School of Biotechnology
Academic biography1990-1991; Post Doctoral Fellow, Department of Pharmacology, New York Medical College, Valhalla, NY, USA: 1991-1992; Research Associate, Department of Physiology & Biophysics, University of Tennessee, Memphis, TN, USA, 1992-1995; Instructor, Department of Surgery, Johns Hopkins University Hospital, Baltimore MD, USA; 1995-1997 Assistant Professor, Department of Surgery, Georgetown University, Washington DC, USA, 1997-1999; Associate Professor, Department of Surgery, Georgetown University, Washington DC, USA; 1999 Professor of Surgery, University of Rochester Medical Center, Rochester NY, USA, 1999-2005; Adjunct Professor, Department of Surgery, University of Rochester Medical Center, Rochester NY, USA, 1999-2001; Wellcome Trust New Blood Fellow/Senior Lecturer, School of Biotechnology, DCU, 2001-2015; Associate Professor, School of Biotechnology, DCU, 2001-2006; Director, Vascular Health Research Centre,DCU, 2016-to date; Full Professor, School of Biotechnology
Research interestsCardiovascular diseases remain a major cause of mortality worldwide.
Vascular biology is an exciting and rapidly advancing area of biomedical research that has led to significant insights into the treatment not only of vascular diseases such as atherosclerosis, arteriosclerosis, in-stent restenosis and hypertension, but also diabetes and tumor development.
MAJOR RESEARCH AREAS
The role of gene regulatory networks in controlling resident vascular stem cell fate and myogenic and myeloid differentiation
The role of mechanical stimuli in dictating developmental gene regulatory network control of vascular smooth muscle and endothelial cell phenotype and fate.
Lineage tracing analysis and epigenetic profiling of resident vascular stem cells
Vascular tissue engineering