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Denise Harold

DR

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Dr Denise Harold is an Assistant Professor in Genomics at the School of Biotechnology in DCU.

Her research focuses on the genetic epidemiology of human complex traits, which is crucial to understanding the molecular pathogenesis of these disorders and determining potential therapeutic targets. 

Denise completed her PhD and postdoctoral research at Cardiff University, where she played a key role in several genome-wide association studies and sequencing studies of Alzheimer's disease, which successfully identified several risk loci for the disease. She has also worked on Huntington's disease, identifying genetic modifiers influencing age at onset of motor symptoms. Subsequent postdoctoral research at Trinity College Dublin involved identity-by-descent mapping approaches to identifying susceptibility variants for schizophrenia.

Denise's current research at DCU aims to understand the commonalities in aetiology of age-related chronic diseases, particularly regarding the role of mitochondrial genetic variation. Given her expertise in genomics and the multidisciplinary environment at DCU, she is also open to collaborating on projects outside of her own area, and has for example contributed to studies on the relationship between mitochondrial DNA heteroplasmy and one-carbon metabolism; transcriptomic responses to Fasciola hepatica infection; gene expression profiling of aquatic invertebrates exposed to pharmaceuticals.


Peer Reviewed Journal

Year Publication
2024 Walsh, D.J.; Bernard, D.J.; Fiddler, J.L.; Pangilinan, F.; Esposito, M.; Harold, D.; Field, M.S.; Parle-Mcdermott, A.; Brody, L.C. (2024) 'Vitamin B12 status and folic acid supplementation influence mitochondrial heteroplasmy levels in mice'. PNAS nexus, 3 . [Link] [DOI]
2022 Walsh, D.J.; Bernard, D.J.; Pangilinan, F.; Esposito, M.; Harold, D.; Parle-McDermott, A.; Brody, L.C. (2022) 'Mito-SiPE is a sequence-independent and PCR-free mtDNA enrichment method for accurate ultra-deep mitochondrial sequencing'. Communications biology, 5 . [Link] [DOI]
2021 Femminella, G.D.; Harold, D.; Scott, J.; Williams, J.; Edison, P. (2021) 'The Differential Influence of Immune, Endocytotic, and Lipid Metabolism Genes on Amyloid Deposition and Neurodegeneration in Subjects at Risk of Alzheimer's Disease'. JOURNAL OF ALZHEIMERS DISEASE, 79 . [Link] [DOI]
2021 Connick, K; Lalor, R; Murphy, A; Glasgow, A; Breen, C; Malfait, Z; Harold, D; O'Neill, SM (2021) 'RNA-seq analysis of murine peyer's patches at 6 and 18 h post infection with Fasciola hepatica metacecariae'. Veterinary Parasitology, 302 . [DOI]
2021 Hubbard, L.; Rees, E.; Morris, D.W.; Lynham, A.J.; Richards, A.L.; Pardiñas, A.F.; Legge, S.E.; Harold, D.; Zammit, S.; Corvin, A.C.; Gill, M.G.; Hall, J.; Holmans, P.; O'Donovan, M.C.; Owen, M.J.; Donohoe, G.; Kirov, G.; Pocklington, A.; Walters, J.T.R. (2021) 'Rare Copy Number Variants Are Associated With Poorer Cognition in Schizophrenia'. Biological Psychiatry, 90 . [Link] [DOI]
2020 Foley, C; Heron, EA; Harold, D; Walters, J; Owen, M; O'Donovan, M; Sebat, J; Kelleher, E; Mooney, C; Durand, A; Pinto, C; Cormican, P; Morris, D; Donohoe, G; Gill, M; Gallagher, L; Corvin, A (2020) 'Identifying schizophrenia patients who carry pathogenic genetic copy number variants using standard clinical assessment: retrospective cohort study'. The British journal of psychiatry : the journal of mental science, 216 (5). [DOI]
2020 Holland, J.F.; Cosgrove, D.; Whitton, L.; Harold, D.; Corvin, A.; Gill, M.; Mothersill, D.O.; Morris, D.W.; Donohoe, G. (2020) 'Effects of complement gene-set polygenic risk score on brain volume and cortical measures in patients with psychotic disorders and healthy controls'. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 183 . [Link] [DOI]
2019 Kunkle, B.W.; Grenier-Boley, B.; Sims, R.; Bis, J.C.; Damotte, V.; Naj, A.C.; Boland, A.; Vronskaya, M.; van der Lee, S.J.; Amlie-Wolf, A.; Bellenguez, C.; Frizatti, A.; Chouraki, V.; Martin, E.R.; Sleegers, K.; Badarinarayan, N.; Jakobsdottir, J.; Hamilton-Nelson, K.L.; Moreno-Grau, S.; Olaso, R.; Raybould, R.; Chen, Y.; Kuzma, A.B.; Hiltunen, M.; Morgan, T.; Ahmad, S.; Vardarajan, B.N.; Epelbaum, J.; Hoffmann, P.; Boada, M.; Beecham, G.W.; Garnier, J.G.; Harold, D.; Fitzpatrick, A.L.; Valladares, O.; Moutet, M.L.; Gerrish, A.; Smith, A.V.; Qu, L.; Bacq, D.; Denning, N.; Jian, X.; Zhao, Y.; Del Zompo, M.; Fox, N.C.; Choi, S.H.; Mateo, I.; Hughes, J.T.; Adams, H.H.; Malamon, J.; Sanchez-Garcia, F.; Patel, Y.; Brody, J.A.; Dombroski, B.A.; Naranjo, M.C.D.; Daniilidou, M.; Eiriksdottir, G.; Mukherjee, S.; Wallon, D.; Uphill, J.; Aspelund, T.; Cantwell, L.B.; Garzia, F.; Galimberti, D.; Hofer, E.; Butkiewicz, M.; Fin, B.; Scarpini, E.; Sarnowski, C.; Bush, W.S.; Meslage, S.; Kornhuber, J.; White, C.C.; Song, Y.; Barber, R.C.; Engelborghs, S.; Sordon, S.; Voijnovic, D.; Adams, P.M.; Vandenberghe, R.; Mayhaus, M.; Cupples, L.A.; Albert, M.S.; De Deyn, P.P.; Gu, W.; Himali, J.J.; Beekly, D.; Squassina, A.; Hartmann, A.M.; Orellana, A.; Blacker, D.; Rodriguez-Rodriguez, E.; Lovestone, S.; Garcia, M.E.; Doody, R.S.; Munoz-Fernadez, C.; Sussams, R.; Lin, H.; Fairchild, T.J.; Benito, Y.A. (2019) 'Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing'. Nature Genetics, 51 . [Link] [DOI]
2019 Holland, J.F.; Cosgrove, D.; Whitton, L.; Harold, D.; Corvin, A.; Gill, M.; Mothersill, D.O.; Morris, D.W.; Donohoe, G. (2019) 'Beyond C4: Analysis of the complement gene pathway shows enrichment for IQ in patients with psychotic disorders and healthy controls'. GENES BRAIN AND BEHAVIOR, 18 . [Link] [DOI]
2019 Harold, D.; Connolly, S.; Riley, B.P.; Kendler, K.S.; McCarthy, S.E.; McCombie, W.R.; Richards, A.; Owen, M.J.; O'Donovan, M.C.; Walters, J.T.R.; Donnelly, P.; Bates, L.; Barroso, I.; Blackwell, J.M.; Bramon, E.; Brown, M.A.; Casas, J.P.; Corvin, A.; Deloukas, P.; Duncanson, A.; Jankowski, J.; Markus, H.S.; Mathew, C.G.; Palmer, C.N.A.; Plomin, R.; Rautanen, A.; Sawcer, S.J.; Trembath, R.C.; Viswanathan, A.C.; Wood, N.W.; Spencer, C.C.A.; Band, G.; Bellenguez, C.; Freeman, C.; Hellenthal, G.; Giannoulatou, E.; Hopkins, L.; Pirinen, M.; Pearson, R.; Strange, A.; Su, Z.; Vukcevic, D.; Langford, C.; Hunt, S.E.; Edkins, S.; Gwilliam, R.; Blackburn, H.; Bumpstead, S.J.; Dronov, S.; Gillman, M.; Gray, E.; Hammond, N.; Jayakumar, A.; McCann, O.T.; Liddle, J.; Potter, S.C.; Ravindrarajah, R.; Ricketts, M.; Waller, M.; Weston, P.; Widaa, S.; Whittaker, P.; Ripke, S.; Neale, B.M.; Farh, K.H.; Holmans, P.A.; Lee, P.; Bulik-Sullivan, B.; Collier, D.A.; Huang, H.; Pers, T.H.; Agartz, I.; Agerbo, E.; Albus, M.; Alexander, M.; Amin, F.; Bacanu, S.A.; Begemann, M.; Belliveau, R.A.; Bene, J.; Bergen, S.E.; Bevilacqua, E.; Bigdeli, T.B.; Black, D.W.; Bruggeman, R.; Buccola, N.G.; Buckner, R.L.; Byerley, W.; Cahn, W.; Cai, G.; Campion, D.; Cantor, R.M.; Carr, V.J.; Carrera, N.; Catts, S.V.; Chambert, K.D.; Chan, R.C.K.; Chan, R.Y.L.; Chen, E.Y.H.; Cheng, W. (2019) 'Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia'. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 180 . [Link] [DOI]
2018 Cosgrove, D.; Mothersill, D.O.; Whitton, L.; Harold, D.; Kelly, S.; Holleran, L.; Holland, J.; Anney, R.; Richards, A.; Mantripragada, K.; Owen, M.; O'Donovan, M.C.; Gill, M.; Corvin, A.; Morris, D.W.; Donohoe, G. (2018) 'Effects of MiR-137 genetic risk score on brain volume and cortical measures in patients with schizophrenia and controls'. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 177 . [Link] [DOI]
2018 Anttila, V.; Bulik-Sullivan, B.; Finucane, H.K.; Walters, R.K.; Bras, J.; Duncan, L.; Escott-Price, V.; Falcone, G.J.; Gormley, P.; Malik, R.; Patsopoulos, N.A.; Ripke, S.; Wei, Z.; Yu, D.; Lee, P.H.; Turley, P.; Grenier-Boley, B.; Chouraki, V.; Kamatani, Y.; Berr, C.; Letenneur, L.; Hannequin, D.; Amouyel, P.; Boland, A.; Deleuze, J.F.; Duron, E.; Vardarajan, B.N.; Reitz, C.; Goate, A.M.; Huentelman, M.J.; Ilyas Kamboh, M.; Larson, E.B.; Rogaeva, E.; George-Hyslop, P.S.; Hakonarson, H.; Kukull, W.A.; Farrer, L.A.; Barnes, L.L.; Beach, T.G.; Yesim Demirci, F.; Head, E.; Hulette, C.M.; Jicha, G.A.; Kauwe, J.S.K.; Kaye, J.A.; Leverenz, J.B.; Levey, A.I.; Lieberman, A.P.; Pankratz, V.S.; Poon, W.W.; Quinn, J.F.; Saykin, A.J.; Schneider, L.S.; Smith, A.G.; Sonnen, J.A.; Stern, R.A.; Van Deerlin, V.M.; Van Eldik, L.J.; Harold, D.; Russo, G.; Rubinsztein, D.C.; Bayer, A.; Tsolaki, M.; Proitsi, P.; Fox, N.C.; Hampel, H.; Owen, M.J.; Mead, S.; Passmore, P.; Morgan, K.; Nöthen, M.M.; Rossor, M.; Lupton, M.K.; Hoffmann, P.; Kornhuber, J.; Lawlor, B.; McQuillin, A.; Al-Chalabi, A.; Bis, J.C.; Ruiz, A.; Boada, M.; Seshadri, S.; Beiser, A.; Rice, K.; Van Der Lee, S.J.; De Jager, P.L.; Geschwind, D.H.; Riemenschneider, M.; Riedel-Heller, S.; Rotter, J.I.; Ransmayr, G.; Hyman, B.T.; Cruchaga, C.; Alegret, M.; Winsvold, B.; Palta, P.; Farh, K.H.; Cuenca-Leon, E.; Furlotte, N.; Kurth, T. (2018) 'Analysis of shared heritability in common disorders of the brain'. Science, 360 . [Link] [DOI]
2018 Peloso, G.M.; van der Lee, S.J.; Sims, R.; van der Lee, S.J.; Naj, A.C.; Bellenguez, C.; Badarinarayan, N.; Jakobsdottir, J.; Kunkle, B.W.; Boland, A.; Raybould, R.; Bis, J.C.; Martin, E.R.; Grenier-Boley, B.; Heilmann-Heimbach, S.; Chouraki, V.; Kuzma, A.B.; Sleegers, K.; Vronskaya, M.; Ruiz, A.; Graham, R.R.; Olaso, R.; Hoffmann, P.; Grove, M.L.; Vardarajan, B.N.; Hiltunen, M.; Nöthen, M.M.; White, C.C.; Hamilton-Nelson, K.L.; Epelbaum, J.; Maier, W.; Choi, S.H.; Beecham, G.W.; Dulary, C.; Herms, S.; Smith, A.V.; Funk, C.C.; Derbois; Forstner, A.J.; Ahmad, S.; Li, H.; Bacq, D.; Harold, D.; Satizabal, C.L.; Valladares, O.; Squassina, A.; Thomas, R.; Brody, J.A.; Qu, L.; Sánchez-Juan, P.; Morgan, T.; Wolters, F.J.; Zhao, Y.; Garcia, F.S.; Denning, N.; Fornage, M.; Malamon, J.; Naranjo, M.C.D.; Majounie, E.; Mosley, T.H.; Dombroski, B.; Wallon, D.; Lupton, M.K.; Dupuis, J.; Whitehead, P.; Fratiglioni, L.; Medway, C.; Jian, X.; Mukherjee, S.; Keller, L.; Brown, K.; Lin, H.; Cantwell, L.B.; Panza, F.; McGuinness, B.; Moreno-Grau, S.; Burgess, J.D.; Solfrizzi, V.; Proitsi, P.; Adams, H.H.; Allen, M.; Seripa, D.; Pastor, P.; Cupples, L.A.; Price, N.D.; Hannequin, D.; Frank-García, A.; Levy, D.; Chakrabarty, P.; Caffarra, P.; Giegling, I.; Beiser, A.S.; Giedraitis, V.; Hampel, H.; Garcia, M.E.; Wang, X.; Lannfelt, L.; Mecocci, P.; Eiriksdottir, G.; Crane, P.K.; Pasquier, F.; Boccardi, V.; Henández, I.; Barber, R.C.; Scherer, M.; Tarraga, L.; Adams, P.M.; Leber, M.; Chen, Y.; Albert, M.S.; Riedel-Heller, S.; Emilsson, V.; Beekly, D.; Braae, A.; Schmidt, R.; Blacker, D.; Masullo, C.; Schmidt, H.; Doody, R.S.; Spalletta, G.; Longstreth, W.T.; Fairchild, T.J.; Bossù, P.; Lopez, O.L.; Frosch, M.P.; Sacchinelli, E.; Ghetti, B.; Yang, Q.; Huebinger, R.M.; Jessen, F.; Li, S.; Kamboh, M.I.; Morris, J.; Sotolongo-Grau, O.; Katz, M.J.; Corcoran, C.; Dunstan, M.; Braddel, A.; Thomas, C.; Meggy, A.; Marshall, R.; Gerrish, A.; Chapman, J.; Aguilar, M.; Taylor, S.; Hill, M.; Fairén, M.D.; Hodges, A.; Vellas, B.; Soininen, H.; Kloszewska, I.; Daniilidou, M.; Uphill, J.; Patel, Y.; Hughes, J.T.; Lord, J.; Turton, J.; Hartmann, A.M.; Cecchetti, R.; Fenoglio, C.; Serpente, M.; Arcaro, M.; Caltagirone, C.; Orfei, M.D.; Ciaramella, A.; Pichler, S.; Mayhaus, M.; Gu, W.; Lleó, A.; Fortea, J.; Blesa, R.; Barber, I.S.; Brookes, K.; Cupidi, C.; Maletta, R.G.; Carrell, D.; Sorbi, S.; Moebus, S.; Urbano, M.; Pilotto, A.; Kornhuber, J.; Bosco, P.; Todd, S.; Craig, D.; Johnston, J.; Gill, M.; Lawlor, B.; Lynch, A.; Fox, N.C.; Hardy, J.; Albin, R.L.; Apostolova, L.G.; Arnold, S.E.; Asthana, S.; Atwood, C.S.; Baldwin, C.T.; Barnes, L.L.; Barral, S.; Beach, T.G.; Becker, J.T.; Bigio, E.H.; Bird, T.D.; Boeve, B.F.; Bowen, J.D.; Boxer, A.; Burke, J.R.; Burns, J.M.; Buxbaum, J.D.; Cairns, N.J.; Cao, C.; Carlson, C.S.; Carlsson, C.M.; Carney, R.M.; Carrasquillo, M.M.; Carroll, S.L.; Diaz, C.C.; Chui, H.C.; Clark, D.G.; Cribbs, D.H.; Crocco, E.A.; DeCarli, C.; Dick, M.; Duara, R.; Evans, D.A.; Faber, K.M.; Fallon, K.B.; Fardo, D.W.; Farlow, M.R.; Ferris, S.; Foroud, T.M.; Galasko, D.R.; Gearing, M.; Geschwind, D.H.; Gilbert, J.R.; Graff-Radford, N.R.; Green, R.C.; Growdon, J.H.; Hamilton, R.L.; Harrell, L.E.; Honig, L.S.; Huentelman, M.J.; Hulette, C.M.; Hyman, B.T.; Jarvik, G.P.; Abner, E.; Jin, L.W.; Jun, G.; Karydas, A.; Kaye, J.A.; Kim, R.; Kowall, N.W.; Kramer, J.H.; LaFerla, F.M.; Lah, J.J.; Leverenz, J.B.; Levey, A.I.; Li, G.; Lieberman, A.P.; Lunetta, K.L.; Lyketsos, C.G. (2018) 'Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease'. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, . [Link] [DOI]
2018 (2018) 'Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection'. Nature Genetics, . [Link] [DOI]
2018 Donohoe, G.; Holland, J.; Mothersill, D.; McCarthy-Jones, S.; Cosgrove, D.; Harold, D.; Richards, A.; Mantripragada, K.; Owen, M.J.; O'Donovan, M.C.; Gill, M.; Corvin, A.; Morris, D.W. (2018) 'Genetically predicted complement component 4A expression: Effects on memory function and middle temporal lobe activation'. Psychological Medicine, 48 . [Link] [DOI]
2017 Chao, M.J.; Gillis, T.; Atwal, R.S.; Mysore, J.S.; Arjomand, J.; Harold, D.; Holmans, P.; Jones, L.; Orth, M.; Myers, R.H.; Kwak, S.; Wheeler, V.C.; MacDonald, M.E.; Gusella, J.F.; Lee, J.M. (2017) 'Haplotype-based stratification of Huntington's disease'. European Journal of Human Genetics, 25 . [Link] [DOI]
2017 Cosgrove, D.; Mothersill, O.; Kendall, K.; Konte, B.; Harold, D.; Giegling, I.; Hartmann, A.; Richards, A.; Mantripragada, K.; Owen, M.J.; O'Donovan, M.C.; Gill, M.; Rujescu, D.; Walters, J.; Corvin, A.; Morris, D.W.; Donohoe, G. (2017) 'Cognitive characterization of schizophrenia risk variants involved in synaptic transmission: Evidence of CACNA1C's role in working memory'. Neuropsychopharmacology, 42 . [Link] [DOI]
2017 Cosgrove D; Harold D; Mothersill O; Anney R; Hill MJ; Bray NJ; Blokland G; Petryshen T; ; Richards A; Mantripragada K; Owen M; O'Donovan MC; Gill M; Corvin A; Morris DW; Donohoe G; (2017) 'MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls'. Translational Psychiatry, 7 (1). [DOI]
2017 Lee, J.M.; Chao, M.J.; Harold, D.; Elneel, K.A.; Gillis, T.; Holmans, P.; Jones, L.; Orth, M.; Myers, R.H.; Kwak, S.; Wheeler, V.C.; MacDonald, M.E.; Gusella, J.F. (2017) 'A modifier of Huntington's disease onset at the MLH1 locus'. Human Molecular Genetics, 26 . [Link] [DOI]
2017 Sims, R.; Van Der Lee, S.J.; Naj, A.C.; Bellenguez, C.; Badarinarayan, N.; Jakobsdottir, J.; Kunkle, B.W.; Boland, A.; Raybould, R.; Bis, J.C.; Martin, E.R.; Grenier-Boley, B.; Heilmann-Heimbach, S.; Chouraki, V.; Kuzma, A.B.; Sleegers, K.; Vronskaya, M.; Ruiz, A.; Graham, R.R.; Olaso, R.; Hoffmann, P.; Grove, M.L.; Vardarajan, B.N.; Hiltunen, M.; Nöthen, M.M.; White, C.C.; Hamilton-Nelson, K.L.; Epelbaum, J.; Maier, W.; Choi, S.H.; Beecham, G.W.; Dulary, C.; Herms, S.; Smith, A.V.; Funk, C.C.; Derbois, C.; Forstner, A.J.; Ahmad, S.; Li, H.; Bacq, D.; Harold, D.; Satizabal, C.L.; Valladares, O.; Squassina, A.; Thomas, R.; Brody, J.A.; Qu, L.; Sánchez-Juan, P.; Morgan, T.; Wolters, F.J.; Zhao, Y.; Garcia, F.S.; Denning, N.; Fornage, M.; Malamon, J.; Naranjo, M.C.D.; Majounie, E.; Mosley, T.H.; Dombroski, B.; Wallon, D.; Lupton, M.K.; Dupuis, J.; Whitehead, P.; Fratiglioni, L.; Medway, C.; Jian, X.; Mukherjee, S.; Keller, L.; Brown, K.; Lin, H.; Cantwell, L.B.; Panza, F.; McGuinness, B.; Moreno-Grau, S.; Burgess, J.D.; Solfrizzi, V.; Proitsi, P.; Adams, H.H.; Allen, M.; Seripa, D.; Pastor, P.; Cupples, L.A.; Price, N.D.; Hannequin, D.; Frank-García, A.; Levy, D.; Chakrabarty, P.; Caffarra, P.; Giegling, I.; Beiser, A.S.; Giedraitis, V.; Hampel, H.; Garcia, M.E.; Wang, X.; Lannfelt, L.; Mecocci, P.; Eiriksdottir, G.; Crane, P.K.; Pasquier, F.; Boccardi, V. (2017) 'Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease'. Nature Genetics, 49 . [Link] [DOI]
2016 (2016) 'Corrigendum to “Genome-wide association interaction analysis for Alzheimer's disease.” [Neurobiol. Aging (2014) 35 (2436–2443)] (S0197458014003777)(10.1016/j.neurobiolaging.2014.05.014)'. Neurobiology of Aging, . [Link] [DOI]
2016 Whitton, L.; Cosgrove, D.; Clarkson, C.; Harold, D.; Kendall, K.; Richards, A.; Mantripragada, K.; Owen, M.J.; O'Donovan, M.C.; Walters, J.; Hartmann, A.; Konte, B.; Rujescu, D.; Gill, M.; Corvin, A.; Rea, S.; Donohoe, G.; Morris, D.W. (2016) 'Cognitive analysis of schizophrenia risk genes that function as epigenetic regulators of gene expression'. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 171 . [Link] [DOI]
2016 Jun G; Ibrahim-Verbaas CA; Vronskaya M; Lambert JC; Chung J; Naj AC; Kunkle BW; Wang LS; Bis JC; Bellenguez C; Harold D; Lunetta KL; Destefano AL; Grenier-Boley B; Sims R; Beecham GW; Smith AV; Chouraki V; Hamilton-Nelson KL; Ikram MA; Fievet N; Denning N; Martin ER; Schmidt H; Kamatani Y; Dunstan ML; Valladares O; Laza AR; Zelenika D; Ramirez A; Foroud TM; Choi SH; Boland A; Becker T; Kukull WA; van der Lee SJ; Pasquier F; Cruchaga C; Beekly D; Fitzpatrick AL; Hanon O; Gill M; Barber R; Gudnason V; Campion D; Love S; Bennett DA; Amin N; Berr C; Tsolaki M; Buxbaum JD; Lopez OL; Deramecourt V; Fox NC; Cantwell LB; Tárraga L; Dufouil C; Hardy J; Crane PK; Eiriksdottir G; Hannequin D; Clarke R; Evans D; Mosley TH; Letenneur L; Brayne C; Maier W; De Jager P; Emilsson V; Dartigues JF; Hampel H; Kamboh MI; de Bruijn RF; Tzourio C; Pastor P; Larson EB; Rotter JI; O'Donovan MC; Montine TJ; Nalls MA; Mead S; Reiman EM; Jonsson PV; Holmes C; St George-Hyslop PH; Boada M; Passmore P; Wendland JR; Schmidt R; Morgan K; Winslow AR; Powell JF; Carasquillo M; Younkin SG; Jakobsdóttir J; Kauwe JS; Wilhelmsen KC; Rujescu D; Nöthen MM; Hofman A; Jones L; ; Haines JL; Psaty BM; Van Broeckhoven C; Holmans P; Launer LJ; Mayeux R; Lathrop M; Goate AM; Escott-Price V; Seshadri S; Pericak-Vance MA; Amouyel P; Williams J; van Duijn CM; Schellenberg GD; Farrer LA; (2016) 'A novel Alzheimer disease locus located near the gene encoding tau protein'. Molecular Psychiatry, 21 (1). [DOI]
2015 Fan Z; Harold D; Pasqualetti G; Williams J; Brooks DJ; Edison P; (2015) 'Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?'. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56 (5). [DOI]
2015 International Genomics of Alzheimer's Disease Consortium (IGAP) (2015) 'Convergent genetic and expression data implicate immunity in Alzheimer's disease'. Alzheimer's and Dementia, 11 (6). [DOI]
2015 Escott-Price V; Sims R; Bannister C; Harold D; Vronskaya M; Majounie E; Badarinarayan N; ; ; Morgan K; Passmore P; Holmes C; Powell J; Brayne C; Gill M; Mead S; Goate A; Cruchaga C; Lambert JC; van Duijn C; Maier W; Ramirez A; Holmans P; Jones L; Hardy J; Seshadri S; Schellenberg GD; Amouyel P; Williams J; (2015) 'Common polygenic variation enhances risk prediction for Alzheimer's disease'. Brain, 138 (Pt 12). [DOI]
2015 Correia K; Harold D; Kim KH; Holmans P; Jones L; Orth M; Myers RH; Kwak S; Wheeler VC; MacDonald ME; Gusella JF; Lee JM; (2015) 'The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington's Disease'. Journal Of Huntington'S Disease, 4 (3). [DOI]
2015 Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium (2015) 'Identification of Genetic Factors that Modify Clinical Onset of Huntington's Disease'. Cell, 162 (3). [DOI]
2015 Desikan RS; Schork AJ; Wang Y; Witoelar A; Sharma M; McEvoy LK; Holland D; Brewer JB; Chen CH; Thompson WK; Harold D; Williams J; Owen MJ; O'Donovan MC; Pericak-Vance MA; Mayeux R; Haines JL; Farrer LA; Schellenberg GD; Heutink P; Singleton AB; Brice A; Wood NW; Hardy J; Martinez M; Choi SH; DeStefano A; Ikram MA; Bis JC; Smith A; Fitzpatrick AL; Launer L; van Duijn C; Seshadri S; Ulstein ID; Aarsland D; Fladby T; Djurovic S; Hyman BT; Snaedal J; Stefansson H; Stefansson K; Gasser T; Andreassen OA; Dale AM; ; (2015) 'Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus'. Molecular Psychiatry, 20 (12). [DOI]
2014 (2014) 'Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis'. PLoS Medicine, . [Link] [DOI]
2014 Gusareva ES; Carrasquillo MM; Bellenguez C; Cuyvers E; Colon S; Graff-Radford NR; Petersen RC; Dickson DW; Mahachie John JM; Bessonov K; Van Broeckhoven C; ; Harold D; Williams J; Amouyel P; Sleegers K; Ertekin-Taner N; Lambert JC; Van Steen K; Ramirez A; (2014) 'Genome-wide association interaction analysis for Alzheimer's disease'. Neurobiology of Aging, 35 (11). [DOI]
2014 (2014) 'Erratum to Polymorphisms in BACE2 may affect the age of onset Alzheimer's dementia in Down syndrome [Neurobiol. Aging 35 (2014) 1513.e1-1513.e5]'. Neurobiology of Aging, . [Link] [DOI]
2014 Escott-Price V; Bellenguez C; Wang LS; Choi SH; Harold D; Jones L; Holmans P; Gerrish A; Vedernikov A; Richards A; DeStefano AL; Lambert JC; Ibrahim-Verbaas CA; Naj AC; Sims R; Jun G; Bis JC; Beecham GW; Grenier-Boley B; Russo G; Thornton-Wells TA; Denning N; Smith AV; Chouraki V; Thomas C; Ikram MA; Zelenika D; Vardarajan BN; Kamatani Y; Lin CF; Schmidt H; Kunkle B; Dunstan ML; Vronskaya M; ; Johnson AD; Ruiz A; Bihoreau MT; Reitz C; Pasquier F; Hollingworth P; Hanon O; Fitzpatrick AL; Buxbaum JD; Campion D; Crane PK; Baldwin C; Becker T; Gudnason V; Cruchaga C; Craig D; Amin N; Berr C; Lopez OL; De Jager PL; Deramecourt V; Johnston JA; Evans D; Lovestone S; Letenneur L; Hernández I; Rubinsztein DC; Eiriksdottir G; Sleegers K; Goate AM; Fiévet N; Huentelman MJ; Gill M; Brown K; Kamboh MI; Keller L; Barberger-Gateau P; McGuinness B; Larson EB; Myers AJ; Dufouil C; Todd S; Wallon D; Love S; Rogaeva E; Gallacher J; George-Hyslop PS; Clarimon J; Lleo A; Bayer A; Tsuang DW; Yu L; Tsolaki M; Bossù P; Spalletta G; Proitsi P; Collinge J; Sorbi S; Garcia FS; Fox NC; Hardy J; Naranjo MC; Bosco P; Clarke R; Brayne C; Galimberti D; Scarpini E; Bonuccelli U; Mancuso M; Siciliano G; Moebus S; Mecocci P; Zompo MD; Maier W; Hampel H; Pilotto A; Frank-García A; Panza F; Solfrizzi V; Caffarra P; Nacmias B; Perry W; Mayhaus M; Lannfelt L; Hakonarson H; Pichler S; Carrasquillo MM; Ingelsson M; Beekly D; Alvarez V; Zou F; Valladares O; Younkin SG; Coto E; Hamilton-Nelson KL; Gu W; Razquin C; Pastor P; Mateo I; Owen MJ; Faber KM; Jonsson PV; Combarros O; O'Donovan MC; Cantwell LB; Soininen H; Blacker D; Mead S; Mosley TH; Bennett DA; Harris TB; Fratiglioni L; Holmes C; de Bruijn RF; Passmore P; Montine TJ; Bettens K; Rotter JI; Brice A; Morgan K; Foroud TM; Kukull WA; Hannequin D; Powell JF; Nalls MA; Ritchie K; Lunetta KL; Kauwe JS; Boerwinkle E; Riemenschneider M; Boada M; Hiltunen M; Martin ER; Schmidt R; Rujescu D; Dartigues JF; Mayeux R; Tzourio C; Hofman A; Nöthen MM; Graff C; Psaty BM; Haines JL; Lathrop M; Pericak-Vance MA; Launer LJ; Van Broeckhoven C; Farrer LA; van Duijn CM; Ramirez A; Seshadri S; Schellenberg GD; Amouyel P; Williams J; ; (2014) 'Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease'. PLoS ONE, 9 (6). [DOI]
2014 Traylor, M; Adib-Samii, P; Harold, D; , ; , ; Dichgans, M; Williams, J; Lewis, CM; Markus, HS; , ; , (2014) 'Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease'. Annals of Neurology, 79 (5). [DOI]
2014 Hinney A; Albayrak O; Antel J; Volckmar AL; Sims R; Chapman J; Harold D; Gerrish A; Heid IM; Winkler TW; Scherag A; Wiltfang J; Williams J; Hebebrand J; ; ; ; (2014) 'Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity'. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics, 165B (4). [DOI]
2014 (2014) 'Erratum to Polymorphisms in BACE2 may affect the age of onset Alzheimer's dementia in Down syndrome [Neurobiol. Aging 35, (2014), 1513.e1-1513.e5], doi:10.1016/j.neurobiolaging.2013.12.022'. Neurobiology of Aging, . [Link] [DOI]
2014 Mok KY; Jones EL; Hanney M; Harold D; Sims R; Williams J; Ballard C; Hardy J; (2014) 'Polymorphisms in BACE2 may affect the age of onset Alzheimer's dementia in Down syndrome'. Neurobiology of Aging, 35 (6). [DOI]
2014 Ruiz A; Heilmann S; Becker T; Hernández I; Wagner H; Thelen M; Mauleón A; Rosende-Roca M; Bellenguez C; Bis JC; Harold D; Gerrish A; Sims R; Sotolongo-Grau O; Espinosa A; Alegret M; Arrieta JL; Lacour A; Leber M; Becker J; Lafuente A; Ruiz S; Vargas L; Rodríguez O; Ortega G; Dominguez MA; ; Mayeux R; Haines JL; Pericak-Vance MA; Farrer LA; Schellenberg GD; Chouraki V; Launer LJ; van Duijn C; Seshadri S; Antúnez C; Breteler MM; Serrano-Ríos M; Jessen F; Tárraga L; Nöthen MM; Maier W; Boada M; Ramírez A; (2014) 'Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene'. Translational Psychiatry, 4 . [DOI]
2014 Benitez BA; Jin SC; Guerreiro R; Graham R; Lord J; Harold D; Sims R; Lambert JC; Gibbs JR; Bras J; Sassi C; Harari O; Bertelsen S; Lupton MK; Powell J; Bellenguez C; Brown K; Medway C; Haddick PC; van der Brug MP; Bhangale T; Ortmann W; Behrens T; Mayeux R; Pericak-Vance MA; Farrer LA; Schellenberg GD; Haines JL; Turton J; Braae A; Barber I; Fagan AM; Holtzman DM; Morris JC; ; ; ; ; ; Williams J; Kauwe JS; Amouyel P; Morgan K; Singleton A; Hardy J; Goate AM; Cruchaga C; (2014) 'Missense variant in TREML2 protects against Alzheimer's disease'. Neurobiology of Aging, 35 (6). [DOI]
2013 Chapuis J; Hansmannel F; Gistelinck M; Mounier A; Van Cauwenberghe C; Kolen KV; Geller F; Sottejeau Y; Harold D; Dourlen P; Grenier-Boley B; Kamatani Y; Delepine B; Demiautte F; Zelenika D; Zommer N; Hamdane M; Bellenguez C; Dartigues JF; Hauw JJ; Letronne F; Ayral AM; Sleegers K; Schellens A; Broeck LV; Engelborghs S; De Deyn PP; Vandenberghe R; O'Donovan M; Owen M; Epelbaum J; Mercken M; Karran E; Bantscheff M; Drewes G; Joberty G; Campion D; Octave JN; Berr C; Lathrop M; Callaerts P; Mann D; Williams J; Buée L; Dewachter I; Van Broeckhoven C; Amouyel P; Moechars D; Dermaut B; Lambert JC; ; (2013) 'Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology'. Molecular Psychiatry, 18 (11). [DOI]
2013 Chapman J; Rees E; Harold D; Ivanov D; Gerrish A; Sims R; Hollingworth P; Stretton A; ; Holmans P; Owen MJ; O'Donovan MC; Williams J; Kirov G; (2013) 'A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk'. Human Molecular Genetics, 22 (4). [DOI]
2013 (2013) 'Erratum: Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease (Molecular Psychiatry (2013) 18 (521) DOI: 10.1038/mp.2012.75))'. Molecular Psychiatry, . [Link] [DOI]
2013 Jones EL; Mok K; Hanney M; Harold D; Sims R; Williams J; Ballard C; (2013) 'Evidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome'. Neurobiology of Aging, 34 (10). [DOI]
2013 Lambert JC; Grenier-Boley B; Harold D; Zelenika D; Chouraki V; Kamatani Y; Sleegers K; Ikram MA; Hiltunen M; Reitz C; Mateo I; Feulner T; Bullido M; Galimberti D; Concari L; Alvarez V; Sims R; Gerrish A; Chapman J; Deniz-Naranjo C; Solfrizzi V; Sorbi S; Arosio B; Spalletta G; Siciliano G; Epelbaum J; Hannequin D; Dartigues JF; Tzourio C; Berr C; Schrijvers EM; Rogers R; Tosto G; Pasquier F; Bettens K; Van Cauwenberghe C; Fratiglioni L; Graff C; Delepine M; Ferri R; Reynolds CA; Lannfelt L; Ingelsson M; Prince JA; Chillotti C; Pilotto A; Seripa D; Boland A; Mancuso M; Bossù P; Annoni G; Nacmias B; Bosco P; Panza F; Sanchez-Garcia F; Del Zompo M; Coto E; Owen M; O'Donovan M; Valdivieso F; Caffarra P; Caffara P; Scarpini E; Combarros O; Buée L; Campion D; Soininen H; Breteler M; Riemenschneider M; Van Broeckhoven C; Alpérovitch A; Lathrop M; Trégouët DA; Williams J; Amouyel P; (2013) 'Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease'. Molecular Psychiatry, 18 (4). [DOI]
2013 Lambert JC; Ibrahim-Verbaas CA; Harold D; Naj AC; Sims R; Bellenguez C; DeStafano AL; Bis JC; Beecham GW; Grenier-Boley B; Russo G; Thorton-Wells TA; Jones N; Smith AV; Chouraki V; Thomas C; Ikram MA; Zelenika D; Vardarajan BN; Kamatani Y; Lin CF; Gerrish A; Schmidt H; Kunkle B; Dunstan ML; Ruiz A; Bihoreau MT; Choi SH; Reitz C; Pasquier F; Cruchaga C; Craig D; Amin N; Berr C; Lopez OL; De Jager PL; Deramecourt V; Johnston JA; Evans D; Lovestone S; Letenneur L; Morón FJ; Rubinsztein DC; Eiriksdottir G; Sleegers K; Goate AM; Fiévet N; Huentelman MW; Gill M; Brown K; Kamboh MI; Keller L; Barberger-Gateau P; McGuiness B; Larson EB; Green R; Myers AJ; Dufouil C; Todd S; Wallon D; Love S; Rogaeva E; Gallacher J; St George-Hyslop P; Clarimon J; Lleo A; Bayer A; Tsuang DW; Yu L; Tsolaki M; Bossù P; Spalletta G; Proitsi P; Collinge J; Sorbi S; Sanchez-Garcia F; Fox NC; Hardy J; Deniz Naranjo MC; Bosco P; Clarke R; Brayne C; Galimberti D; Mancuso M; Matthews F; ; ; ; ; Moebus S; Mecocci P; Del Zompo M; Maier W; Hampel H; Pilotto A; Bullido M; Panza F; Caffarra P; Nacmias B; Gilbert JR; Mayhaus M; Lannefelt L; Hakonarson H; Pichler S; Carrasquillo MM; Ingelsson M; Beekly D; Alvarez V; Zou F; Valladares O; Younkin SG; Coto E; Hamilton-Nelson KL; Gu W; Razquin C; Pastor P; Mateo I; Owen MJ; Faber KM; Jonsson PV; Combarros O; O'Donovan MC; Cantwell LB; Soininen H; Blacker D; Mead S; Mosley TH; Bennett DA; Harris TB; Fratiglioni L; Holmes C; de Bruijn RF; Passmore P; Montine TJ; Bettens K; Rotter JI; Brice A; Morgan K; Foroud TM; Kukull WA; Hannequin D; Powell JF; Nalls MA; Ritchie K; Lunetta KL; Kauwe JS; Boerwinkle E; Riemenschneider M; Boada M; Hiltuenen M; Martin ER; Schmidt R; Rujescu D; Wang LS; Dartigues JF; Mayeux R; Tzourio C; Hofman A; Nöthen MM; Graff C; Psaty BM; Jones L; Haines JL; Holmans PA; Lathrop M; Pericak-Vance MA; Launer LJ; Farrer LA; van Duijn CM; Van Broeckhoven C; Moskvina V; Seshadri S; Williams J; Schellenberg GD; Amouyel P; (2013) 'Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease'. Nature Genetics, 45 (12). [DOI]
2013 Cruchaga C; Kauwe JS; Harari O; Jin SC; Cai Y; Karch CM; Benitez BA; Jeng AT; Skorupa T; Carrell D; Bertelsen S; Bailey M; McKean D; Shulman JM; De Jager PL; Chibnik L; Bennett DA; Arnold SE; Harold D; Sims R; Gerrish A; Williams J; Van Deerlin VM; Lee VM; Shaw LM; Trojanowski JQ; Haines JL; Mayeux R; Pericak-Vance MA; Farrer LA; Schellenberg GD; Peskind ER; Galasko D; Fagan AM; Holtzman DM; Morris JC; ; ; ; Goate AM; (2013) 'GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease'. Neuron, 78 (2). [DOI]
2013 Moskvina V; Harold D; Russo G; Vedernikov A; Sharma M; Saad M; Holmans P; Bras JM; Bettella F; Keller MF; Nicolaou N; Simón-Sánchez J; Gibbs JR; Schulte C; Durr A; Guerreiro R; Hernandez D; Brice A; Stefánsson H; Majamaa K; Gasser T; Heutink P; Wood N; Martinez M; Singleton AB; Nalls MA; Hardy J; Owen MJ; O'Donovan MC; Williams J; Morris HR; Williams NM; ; (2013) 'Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk'. JAMA Neurology, 70 (10). [DOI]
2013 (2013) 'Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics (2009) 41 (1088-1093))'. Nature Genetics, . [Link] [DOI]
2013 Brayne C; Barker RA; Harold D; Ince PG; Savva GM; Williams J; Williams-Gray CH; Wharton SB; (2013) 'From molecule to clinic and community for neurodegeneration: research to bridge translational gaps'. Journal of Alzheimer's Disease, 33 Suppl 1 . [DOI]
2013 Lee SH; Harold D; Nyholt DR; ; ; ; Goddard ME; Zondervan KT; Williams J; Montgomery GW; Wray NR; Visscher PM; (2013) 'Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis'. Human Molecular Genetics, 22 (4). [DOI]
2012 (2012) 'From molecule to clinic and community for neurodegeneration: Research to bridge translational gaps'. Advances in Alzheimer's Disease, . [Link] [DOI]
2012 Gerrish A; Russo G; Richards A; Moskvina V; Ivanov D; Harold D; Sims R; Abraham R; Hollingworth P; Chapman J; Hamshere M; Pahwa JS; Dowzell K; Williams A; Jones N; Thomas C; Stretton A; Morgan AR; Lovestone S; Powell J; Proitsi P; Lupton MK; Brayne C; Rubinsztein DC; Gill M; Lawlor B; Lynch A; Morgan K; Brown KS; Passmore PA; Craig D; McGuinness B; Todd S; Johnston JA; Holmes C; Mann D; Smith AD; Love S; Kehoe PG; Hardy J; Mead S; Fox N; Rossor M; Collinge J; Maier W; Jessen F; Kölsch H; Heun R; Schürmann B; van den Bussche H; Heuser I; Kornhuber J; Wiltfang J; Dichgans M; Frölich L; Hampel H; Hüll M; Rujescu D; Goate AM; Kauwe JS; Cruchaga C; Nowotny P; Morris JC; Mayo K; Livingston G; Bass NJ; Gurling H; McQuillin A; Gwilliam R; Deloukas P; Davies G; Harris SE; Starr JM; Deary IJ; Al-Chalabi A; Shaw CE; Tsolaki M; Singleton AB; Guerreiro R; Mühleisen TW; Nöthen MM; Moebus S; Jöckel KH; Klopp N; Wichmann HE; Carrasquillo MM; Pankratz VS; Younkin SG; Jones L; Holmans PA; O'Donovan MC; Owen MJ; Williams J; (2012) 'The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease'. Journal of Alzheimer's Disease, 28 (2). [DOI]
2012 Hollingworth P; Sweet R; Sims R; Harold D; Russo G; Abraham R; Stretton A; Jones N; Gerrish A; Chapman J; Ivanov D; Moskvina V; Lovestone S; Priotsi P; Lupton M; Brayne C; Gill M; Lawlor B; Lynch A; Craig D; McGuinness B; Johnston J; Holmes C; Livingston G; Bass NJ; Gurling H; McQuillin A; ; ; Holmans P; Jones L; Devlin B; Klei L; Barmada MM; Demirci FY; DeKosky ST; Lopez OL; Passmore P; Owen MJ; O'Donovan MC; Mayeux R; Kamboh MI; Williams J; (2012) 'Genome-wide association study of Alzheimer's disease with psychotic symptoms'. Molecular Psychiatry, 17 (12). [DOI]
2012 Proitsi, P.; Lupton, M.K.; Dudbridge, F.; Tsolaki, M.; Hamilton, G.; Daniilidou, M.; Pritchard, M.; Lord, K.; Martin, B.M.; Craig, D.; Todd, S.; McGuinness, B.; Hollingworth, P.; Harold, D.; Kloszewska, I.; Soininen, H.; Mecocci, P.; Velas, B.; Gill, M.; Lawlor, B.; Rubinsztein, D.C.; Brayne, C.; Passmore, P.A.; Williams, J.; Lovestone, S.; Powell, J.F. (2012) 'Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation'. Neurobiology of Aging, . [Link]
2012 Proitsi P; Lupton MK; Dudbridge F; Tsolaki M; Hamilton G; Daniilidou M; Pritchard M; Lord K; Martin BM; Johnson J; Craig D; Todd S; McGuinness B; Hollingworth P; Harold D; Kloszewska I; Soininen H; Mecocci P; Velas B; Gill M; Lawlor B; Rubinsztein DC; Brayne C; Passmore PA; Williams J; Lovestone S; Powell JF; (2012) 'Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation'. Neurobiology of Aging, 33 (8). [DOI]
2012 Hudson G; Sims R; Harold D; Chapman J; Hollingworth P; Gerrish A; Russo G; Hamshere M; Moskvina V; Jones N; Thomas C; Stretton A; Holmans PA; O'Donovan MC; Owen MJ; Williams J; Chinnery PF; ; (2012) 'No consistent evidence for association between mtDNA variants and Alzheimer disease'. Neurology, 78 (14). [DOI]
2012 Hollingworth, P.; Sweet, R.; Sims, R.; Harold, D.; Russo, G.; Abraham, R.; Stretton, A.; Jones, N.; Gerrish, A.; Chapman, J.; Ivanov, D.; Moskvina, V.; Lovestone, S.; Priotsi, P.; Lupton, M.; Brayne, C.; Gill, M.; Lawlor, B.; Lynch, A.; Craig, D.; McGuinness, B.; Johnston, J.; Holmes, C.; Livingston, G.; Bass, N.J.; Gurling, H.; McQuillin, A.; Holmans, P.; Jones, L.; Devlin, B.; Klei, L.; Barmada, M.M.; Demirci, F.Y.; Dekosky, S.T.; Lopez, O.L.; Passmore, P.; Owen, M.J.; O'Donovan, M.C.; Mayeux, R.; Kamboh, M.I.; Williams, J. (2012) 'Genome-wide association study of Alzheimer's disease with psychotic symptoms'. Molecular Psychiatry, . [Link] [DOI]
2012 Lescai F; Bonfiglio S; Bacchelli C; Chanudet E; Waters A; Sisodiya SM; Kasperavičiūtė D; Williams J; Harold D; Hardy J; Kleta R; Cirak S; Williams R; Achermann JC; Anderson J; Kelsell D; Vulliamy T; Houlden H; Wood N; Sheerin U; Tonini GP; Mackay D; Hussain K; Sowden J; Kinsler V; Osinska J; Brooks T; Hubank M; Beales P; Stupka E; (2012) 'Characterisation and validation of insertions and deletions in 173 patient exomes'. PLoS ONE, 7 (12). [DOI]
2011 Reitz C; Cheng R; Rogaeva E; Lee JH; Tokuhiro S; Zou F; Bettens K; Sleegers K; Tan EK; Kimura R; Shibata N; Arai H; Kamboh MI; Prince JA; Maier W; Riemenschneider M; Owen M; Harold D; Hollingworth P; Cellini E; Sorbi S; Nacmias B; Takeda M; Pericak-Vance MA; Haines JL; Younkin S; Williams J; van Broeckhoven C; Farrer LA; St George-Hyslop PH; Mayeux R; ; (2011) 'Meta-analysis of the association between variants in SORL1 and Alzheimer disease'. Archives of Neurology, 68 (1). [DOI]
2011 Sims R; Dwyer S; Harold D; Gerrish A; Hollingworth P; Chapman J; Jones N; Abraham R; Ivanov D; Pahwa JS; Moskvina V; Dowzell K; Thomas C; Stretton A; Lovestone S; Powell J; Proitsi P; Lupton MK; Brayne C; Rubinsztein DC; Gill M; Lawlor B; Lynch A; Morgan K; Brown KS; Passmore PA; Craig D; McGuiness B; Todd S; Johnston JA; Holmes C; Mann D; Smith AD; Love S; Kehoe PG; Hardy J; Mead S; Fox N; Rossor M; Collinge J; Livingston G; Bass NJ; Gurling H; McQuillin A; Jones L; Holmans PA; O'Donovan M; Owen MJ; Williams J; (2011) 'No evidence that extended tracts of homozygosity are associated with Alzheimer's disease'. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics, 156B (7). [DOI]
2011 Lupton MK; Proitsi P; Danillidou M; Tsolaki M; Hamilton G; Wroe R; Pritchard M; Lord K; Martin BM; Kloszewska I; Soininen H; Mecocci P; Vellas B; Harold D; Hollingworth P; Lovestone S; Powell JF; (2011) 'Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease'. PLoS ONE, 6 (2). [DOI]
2011 Hollingworth P; Harold D; Sims R; Gerrish A; Lambert JC; Carrasquillo MM; Abraham R; Hamshere ML; Pahwa JS; Moskvina V; Dowzell K; Jones N; Stretton A; Thomas C; Richards A; Ivanov D; Widdowson C; Chapman J; Lovestone S; Powell J; Proitsi P; Lupton MK; Brayne C; Rubinsztein DC; Gill M; Lawlor B; Lynch A; Brown KS; Passmore PA; Craig D; McGuinness B; Todd S; Holmes C; Mann D; Smith AD; Beaumont H; Warden D; Wilcock G; Love S; Kehoe PG; Hooper NM; Vardy ER; Hardy J; Mead S; Fox NC; Rossor M; Collinge J; Maier W; Jessen F; Rüther E; Schürmann B; Heun R; Kölsch H; van den Bussche H; Heuser I; Kornhuber J; Wiltfang J; Dichgans M; Frölich L; Hampel H; Gallacher J; Hüll M; Rujescu D; Giegling I; Goate AM; Kauwe JS; Cruchaga C; Nowotny P; Morris JC; Mayo K; Sleegers K; Bettens K; Engelborghs S; De Deyn PP; Van Broeckhoven C; Livingston G; Bass NJ; Gurling H; McQuillin A; Gwilliam R; Deloukas P; Al-Chalabi A; Shaw CE; Tsolaki M; Singleton AB; Guerreiro R; Mühleisen TW; Nöthen MM; Moebus S; Jöckel KH; Klopp N; Wichmann HE; Pankratz VS; Sando SB; Aasly JO; Barcikowska M; Wszolek ZK; Dickson DW; Graff-Radford NR; Petersen RC; ; van Duijn CM; Breteler MM; Ikram MA; DeStefano AL; Fitzpatrick AL; Lopez O; Launer LJ; Seshadri S; ; Berr C; Campion D; Epelbaum J; Dartigues JF; Tzourio C; Alpérovitch A; Lathrop M; ; Feulner TM; Friedrich P; Riehle C; Krawczak M; Schreiber S; Mayhaus M; Nicolhaus S; Wagenpfeil S; Steinberg S; Stefansson H; Stefansson K; Snaedal J; Björnsson S; Jonsson PV; Chouraki V; Genier-Boley B; Hiltunen M; Soininen H; Combarros O; Zelenika D; Delepine M; Bullido MJ; Pasquier F; Mateo I; Frank-Garcia A; Porcellini E; Hanon O; Coto E; Alvarez V; Bosco P; Siciliano G; Mancuso M; Panza F; Solfrizzi V; Nacmias B; Sorbi S; Bossù P; Piccardi P; Arosio B; Annoni G; Seripa D; Pilotto A; Scarpini E; Galimberti D; Brice A; Hannequin D; Licastro F; Jones L; Holmans PA; Jonsson T; Riemenschneider M; Morgan K; Younkin SG; Owen MJ; O'Donovan M; Amouyel P; Williams J; (2011) 'Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease'. Nature Genetics, 43 (5). [DOI]
2011 Hollingworth P; Harold D; Jones L; Owen MJ; Williams J; (2011) 'Alzheimer's disease genetics: current knowledge and future challenges'. International Journal of Geriatric Psychiatry, 26 (8). [DOI]
2010 Seshadri S; Fitzpatrick AL; Ikram MA; DeStefano AL; Gudnason V; Boada M; Bis JC; Smith AV; Carassquillo MM; Lambert JC; Harold D; Schrijvers EM; Ramirez-Lorca R; Debette S; Longstreth WT; Janssens AC; Pankratz VS; Dartigues JF; Hollingworth P; Aspelund T; Hernandez I; Beiser A; Kuller LH; Koudstaal PJ; Dickson DW; Tzourio C; Abraham R; Antunez C; Du Y; Rotter JI; Aulchenko YS; Harris TB; Petersen RC; Berr C; Owen MJ; Lopez-Arrieta J; Varadarajan BN; Becker JT; Rivadeneira F; Nalls MA; Graff-Radford NR; Campion D; Auerbach S; Rice K; Hofman A; Jonsson PV; Schmidt H; Lathrop M; Mosley TH; Au R; Psaty BM; Uitterlinden AG; Farrer LA; Lumley T; Ruiz A; Williams J; Amouyel P; Younkin SG; Wolf PA; Launer LJ; Lopez OL; van Duijn CM; Breteler MM; ; ; ; (2010) 'Genome-wide analysis of genetic loci associated with Alzheimer disease'. Jama, 303 (18). [DOI]
2010 Jones L; Holmans PA; Hamshere ML; Harold D; Moskvina V; Ivanov D; Pocklington A; Abraham R; Hollingworth P; Sims R; Gerrish A; Pahwa JS; Jones N; Stretton A; Morgan AR; Lovestone S; Powell J; Proitsi P; Lupton MK; Brayne C; Rubinsztein DC; Gill M; Lawlor B; Lynch A; Morgan K; Brown KS; Passmore PA; Craig D; McGuinness B; Todd S; Holmes C; Mann D; Smith AD; Love S; Kehoe PG; Mead S; Fox N; Rossor M; Collinge J; Maier W; Jessen F; Schürmann B; Heun R; Kölsch H; van den Bussche H; Heuser I; Peters O; Kornhuber J; Wiltfang J; Dichgans M; Frölich L; Hampel H; Hüll M; Rujescu D; Goate AM; Kauwe JS; Cruchaga C; Nowotny P; Morris JC; Mayo K; Livingston G; Bass NJ; Gurling H; McQuillin A; Gwilliam R; Deloukas P; Al-Chalabi A; Shaw CE; Singleton AB; Guerreiro R; Mühleisen TW; Nöthen MM; Moebus S; Jöckel KH; Klopp N; Wichmann HE; Rüther E; Carrasquillo MM; Pankratz VS; Younkin SG; Hardy J; O'Donovan MC; Owen MJ; Williams J; (2010) 'Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease'. PLoS ONE, 5 (11). [DOI]
2010 Cruchaga C; Kauwe JS; Mayo K; Spiegel N; Bertelsen S; Nowotny P; Shah AR; Abraham R; Hollingworth P; Harold D; Owen MM; Williams J; Lovestone S; Peskind ER; Li G; Leverenz JB; Galasko D; ; Morris JC; Fagan AM; Holtzman DM; Goate AM; (2010) 'SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease'. PLoS Genetics, 6 (9). [DOI]
2010 Kauwe JS; Bertelsen S; Mayo K; Cruchaga C; Abraham R; Hollingworth P; Harold D; Owen MJ; Williams J; Lovestone S; Morris JC; Goate AM; ; (2010) 'Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease'. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics, 153B (4). [DOI]
2010 Jones L; Harold D; Williams J; (2010) 'Genetic evidence for the involvement of lipid metabolism in Alzheimer's disease'. Biochimica et biophysica acta, 1801 (8). [DOI]
2010 Pagnamenta AT; Bacchelli E; de Jonge MV; Mirza G; Scerri TS; Minopoli F; Chiocchetti A; Ludwig KU; Hoffmann P; Paracchini S; Lowy E; Harold DH; Chapman JA; Klauck SM; Poustka F; Houben RH; Staal WG; Ophoff RA; O'Donovan MC; Williams J; Nöthen MM; Schulte-Körne G; Deloukas P; Ragoussis J; Bailey AJ; Maestrini E; Monaco AP; ; (2010) 'Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia'. Biological Psychiatry, 68 (4). [DOI]
2009 Harold, D.; Abraham, R.; Hollingworth, P.; Sims, R.; Gerrish, A.; Hamshere, M.L.; Pahwa, J.S.; Moskvina, V.; Dowzell, K.; Williams, A.; Jones, N.; Thomas, C.; Stretton, A.; Morgan, A.R.; Lovestone, S.; Powell, J.; Proitsi, P.; Lupton, M.K.; Brayne, C.; Rubinsztein, D.C.; Gill, M.; Lawlor, B.; Lynch, A.; Morgan, K.; Brown, K.S.; Passmore, P.A.; Craig, D.; McGuinness, B.; Todd, S.; Holmes, C.; Mann, D.; Smith, A.D.; Love, S.; Kehoe, P.G.; Hardy, J.; Mead, S.; Fox, N.; Rossor, M.; Collinge, J.; Maier, W.; Jessen, F.; Schürmann, B.; Heun, R.; Van Den Bussche, H.; Heuser, I.; Kornhuber, J.; Wiltfang, J.; Dichgans, M.; Frölich, L.; Hampel, H.; Hüll, M.; Rujescu, D.; Goate, A.M.; Kauwe, J.S.K.; Cruchaga, C.; Nowotny, P.; Morris, J.C.; Mayo, K.; Sleegers, K.; Bettens, K.; Engelborghs, S.; De Deyn, P.P.; Van Broeckhoven, C.; Livingston, G.; Bass, N.J.; Gurling, H.; McQuillin, A.; Gwilliam, R.; Deloukas, P.; Al-Chalabi, A.; Shaw, C.E.; Tsolaki, M.; Singleton, A.B.; Guerreiro, R.; Guerreiro, R.; Nöthen, M.M.; Moebus, S.; Jöckel, K.-H.; Klopp, N.; Wichmann, H.-E.; Carrasquillo, M.M.; Pankratz, V.S.; Younkin, S.G.; Holmans, P.A.; O'Donovan, M.; Owen, M.J.; Williams, J. (2009) 'Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics) (2009) 41 (1088-1093))'. Nature Genetics, . [Link] [DOI]
2009 Harold D; Abraham R; Hollingworth P; Sims R; Gerrish A; Hamshere ML; Pahwa JS; Moskvina V; Dowzell K; Williams A; Jones N; Thomas C; Stretton A; Morgan AR; Lovestone S; Powell J; Proitsi P; Lupton MK; Brayne C; Rubinsztein DC; Gill M; Lawlor B; Lynch A; Morgan K; Brown KS; Passmore PA; Craig D; McGuinness B; Todd S; Holmes C; Mann D; Smith AD; Love S; Kehoe PG; Hardy J; Mead S; Fox N; Rossor M; Collinge J; Maier W; Jessen F; Schürmann B; Heun R; van den Bussche H; Heuser I; Kornhuber J; Wiltfang J; Dichgans M; Frölich L; Hampel H; Hüll M; Rujescu D; Goate AM; Kauwe JS; Cruchaga C; Nowotny P; Morris JC; Mayo K; Sleegers K; Bettens K; Engelborghs S; De Deyn PP; Van Broeckhoven C; Livingston G; Bass NJ; Gurling H; McQuillin A; Gwilliam R; Deloukas P; Al-Chalabi A; Shaw CE; Tsolaki M; Singleton AB; Guerreiro R; Mühleisen TW; Nöthen MM; Moebus S; Jöckel KH; Klopp N; Wichmann HE; Carrasquillo MM; Pankratz VS; Younkin SG; Holmans PA; O'Donovan M; Owen MJ; Williams J; (2009) 'Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease'. Nature Genetics, 41 (10). [DOI]
2008 Morgan AR; Hamilton G; Turic D; Jehu L; Harold D; Abraham R; Hollingworth P; Moskvina V; Brayne C; Rubinsztein DC; Lynch A; Lawlor B; Gill M; O'Donovan M; Powell J; Lovestone S; Williams J; Owen MJ; (2008) 'Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease'. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics, 147B (6). [DOI]
2007 Harold D; Jehu L; Turic D; Hollingworth P; Moore P; Summerhayes P; Moskvina V; Foy C; Archer N; Hamilton BA; Lovestone S; Powell J; Brayne C; Rubinsztein DC; Jones L; O'Donovan MC; Owen MJ; Williams J; (2007) 'Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease'. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics, 144B (4). [DOI]
2006 Harold, D.; Paracchini, S.; Scerri, T.; Dennis, M.; Cope, N.; Hill, G.; Moskvina, V.; Walter, J.; Richardson, A.J.; Owen, M.J.; Stein, J.F.; Green, E.D.; O'Donovan, M.C.; Williams, J.; Monaco, A.P. (2006) 'Linkage disequilibrium structure of KIAA0319 and DCDC2, two candidate susceptibility genes for developmental dyslexia'. Molecular Psychiatry, . [Link] [DOI]
2006 Harold D; Paracchini S; Scerri T; Dennis M; Cope N; Hill G; Moskvina V; Walter J; Richardson AJ; Owen MJ; Stein JF; Green ED; O'Donovan MC; Williams J; Monaco AP; (2006) 'Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia'. Molecular Psychiatry, 11 (12). [DOI]
2006 Harold, D.; MacGregor, S.; Patterson, C.E.; Hollingworth, P.; Moore, P.; Owen, M.J.; Williams, J.; O'Donovan, M.; Passmore, P.; McIlroy, S.; Jones, L. (2006) 'A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease'. Pharmacogenetics and Genomics, . [Link]
2005 Cope N; Harold D; Hill G; Moskvina V; Stevenson J; Holmans P; Owen MJ; O'Donovan MC; Williams J; (2005) 'Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia'. American Journal of Human Genetics, 76 (4). [DOI]
2004 Barratt, B.J.; Payne, F.; Lowe, C.E.; Hermann, R.; Healy, B.C.; Harold, D.; Concannon, P.; Gharani, N.; McCarthy, M.I.; Olavesen, M.G.; McCormack, R.; Guja, C.; Ionescu-Tîrgovişte, C.; Undlien, D.E.; Rønningen, K.S.; Gillespie, K.M.; Tuomilehto-Wolf, E.; Tuomilehto, J.; Bennett, S.T.; Clayton, D.G.; Cordell, H.J.; Todd, J.A. (2004) 'Remapping the insulin gene/IDDM2 locus in type 1 diabetes'. Diabetes, . [Link] [DOI]
2004 Busby V; Goossens S; Nowotny P; Hamilton G; Smemo S; Harold D; Turic D; Jehu L; Myers A; Womick M; Woo D; Compton D; Doil LM; Tacey KM; Lau KF; Al-Saraj S; Killick R; Pickering-Brown S; Moore P; Hollingworth P; Archer N; Foy C; Walter S; Lendon C; Iwatsubo T; Morris JC; Norton J; Mann D; Janssens B; Hardy J; O'Donovan M; Jones L; Williams J; Holmans P; Owen MJ; Grupe A; Powell J; van Hengel J; Goate A; Van Roy F; Lovestone S; (2004) 'Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease'. NeuroMolecular Medicine, 5 (2). [DOI]
2003 Harold D; Peirce T; Moskvina V; Myers A; Jones S; Hollingworth P; Moore P; Lovestone S; Powell J; Foy C; Archer N; Walter S; Edmonson A; McIlroy S; Craig D; Passmore PA; Goate A; Hardy J; O'Donovan M; Williams J; Liddell M; Owen MJ; Jones L; (2003) 'Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease'. Human Genetics, 113 (3). [DOI]
2000 Breen, G.; Harold, D.; Ralston, S.; Shaw, D.; Clair, D.St. (2000) 'Determining SNP allele frequencies in DNA pools'. BioTechniques, . [Link]

Other Publication

Year Publication
2021 O'Flynn, D.; Lawler, J.; Yusuf, A.; Parle-Mcdermott, A.; Harold, D.; Mc Cloughlin, T.; Holland, L.; Regan, F.; White, B. (2021) A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic. [Link] [DOI]
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