X; Shan, C; Xue, S; Wang, R; Dai, X; Wang, J; Larkin, C; Wang, J; Meng, J (2023) 'Urotensin II/GPR14 Pathway Regulates Chronic Itch in Mice'. The Journal of investigative dermatology, 143 (12). [DOI] | |
| 2022 | Steinhoff, M.; Ahmad, F.; Pandey, A.; Datsi, A.; AlHammadi, A.; Al-Khawaga, S.; Al-Malki, A.; Meng, J.; Alam, M.; Buddenkotte, J. (2022) 'Neuroimmune communication regulating pruritus in atopic dermatitis'. Journal of Allergy and Clinical Immunology, 149 . [Link] [DOI] | |
| 2022 | Zhu, R; Yang, H; Xue, S; Fan, Q; Zhang, W; Wang, R; Chen, W; Li, L; Wang, J; Meng, J (2022) 'Intervening GSK3 Signaling Attenuates Cutaneous Inflammation and Itch in Mice: Implication for Future Therapeutic Development'. The Journal of investigative dermatology, 143 (2). [DOI] | |
| 2022 | Chen, W.; Li, Y.; Steinhoff, M.; Zhang, W.; Buddenkotte, J.; Buhl, T.; Zhu, R.; Yan, X.; Lu, Z.; Xiao, S.; Wang, J.; Meng, J. (2022) 'The PLAUR signaling promotes chronic pruritus'. FASEB Journal, 36 . [Link] [DOI] | |
| 2022 | Zhang, W; Chen, W; Shan, C; Wang, R; Li, L; Wang, J; Meng, J (2022) 'IL-13 Activates Cutaneous Schwann Cells to Promote CCL7-Dependent Pruritic Signaling in Atopic Dermatitis'. The Journal of investigative dermatology, 143 (11). [DOI] | |
| 2022 | Lu, Z; Xiao, S; Chen, W; Zhu, R; Yang, H; Steinhoff, M; Li, Y; Cheng, W; Yan, X; Li, L; Xue, S; Larkin, C; Zhang, W; Fan, Q; Wang, R; Wang, J; Meng, J (2022) 'IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis'. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36 (6). [DOI] | |
| 2021 | Xiao, S.; Lu, Z.; Steinhoff, M.; Li, Y.; Buhl, T.; Fischer, M.; Chen, W.; Cheng, W.; Zhu, R.; Yan, X.; Yang, H.; Liu, Y.; Dou, Y.; Wang, W.; Wang, J.; Meng, J. (2021) 'Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis'. Brain, Behavior, and Immunity, 98 . [Link] [DOI] | |
| 2021 | Wang, W.; Kong, M.; Dou, Y.; Xue, S.; Liu, Y.; Zhang, Y.; Chen, W.; Li, Y.; Dai, X.; Meng, J.; Wang, J. (2021) 'Selective expression of a snare-cleaving protease in peripheral sensory neurons attenuates pain-related gene transcription and neuropeptide release'. International Journal of Molecular Sciences, 22 . [Link] [DOI] | |
| 2021 | Larkin, C.; Chen, W.; Szabó, I.L.; Shan, C.; Dajnoki, Z.; Szegedi, A.; Buhl, T.; Fan, Y.; O'Neill, S.; Walls, D.; Cheng, W.; Xiao, S.; Wang, J.; Meng, J. (2021) 'Novel insights into the TRPV3-mediated itch in atopic dermatitis'. Journal of Allergy and Clinical Immunology, 147 . [Link] [DOI] | |
| 2019 | Tang, M; Meng, J; Wang, J (2019) 'New Engineered-Botulinum Toxins Inhibit the Release of Pain-Related Mediators'. International Journal of Molecular Sciences, 21 (1). [DOI] | |
| 2019 | Meng, J; Chen, W; Wang, J (2019) 'Interventions in the B-type natriuretic peptide signalling pathway as a means of controlling chronic itch'. British Journal of Pharmacology, 177 (5). [DOI] | |
| 2019 | Szöllősi, A.G.; McDonald, I.; Szabó, I.L.; Meng, J.; van den Bogaard, E.; Steinhoff, M. (2019) 'TLR3 in Chronic Human Itch: A Keratinocyte-Associated Mechanism of Peripheral Itch Sensitization'. Journal of Investigative Dermatology, 139 . [Link] [DOI] | |
| 2019 | Meng, J.; Wang, J.; Buddenkotte, J.; Buhl, T.; Steinhoff, M. (2019) 'Role of SNAREs in Atopic Dermatitis–Related Cytokine Secretion and Skin-Nerve Communication'. Journal of Investigative Dermatology, 139 . [Link] [DOI] | |
| 2018 | Meng, J.; Moriyama, M.; Feld, M.; Buddenkotte, J.; Buhl, T.; Szöllösi, A.; Zhang, J.; Miller, P.; Ghetti, A.; Fischer, M.; Reeh, P.W.; Shan, C.; Wang, J.; Steinhoff, M. (2018) 'New mechanism underlying IL-31–induced atopic dermatitis'. Journal of Allergy and Clinical Immunology, 141 . [Link] [DOI] | |
| 2017 | Nugent, M; Yusef, YR; Meng, J; Wang, J; Dolly, JO (2017) 'A SNAP-25 cleaving chimera of botulinum neurotoxin /A and /E prevents TNFα-induced elevation of the activities of native TRP channels on early postnatal rat dorsal root ganglion neurons'. Neuropharmacology, 138 . [DOI] | |
| 2017 | Wang, J.; Casals-Diaz, L.; Zurawski, T.; Meng, J.; Moriarty, O.; Nealon, J.; Edupuganti, O.P.; Dolly, O. (2017) 'A novel therapeutic with two SNAP-25 inactivating proteases shows long-lasting anti-hyperalgesic activity in a rat model of neuropathic pain'. Neuropharmacology, 118 . [Link] [DOI] | |
| 2016 | Meng, J (2016) 'Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer'. Oncotarget, 8 (25). [DOI] | |
| 2016 | Wang, J; Meng, J; Nugent, M; Tang, M; Dolly, JO (2016) 'Neuronal entry and high neurotoxicity of botulinum neurotoxin A require its N-terminal binding sub-domain'. Scientific Reports, 7 . [DOI] | |
| 2016 | Meng, Jianghui; Wang, Jiafu; Steinhoff, Martin; Dolly, James Oliver (2016) 'TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion'. Scientific Reports, 6 . [DOI] | |
| 2016 | Meng, J.; Wang, J.; Steinhoff, M.; Dolly, J.O. (2016) 'TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion'. Scientific Reports, 6 . [Link] [DOI] | |
| 2014 | Ma, H; Meng, J; Wang, J; Hearty, S; Dolly, JO; O'Kennedy, R (2014) 'Targeted delivery of a SNARE protease to sensory neurons using a single chain antibody (scFv) against the extracellular domain of P2X(3) inhibits the release of a pain mediator'. The Biochemical journal, 462 (2). [DOI] | |
| 2013 | Meng, J; Dolly, JO; Wang, J (2013) 'Selective cleavage of SNAREs in sensory neurons unveils protein complexes mediating peptide exocytosis triggered by different stimuli'. Molecular Neurobiology, 50 (2). [DOI] | |
| 2014 | Boddul, S.V.; Meng, J.; Dolly, J.O.; Wang, J. (2014) 'SNAP-23 and VAMP-3 contribute to the release of IL-6 and TNFα from a human synovial sarcoma cell line'. FEBS Journal, 281 . [Link] [DOI] | |
| 2013 | Meng, J; Wang, J; Lawrence, GW; Dolly, JO (2013) 'Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons'. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27 (8). [DOI] | |
| 2012 | Wang, J; Zurawski, TH; Bodeker, MO; Meng, J; Boddul, S; Aoki, KR; Dolly, JO (2012) 'Longer-acting and highly potent chimaeric inhibitors of excessive exocytosis created with domains from botulinum neurotoxin A and B'. The Biochemical journal, 444 (1). [DOI] | |
| 2012 | Wang, J; Zurawski, TH; Meng, J; Lawrence, GW; Aoki, KR; Wheeler, L; Dolly, JO (2012) 'Novel chimeras of botulinum and tetanus neurotoxins yield insights into their distinct sites of neuroparalysis'. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26 (12). [DOI] | |
| 2010 | Wang, J; Zurawski, TH; Meng, J; Lawrence, G; Olango, WM; Finn, DP; Wheeler, L; Dolly, JO (2010) 'A dileucine in the protease of botulinum toxin A underlies its long-lived neuroparalysis: transfer of longevity to a novel potential therapeutic'. The Journal of biological chemistry, 286 (8). [DOI] | |
| 2009 | Meng, J.; Ovsepian, S.V.; Wang, J.; Pickering, M.; Sasse, A.; Aoki, K.R.; Lawrence, G.W.; Dolly, J.O. (2009) 'Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential'. Journal of Neuroscience, 29 . [Link] [DOI] | |
| 2008 | Wang, J; Meng, J; Lawrence, GW; Zurawski, TH; Sasse, A; Bodeker, MO; Gilmore, MA; Fernández-Salas, E; Francis, J; Steward, LE; Aoki, KR; Dolly, JO (2008) 'Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics'. The Journal of biological chemistry, 283 (25). [DOI] | |
| 2008 | Cheong, SC; Wang, Y; Meng, JH; Hill, R; Sweeney, K; Kirn, D; Lemoine, NR; Hallden, G (2008) 'E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models'. Cancer Gene Therapy, 15 :40-50. [DOI] | |
| 2007 | Meng, J.; Wang, J.; Lawrence, G.; Dolly, J.O. (2007) 'Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential'. Journal of Cell Science, 120 . [Link] [DOI] | |
| 2015 | Meng, J; Wang, J (2015) 'Role of SNARE proteins in tumourigenesis and their potential as targets for novel anti-cancer therapeutics'. Biochimica et biophysica acta, 1856 (1). [DOI] | |
| 2011 | Dolly, JO; Wang, J; Zurawski, TH; Meng, J (2011) 'Novel therapeutics based on recombinant botulinum neurotoxins to normalize the release of transmitters and pain mediators'. The FEBS journal, 278 (23). [DOI] | |
| 2009 | Dolly, JO; Lawrence, GW; Meng, J; Wang, J; Ovsepian, SV (2009) 'Neuro-exocytosis: botulinum toxins as inhibitory probes and versatile therapeutics'. Current Opinion in Pharmacology, 9 (3). [DOI] |
Book Chapter
| Year | Publication | |
|---|---|---|
| 2009 | Dolly, J.O.; Meng, J.; Wang, J.; Lawrence, G.W.; Bodeker, M.; Zurawski, T.H.; Sasse, A. (2009) 'Multiple steps in the blockade of exocytosis by botulinum neurotoxins' In: Botulinum Toxin: Therapeutic Clinical Practice and Science, Expert Consult - Online and Print. [Link] [DOI] | |
| 2009 | Dolly, J.O.; Meng, J.; Wang, J.; Lawrence, G.W.; Bodeker, M.; Zurawski, T.H.; Sasse, A. (2009) 'Multiple Steps in the Blockade of Exocytosis by Botulinum Neurotoxins' In: Botulinum Toxin: Therapeutic Clinical Practice and Science. [Link] [DOI] |
Other Publication
| Year | Publication | |
|---|---|---|
| 2022 | Yang, H.; Chen, W.; Zhu, R.; Wang, J.; Meng, J. (2022) Critical Players and Therapeutic Targets in Chronic Itch. [Link] [DOI] | |
| 2021 | Xue, S; Zhu, R; Chen, W; Yang, H; Wang, J; Meng, J (2021) Inhibiting Keratinocyte-Derived Signal Transducer and Activator of Transcription 6 Improved Atopic Dermatitis in Mice. [DOI] | |
| 2015 | Meng, J.; Wang, J.; Steinhoff, M.; Dolly, O. (2015) TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/Syntaxin1/SNAP-25 mediated fusion. | |
| 2020 | Meng, J.; Chen, W.; Wang, J. (2020) Interventions in the B-type natriuretic peptide signalling pathway as a means of controlling chronic itch. [Link] [DOI] | |
| 2022 | Wang, Jiafu; Wang, Wanzhi; Kong, Miaomiao; Dou, Yu; Xue, Shanghai; Liu, Yang; Zhang, Yinghao; Chen, Weiwei; Li, Yanqing; Dai, Xiaolong; Meng, Jianghui (2022) Selective Expression of the Protease of Botulinum Neurotoxin Type A1 in Nociceptive Neurons Persistently Blocks Neurotransmission. | |
| 2022 | Meng, Jianghui; Wang, Jiafu; Xiao, Song; Chen, Weiwei; Zhu, Renkai; Yang, Hua; Li, Yanqing; Cheng, Wenke; Yan, Xinrong; Li, Lianlian; Xue, Shanghai; Larkin, Ciara; Zhang, Wenhao; Fan, Qianqian; Wang, Ruizhen; Joy, Febu; Buddenkotte, Jorg; Steinhoff, Martin (2022) INTERLEUKIN-20 PROMOTES NEURO-INFLAMMATION AND PRURITUS IN ATOPIC DERMATITIS. | |
| 2021 | Meng, J.; Li, Y.; Fischer, M.J.M.; Steinhoff, M.; Chen, W.; Wang, J. (2021) Th2 Modulation of Transient Receptor Potential Channels: An Unmet Therapeutic Intervention for Atopic Dermatitis. [Link] [DOI] | |
| 2021 | Meng, Jianghui; Wang, Jiafu; Buddenkotte, Joerg; Buhl, Timo; Steinhoff, Martin (2021) ROLE OF SNARES IN ATOPIC DERMATITIS-RELATED CYTOKINE SECRETION AND SKINNERVE COMMUNICATION. | |
| 2021 | Wang, Jiafu; Tang, Minhong; Meng, Jianghui (2021) NOVEL SECRETION INHIBITORS OF PAIN-RELATED MEDIATORS WITH POTENTIAL FOR RELIEVING CHRONIC PAIN. | |
| 2018 | Meng, J. M.; Moriyama, M. M.; Feld, M. F.; Buddenkotte, J. B.; Buhl, T. B.; Szollosi, A. S.; Zhang, J. Z.; Miller, P. M.; Ghetti, A. G.; Fischer, M. F.; Reeh, P. R.; Shan, C. S.; Wang, J. W.; Steinhoff, M. S. (2018) Role of brain-derived natriuretic peptide in atopic dermatitis. |
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