Patricia Johnson

Dr

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Dr Johnson’s career spans several years of researching in the area of Biomedical Science. Her PhD project explored the underlying immune mechanisms involved in the development of immune pathologies associated with primary and secondary vasculitis (published manuscripts: Clin Exp Immunol 1997; 108:234-242. Clin Exp Immunol 1997; 111:98-105). Owing to her contributions to this area, she was commissioned to carry out a review of associated patent literature and intellectual property (ExpOpin in Therapeutic Patents. 2002 12 (10) 1517-1525.) and to present an educational article for Nature Encyclopaedia of Life Sciences. (Nature Publishing Group. 2003). Dr Johnson continued to work post-doctorally in the area of Biomedical Science contributing to an EU project with Professor Kingston Mills, (TCD, formerly NUIM) on DNA vaccines against influenza virus. (J of Gen Virol 2000, 81;1737-1745). These studies occasioned further investigations on the immunomodulation associated with mixed infections (J Infect Dis 2000 182(4):1286-9). Success with DNA vaccine studies led to further funding from Glaxo Smithkline, to investigate DNA vaccine constructs encoding surface glycoproteins from HIV (J of Clin Virol. 2000 18:303 and Vaccine 2005 Jan 4;23(7):963-74). On completion her postdoctoral study she established her own research team, the Viral Immunology Group (VIG), at the Institute of Immunology, NUIM, under the PPRTLI programme. Her research team identified a novel immune-modulation mechanism associated with influenza virus (J. Gen Virol 2005, 86, 1885-90). She then secured funding from the EU to develop a novel vaccine construct against childhood respiratory diseases, leading to published studies;- J. Leuk Biol 2007 Apr;81(4):952-6; J Virol. 2008 82(9299-302). In May 2005 Dr Johnson moved to a tenured position in DCU and continued to grow her research laboratory. She has since secured funding from the Wellcome Trust, HRB, IRCSET, EI and MUH with several published, in submission or submission-ready manuscripts from these projects (Drug Discovery Today-DM 2010; 6(4): 107-112; Br J Anaesth. 2014 113 Suppl 1:i56-62, BJA ms no#-2013-01344: In submission JI-CE 13-03246: Submission ready JCI, JCV). Dr Johnson has also presented her findings at many national and international meetings and has participated in numerous research-support roles; She has acted as expert reviewer for the EU 5th  Framework Control of Infectious Disease Programme and has attended and reviewed two mid-term EU 5th  framework progress meetings at Epalinges University Campus Lausanne, and the Istituto Superiore di Sanità, Rome. She have also organized and hosted and 5th & 6th  EU framework meetings and served as coordinator for the joint ISI/UIG Annual Meeting at NUIM and ISI annual meeting held in DCU. Dr Johnson has successfully supervised three PhD students to completion directly under her supervision. All of her students have presented their findings at international meetings and have published their findings in peer reviewed medium to high impact journals in the field. Dr Johnson has also acted as research supervisor to a successful MD candidate and is currently supervising an additional PhD candidate and postgraduate Erasmus Training Programme student. In addition, she has supervised numerous undergraduate and short research projects students (> 25) in both DCU and NUIM.

Book Chapter

Year Publication
2003 Johnson PA (2003) 'Immune Vasculitis' In: : Nature Publishing Group(Eds.). Nature Encyclopedia of Life Sciences. : 0.

Peer Reviewed Journal

Year Publication
2021 Maguire, PT;Loughran, ST;Harvey, R;Johnson, PA (2021) 'A TLR5 mono-agonist restores inhibited immune responses to Streptococcus pneumoniae during influenza virus infection in human monocytes'. PLoS ONE, 16 (10). [DOI]
2020 McQuaid SL;Loughran ST;Power PA;Maguire P;Szczygiel A;Johnson PA; (2020) 'Low-dose IL-2 induces CD56bright NK regulation of T cells via NKp44 and NKp46'. Clinical and Experimental Immunology, 200 (3). [DOI]
2019 O'Reilly D.;Johnson P.;Buchanan P. (2019) 'Hypoxia induced cancer stem cell enrichment promotes resistance to androgen deprivation therapy in prostate cancer'. Steroids, 152 . [DOI]
2018 Loughran, ST;Power, PA;Maguire, PT;McQuaid, SL;Buchanan, PJ;Jonsdottir, I;Newman, RW;Harvey, R;Johnson, PA (2018) 'Influenza infection directly alters innate IL-23 and IL-12p70 and subsequent IL-17A and IFN-gamma responses to pneumococcus in vitro in human monocytes'. PLoS ONE, 13 . [DOI]
2018 McQuaid, S;Loughran, S;Power, P;Maguire, P;Walls, D;Cusi, MG;Orvell, C;Johnson, P (2018) 'Haemagglutinin-neuraminidase from HPIV3 mediates human NK regulation of T cell proliferation via NKp44 and NKp46'. Journal of General Virology, 99 :763-767. [DOI]
2014 Buckley A, McQuaid S, Johnson PA, Buggy DJ, (2014) 'Serum from women undergoing breast cancer surgery, randomized to distinct anaesthetic techniques, exerts different effects on healthy Natural Killer cell anti-tumour activity: A Pilot Study'. British Journal of Anaesthesia, 113 (Suppl 1):56-62.
2014 Buckley A.;McQuaid S.;Johnson P.;Buggy D. (2014) 'Effect of anaesthetic technique on the natural killer cell anti-tumour activity of serum from women undergoing breast cancer surgery: A pilot study'. British Journal of Anaesthesia, 113 (SUPPL. 1):i56-i62. [DOI]
2010 Power P, Loughran S and Johnson PA. (2010) 'Modelling the Effect of Infection on Asthma. Drug Discovery Today-Disease Models 2010; 6 (4): 107-112'. 6 :107-112.
2009 Madsen D, Cantwell ER, O’Brien T, Johnson PA and Mahon BP (2009) 'AAV-2 induces cell mediated immune responses directed against multiple epitopes of the capsid protein VP1'. Journal of General Virology, 90 :2622-2633.
2008 Noone, C.M., Lewis, E.A., Loetscher, M., Newman, R.W., Johnson, P.A. (2008) 'Natural killer cells regulate T cell proliferation during Human Parainfluenza Virus infection'. Journal of Virology, 82 .
2007 Noone CM, Lewis EA, Newman RW and Johnson PA (2007) 'Artificially generated dendritic cells misdirect antiviral immune responses'. JOURNAL OF LEUKOCYTE BIOLOGY, 8 :952-956.
2007 Noone, C;Manahan, E;Newman, R;Johnson, P (2007) 'Artificially generated dendritic cells misdirect antiviral immune responses'. Journal Of Leukocyte Biology, 81 :952-956. [DOI]
2005 Daly L M,. Johnson PA. Nicolson C, Robertson J and Kingston H.G. Mills (2005) 'Innate IL-10 rpromotes the induction of type 2 T cell responses with plasmid DNA coding for HIVgp120'. Vaccine, 23 :967-974.
2005 Noone C M, Frawely AB, Doyle MF, Mahon BP, Mills KH and. Johnson PA (2005) 'Novel mechanism of immunosuppression by influenza virus haemagglutinin: selective suppression of IL-12p35 transcription'. Journal of General Virology, 86 :1885-1890.
2002 Johnson P.A. (2002) 'Molecules that target key events in macrophage migration'. EXPERT OPINION IN THERAPEUTIC PATENTS, 12 :1517-1525.
2000 Daly LM, Johnson PA, Mills KHG (2000) 'DNA vaccines strategies for selective induction of Th1 or Th2 cells. Journal of Clinical Virology'. Journal of Clinical Virology, 18 :303-303.
2000 Johnson PA, Conway M, Daly L, Nicolson C, Robertson J, Mills KHG (2000) 'Plasmid DNA coding for influenza virus haemagglutinin induces Th1 cells and protects against respiratory infection despite its limited ability to generate antibody'. Journal of General Virology, 81 :1737-1745.
2000 McGuirk P, Johnson PA, Ryan EJ and Mills KHG (2000) 'Filamentous haemagglutin and pertussis toxin from Bordetella pertussis modulate immune responses to unrelated antigens'. JOURNAL OF INFECTIOUS DISEASE, 182 :1286-1289.
1999 Johnson PA, Conway M, Cox-Brokstad R, Haaheim L, Daly J, Robertson J, Mills KHG. (1999) 'Selective Induction of Th1 cells with Plasmid DNA coding for influenza virus haemaggluttin. In Proceedings of European Biotechnology meeting on Vaccines'. .
1998 Johnson PA, Conway M and Mills KHG (1998) 'DNA vaccines: Mechanism of antigen presentation leading to selective induction of Th1 cells'. Immunology, 95 .
1997 Johnson PA, Alexander HD, McMillan SA, Maxwell AP (1997) 'Up-regulation of the endothelial cell adhesion molecule intercellular adhesion molecule-1 (ICAM-1) by autoantibodies in autoimmune vasculitis'. 108 :234-242.
1997 Johnson PA, Alexander HD, McMillan SA, Maxwell AP (1997) 'The up-regulation of the granulocyte adhesion molecule Mac-1 in Autoimmune Vasculitis'. 107 :513-519.

Review Articles

Year Publication
2009 Power P.;Loughran S.;Johnson P. (2009) Modelling the effect of infection on asthma. REV [DOI]
Certain data included herein are derived from the © Web of Science (2022) of Clarivate. All rights reserved.

Honors and Awards

Date Title Awarding Body
01/01/2013 Shortlist (contributing author) for Delaney Medal in Anesthesiology Council of the College of Anaesthetists
01/01/2013 Shortlisted in the top 6 abstracts at Eu Soc Anaesthesiology European Society of Anaesthesiology
01/01/2005 EU Marie Curie Award
01/01/2005 Poster prize British Society for Immunology/Irish Society fo
01/01/2005 Prize winding finalist at the RDS Science Communication Foru
01/01/2005 Centres for Science, Engineering and Technology (CESET) Awar
01/01/2005 Shortlisted for the Health Research Board Watts Medal Award
01/01/2005 EU Fifth Framework Award

Committees

Committee Function From / To
Irish Society for Immunology -
European Union 5th Framework expert reviewer -
Data Monitor Infectious Disease -

Research Interests

Viral Immunology particularly immune responses associated with respiratory viruses such as Human Parainfluenza Virus (HPIV), Influenza, Respiratory Syncytial Virus (RSV) and Rhino Virus (RV). Viral subversion of immune responses and the induction of immune regulation. Role of anti-viral immune responses in the development of associated secondary conditions such as bacterial superinfections and asthma. Development of human cellular model systems to predict immune responses to viruses, viral vaccines and other therapeutic interventions.

Internal Collaborators

Type Name Company Role
Internal Professor Ralph Tripp University Of Georgia, Atlanta Academic

External Collaborators

Type Name Company Role
External Professor Ingileif jonsdottir Faculty of Medicine, School of Health Sciences, University of Iceland, Academic
External Prof Ralph Tripp University of Georgia Academic
External Prof Andrew Bowie TCD Academic
External Michelle Epstein, Medical University, Vienna
External Dr Derek Doherty Institute for Molecular Medicine, TCD Academic
External Dr Ruth Harvey National Institute of Biological Standards and Controls Academic
External Maria Grazia Cusi University of Sienna, Italy
External Dr Christian Moser Berna Biotech, Bern Switzerland
External Professor Wolfgand Neubert Max Plank Institute, Munich
External Professor Kingston Mills Trinity College Dublin