School of Chemical Sciences
Academic staff - Organic Chemistry
Academic biographyNessan Kerrigan obtained his B.Sc. in Chemistry from University College Dublin (1992-1996). He then completed his Ph.D. in Chemistry at University College Dublin (1996-2000) under the direction of Professor Declan G. Gilheany. He spent a year in industry working as a process development chemist for Merck before carrying out postdoctoral research at the University of Glasgow (2002-2004) with Professor David J. Procter. He carried out further postdoctoral research at the University of Pittsburgh (2004-2006) with Prof. Scott G. Nelson. Dr. Kerrigan began his independent research career at Oakland University in 2006. The Kerrigan group carries out research in the area of synthetic organic chemistry. Most of their work is of the basic/fundamental chemistry research kind and is focused on the development of new efficient methods for the construction of biologically interesting organic molecules. In August 2017, Dr. Kerrigan returned to Ireland to take up a position as Lecturer in the School of Chemical Sciences at Dublin City University.
Research interestsOur group’s research is concerned with the development of efficient enantioselective and diastereoselective synthetic methods, and their application to the synthesis of drug molecules and natural products. We also carry out extensive mechanistic studies of our new reactions, principally through NMR spectroscopy (e.g. 31P NMR and 1H NMR), to gain mechanistic insight, identify intermediates, and establish general patterns of reactivity. Much of our studies in recent years have involved the development of chiral organic nucleophile-catalyzed synthetic methods. Specifically, we have developed a number of chiral phosphine-catalyzed reactions of ketenes providing versatile methods for the asymmetric synthesis of biologically important molecules such as β-lactones (ketene dimers and saturated β-lactones) and β-lactams.
In 2012, we disclosed the first catalytic asymmetric heterodimerization of ketenes. This reaction was catalyzed by an alkaloid nucleophile (a quinine or quinidine derivative) to give a β-lactone ketene heterodimer product. One current avenue of intense research in our lab involves elaboration of our ketene heterodimer products to cancer therapeutic agents and complex molecules isolated from mycobacterium tuberculosis. We also have an interest in sulfur and phosphorus chemistry, as well as the development of new transition metal-catalyzed cross-coupling reactions. In the area of sulfoxonium ylide chemistry, we published a modification of the Johnson-Corey-Chaykovsky reaction which facilitated a synthesis of gamma-lactones, through interception of a sulfoxonium ylide-derived betaine intermediate by a ketene molecule. This work has more recently led to us to investigate new reactions of vinyl sulfoxonium salts, providing routes to pharmaceutically important cyclic molecules.