Brian Freeland

Assist. Prof

Contact Details


Assistant Professor in Bioprocess Engineering
School of Biotechnology, Lonsdale building
Glasnevin Campus
Dublin City University
Dublin 9, Ireland
T:Ext. 8515

E:Brian.Freeland@dcu.ie
W:https://www.linkedin.com/in/brianfreelanddcu
Profile Photo
Internal lab website: https://sites.google.com/dcu.ie/amb-lab/home

Dr. Brian Freeland completed his degree in Mechatronic Engineering in 2005, MSc in Mechanical with Bioprocessing Engineering in 2009 and PhD in 2020. His PhD work surrounds process control and optimisation in the field of nanomaterials. He has worked applying Process Analytical Tools for several years to control and optimise Bioprocesses. He has several years’ experience working as an automation engineer in the biopharmaceutical and aerospace sensor industries.

He received a post of Lecturer of Bioprocess Engineering in the School of Biotechnology in 2015 and Assistant Professor of 
Bioprocess Engineering in 2020. He is Co-Lead in the Grain-4-Lab project and a principle investigator in the Advanced Processing Technology Research Centre at DCU. Currently, his main research interests are bioprocess development,  PAT, bioprocess control, automation and biomaterials. 

Book Chapter

Year Publication
2021 Brian Freeland, Eanna McCarthy, Sithara Sreenilayam, Greg Foley and Dermot Brabazon (2021) 'Pulsed laser ablation in liquid (PLAL) for nanoparticle generation' In: Laser Micro- and Nano-Scale Processing, Fundamentals and applications. UK : IOP Publishing. [Link] [DOI]
2017 Freeland B.;Ahad I.;Foley G.;Brabazon D. (2017) 'Advanced characterisation techniques for nanostructures' In: Micro and Nanomanufacturing. [DOI]
2017 Brian Freeland, Inam Ul Ahad, Greg Foley & Dermot Brabazon (2017) 'Micro and Nanomanufacturing' In: Advanced Characterisation Techniques for Nanostructures. UK : Elsevier.
2017 Freeland, Brian and Ahad, Inam Ul and Foley, Greg and Brabazon, Dermot (2017) 'Advanced characterisation techniques for nanostructures' In: : Springer International Publishing.
2013 Marison, I;Hennessy, S;Foley, R;Schuler, M;Sivaprakasam, S;Freeland, B (2013) 'The Choice of Suitable Online Analytical Techniques and Data Processing for Monitoring of Bioprocesses' In: MEASUREMENT, MONITORING, MODELLING AND CONTROL OF BIOPROCESSES. BERLIN : SPRINGER-VERLAG BERLIN. [DOI]

Peer Reviewed Journal

Year Publication
2022 Paul Cannon;Brian Freeland;Margaux Jaquiery;Enda McGlynn;Jennifer Gaughran (2022) 'Single-Step Functionalization of Silicon Nanoparticles Providing Efficient DNA Binding'. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, . [DOI]
2022 Brian Freeland;Eanna McCarthy;Rengesh Balakrishnan;Samantha Fahy;Adam Boland;Keith D. Rochfort;Michal Dabros;Roger Marti;Susan M. Kelleher;Jennifer Gaughran (2022) 'A Review of Polylactic Acid as a Replacement Material for Single-Use Laboratory Components'. Processes (Mdpi), (15(9), 2989). [Link] [DOI]
2021 Donnelly, D, Blanchard, L, Dabros, M, O’Hara, S, Brabazon, D Foley, G and 4 Freeland, B (2021) 'A High-Density Yeast Propagation System for Brewery Yeast'. Journal of the American Society of Brewing Chemists, 80 .
2021 Kottelat, J.; Freeland, B.; Dabros, M (2021) 'Novel Strategy for the Calorimetry-Based Control of Fed-Batch Cultivations of Saccharomyces cerevisiae'. Advanced Manufacturing Processes, 9 (723). [Link] https://doi.org/10.3390/pr9040723
2021 Brian Freeland, Ronan McCann, Paul O’Neill, Sithara Sreenilayam, Manuel Tiefenthaler, Michal Dabros, Mandy Juillerat, Greg Foley & Dermot Brabazon (2021) 'Real-time monitoring and control for high-efficiency autonomous laser fabrication of silicon nanoparticle colloids'. International Journal of Advanced Manufacturing Technology, . [Link] https://doi.org/10.1007/s00170-021-06772-6
2021 Cian Hughes, Ronán M McCann, Brian Freeland, Dermot Brabazon (2021) 'Electrochemical and chronoamperometry assessment of nano‑gold sensor surfaces produced via novel laser fabrication methods'. Journal of Electroanalytical Chemistry, 880 . [Link] https://doi.org/10.1016/j.jelechem.2020.114813
2020 Brignoli, Y;Freeland, B;Cunningham, D;Dabros, M (2020) 'Control of Specific Growth Rate in Fed-Batch Bioprocesses: Novel Controller Design for Improved Noise Management'. Processes, 8 . [DOI]
2020 Freeland B.;McCann R.;Alkan G.;Friedrich B.;Foley G.;Brabazon D. (2020) 'Stable nano-silver colloid production via Laser Ablation Synthesis in Solution (LASiS) under laminar recirculatory flow'. Advances in Materials and Processing Technologies, . [DOI]
2015 Tassinari B.;Conaghan S.;Freeland B.;Marison I. (2015) 'Application of Turbidity Meters for the Quantitative Analysis of Flocculation in a Jar Test Apparatus'. Journal of Environmental Engineering, ASCE, 141 (9). [DOI]
2012 Schuler M.;Sivaprakasam S.;Freeland B.;Hama A.;Hughes K.;Marison I. (2012) 'Investigation of the potential of biocalorimetry as a process analytical technology (PAT) tool for monitoring and control of Crabtree-negative yeast cultures'. Applied Microbiology and Biotechnology, 93 (2):575-584. [DOI]

Conference Publication

Year Publication
2021 Sithara Sreenilayam Pavithran, Ronan McCann, Éanna McCarthy, Brian Freeland, Karsten Fleischer, Stephen Goodnick, Stuart Bowden, Christiana Honsberg and Dermot Brabazon (2021) ESAFORM 2021 24th International Conference on Material Forming Silver and Copper nano-colloid generation via Pulsed Laser Ablation in Liquid: Recirculation nanoparticle production mode [Link]
2020 Freeland B.;McCann R.;Foley G.;Brabazon D. (2020) Proceedings of SPIE - The International Society for Optical Engineering High-efficiency generation of nanomaterials via laser ablation synthesis in solution with in-situ diagnostics for closed-loop control [DOI]
2020 Brian Freeland; Ronan McCann; Greg Foley; Dermot Brabazon (2020) Proc. SPIE 11269, Synthesis and Photonics of Nanoscale Materials XVII High-efficiency generation of nanomaterials via laser ablation synthesis in solution with in-situ diagnostics for closed-loop control San Francisco, California, United States, [Link] https://doi.org/10.1117/12.2545878
2019 B Freeland1, 2, 3, R McCann1, 2 (a), P.O’Neill1, 2, K Bagga1, 2, G Foley3 and D Brabazon1 (2019) 22nd Sir Bernard Crossland Symposium Flow-regime and laser wavelength optimization of Silicon Nanoparticle fabrication via laser ablation synthesis in solution (LASiS) Belfast, University of Ulster, 17/04/2019- 18/04/2019
2009 Brian Freeland, Sumsun Naher, Greg Foley and Dermot Brabazon (2009) EdTech 2009 The use of virtual learning environments to aid teaching of heat transfer and Artificial Neural Network modelling in Bioprocess Engineering
2008 Development of a heat transfer and artificial neural networks teaching laboratory practical for biotechnology students Freeland, Brian and Naher, Sumsun and Foley, Greg and Brabazon, Dermot (2008) International Symposium for Engineering Education Development of a heat transfer and artificial neural networks teaching laboratory practical for biotechnology students Dublin City University, [Link]
2007 Brian Freeland, John M. Tobin and Greg Foley (2007) International Symposium for Engineering Education A PROJECT AND COMPETITION TO DESIGN AND BUILD A SIMPLE HEAT EXCHANGER Dublin City University, Ireland, [Link]

Conference Contribution

Year Publication
2019 D Donnelly, L Lucien Blanchard, D Brabazon, S O'Hara, B Freeland (2019) ASBC Meeting A high-density yeast propagation system for brewing yeast New Orleans, 24/06/2019-25/06/2019.
2019 Allan Robert McGivern, Brian Freeland, Konstantinos Grintzalis (2019) BSAC SPRING CONFERENCE 2019 A miniaturised method for measuring inhibition of bacterial growth International Convention Centre, Birmingham, UK, 21/03/2019-22/03/2019.
2018 B.Freeland,R.McCann, T.Stornetta, P.O'Neill, G.Foley, D.Brabazon (2018) Advances in Materials and Processing Technologies (AMPT) Scalable laser based synthesis of nanoparticles via integrative process control Dublin City University, 03/09/2018-07/09/2018.
2018 B.Freeland (2018) Applied Microbial bioprocessing research Science Faculty Research conversations DCU, .
2018 R. McCann, C. Hughes, B. Freeland, D. Brabazon (2018) Laser direct writing and colloidal ink jetting for conductive track fabrication on organic substrates NANOTEXNOLOGY 2018 Thessaloniki, Greece, 30/06/2018-07/07/2018.
2017 B Freeland, R McCann, K Bagga, P O Neill, G Foley, D Brabazon (2017) Bioprocessing India 2017 Targeted laser-based synthesis of nanoparticles for biotechnology Guwahati, India, 09/12/2017-11/03/2018.
2017 B.Freeland, R.McCann, K.Bagga, P.Pulito, A.Nogue,G.Foley and D.Brabazon (2017) COLA 2017 Optimisation of Multi-wavelength continuous nanoparticle fabrication via Pulsed Laser Ablation in Liquids Marseille, 03/09/2017-08/09/2017.
2017 B Freeland, R McCann, K Bagga, P O'Neill, G Foley, D Brabazon (2017) ESAFORM 2017 Nanoparticle fabrication via pulsed laser ablation in liquids: Steps towards scale up Dublin, 26/04/2017-26/05/2017.
2016 K. Bagga, R. McCann, R. Groarke, B. Freeland, M. Vázquez, D. Brabazon, (2016) Materials Science & Technology 2016 Laser assisted synthesis of ligand free nanostructures for sensing applications Salt Lake City, UT, USA, 23/10/2016-27/10/2016.
2016 B.Freeland, D.Brabazon (2016) ACTTiVAte, Horizon 2020 APT Elevator pitch Madrid, .
2016 R.McCann, C.Hughes, B.Freeland, K.Bagga, R.Groarke,
A.Stalcup, M.Vázquez, D.Brabazon (2016) IOP Spring Meeting Confined atmospheric pulsed laser deposition: A new route to nanostructured ultrathin films (Belfast, 20/02/2016-21/02/2016.
2016 B.Freeland, K.Bagga, R.McCann, E.McCarthy, G.Foley, R.O’Kennedy, D.Brabazon (2016) 4th Conference on Advanced Nanoparticle Generation and Excitation by Lasers in Liquids Laser assisted synthesis of nanostructures with controlled viscosity for printing and biological sensing applications Essen, Germany, 09/05/2016-12/05/2016.
2012 B.Freeland, H.Cole, I.W.Marison (2012) NI Academic developer forum LabVIEW applications in Bioprocessing & Process Analytical Technology TCD, .
2011 B.Freeland, M.M.Schuler, S.Sivaprakasam, I.W.Marison (2011) Biothermodynamics of Metabolic and Ecological Networks On-line evaluation of the overall heat transfer coefficient for enhanced reliability of heat-based biomass estimation WE-Heraeus-Seminar, Bonn, Germany, .
2010 B.Freeland, MM.Schuler, S.Sivaprakasam & I.W.Marison (2010) European Symposium on Biochemical Engineering Sciences Artificial Neural Networks (ANNs) for on-line biomass estimation applied to fed-batch cultures of yeast cells Bologna, .
2010 B.Freeland, MM.Schuler, S.Sivaprakasam & I.W.Marison (2010) International Society for Biological Calorimetry ANN model for the prediction of overall heat transfer coefficient in bench scale bioreactors Lugo, Spain, .
2009 B. Freeland, S.Naher., G. Foley and D.Brabazon (2009) EDTech The use of virtual learning environments to aid teaching of heat transfer and Artificial Neural Network modelling in Bioprocess Engineering National College of Ireland, IFSC, .
2008 G. Foley, B.Freeland (2008) Science and mathematics education conference Teaching engineering modules within an interdisciplinary biotechnology degree program – the role of workbooks DCU, .
2009 B. Freeland, S.Naher, G. Foley and D.Brabazon (2009) School of Biotechnology Research Day Heat transfer in a stirred tank bioreactor: data analysis with artificial neural networks DCU, .
2008 B. Freeland, S.Naher., G. Foley and D.Brabazon (2008) International Symposium for Engineering Education Development of a heat transfer and artificial neural networks teaching laboratory practical for biotechnology students DCU, .
2008 B. Freeland, S.Naher, G.Foley and D.Brabazon (2008) Symposium for Mechanical Engineering Research Practice Heat transfer and artificial neural networks research in bio processing DCU, .
2007 B. Freeland, J.Tobin, G. Foley (2007) International Symposium for Engineering Education A biotechnology student project and competition to design and build a simple heat exchanger DCU, .

Online Article

Year Publication
2017 B Freeland, R McCann, K Bagga, P O'Neill, G Foley, D Brabazon (2017) Advantages of the 180° Frequency Power Spectrum (FPS) Method in DLS. ELEA [Link]
Certain data included herein are derived from the © Web of Science (2022) of Clarivate. All rights reserved.

Research Interests

Applying Process Analytical Technology (PAT) tools to understand and control complex systems including Bioprocessing & nano fabrication. Using On-line spectroscopy, Biocalorimetry, Gas Analysis, soft-sensors & ANN.

Nanotechnology: Fabrication of Nanoparticles via Pulsed Laser Ablation in Liquids (PLAL).

Control and optimisation of high cell density microbial bioprocesses.

Industrial automation, Beckhoff Automation, LabView & laser machining.

Research Projects

Title Role Description Start date End date
Grain-4-Lab: Laboratory-grade bioplastics production from native renewable waste-streams: promoting a circular Irish bioeconomy Co-Lead 01/01/2021 31/12/2021
Liquid yeast Bioprocessing tests for WHC lab PI 01/03/2022 01/04/2022
DEVELOPMENT AND OPTIMIZATION OF A MICROBIAL FERMENTATION PROCESS FROM MEDIA SELECTION TO PILOT-SCALE PRODUCTION USING ADVANCED MATERIALS PROCESSING TECHNIQUES DCU Co-PI 01/12/2019 01/05/2024
Production of fermentation biomass Principle Investigator 03/07/2017 02/07/2018
Undergraduate Summer Research Internship Scheme 2017 Principle Investigator 05/06/2017 11/09/2017
Implementation of process control for high cell density Brewing yeast DCU PI 04/01/2019 04/01/2020
IRISH ENGINEERING GRADUATES ADVANCING GLOBAL MANUFACTURING COMPETITIVENESS: DESIGN SIMULATION FOR THE PROCESS INDUSTRIES Fermentation Work Package Leader 04/01/2016 01/01/2018
Increasing the Conformance of Academia towards Rehabilitation Engineering (i-CARE) CO PI 01/11/2017 01/11/2020
Production of high quality yeast protein Principle Investigator 03/04/2017 04/05/2017
Bench-scale manufacture & optimisation of yeast cultures Principle Investigator 01/03/2017 22/03/2017
Production of high quality yeast protein based on whey permeate DCU PI 01/04/2017 30/09/2017

Current Postgraduate Students

Student Name Degree Supervision
Sorensen ,Helena Mylise PhD-track Supervisor
Cannon ,Paul MSc Supervisor

Internal Collaborators

Type Name Company Role
Internal Keith D Rochfort School of Nursing, Psychotherapy and Community Health, DCU Academic
Internal Dr. Greg Foley School of Biotechnology, DCU Academic
Internal Prof. Dermot Brabazon I-Form, DCU Academic
Internal Susan M Kelleher School of Chemical Sciences, DCU Academic
Internal Eanna McCarthy, I-Form Academic
Internal Sithara Sreenilayam I-Form, DCU Academic
Internal Jennifer Gaughran School of Physics, DCU Academic

Teaching Interests

Bioprocess control,  automation & process analytical tools (PAT).

Modules Coordinated

Term Title Subject
2022 Biopharmaceutical Facility Design & Operation BE587
2022 Biopharmaceutical Industry Regulation & Mgt BE583
2022 Bioreactor Design, Modelling & Monitoring BE584
2022 Transport Processes BE223
2022 Bioreactors and Primary Separations BE322
2022 Biopharmaceutical Industry Regulation & Mgmt BE418
2022 Biopharmaceutical Facility Design & Operation BE419
2022 Bioprocessing Laboratory BE451
2022 Bioprocessing Laboratory 1 BE560